Ectopic chromosome around centrosome in metaphase cells as a marker of high-risk human papillomavirus-associated cervical intraepithelial neoplasias.


:This report describes the appearance of ectopic chromosome around centrosome (ECAC) in metaphase cell nuclei of high-risk HPV-associated cervical neoplasms. ECAC are clearly visible on HE-stained sections as a tiny (approx. 0.7 micro), round, dark structure or an aggregate of filamentous chromosome, often symmetrical at bilateral centrosomes. They appear in CINs from an early stage (CIN I), with the highest incidence in HPV16-associated CIN II-III (75%), and are less common in HPV-related invasive carcinomas (21%) and in lesions associated with high-risk HPV types other than 16. Rates for ECAC-positive nuclei in metaphase preparations (ECAC rate) for each lesion ranged 3.6-30%, the average being 14.5%. ECAC appeared very rarely in CINs associated with intermediate-risk HPVs and was never encountered in HPV6/11-induced condylomas or HPV-unrelated neoplasms in other organs. ECAC may be morphologic evidence of HPV-induced chromosomal instability working as a background mechanism in cervical carcinogenesis and also a useful marker for the histopathologic differentiation of high-risk CINs.


Int J Cancer


Furuta R,Hirai Y,Katase K,Tate S,Kawaguchi T,Akiyama F,Kato Y,Kumada K,Iwasaka T,Yaegashi N,Kanazawa K,Yoshikawa H,Kitagawa T





Has Abstract


2003-08-20 00:00:00












  • Fibronectin isoforms are differentially expressed in normal and adenomatous human anterior pituitaries.

    abstract::The expression of fibronectin (FN) isoforms containing the extradomains A and B (ED-A+ and ED-B+ FNs) as well as a differentially O-glycosylated oncofetal form of the protein (onf-FN) was investigated in 6 normal human anterior pituitaries and 25 human pituitary adenomas. In normal tissue, immunohistochemical experime...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Farnoud MR,Farhadian F,Samuel JL,Derome P,Peillon F,Li JY

    更新日期:1995-03-29 00:00:00

  • Transcription factor co-repressors in cancer biology: roles and targeting.

    abstract::Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Battaglia S,Maguire O,Campbell MJ

    更新日期:2010-06-01 00:00:00

  • Effectiveness of sorafenib dose modifications on treatment outcome of hepatocellular carcinoma: Analysis in real-life settings.

    abstract::Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tak KY,Nam HC,Choi JY,Yoon SK,Kim CW,Kim HY,Lee SW,Lee HL,Chang UI,Song DS,Yang JM,Kwon JH,Yoo SH,Sung PS,Choi SW,Song MJ,Kim SH,Jang JW

    更新日期:2020-10-01 00:00:00

  • Limitations of reduced-field irradiated volume and technique in conventional radiation therapy of prostate cancer: implications for conformal 3-D treatment.

    abstract::In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reduced-field treatment factors, such as reduced-field (RF) irradiated volume, RF technique, photon energy of treatment, and dose on survival endpoints and loc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gagnon GJ,Harter KW,Berg CD,Lynch JH,Cornell DR,Kuettel MR,Dritschilo A

    更新日期:2000-10-20 00:00:00

  • High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma.

    abstract::Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fukuzawa R,Umezawa A,Ochi K,Urano F,Ikeda H,Hata J

    更新日期:1999-08-12 00:00:00

  • Interval cancers in the Norwegian breast cancer screening program: frequency, characteristics and use of HRT.

    abstract::Breast cancers diagnosed between screening examinations among women who attend a breast cancer screening program are defined as interval cancers. The Norwegian Breast Cancer Screening Program started as a pilot project in 1996, and data from the first 2-year interval are available. Our study quantifies interval cancer...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang H,Bjurstam N,Bjørndal H,Braaten A,Eriksen L,Skaane P,Vitak B,Hofvind S,Thoresen SØ

    更新日期:2001-11-01 00:00:00

  • Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia.

    abstract::Antitumor immunity in chronic lymphocytic leukemia (CLL) is hampered by highly dysfunctional T-cells. Although certain T-cell subsets have been reported to be of prognostic significance in this disease, their interplay is complex and it remains incompletely understood which of these subsets significantly drive CLL pro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rissiek A,Schulze C,Bacher U,Schieferdecker A,Thiele B,Jacholkowski A,Flammiger A,Horn C,Haag F,Tiegs G,Zirlik K,Trepel M,Tolosa E,Binder M

    更新日期:2014-11-15 00:00:00

  • Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy.

    abstract::Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase-specific replication-competent adenovirus (Telomelysin: OBP-301), in which the human telomerase reverse transcriptase (hTERT) promoter regulates viral replica...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fujiwara T,Kagawa S,Kishimoto H,Endo Y,Hioki M,Ikeda Y,Sakai R,Urata Y,Tanaka N,Fujiwara T

    更新日期:2006-07-15 00:00:00

  • Murine spontaneous T-cell leukemia constitutively expressing IL-2 receptor--a model for human T-cell malignancies expressing IL-2 receptor.

    abstract::We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lugasi H,Hajos S,Murphy JR,Strom TB,Nichols J,Peñarroja C,Naor D

    更新日期:1990-01-15 00:00:00

  • Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study.

    abstract::Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dalstein V,Riethmuller D,Prétet JL,Le Bail Carval K,Sautière JL,Carbillet JP,Kantelip B,Schaal JP,Mougin C

    更新日期:2003-09-01 00:00:00

  • Mechanism of antitumor action of PKC activator, gnidimacrin.

    abstract::Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells. Gnidimacrin did bind...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoshida M,Yokokura H,Hidaka H,Ikekawa T,Saijo N

    更新日期:1998-07-17 00:00:00

  • The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma.

    abstract::Cytogenetic deletions of the short arm of chromosome 9, 9p, have been detected in cell lines of malignant mesothelioma as well as in tumor material. Many tumor types carry deletions of chromosome 9 or more specifically of 9p21. The tumor-suppressor genes, CDKN2A and CDKN2B, each of which encodes a structurally and fun...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Prins JB,Williamson KA,Kamp MM,Van Hezik EJ,Van der Kwast TH,Hagemeijer A,Versnel MA

    更新日期:1998-02-09 00:00:00

  • Serological survey and virus isolation of simian T-cell leukemia/T-lymphotropic virus type I (STLV-I) in non-human primates in their native countries.

    abstract::Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ishikawa K,Fukasawa M,Tsujimoto H,Else JG,Isahakia M,Ubhi NK,Ishida T,Takenaka O,Kawamoto Y,Shotake T

    更新日期:1987-08-15 00:00:00

  • Improving identification of lynch syndrome patients: a comparison of research data with clinical records.

    abstract::Current evidence suggests poor identification and referral of Lynch syndrome patients. This study evaluated the strategies by which patients with endometrial cancer were referred to genetics services. Data from clinic-based patients with endometrial cancer enrolled through the Australian National Endometrial Cancer po...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tan YY,McGaughran J,Ferguson K,Walsh MD,Buchanan DD,Young JP,Webb PM,Obermair A,Spurdle AB,ANECS Group.

    更新日期:2013-06-15 00:00:00

  • Nanomedicine in management of hepatocellular carcinoma: Challenges and opportunities.

    abstract::Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Mohamed NK,Hamad MA,Hafez MZ,Wooley KL,Elsabahy M

    更新日期:2017-04-01 00:00:00

  • Increased monocyte-mediated cytostasis of lymphoid cell lines in breast and lung cancer patients.

    abstract::Peripheral blood mononuclear cells of most normal adults and patients with breast or lung cancer were found to inhibit [3H] thymidine uptake by lymphoid cell lines in a growth inhibition assay. At effector:target cell ratios between 5:1 and 20:1, lung cancer patients and breast cancer patients, when compared to normal...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jerrells TR,Dean JH,Richardson G,Cannon GB,Herberman RB

    更新日期:1979-06-15 00:00:00

  • Secondary specific immune response in vitro to MSV tumor cells.

    abstract::The interactions which occur between antigenic tumor cells and normal or immune lymphoid cells in a 3-day in vitro culture, have been studied with a murine sarcoma virus (MSV)-induced tumor. The 3H-thymidine incorporation of lymphoma cells growing in suspension, and the radioactive-chromium release of freshly sampled ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Senik A,Hebrero FP,Levy JP

    更新日期:1975-12-15 00:00:00

  • Treatment of melanoma of unknown primary in the era of immunotherapy and targeted therapy: A Dutch population-based study.

    abstract::Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

    更新日期:2020-01-01 00:00:00

  • Detection of telomerase activity and correlation with mitotic and apoptotic indices, Ki-67 and expression of cyclins D1 and A in cutaneous melanoma.

    abstract::Telomerase plays a key role in carcinogenesis. It is activated in most immortal cell lines and human cancers, including cutaneous melanoma (CM). Increased cell proliferation and deregulation of the cell cycle occur in human cancers. Links between telomerase activity (TA), cell proliferation, cell death and expression ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Miracco C,Pacenti L,Santopietro R,Biagioli M,Fimiani M,Perotti R,Rubegni P,Pirtoli L,Luzi P

    更新日期:2000-11-01 00:00:00

  • Chemical carcinogen Epstein-Barr virus (EBV) synergism: EBV genome amplification and site-specific mutation during transformation.

    abstract::When treated with chemical carcinogens, peripheral blood lymphocytes (PBLs) from normal adults or patients with acquired immunodeficiency syndrome (AIDS) were more readily transformed than non-treated PBLs into immortalized lymphoblastoid cell lines (LCLs) by the Epstein-Barr virus (EBV, FF41-1). Chemical carcinogens ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Henderson EE,Franks C,Fronko G

    更新日期:1989-01-15 00:00:00

  • Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer.

    abstract::AKT/PKB is a central signaling molecule related to stimulation of cell proliferation and inhibition of apoptosis. Perturbations of AKT expression and function play an important role in tumor development and progression. We wanted to determine (a) whether AKT is overexpressed in human prostatic tumors, (b) whether AKT ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Liao Y,Grobholz R,Abel U,Trojan L,Michel MS,Angel P,Mayer D

    更新日期:2003-11-20 00:00:00

  • Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer.

    abstract::UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degradation, but recent findings have...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lacko M,Roelofs HM,Te Morsche RH,Voogd AC,Ophuis MB,Peters WH,Manni JJ

    更新日期:2010-12-15 00:00:00

  • A case-control study of diet and lung cancer in northeast China.

    abstract::A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hu J,Johnson KC,Mao Y,Xu T,Lin Q,Wang C,Zhao F,Wang G,Chen Y,Yang Y

    更新日期:1997-06-11 00:00:00

  • Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display.

    abstract::We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rae FK,Stephenson SA,Nicol DL,Clements JA

    更新日期:2000-12-01 00:00:00

  • Deciphering the roles of FOXO1 in human neoplasms.

    abstract::Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Jiang S,Li T,Yang Z,Hu W,Yang Y

    更新日期:2018-10-01 00:00:00

  • Expression of sperm protein 17 (Sp17) in ovarian cancer.

    abstract::Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Straughn JM Jr,Shaw DR,Guerrero A,Bhoola SM,Racelis A,Wang Z,Chiriva-Internati M,Grizzle WE,Alvarez RD,Lim SH,Strong TV

    更新日期:2004-03-01 00:00:00

  • Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.

    abstract::Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Copeland BT,Bowman MJ,Boucheix C,Ashman LK

    更新日期:2013-10-15 00:00:00

  • CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma.

    abstract::CpG island methylator phenotype (CIMP) involves the targeting of multiple genes by promoter hypermethylation. Telomerase plays an important role in the development of cellular immortality and oncogenesis. To gain insight into the role of epigenetic aberration of telomerase-related genes in hepatocarcinogenesis, we det...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang C,Guo X,Jiang G,Zhang L,Yang Y,Shen F,Wu M,Wei L

    更新日期:2008-09-01 00:00:00

  • Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer.

    abstract::Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dowling P,Clarke C,Hennessy K,Torralbo-Lopez B,Ballot J,Crown J,Kiernan I,O'Byrne KJ,Kennedy MJ,Lynch V,Clynes M

    更新日期:2012-08-15 00:00:00

  • Long-term results of neoadjuvant radiation therapy for breast cancer.

    abstract::Our aim was to determine the long-term outcome and the possible role of neoadjuvant (preoperative) radiation therapy for breast cancers unsuitable for primary conservative surgery. From 1977 to 1992, 75 unifocal non-inflammatory and non-metastatic T2 and T3 breast cancers were treated in our department. All these pati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Calitchi E,Kirova YM,Otmezguine Y,Feuilhade F,Piedbois Y,Le Bourgeois JP

    更新日期:2001-08-20 00:00:00