Using reporter genes to label selected neuronal populations in transgenic mice for gene promoter, anatomical, and physiological studies.

abstract：:The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs). They belong to the group of CAG-repeat or polyglutamine diseases and share pathologically expanded and meiotically unstable glutamine-encod...

journal_title：Progress in neurobiology

authors： Rüb U,Schöls L,Paulson H,Auburger G,Kermer P,Jen JC,Seidel K,Korf HW,Deller T

更新日期：2013-05-01 00:00:00

abstract：:Multivariate time series analysis is extensively used in neurophysiology with the aim of studying the relationship between simultaneously recorded signals. Recently, advances on information theory and nonlinear dynamical systems theory have allowed the study of various types of synchronization from time series. In thi...

journal_title：Progress in neurobiology

authors： Pereda E,Quiroga RQ,Bhattacharya J

更新日期：2005-09-01 00:00:00

abstract：:Glutamate is a potent candidate of the excitatory transmitter at the invertebrate NMJ and the synapse of the vertebrate CNS. But pharmacological studies have not been enough to prove that glutamate functions as an excitatory neurotransmitter. During the past 10 years, we have been studying the effects of various compo...

journal_title：Progress in neurobiology

authors： Shinozaki H

更新日期：1988-01-01 00:00:00

abstract：:The advent of proteomics techniques has been enthusiastically accepted in most areas of biology and medicine. In neuroscience, a host of applications was proposed ranging from neurotoxicology, neurometabolism, determination of the proteome of the individual brain areas in health and disease, to name a few. Only recent...

journal_title：Progress in neurobiology

authors： Lubec G,Krapfenbauer K,Fountoulakis M

更新日期：2003-02-01 00:00:00

abstract：:Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries. Preconditioning has been observed in multiple organisms and can occur in the brain as well as other tissues. Extensive animal studies suggest that the brain can be preconditioned t...

journal_title：Progress in neurobiology

authors： Stetler RA,Leak RK,Gan Y,Li P,Zhang F,Hu X,Jing Z,Chen J,Zigmond MJ,Gao Y

更新日期：2014-03-01 00:00:00

abstract：:This article reviews the application of information-theoretical analysis, employing measures of entropy and mutual information, for the study of aging and aging-related diseases. The research of aging and aging-related diseases is particularly suitable for the application of information theory methods, as aging proces...

journal_title：Progress in neurobiology

authors： Blokh D,Stambler I

更新日期：2017-10-01 00:00:00

abstract：:To understand the cellular mechanisms underlying behaviours in mammals, the respective contributions of the individual properties characterizing each neuron, as opposed to the properties emerging from the organization of these neurons in functional networks, have to be evaluated. This requires the use, in the same spe...

journal_title：Progress in neurobiology

authors： Vibert N,De Waele C,Serafin M,Babalian A,Mühlethaler M,Vidal PP

更新日期：1997-02-01 00:00:00

abstract：:Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturb...

journal_title：Progress in neurobiology

authors： Crowley EK,Nolan YM,Sullivan AM

更新日期：2019-01-01 00:00:00

abstract：:Psychosocial and biological factors have been implicated in paedophilia, such as alterations in brain structure and function. The purpose of this paper is to review the expanding body of literature on this topic including brain abnormality case reports, as well as structural and functional neuroimaging studies. Case s...

journal_title：Progress in neurobiology

authors： Mohnke S,Müller S,Amelung T,Krüger TH,Ponseti J,Schiffer B,Walter M,Beier KM,Walter H

更新日期：2014-11-01 00:00:00

abstract：:Any biological structure can be studied using mutations that interfere either with its emergence or its function. We investigate spontaneous and induced mutations in the mouse that affect neuromuscular development and function. The wobbler mouse (phenotype WR, genotype wr/wr) suffers from muscular atrophy because of t...

journal_title：Progress in neurobiology

authors： Jockusch H,Kaupmann K,Gronemeier M,Schleef M,Klocke R

更新日期：1994-02-01 00:00:00

abstract：:Retrospective studies in humans suggest that chronic maternal stress during pregnancy, associated with raised plasma levels of CRH, ACTH and cortisol may increase the likelihood of preterm birth, developmental delays and behavioural abnormalities in the children. In adulthood, it may contribute to the significant asso...

journal_title：Progress in neurobiology

authors： Weinstock M

更新日期：2001-12-01 00:00:00

abstract：:Because the treatment and management of neuropathic pain are extremely complicated, the characterization of novel analgesics and neuroprotectors with safe toxicological profiles is a crucial need to develop efficient therapies. Several investigations revealed that the natural neurosteroid allopregnanolone (AP) exerts ...

journal_title：Progress in neurobiology

authors： Patte-Mensah C,Meyer L,Taleb O,Mensah-Nyagan AG

更新日期：2014-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a movement disorder that is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. Although majority of the PD cases are sporadic several genetic mutations have also been linked to the disease...

journal_title：Progress in neurobiology

authors： Subramaniam SR,Chesselet MF

更新日期：2013-07-01 00:00:00

abstract：:Preclinical and clinical neurophysiological and neurorehabilitation research has generated rather surprising levels of recovery of volitional sensory-motor function in persons with chronic motor paralysis following a spinal cord injury. The key factor in this recovery is largely activity-dependent plasticity of spinal...

journal_title：Progress in neurobiology

authors： Taccola G,Sayenko D,Gad P,Gerasimenko Y,Edgerton VR

更新日期：2018-01-01 00:00:00

abstract：:The transplantation of cells that secrete neuroactive substances with analgesic properties into the CNS is a novel method that challenges current approaches in treating chronic pain. This review covers pre-clinical and clinical studies from both allogeneic and xenogeneic sources. One cell source that has been utilized...

journal_title：Progress in neurobiology

authors： Czech KA,Sagen J

更新日期：1995-08-01 00:00:00

abstract：:It seems likely that the Alzheimer disease (AD)-related dendritic changes addressed in this article are induced by two principally different processes. One process is linked to the plastic response associated with deafferentation, that is, long-lasting transneuronally induced regressive changes in dendritic geometry a...

journal_title：Progress in neurobiology

authors： Anderton BH,Callahan L,Coleman P,Davies P,Flood D,Jicha GA,Ohm T,Weaver C

更新日期：1998-08-01 00:00:00

abstract：:While selective neuronal death has been an influential theme in Huntington's disease (HD), there is now a preponderance of evidence that significant neuronal dysfunction precedes frank neuronal death. The best evidence for neuronal dysfunction is the observation that gene expression is altered in HD brain, suggesting ...

journal_title：Progress in neurobiology

authors： Cha JH

更新日期：2007-11-01 00:00:00

abstract：:Gene expression patterns in neurons are complex and are modulated in response to multiple extracellular stimuli. In addition, during development and as neurons differentiate into distinct neuronal phenotypes, there is a co-ordinated activation and repression of a variety of genes. It is becoming increasingly evident t...

journal_title：Progress in neurobiology

authors： Quinn JP

更新日期：1996-11-01 00:00:00

abstract：:The spectrum of inflammatory diseases is nowadays considered to include diverse diseases of the central nervous system (CNS). Current evidence suggests that syndromes such as Alzheimer's disease (AD) have important inflammatory and immune components and may be amenable to treatment by anti-inflammatory and immunothera...

journal_title：Progress in neurobiology

authors： Shen Y,Meri S

更新日期：2003-08-01 00:00:00

abstract：:It is suggested that the anatomical structures which mediate consciousness evolved as decisive embellishments to a (non-conscious) design strategy present even in the simplest unicellular organisms. Consciousness is thus not the pinnacle of a hierarchy whose base is the primitive reflex, because reflexes require a ner...

journal_title：Progress in neurobiology

authors： Cotterill RM

更新日期：2001-05-01 00:00:00

abstract：:The electrophysiological alterations provoked by axotomy have now been studied for almost half a century, in a number of different cell types. Consequently, it is now possible to detail some common mechanisms underlying these changes and to sort out certain trends in the data. The major phenomena reviewed in this sect...

journal_title：Progress in neurobiology

authors： Titmus MJ,Faber DS

更新日期：1990-01-01 00:00:00

abstract：:Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these diseases is continuously evolving. The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases. The development of desi...

journal_title：Progress in neurobiology

authors： Butini S,Nikolic K,Kassel S,Brückmann H,Filipic S,Agbaba D,Gemma S,Brogi S,Brindisi M,Campiani G,Stark H

更新日期：2016-07-01 00:00:00

abstract：:Despite huge improvements in neurobiological approaches for investigating the functional properties of neurotransmitter receptors and ion channels, many difficulties are still encountered when focusing on the human brain. Electrophysiological studies aimed at performing direct determinations on human nervous tissue ar...

journal_title：Progress in neurobiology

authors： Eusebi F,Palma E,Amici M,Miledi R

更新日期：2009-05-01 00:00:00

abstract：:Recent evidence has shown that neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD). However, different components of the brain's immune system may exert diverse effects on neuroinflammatory events in PD. The adaptive immune response, especially the T cell response, can trigger type 1 pro...

journal_title：Progress in neurobiology

authors： Chen Z,Chen S,Liu J

更新日期：2018-10-01 00:00:00

abstract：:Removal from receptors of neurotransmitters just released into synapses is one of the major steps in neurotransmission. Transporters situated on the plasma membrane of nerve endings and glial cells perform the process of neurotransmitter (re)uptake. Because the density of transporters in the membranes can fluctuate, t...

journal_title：Progress in neurobiology

authors： Raiteri L,Raiteri M

更新日期：2015-11-01 00:00:00

abstract：:Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationship between these two systems. Metabolic inhibition predisposes neuron...

journal_title：Progress in neurobiology

authors： Greene JG,Greenamyre JT

更新日期：1996-04-01 00:00:00

abstract：:Coherent high-frequency neuronal activity has been proposed as a physiological indicator of perceptual and higher cognitive processes. Some of these processes can only be investigated in humans and the use of non-invasive recording techniques appears to be a prerequisite for investigating their physiological substrate...

journal_title：Progress in neurobiology

authors： Pulvermüller F,Birbaumer N,Lutzenberger W,Mohr B

更新日期：1997-08-01 00:00:00

abstract：:Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals, is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns. A cortical column is considered the basic module of cortical processing present in all cortical areas. It is believed to contain a charac...

journal_title：Progress in neurobiology

authors： Feldmeyer D,Brecht M,Helmchen F,Petersen CC,Poulet JF,Staiger JF,Luhmann HJ,Schwarz C

更新日期：2013-04-01 00:00:00

abstract：:There has been an abundance of literature devoted to the involvement of noradrenaline in basic rapid eye movement (REM) sleep processes since the subject was first investigated in 1964. Nowadays, the great majority of studies highlight the need for silence in the locus coeruleus noradrenergic neurons as a condition fo...

journal_title：Progress in neurobiology

authors： Gottesmann C

更新日期：2008-07-01 00:00:00

abstract：:This article reviews neuroimaging studies of conscious and voluntary regulation of various emotional states (sexual arousal, sadness, negative emotion). The results of these studies show that metacognition and cognitive recontextualization selectively alters the way the brain processes and reacts to emotional stimuli....

journal_title：Progress in neurobiology

authors： Beauregard M

更新日期：2007-03-01 00:00:00