Abstract：
:Gene expression patterns in neurons are complex and are modulated in response to multiple extracellular stimuli. In addition, during development and as neurons differentiate into distinct neuronal phenotypes, there is a co-ordinated activation and repression of a variety of genes. It is becoming increasingly evident that negative regulatory elements are present in neuronal-specific promoters. These elements have been shown, in part, to restrict promoter activity to the correct physiological cell type, both in transient transfection and in transgenic mouse models. Repression can be effected by different mechanisms depending on location within the promoter of silencer complexes and their relationship to other bound transcription factors. This review will discuss the molecular mechanisms regulating promoter function, in particular: (1) the combinatorial interaction between transcription factors which generate regulated promoter function; and (2) the restriction of promoter function to the correct cell type by bound repressor molecules. Determination of the mechanism of regulated gene expression will allow advances in gene therapy and definition of novel targets for pharmaceutical intervention. At the more basic level, functional dissection of the promoters of specific neuronal expressed genes will provide information of importance in two key areas of neurobiology: (1) the mechanism by which extracellular factors, such as neurotrophins and cytokines, regulate gene expression; (2) the events which lead to the tissue-specific expression of genes in subpopulations of neurons, both in the adult and during development.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Quinn JPdoi
10.1016/s0301-0082(96)00041-xsubject
Has Abstractpub_date
1996-11-01 00:00:00pages
363-79issue
4eissn
0301-0082issn
1873-5118pii
S030100829600041Xjournal_volume
50pub_type
杂志文章,评审abstract：:Steroid hormones act via evolutionarily conserved nuclear receptors to regulate neuronal phenotype during development, maturity and disease. Steroid hormones exert 'global' effects in organisms to produce coordinated physiological responses whereas, at the 'local' level, individual neurons can respond to a steroidal s...
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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journal_title：Progress in neurobiology
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更新日期：2002-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1999-04-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2001-12-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2017.03.008
更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-11-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：1985-01-01 00:00:00
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journal_title：Progress in neurobiology
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pub_type： 历史文章,杂志文章
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journal_title：Progress in neurobiology
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更新日期：2000-10-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2005-05-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：1998-02-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2006.09.004
更新日期：2006-10-01 00:00:00
abstract：:Parkinson's disease (PD) is a movement disorder that is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. Although majority of the PD cases are sporadic several genetic mutations have also been linked to the disease...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2013.04.004
更新日期：2013-07-01 00:00:00
abstract：:Nitric oxide (NO), a diffusible molecule acting as an intercellular and intracellular messenger in many tissues, plays multiple roles in the nervous system. In addition to regulating proliferation, survival and differentiation of neurons, NO is also involved in synaptic activity, neural plasticity and memory formation...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2008.01.002
更新日期：2008-04-01 00:00:00
