Abstract：
:Recent evidence has shown that neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD). However, different components of the brain's immune system may exert diverse effects on neuroinflammatory events in PD. The adaptive immune response, especially the T cell response, can trigger type 1 pro-inflammatory activities and suppress type 2 anti-inflammatory activities, eventually resulting in deregulated neuroinflammation and subsequent dopaminergic neurodegeneration. Additionally, studies have increasingly shown that therapies targeting T cells can alleviate neurodegeneration and motor behavior impairment in animal models of PD. Therefore, we conclude that abnormal T cell-mediated immunity is a fundamental pathological process that may be a promising translational therapeutic target for Parkinson's disease.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Chen Z,Chen S,Liu Jdoi
10.1016/j.pneurobio.2018.08.002subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1-23eissn
0301-0082issn
1873-5118pii
S0301-0082(18)30061-3journal_volume
169pub_type
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