Abstract:
:An important biological consequence of the initial interactions between the cell surface and its extracellular environment is the diversity of cellular responses ranging from overt repulsion or avoidance reaction to stable adhesion or final positioning. It is now evident that positive and negative guiding mechanisms are equally relevant to normal pattern formation during development and decisive for the outcome of a regenerative process. In this context, the present review summarizes the knowledge about the extracellular matrix glycoprotein tenascin-R, a member of the tenascin gene family. In contrast to all other known family members, tenascin-R is exclusively expressed in the central nervous system of vertebrates by oligodendrocytes and neuronal subsets at later developmental stages and in adulthood. We focus on the glycoprotein's structure, tissue distribution and functional implications in the molecular control of axon targeting, neural cell adhesion, migration and differentiation during nervous system morphogenesis and pathology.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Pesheva P,Probstmeier Rdoi
10.1016/s0301-0082(99)00061-1keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
465-93issue
5eissn
0301-0082issn
1873-5118pii
S0301-0082(99)00061-1journal_volume
61pub_type
杂志文章,评审abstract::One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research i...
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journal_title:Progress in neurobiology
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abstract::Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturb...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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abstract::Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries. Preconditioning has been observed in multiple organisms and can occur in the brain as well as other tissues. Extensive animal studies suggest that the brain can be preconditioned t...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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doi:10.1016/j.pneurobio.2006.06.001
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journal_title:Progress in neurobiology
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更新日期:2001-12-01 00:00:00
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journal_title:Progress in neurobiology
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doi:10.1016/j.pneurobio.2014.09.002
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journal_title:Progress in neurobiology
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doi:10.1016/j.pneurobio.2016.07.003
更新日期:2017-04-01 00:00:00
abstract::Firstly, the noetic value of the ontogenetic approach to the problems of learning and memory is emphasized; then the heterochrony and uneven time course of the development of neural systems are accentuated, which fully holds for the basic cognitive functions. Contrary to a broadly accepted opinion, that inhibitory lea...
journal_title:Progress in neurobiology
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更新日期:1997-11-01 00:00:00
abstract::As the population ages, the economic and societal impacts of neurodegenerative and neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive disorders are common and are linked to increased disability, high healthcare utilisation, cognitive decline and premature mortality. Considerab...
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abstract::The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal inclusions seen in the disease, and more recently, when the implication of C9ORF72 expansion in familial and sporadic cases of ALS and frontotemp...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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更新日期:2017-06-01 00:00:00
abstract::An understanding of how axons elongate is needed to develop rational strategies to treat neurological diseases and nerve injury. Growth cone-mediated neuronal elongation is currently viewed as occurring through cytoskeletal dynamics involving the polymerization of actin and tubulin subunits at the tip of the axon. How...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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更新日期:1997-04-01 00:00:00
abstract::Although more than 8000 papers of apoptosis are published annually, there are very few reports concerning necrosis in the past few years. A number of recent studies using lower species animals have suggested that the cornu Ammonis (CA) 1 neuronal death after brief global cerebral ischemia occurs by apoptosis, an activ...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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