解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Mutations in genes regulating mTOR pathway signaling are now recognized as a significant cause of epilepsy. Interestingly, these mTORopathies are often caused by somatic mutations, affecting variable numbers of neurons. To better understand how this variability affects disease phenotype, we developed a mouse model in ...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101974
更新日期:2020-12-09 00:00:00
abstract::Reconstructing the genealogy of every cell that makes up an organism remains a long-standing challenge in developmental biology. Besides its relevance for understanding the mechanisms underlying normal and pathological development, resolving the lineage origin of cell types will be crucial to create these types on-dem...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2020.101966
更新日期:2020-11-26 00:00:00
abstract::Brain lactate formation, intercellular exchange and utilization has been implicated in memory formation. However, the individual role of either neuronal or astroglial monocarboxylate transporters for the acquisition and consolidation of information remains incomplete. Using novel transgenic mice and a viral vector app...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101888
更新日期:2020-11-01 00:00:00
abstract::Preeclampsia is a hypertensive disorder of pregnancy that can involve dangerous neurological symptoms such as spontaneous seizures (eclampsia). Despite being diseases specific to the pregnant state, preeclampsia and eclampsia have long-lasting neurological consequences later in life, including changes in brain structu...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101938
更新日期:2020-10-29 00:00:00
abstract::Chronic constipation is one of the most prominent prodromal symptoms in Parkinson's disease (PD), and Lewy bodies, enriched with aggregated α-Synuclein (α-Syn), propagation from the gut into the brain has been proposed to play a key role in PD etiopathogenesis. BDNF (Brain-derived neurotrophic factor) and Netrin-1 pro...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101905
更新日期:2020-09-07 00:00:00
abstract::Following rapid methodological advances, ultra-high field (UHF) functional and anatomical magnetic resonance imaging (MRI) has been repeatedly and successfully used for the investigation of the human auditory system in recent years. Here, we review this work and argue that UHF MRI is uniquely suited to shed light on h...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101887
更新日期:2020-08-01 00:00:00
abstract::Behavioral responses to a perceptual stimulus are typically faster with repeated exposure to the stimulus (behavioral priming). This implicit learning mechanism is critical for survival but impaired in a variety of neurological disorders, including Alzheimer's disease. Many studies of the neural bases for behavioral p...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101788
更新日期:2020-06-01 00:00:00
abstract::Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory or...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2020.101758
更新日期:2020-05-01 00:00:00
abstract::White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI) and myelination has been suggested as a possible mechanism. Here, we set out to identify molecular and cellular changes ass...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101770
更新日期:2020-04-01 00:00:00
abstract::Brain sex differences are programmed largely by sex hormone secretions and direct sex chromosome effects in early life, and are subsequently modulated by early life experiences. The brain's resident immune cells, called microglia, actively contribute to brain development. Recent research has shown that microglia are s...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.09.002
更新日期:2019-05-01 00:00:00
abstract::Several lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2019.03.001
更新日期:2019-05-01 00:00:00
abstract::Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturb...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.11.003
更新日期:2019-01-01 00:00:00
abstract::Neural stem and progenitor cells (NSPCs) are the primary source of new neurons in the brain and serve critical roles in tissue homeostasis and plasticity throughout life. Within the vertebrate brain, NSPCs are located within distinct neurogenic niches differing in their location, cellular composition, and proliferativ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.06.004
更新日期:2018-11-01 00:00:00
abstract::Recent evidence has shown that neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD). However, different components of the brain's immune system may exert diverse effects on neuroinflammatory events in PD. The adaptive immune response, especially the T cell response, can trigger type 1 pro...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.08.002
更新日期:2018-10-01 00:00:00
abstract::Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which affects about 0.3% of the general population. As the population in the developed world ages, this creates an escalating burden on society both in economic terms and in quality of life for these patients and for the families that supp...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.04.005
更新日期:2018-09-01 00:00:00
abstract::The K+-Cl- co-transporter KCC2 is a neuron-specific, Cl- extruder that uses K+ gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly-directed electrochemical Cl- gradient across the neuronal membrane is fundamental for a proper function of postsynaptic GABAA recep...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.11.002
更新日期:2018-03-01 00:00:00
abstract::The present critical review analyzes the question of how nanoparticles from continuously growing industrial production and use of nanomaterials may impact human brain health. Available evidence suggests incomplete effectiveness of protective barriers of the brain against nanoparticles translocation to the brain. This ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.10.003
更新日期:2018-01-01 00:00:00
abstract::Preclinical and clinical neurophysiological and neurorehabilitation research has generated rather surprising levels of recovery of volitional sensory-motor function in persons with chronic motor paralysis following a spinal cord injury. The key factor in this recovery is largely activity-dependent plasticity of spinal...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.10.004
更新日期:2018-01-01 00:00:00
abstract::Although aberrant metabolism and deposition of iron has been associated with aging and neurodegeneration, the contribution of iron to neuropathology is unclear. Well-designed model systems that are suited to studying the putative pathological effect of iron are likely to be essential if such unresolved details are to ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.08.004
更新日期:2017-11-01 00:00:00
abstract::This article reviews the application of information-theoretical analysis, employing measures of entropy and mutual information, for the study of aging and aging-related diseases. The research of aging and aging-related diseases is particularly suitable for the application of information theory methods, as aging proces...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.03.005
更新日期:2017-10-01 00:00:00
abstract::Brain has exceptional high requirement for energy metabolism with glucose as the exclusive energy source. Decrease of brain energy metabolism and glucose uptake has been found in patients of Alzheimer's, Parkinson's and other neurodegenerative diseases, providing a clear link between neurodegenerative disorders and en...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2015.10.005
更新日期:2017-10-01 00:00:00
abstract::Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, hallmarks of aging and...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.03.006
更新日期:2017-10-01 00:00:00
abstract::One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research i...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.03.003
更新日期:2017-10-01 00:00:00
abstract::Long-term consequences of anesthetic exposure in humans are not well understood. It is possible that alterations in brain function occur beyond the initial anesthetic administration. Research in children and adults has reported cognitive and/or behavioral changes after surgery and general anesthesia that may be short ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.01.005
更新日期:2017-06-01 00:00:00
abstract::Dementia encapsulates a set of symptoms that include loss of mental abilities such as memory, problem solving or language, and reduces a person's ability to perform daily activities. Alzheimer's disease is the most common form of dementia, however dementia can also occur in other neurological disorders such as Hunting...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.03.008
更新日期:2017-06-01 00:00:00
abstract::It is suggested that the brain undergoes plastic changes in order to adapt to changing environmental needs. Sensory deprivation results in decreased input to the brain leading to adaptive or maladaptive changes. Although several theories hypothesize the mechanism of these adaptive and maladaptive changes, the course o...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.03.010
更新日期:2017-06-01 00:00:00
abstract::Narcolepsy is a neurological disorder that afflicts 1 in 2000 individuals and is characterized by excessive daytime sleepiness and cataplexy-a sudden loss of muscle tone triggered by positive emotions. Features of narcolepsy include dysregulation of arousal state boundaries as well as autonomic and metabolic disturban...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2015.12.002
更新日期:2017-05-01 00:00:00
abstract::Parkinson's disease is the second most common neurodegenerative disorder, characterized by the manifestation of motor symptoms, which are mainly attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra. Based on advancements in the understanding of the pathophysiology of the disease,...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.07.003
更新日期:2017-04-01 00:00:00
abstract::Auditory verbal hallucinations (AVH) occur in psychotic disorders, but also as a symptom of other conditions and even in healthy people. Several current theories on the origin of AVH converge, with neuroimaging studies suggesting that the language, auditory and memory/limbic networks are of particular relevance. Howev...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.11.002
更新日期:2017-01-01 00:00:00
abstract::Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical, cellular, and biochemical manifestations that are currently not understood in combination. This has led to many views of AD, e.g. the amyloid, tau, presenilin, oxidative stress, and metal hypotheses. The amyloid hypothesis has do...
journal_title:Progress in neurobiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.pneurobio.2016.06.004
更新日期:2016-08-01 00:00:00
abstract::Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these diseases is continuously evolving. The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases. The development of desi...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.03.011
更新日期:2016-07-01 00:00:00
abstract::The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal inclusions seen in the disease, and more recently, when the implication of C9ORF72 expansion in familial and sporadic cases of ALS and frontotemp...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.05.004
更新日期:2016-07-01 00:00:00
abstract::Cognitive neuroscientists in the late 20th century began the task of identifying the part(s) of the brain concerned with normal behavior as manifest in the psychological capacities as affective powers, reasoning, behaving purposively and the pursuit of goals, following introduction of the 'functional magnetic resonanc...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.07.001
更新日期:2016-01-01 00:00:00
abstract::Neuromuscular junctions (NMJs) have long been studied as particularly accessible examples of chemical synapses. Nonetheless, some important features of neuromuscular transmission are still poorly understood. One of these is the low statistical variability of the number of transmitter quanta released from motor nerve t...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2015.09.004
更新日期:2015-11-01 00:00:00
abstract::Removal from receptors of neurotransmitters just released into synapses is one of the major steps in neurotransmission. Transporters situated on the plasma membrane of nerve endings and glial cells perform the process of neurotransmitter (re)uptake. Because the density of transporters in the membranes can fluctuate, t...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2015.08.002
更新日期:2015-11-01 00:00:00
abstract::The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psy...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2015.03.005
更新日期:2015-07-01 00:00:00
abstract::Nervous system development, plasticity and regeneration require numerous, coordinated and finely tuned subcellular mechanisms. Phosphoproteins of the stathmin family, originally identified as intracellular signal relay proteins, are mostly or exclusively expressed in the nervous system with a high level of expression ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2014.09.002
更新日期:2015-03-01 00:00:00
abstract::Autism spectrum disorders (ASDs) encompass a range of syndromes that are characterized by social interaction impairments, verbal and nonverbal communication difficulties, and stereotypic or repetitive behaviours. Although there has been considerable progress in understanding the mechanisms underlying the changes in th...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2014.11.002
更新日期:2015-01-01 00:00:00
abstract::Psychosocial and biological factors have been implicated in paedophilia, such as alterations in brain structure and function. The purpose of this paper is to review the expanding body of literature on this topic including brain abnormality case reports, as well as structural and functional neuroimaging studies. Case s...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2014.07.005
更新日期:2014-11-01 00:00:00
abstract::Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper have to be tightly regulated in order to guarantee sufficient copper ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2014.01.002
更新日期:2014-05-01 00:00:00