Abstract：
:The spectrum of inflammatory diseases is nowadays considered to include diverse diseases of the central nervous system (CNS). Current evidence suggests that syndromes such as Alzheimer's disease (AD) have important inflammatory and immune components and may be amenable to treatment by anti-inflammatory and immunotherapeutic approaches. Compelling evidence has been reported that complement activation occurs in the brain with Alzheimer's disease, and that this contributes to the development of a local inflammatory state that is correlated with cognitive dysfunction. The complement system is a critical element of the innate immune system recognizing and killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering the generation of a membranolytic complex, complement proteins interact with cell surface receptors to promote a local inflammatory response that contributes to the protection and healing of the host. Complement activation causes inflammation and cell damage, yet it is an essential component in trying to eliminate cell debris and potentially toxic protein aggregates. It is the balance of these seemingly competing events--the "Yin" and the "Yang"--that influences the ultimate state of neuronal function. Knowledge of the unique molecular interactions that occur in the development of Alzheimer's disease, the functional consequences of those interactions, and the proportional contribution of each element to this disorder, should facilitate the design of effective therapeutic strategies for this disease.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Shen Y,Meri Sdoi
10.1016/j.pneurobio.2003.08.001keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
463-72issue
6eissn
0301-0082issn
1873-5118pii
S0301008203001308journal_volume
70pub_type
杂志文章,评审abstract：:Parkinson's disease is the second most common neurodegenerative disorder, characterized by the manifestation of motor symptoms, which are mainly attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra. Based on advancements in the understanding of the pathophysiology of the disease,...
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2005.09.006
更新日期：2005-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-02-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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