Abstract：
:Synaptic transmission is a finely regulated mechanism of neuronal communication. The release of neurotransmitter at the synapse is not only the reflection of membrane depolarization events, but rather, is the summation of interactions between ion channels, G protein coupled receptors, second messengers, and the exocytotic machinery itself which exposes the components within a synaptic vesicle to the synaptic cleft. The focus of this review is to explore the role of G protein signaling as it relates to neurotransmission, as well as to discuss the recently determined inhibitory mechanism of Gβγ dimers acting directly on the exocytotic machinery proteins to inhibit neurotransmitter release.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Betke KM,Wells CA,Hamm HEdoi
10.1016/j.pneurobio.2012.01.009subject
Has Abstractpub_date
2012-03-01 00:00:00pages
304-21issue
3eissn
0301-0082issn
1873-5118pii
S0301-0082(12)00010-Xjournal_volume
96pub_type
杂志文章,评审abstract：:Cognitive neuroscientists in the late 20th century began the task of identifying the part(s) of the brain concerned with normal behavior as manifest in the psychological capacities as affective powers, reasoning, behaving purposively and the pursuit of goals, following introduction of the 'functional magnetic resonanc...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2016.07.001
更新日期：2016-01-01 00:00:00
abstract：:Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper have to be tightly regulated in order to guarantee sufficient copper ...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2014.01.002
更新日期：2014-05-01 00:00:00
abstract：:It is proposed that altered dendrite length and de novo formation of new dendrite branches in cholinoceptive cells are responsible for long-term memory storage, a process enabled by the degradation of microtubule-associated protein-2. These memories are encoded as modality-specific associable representations. Accordin...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0301-0082(97)00094-4
更新日期：1998-05-01 00:00:00
abstract：:Nitric oxide (NO), a diffusible molecule acting as an intercellular and intracellular messenger in many tissues, plays multiple roles in the nervous system. In addition to regulating proliferation, survival and differentiation of neurons, NO is also involved in synaptic activity, neural plasticity and memory formation...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2008.01.002
更新日期：2008-04-01 00:00:00
abstract：:This article reviews a series of experiments aimed at investigating the reciprocal trophic interactions which regulate the normal morphofunctional features and the plasticity of the adult rodent climbing fibre-Purkinje cell system. Climbing fibre deprivation induces profound functional and structural changes in the Pu...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:Psychosocial and biological factors have been implicated in paedophilia, such as alterations in brain structure and function. The purpose of this paper is to review the expanding body of literature on this topic including brain abnormality case reports, as well as structural and functional neuroimaging studies. Case s...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2014.07.005
更新日期：2014-11-01 00:00:00
abstract：:As the genetics of neurodegenerative disease become better understood, opportunities for genetic susceptibility testing for at-risk individuals will increase. Such testing raises important ethical and practice issues related to test access, informed consent, risk estimation and communication, return of results, and po...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2013.02.005
更新日期：2013-11-01 00:00:00
abstract：:Parkinson's disease was first described in 1817 by James Parkinson. It is one of the most common neurodegenerative disorders, affecting the nigrostriatal pathways involved in the control of movement. Since the introduction of L-DOPA as a therapy in the mid-1960s, clinical management of the symptoms has progressed, but...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2008.05.003
更新日期：2008-08-01 00:00:00
abstract：:Aging of the human brain is associated with "normal" functional, structural, and molecular changes that underlie alterations in cognition, memory, mood and motor function, amongst other processes. Normal aging also imposes a robust constraint on the onset of many neurological diseases, ranging from late onset neurodeg...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2010.11.006
更新日期：2011-02-01 00:00:00
abstract：:Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical, cellular, and biochemical manifestations that are currently not understood in combination. This has led to many views of AD, e.g. the amyloid, tau, presenilin, oxidative stress, and metal hypotheses. The amyloid hypothesis has do...
journal_title：Progress in neurobiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.pneurobio.2016.06.004
更新日期：2016-08-01 00:00:00
abstract：:Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, hallmarks of aging and...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2016.03.006
更新日期：2017-10-01 00:00:00
abstract：:High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-band, transient burst-like phenomenon or steady-state. HFOs may be encountered under physiological or under pathological conditions (pHFO). Here we review the underlying mechanisms of oscillations, at the level of cells and netw...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2012.02.005
更新日期：2012-09-01 00:00:00
abstract：:Depression in the elderly is nowadays a predominant health care problem, mainly due to the progressive aging of the population. It results from psychosocial stress, polypathology, as well as some biochemical changes which occur in the aged brain and can lead to cognitive impairments, increased symptoms from medical il...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0301-0082(99)00050-7
更新日期：2000-07-01 00:00:00
abstract：:The transplantation of cells that secrete neuroactive substances with analgesic properties into the CNS is a novel method that challenges current approaches in treating chronic pain. This review covers pre-clinical and clinical studies from both allogeneic and xenogeneic sources. One cell source that has been utilized...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0301-0082(95)00011-j
更新日期：1995-08-01 00:00:00
abstract：:The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal inclusions seen in the disease, and more recently, when the implication of C9ORF72 expansion in familial and sporadic cases of ALS and frontotemp...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2016.05.004
更新日期：2016-07-01 00:00:00
abstract：:While selective neuronal death has been an influential theme in Huntington's disease (HD), there is now a preponderance of evidence that significant neuronal dysfunction precedes frank neuronal death. The best evidence for neuronal dysfunction is the observation that gene expression is altered in HD brain, suggesting ...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2007.03.004
更新日期：2007-11-01 00:00:00
abstract：:The freely diffusible messenger nitric oxide (NO), generated by NO synthase (NOS)-containing "nitroxergic" (NO-ergic) neurons, is unique among classical synaptic chemical transmitters because of its "non-specificity", molecular "NO-receptors" (e.g. guanylyl cyclase, iron complexes, nitrosylated proteins or DNA) in tar...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0301-0082(96)00062-7
更新日期：1997-03-01 00:00:00
abstract：:An important biological consequence of the initial interactions between the cell surface and its extracellular environment is the diversity of cellular responses ranging from overt repulsion or avoidance reaction to stable adhesion or final positioning. It is now evident that positive and negative guiding mechanisms a...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0301-0082(99)00061-1
更新日期：2000-08-01 00:00:00
abstract：:Brain has exceptional high requirement for energy metabolism with glucose as the exclusive energy source. Decrease of brain energy metabolism and glucose uptake has been found in patients of Alzheimer's, Parkinson's and other neurodegenerative diseases, providing a clear link between neurodegenerative disorders and en...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2015.10.005
更新日期：2017-10-01 00:00:00
abstract：:Glutamate is a potent candidate of the excitatory transmitter at the invertebrate NMJ and the synapse of the vertebrate CNS. But pharmacological studies have not been enough to prove that glutamate functions as an excitatory neurotransmitter. During the past 10 years, we have been studying the effects of various compo...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0301-0082(88)90009-3
更新日期：1988-01-01 00:00:00
abstract：:Nervous system development, plasticity and regeneration require numerous, coordinated and finely tuned subcellular mechanisms. Phosphoproteins of the stathmin family, originally identified as intracellular signal relay proteins, are mostly or exclusively expressed in the nervous system with a high level of expression ...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2014.09.002
更新日期：2015-03-01 00:00:00
abstract：:Narcolepsy is a neurological disorder that afflicts 1 in 2000 individuals and is characterized by excessive daytime sleepiness and cataplexy-a sudden loss of muscle tone triggered by positive emotions. Features of narcolepsy include dysregulation of arousal state boundaries as well as autonomic and metabolic disturban...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2015.12.002
更新日期：2017-05-01 00:00:00
abstract：:(1) The availability of short amino acid sequences of the naturally occurring ACTH 1-39 molecule has made it possible to separate the corticotropic characteristics of the parent molecule from its neurotrophic effects. Potent neurotrophic fragments are ACTH 4-10, an analog of ACTH 4-9 (Org 2766), and alpha-MSH (ACTH 1-...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0301-0082(89)90035-x
更新日期：1989-01-01 00:00:00
abstract：:Behavioral responses to a perceptual stimulus are typically faster with repeated exposure to the stimulus (behavioral priming). This implicit learning mechanism is critical for survival but impaired in a variety of neurological disorders, including Alzheimer's disease. Many studies of the neural bases for behavioral p...
journal_title：Progress in neurobiology
pub_type： 杂志文章
doi：10.1016/j.pneurobio.2020.101788
更新日期：2020-06-01 00:00:00
abstract：:Long-term consequences of anesthetic exposure in humans are not well understood. It is possible that alterations in brain function occur beyond the initial anesthetic administration. Research in children and adults has reported cognitive and/or behavioral changes after surgery and general anesthesia that may be short ...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2017.01.005
更新日期：2017-06-01 00:00:00
abstract：:Neuromuscular junctions (NMJs) have long been studied as particularly accessible examples of chemical synapses. Nonetheless, some important features of neuromuscular transmission are still poorly understood. One of these is the low statistical variability of the number of transmitter quanta released from motor nerve t...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2015.09.004
更新日期：2015-11-01 00:00:00
abstract：:Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturb...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2018.11.003
更新日期：2019-01-01 00:00:00
abstract：:Recent work in neuroscience has shown that the adult central nervous system contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes. While challenging previous dogma that no new neurons are born in the adult mammalian CNS, these findings brin...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2005.04.002
更新日期：2005-04-01 00:00:00
abstract：:Brain damage can sometimes render a patient persistently unresponsive and yet apparently awake, admitting the possibility that the absence of overt voluntary behaviour might conceal a retained capacity for covert cognition. When given instructions to perform a cognitive task, a minority of patients in such a so-called...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2010.01.009
更新日期：2010-05-01 00:00:00
abstract：:Chronic constipation is one of the most prominent prodromal symptoms in Parkinson's disease (PD), and Lewy bodies, enriched with aggregated α-Synuclein (α-Syn), propagation from the gut into the brain has been proposed to play a key role in PD etiopathogenesis. BDNF (Brain-derived neurotrophic factor) and Netrin-1 pro...
journal_title：Progress in neurobiology
pub_type： 杂志文章
doi：10.1016/j.pneurobio.2020.101905
更新日期：2020-09-07 00:00:00
