Abstract：
:Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper have to be tightly regulated in order to guarantee sufficient copper supply for the synthesis of copper-containing enzymes but also to prevent copper-induced oxidative stress. In brain, copper is of importance for normal development. In addition, both copper deficiency as well as excess of copper can seriously affect brain functions. Therefore, this organ possesses ample mechanisms to regulate its copper metabolism. In brain, astrocytes are considered as important regulators of copper homeostasis. Impairments of homeostatic mechanisms in brain copper metabolism have been associated with neurodegeneration in human disorders such as Menkes disease, Wilson's disease and Alzheimer's disease. This review article will summarize the biological functions of copper in the brain and will describe the current knowledge on the mechanisms involved in copper transport, storage and export of brain cells. The role of copper in diseases that have been connected with disturbances in brain copper homeostasis will also be discussed.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Scheiber IF,Mercer JF,Dringen Rdoi
10.1016/j.pneurobio.2014.01.002subject
Has Abstractpub_date
2014-05-01 00:00:00pages
33-57eissn
0301-0082issn
1873-5118pii
S0301-0082(14)00012-4journal_volume
116pub_type
杂志文章,评审abstract：:Cognitive neuroscientists in the late 20th century began the task of identifying the part(s) of the brain concerned with normal behavior as manifest in the psychological capacities as affective powers, reasoning, behaving purposively and the pursuit of goals, following introduction of the 'functional magnetic resonanc...
journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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journal_title：Progress in neurobiology
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更新日期：2003-02-01 00:00:00
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journal_title：Progress in neurobiology
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更新日期：2016-07-01 00:00:00
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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doi：10.1016/j.pneurobio.2011.06.004
更新日期：2011-12-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：1996-10-01 00:00:00
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journal_title：Progress in neurobiology
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更新日期：2001-05-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0301-0082(97)00078-6
更新日期：1998-04-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2011.07.010
更新日期：2011-10-01 00:00:00
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2018-11-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2013.07.004
更新日期：2014-02-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章
doi：10.1016/j.pneurobio.2020.101887
更新日期：2020-08-01 00:00:00
abstract：:GABA and the GABAA and GABAB receptors play a pivotal role in the coordination of the central vestibular pathways. The commissural inhibition, which exists between the two vestibular nucleus complexes (VNCs) and which is responsible for enhancing the dynamic sensitivity of VNC neurons to head acceleration, is known to...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2004.11.001
更新日期：2005-01-01 00:00:00
