Staging Alzheimer's disease progression with multimodality neuroimaging.

abstract：:Autism spectrum disorders (ASDs) encompass a range of syndromes that are characterized by social interaction impairments, verbal and nonverbal communication difficulties, and stereotypic or repetitive behaviours. Although there has been considerable progress in understanding the mechanisms underlying the changes in th...

journal_title：Progress in neurobiology

authors： Chmielewski WX,Beste C

更新日期：2015-01-01 00:00:00

abstract：:Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals, is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns. A cortical column is considered the basic module of cortical processing present in all cortical areas. It is believed to contain a charac...

journal_title：Progress in neurobiology

authors： Feldmeyer D,Brecht M,Helmchen F,Petersen CC,Poulet JF,Staiger JF,Luhmann HJ,Schwarz C

更新日期：2013-04-01 00:00:00

abstract：:An important biological consequence of the initial interactions between the cell surface and its extracellular environment is the diversity of cellular responses ranging from overt repulsion or avoidance reaction to stable adhesion or final positioning. It is now evident that positive and negative guiding mechanisms a...

journal_title：Progress in neurobiology

authors： Pesheva P,Probstmeier R

更新日期：2000-08-01 00:00:00

abstract：:Neural stem and progenitor cells (NSPCs) are the primary source of new neurons in the brain and serve critical roles in tissue homeostasis and plasticity throughout life. Within the vertebrate brain, NSPCs are located within distinct neurogenic niches differing in their location, cellular composition, and proliferativ...

journal_title：Progress in neurobiology

authors： Lindsey BW,Hall ZJ,Heuzé A,Joly JS,Tropepe V,Kaslin J

更新日期：2018-11-01 00:00:00

abstract：:Depression in the elderly is nowadays a predominant health care problem, mainly due to the progressive aging of the population. It results from psychosocial stress, polypathology, as well as some biochemical changes which occur in the aged brain and can lead to cognitive impairments, increased symptoms from medical il...

journal_title：Progress in neurobiology

authors： Gareri P,Falconi U,De Fazio P,De Sarro G

更新日期：2000-07-01 00:00:00

abstract：:Should patients with Parkinson's disease participate in research involving stem cell treatments? Are induced pluripotent stem cells (iPSC) the ethical solution to the moral issues regarding embryonic stem cells? How can we adapt trial designs to best assess small numbers of patients in receipt of invasive experimental...

journal_title：Progress in neurobiology

authors： Barker RA,de Beaufort I

更新日期：2013-11-01 00:00:00

abstract：:Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these diseases is continuously evolving. The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases. The development of desi...

journal_title：Progress in neurobiology

authors： Butini S,Nikolic K,Kassel S,Brückmann H,Filipic S,Agbaba D,Gemma S,Brogi S,Brindisi M,Campiani G,Stark H

更新日期：2016-07-01 00:00:00

abstract：:Self-supervised models of how the brain represents and categorises the causes of its sensory input can be divided into two classes: those that minimise the mutual information (i.e. redundancy) among evoked responses and those that minimise the prediction error. Although these models have similar goals, the way they ar...

journal_title：Progress in neurobiology

authors： Friston K

更新日期：2002-10-01 00:00:00

abstract：:Most spiking neurons are divided into functional compartments: a dendritic input region, a soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of action potentials, and distal arborizations and terminals carrying the output synapses. The axon trunk and lower order branches ar...

journal_title：Progress in neurobiology

authors： Bucher D,Goaillard JM

更新日期：2011-09-01 00:00:00

abstract：:Animal models have provided invaluable data for identifying the pathogenesis of epileptic disorders. Clearly, the relevance of these experimental findings would be strengthened by the demonstration that similar fundamental mechanisms are at work in the human epileptic brain. Epilepsy surgery has indeed opened the poss...

journal_title：Progress in neurobiology

authors： Avoli M,Louvel J,Pumain R,Köhling R

更新日期：2005-10-01 00:00:00

abstract：:Although more than 8000 papers of apoptosis are published annually, there are very few reports concerning necrosis in the past few years. A number of recent studies using lower species animals have suggested that the cornu Ammonis (CA) 1 neuronal death after brief global cerebral ischemia occurs by apoptosis, an activ...

journal_title：Progress in neurobiology

authors： Yamashima T

更新日期：2000-10-01 00:00:00

abstract：:Gene expression patterns in neurons are complex and are modulated in response to multiple extracellular stimuli. In addition, during development and as neurons differentiate into distinct neuronal phenotypes, there is a co-ordinated activation and repression of a variety of genes. It is becoming increasingly evident t...

journal_title：Progress in neurobiology

authors： Quinn JP

更新日期：1996-11-01 00:00:00

abstract：:This paper focuses on the successive historical papers related to medulla oblongata (M.O.) intracerebral connections, its activities and ascending influences regulating sleep waking behavior. The M.O. certainly influences the quantitative and qualitative processes of waking. However, its neurophysiological properties ...

journal_title：Progress in neurobiology

authors： Gottesmann C

更新日期：1999-09-01 00:00:00

abstract：:Aging of the human brain is associated with "normal" functional, structural, and molecular changes that underlie alterations in cognition, memory, mood and motor function, amongst other processes. Normal aging also imposes a robust constraint on the onset of many neurological diseases, ranging from late onset neurodeg...

journal_title：Progress in neurobiology

authors： Glorioso C,Sibille E

更新日期：2011-02-01 00:00:00

abstract：:Preeclampsia is a hypertensive disorder of pregnancy that can involve dangerous neurological symptoms such as spontaneous seizures (eclampsia). Despite being diseases specific to the pregnant state, preeclampsia and eclampsia have long-lasting neurological consequences later in life, including changes in brain structu...

journal_title：Progress in neurobiology

authors： Johnson AC,Li Z,Orfila JE,Herson PS,Cipolla MJ

更新日期：2020-10-29 00:00:00

abstract：:The cause of sleep is a complex question, which needs first, a clear distinction amongst the different meanings of a causal relationship in the study of a given behavior, second, the requisites to be met by a suggested cause, and third, a precise definition of sleep to distinguish behavioral from polygraphic sleep. Th...

journal_title：Progress in neurobiology

authors： Nicolau MC,Akaârir M,Gamundí A,González J,Rial RV

更新日期：2000-11-01 00:00:00

abstract：:The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psy...

journal_title：Progress in neurobiology

authors： Root DH,Melendez RI,Zaborszky L,Napier TC

更新日期：2015-07-01 00:00:00

abstract：:This review summarizes recent work on the use of reporter genes to label selected neuronal populations in transgenic mice, with particular emphasis on gonadotropin-releasing hormone (GnRH) neurons. Reporter genes discussed are the lacZ, green fluorescent protein (GFP), luc, and bla genes, which encode the reporter pro...

journal_title：Progress in neurobiology

authors： Spergel DJ,Krüth U,Shimshek DR,Sprengel R,Seeburg PH

更新日期：2001-04-01 00:00:00

abstract：:To understand the cellular mechanisms underlying behaviours in mammals, the respective contributions of the individual properties characterizing each neuron, as opposed to the properties emerging from the organization of these neurons in functional networks, have to be evaluated. This requires the use, in the same spe...

journal_title：Progress in neurobiology

authors： Vibert N,De Waele C,Serafin M,Babalian A,Mühlethaler M,Vidal PP

更新日期：1997-02-01 00:00:00

abstract：:At the psychological level, the notion that emotional events may be better remembered is a long accepted view. Its translation into neurobiological mechanisms has led to the proposal of the 'emotional tag' concept, according to which, the activation of the amygdala by emotionality would result in modulation of neural ...

journal_title：Progress in neurobiology

authors： Bergado JA,Lucas M,Richter-Levin G

更新日期：2011-06-01 00:00:00

abstract：:Nervous system development, plasticity and regeneration require numerous, coordinated and finely tuned subcellular mechanisms. Phosphoproteins of the stathmin family, originally identified as intracellular signal relay proteins, are mostly or exclusively expressed in the nervous system with a high level of expression ...

journal_title：Progress in neurobiology

authors： Chauvin S,Sobel A

更新日期：2015-03-01 00:00:00

abstract：:The electrophysiological alterations provoked by axotomy have now been studied for almost half a century, in a number of different cell types. Consequently, it is now possible to detail some common mechanisms underlying these changes and to sort out certain trends in the data. The major phenomena reviewed in this sect...

journal_title：Progress in neurobiology

authors： Titmus MJ,Faber DS

更新日期：1990-01-01 00:00:00

abstract：:Microglia, macrophages that reside in the brain, can express at least 12 different ion channels, including voltage-gated proton channels. The properties of H+ currents in microglia are similar to those in other phagocytes. Proton currents are elicited by depolarizing the membrane potential, but activation also depends...

journal_title：Progress in neurobiology

authors： Eder C,DeCoursey TE

更新日期：2001-06-01 00:00:00

abstract：:As the genetics of neurodegenerative disease become better understood, opportunities for genetic susceptibility testing for at-risk individuals will increase. Such testing raises important ethical and practice issues related to test access, informed consent, risk estimation and communication, return of results, and po...

journal_title：Progress in neurobiology

authors： Roberts JS,Uhlmann WR

更新日期：2013-11-01 00:00:00

abstract：:Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of neurodegenerative disorders (NDs) by stimulating, responding to and interacting with target sites to induce physiological responses while minimizing side-effects. C...

journal_title：Progress in neurobiology

authors： Modi G,Pillay V,Choonara YE,Ndesendo VM,du Toit LC,Naidoo D

更新日期：2009-08-01 00:00:00

abstract：:Steroid hormones act via evolutionarily conserved nuclear receptors to regulate neuronal phenotype during development, maturity and disease. Steroid hormones exert 'global' effects in organisms to produce coordinated physiological responses whereas, at the 'local' level, individual neurons can respond to a steroidal s...

journal_title：Progress in neurobiology

authors： Weeks JC

更新日期：2003-08-01 00:00:00

abstract：:Developing neuronal networks evolve continuously, requiring that neurons modulate both their intrinsic properties and their responses to incoming synaptic signals. Emerging evidence supports roles for the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in this neuronal plasticity. HCN channels seem ...

journal_title：Progress in neurobiology

authors： Bender RA,Baram TZ

更新日期：2008-11-01 00:00:00

abstract：:Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical, cellular, and biochemical manifestations that are currently not understood in combination. This has led to many views of AD, e.g. the amyloid, tau, presenilin, oxidative stress, and metal hypotheses. The amyloid hypothesis has do...

journal_title：Progress in neurobiology

authors： Kepp KP

更新日期：2016-08-01 00:00:00

abstract：:The wide tissue distribution of butyrylcholinesterase (BChE) in organisms makes specific roles possible, although no clear physiologic function has yet been assigned to this enzyme. In vertebrates, it appears e.g. in serum, hemopoietic cells, liver, lung, heart, at cholinergic synapses, in the central nervous system. ...

journal_title：Progress in neurobiology

authors： Mack A,Robitzki A

更新日期：2000-04-01 00:00:00

abstract：:Tissue-specific alternative splicing profoundly effects animal physiology, development and disease, and this is nowhere more evident than in the nervous system. Alternative splicing is a versatile form of genetic control whereby a common pre-mRNA is processed into multiple mRNA isoforms differing in their precise comb...

journal_title：Progress in neurobiology

authors： Grabowski PJ,Black DL

更新日期：2001-10-01 00:00:00