Nanotechnological applications for the treatment of neurodegenerative disorders.

abstract：:Noradrenaline release in areas within the forebrain occurs following activation of noradrenergic cells in the locus coeruleus (LoC). Release of noradrenaline by attentional/arousal/vigilance factors appears to be essential for learning and is responsible for the consolidation of memory. Noradrenaline can activate any ...

journal_title：Progress in neurobiology

authors： Gibbs ME,Summers RJ

更新日期：2002-08-01 00:00:00

abstract：:The spectrum of inflammatory diseases is nowadays considered to include diverse diseases of the central nervous system (CNS). Current evidence suggests that syndromes such as Alzheimer's disease (AD) have important inflammatory and immune components and may be amenable to treatment by anti-inflammatory and immunothera...

journal_title：Progress in neurobiology

authors： Shen Y,Meri S

更新日期：2003-08-01 00:00:00

abstract：:Preeclampsia is a hypertensive disorder of pregnancy that can involve dangerous neurological symptoms such as spontaneous seizures (eclampsia). Despite being diseases specific to the pregnant state, preeclampsia and eclampsia have long-lasting neurological consequences later in life, including changes in brain structu...

journal_title：Progress in neurobiology

authors： Johnson AC,Li Z,Orfila JE,Herson PS,Cipolla MJ

更新日期：2020-10-29 00:00:00

abstract：:Neurologic disease is a major cause of disability in resource-poor countries and a substantial portion of this disease is due to infections of the CNS. A wide variety of emerging and re-emerging viruses contribute to this disease burden. New emerging infections are commonly due to RNA viruses that have expanded their ...

journal_title：Progress in neurobiology

authors： Griffin DE

更新日期：2010-06-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) constitute a unique population of glia that accompany and ensheath the primary olfactory axons. They are thought to be critical for spontaneous growth of olfactory axons within the developing and adult olfactory nervous system, and have recently emerged as potential candidates for ce...

journal_title：Progress in neurobiology

authors： Su Z,He C

更新日期：2010-12-01 00:00:00

abstract：:Behavioral responses to a perceptual stimulus are typically faster with repeated exposure to the stimulus (behavioral priming). This implicit learning mechanism is critical for survival but impaired in a variety of neurological disorders, including Alzheimer's disease. Many studies of the neural bases for behavioral p...

journal_title：Progress in neurobiology

authors： Korzeniewska A,Wang Y,Benz HL,Fifer MS,Collard M,Milsap G,Cervenka MC,Martin A,Gotts SJ,Crone NE

更新日期：2020-06-01 00:00:00

abstract：:In this review first we evaluate evidence on the role of the neurobiological alterations induced by chronic ethanol consumption in the development of ethanol tolerance, dependence and withdrawal. Secondly, we describe the neuropathological consequences of chronic ethanol on cognitive functions and on brain structures....

journal_title：Progress in neurobiology

authors： Fadda F,Rossetti ZL

更新日期：1998-11-01 00:00:00

abstract：:It is suggested that the brain undergoes plastic changes in order to adapt to changing environmental needs. Sensory deprivation results in decreased input to the brain leading to adaptive or maladaptive changes. Although several theories hypothesize the mechanism of these adaptive and maladaptive changes, the course o...

journal_title：Progress in neurobiology

authors： Mohan A,Vanneste S

更新日期：2017-06-01 00:00:00

abstract：:Most spiking neurons are divided into functional compartments: a dendritic input region, a soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of action potentials, and distal arborizations and terminals carrying the output synapses. The axon trunk and lower order branches ar...

journal_title：Progress in neurobiology

authors： Bucher D,Goaillard JM

更新日期：2011-09-01 00:00:00

abstract：:Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different from all other peripheral neurons. The IPANs are transducers of physiological stimuli, including movement of the villi or distortion of the mucosa, contraction of intestinal muscle and changes in the chemistry of the contents ...

journal_title：Progress in neurobiology

authors： Furness JB,Jones C,Nurgali K,Clerc N

更新日期：2004-02-01 00:00:00

abstract：:This article reviews the application of information-theoretical analysis, employing measures of entropy and mutual information, for the study of aging and aging-related diseases. The research of aging and aging-related diseases is particularly suitable for the application of information theory methods, as aging proces...

journal_title：Progress in neurobiology

authors： Blokh D,Stambler I

更新日期：2017-10-01 00:00:00

abstract：:Memorizing new facts and events means that entering information produces specific physical changes within the brain. According to the commonly accepted view, traces of memory are stored through the structural modifications of synaptic connections, which result in changes of synaptic efficiency and, therefore, in forma...

journal_title：Progress in neurobiology

authors： Arshavsky YI

更新日期：2006-10-01 00:00:00

abstract：:Homeoproteins are well known for their role in defining the shape of organs during early development. The late expression of some homeogenes in the nervous system suggests that they might have other, additional functions, possibly in neurite growth and target recognition. The 60 amino acid-long peptide corresponding t...

journal_title：Progress in neurobiology

authors： Joliot A,Le Roux I,Volovitch M,Bloch-Gallego E,Prochiantz A

更新日期：1994-02-01 00:00:00

abstract：:To understand the cellular mechanisms underlying behaviours in mammals, the respective contributions of the individual properties characterizing each neuron, as opposed to the properties emerging from the organization of these neurons in functional networks, have to be evaluated. This requires the use, in the same spe...

journal_title：Progress in neurobiology

authors： Vibert N,De Waele C,Serafin M,Babalian A,Mühlethaler M,Vidal PP

更新日期：1997-02-01 00:00:00

abstract：:Not later than two synapses after their arrival in the cerebellar cortex all excitatory afferent signals are subsequently transformed into inhibitory ones. Guaranteed by the exceedingly ordered and stereotyped synaptic arrangement of its cellular elements, the cerebellar cortex transmits this inhibitory result of cere...

journal_title：Progress in neurobiology

authors： Grüsser-Cornehls U,Bäurle J

更新日期：2001-04-01 00:00:00

abstract：:Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, hallmarks of aging and...

journal_title：Progress in neurobiology

authors： Vartak-Sharma N,Nooka S,Ghorpade A

更新日期：2017-10-01 00:00:00

abstract：:Neuromuscular junctions (NMJs) have long been studied as particularly accessible examples of chemical synapses. Nonetheless, some important features of neuromuscular transmission are still poorly understood. One of these is the low statistical variability of the number of transmitter quanta released from motor nerve t...

journal_title：Progress in neurobiology

authors： Slater CR

更新日期：2015-11-01 00:00:00

abstract：:This paper provides the first review of the memory-enhancing and neuroprotective metabolic mechanisms of action of methylene blue in vivo. These mechanisms have important implications as a new neurobiological approach to improve normal memory and to treat memory impairment and neurodegeneration associated with mitocho...

journal_title：Progress in neurobiology

authors： Rojas JC,Bruchey AK,Gonzalez-Lima F

更新日期：2012-01-01 00:00:00

abstract：:Problems associated with the topic of the mind-brain interaction are reviewed and analyzed. If there is an interaction, then the "mind" and "brain" are independent variables; the mind represents subjective experience and is therefore a non-physical phenomenon. This fact led to the need for a field theory, termed here ...

journal_title：Progress in neurobiology

authors： Libet B

更新日期：2006-02-01 00:00:00

abstract：:Brain damage can sometimes render a patient persistently unresponsive and yet apparently awake, admitting the possibility that the absence of overt voluntary behaviour might conceal a retained capacity for covert cognition. When given instructions to perform a cognitive task, a minority of patients in such a so-called...

journal_title：Progress in neurobiology

authors： Nachev P,Hacker PM

更新日期：2010-05-01 00:00:00

abstract：:Removal from receptors of neurotransmitters just released into synapses is one of the major steps in neurotransmission. Transporters situated on the plasma membrane of nerve endings and glial cells perform the process of neurotransmitter (re)uptake. Because the density of transporters in the membranes can fluctuate, t...

journal_title：Progress in neurobiology

authors： Raiteri L,Raiteri M

更新日期：2015-11-01 00:00:00

abstract：:Rapid developments in medical neuroimaging have made it possible to reconstruct the trajectory of Alzheimer's disease (AD) as it spreads through the living brain. The current review focuses on the progressive signature of brain changes throughout the different stages of AD. We integrate recent findings on changes in c...

journal_title：Progress in neurobiology

authors： Ewers M,Frisoni GB,Teipel SJ,Grinberg LT,Amaro E Jr,Heinsen H,Thompson PM,Hampel H

更新日期：2011-12-01 00:00:00

abstract：:Stimulation of membrane receptors linked to a phospholipase C and the subsequent production of the second messengers diacylglycerol and inositol-1,4,5-trisphosphate (InsP(3)) is a signaling pathway of fundamental importance in eukaryotic cells. Signaling downstream of these initial steps involves mobilization of Ca(2+...

journal_title：Progress in neurobiology

authors： Zitt C,Halaszovich CR,Lückhoff A

更新日期：2002-03-01 00:00:00

abstract：:Endogenous circadian rhythms govern most aspects of physiology and behaviour in mammals, including body temperature, autonomic and endocrine function, and sleep-wake cycles. Such rhythms are generated by the suprachiasmatic nucleus of the hypothalamus (SCN), but are synchronised to the environmental light-dark cycle b...

journal_title：Progress in neurobiology

authors： Ebling FJ

更新日期：1996-10-01 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is one an intriguing set of nine neurodegenerative diseases caused by the expansion of a unstable trinucleotide CAG repeat where the repeat is located within the coding of the affected gene, i.e. the polyglutamine (polyQ) diseases. A gain-of-function mechanism for toxicity in SCA1,...

journal_title：Progress in neurobiology

authors： Orr HT

更新日期：2012-12-01 00:00:00

abstract：:New findings obtained during the past years, especially the discovery of mutations in the genes associated with brain iron metabolism, have provided key insights into the homeostatic mechanisms of brain iron metabolism and the pathological mechanisms responsible for neurodegenerative diseases. The accumulated evidence...

journal_title：Progress in neurobiology

authors： Ke Y,Qian ZM

更新日期：2007-10-01 00:00:00

abstract：:Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical, cellular, and biochemical manifestations that are currently not understood in combination. This has led to many views of AD, e.g. the amyloid, tau, presenilin, oxidative stress, and metal hypotheses. The amyloid hypothesis has do...

journal_title：Progress in neurobiology

authors： Kepp KP

更新日期：2016-08-01 00:00:00

abstract：:Until recently, memory consolidation and storage had been traditionally viewed as a permissive process derived from learning-activated molecular signaling cascades which include activations of the NMDA receptors, CaMKII, PKC, PKA and other kinases, new protein synthesis and CREB-mediated gene expression, and subsequen...

journal_title：Progress in neurobiology

authors： Wang H,Hu Y,Tsien JZ

更新日期：2006-06-01 00:00:00

abstract：:The S-100 is a group of low molecular weight (10-12 kD) calcium-binding proteins highly conserved among vertebrates. It is present in different tissues as dimers of homologous or different subunits (alpha, beta). In the nervous system, the S-100 exists as a mixture composed of beta beta and alpha beta dimers with the ...

journal_title：Progress in neurobiology

authors： Fanò G,Biocca S,Fulle S,Mariggiò MA,Belia S,Calissano P

更新日期：1995-05-01 00:00:00

abstract：:Here, we discuss the identity, heterogeneity and functions of radial glial cells mostly in the developing central nervous system (CNS). First, we define radial glial cells by morphological, cell biological and molecular criteria as true glial cells, akin to astroglia. We then describe the appearance of radial glial ce...

journal_title：Progress in neurobiology

authors： Pinto L,Götz M

更新日期：2007-09-01 00:00:00