Abstract:
:Spinocerebellar ataxia type 1 (SCA1) is one an intriguing set of nine neurodegenerative diseases caused by the expansion of a unstable trinucleotide CAG repeat where the repeat is located within the coding of the affected gene, i.e. the polyglutamine (polyQ) diseases. A gain-of-function mechanism for toxicity in SCA1, like the other polyQ diseases, is thought to have a major role in pathogenesis. Yet, the specific nature of this gain-of-function is a matter of considerable discussion. An issue concerns whether toxicity stems from the native or normal function of the affected protein versus a novel function induced by polyQ expansion. For SCA1 considerable evidence is accumulating that pathology is mediated by a polyQ-induced exaggeration of a native function of the host protein Ataxin-1 (ATXN1) and that phosphorylation of S776 regulates its interaction with other cellular protein and thereby function. In addition, this posttranslational modification modulates toxicity of ATXN1 with an expanded polyglutamine.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Orr HTdoi
10.1016/j.pneurobio.2012.04.003subject
Has Abstractpub_date
2012-12-01 00:00:00pages
179-85issue
3eissn
0301-0082issn
1873-5118pii
S0301-0082(12)00051-2journal_volume
99pub_type
杂志文章,评审abstract::Neurologic disease is a major cause of disability in resource-poor countries and a substantial portion of this disease is due to infections of the CNS. A wide variety of emerging and re-emerging viruses contribute to this disease burden. New emerging infections are commonly due to RNA viruses that have expanded their ...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2009.12.003
更新日期:2010-06-01 00:00:00
abstract::Until recently, memory consolidation and storage had been traditionally viewed as a permissive process derived from learning-activated molecular signaling cascades which include activations of the NMDA receptors, CaMKII, PKC, PKA and other kinases, new protein synthesis and CREB-mediated gene expression, and subsequen...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2006.06.004
更新日期:2006-06-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.07.001
更新日期:2016-01-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2001-06-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2006.06.001
更新日期:2006-06-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101770
更新日期:2020-04-01 00:00:00
abstract::The K+-Cl- co-transporter KCC2 is a neuron-specific, Cl- extruder that uses K+ gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly-directed electrochemical Cl- gradient across the neuronal membrane is fundamental for a proper function of postsynaptic GABAA recep...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.11.002
更新日期:2018-03-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(96)00041-x
更新日期:1996-11-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(98)00029-x
更新日期:1998-10-01 00:00:00
abstract::Psychosocial and biological factors have been implicated in paedophilia, such as alterations in brain structure and function. The purpose of this paper is to review the expanding body of literature on this topic including brain abnormality case reports, as well as structural and functional neuroimaging studies. Case s...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2014.07.005
更新日期:2014-11-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(97)00023-3
更新日期:1997-08-01 00:00:00
abstract::The advent of proteomics techniques has been enthusiastically accepted in most areas of biology and medicine. In neuroscience, a host of applications was proposed ranging from neurotoxicology, neurometabolism, determination of the proteome of the individual brain areas in health and disease, to name a few. Only recent...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(03)00036-4
更新日期:2003-02-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2015.12.002
更新日期:2017-05-01 00:00:00
abstract::At the psychological level, the notion that emotional events may be better remembered is a long accepted view. Its translation into neurobiological mechanisms has led to the proposal of the 'emotional tag' concept, according to which, the activation of the amygdala by emotionality would result in modulation of neural ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2011.03.004
更新日期:2011-06-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2005.09.005
更新日期:2005-08-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(97)00051-8
更新日期:1998-01-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:
更新日期:1995-11-01 00:00:00
abstract::Neural stem and progenitor cells (NSPCs) are the primary source of new neurons in the brain and serve critical roles in tissue homeostasis and plasticity throughout life. Within the vertebrate brain, NSPCs are located within distinct neurogenic niches differing in their location, cellular composition, and proliferativ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(97)00036-1
更新日期:1997-11-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2010.01.008
更新日期:2010-06-01 00:00:00
abstract::Alzheimer's Disease (AD) is a highly complex disease involving a broad range of clinical, cellular, and biochemical manifestations that are currently not understood in combination. This has led to many views of AD, e.g. the amyloid, tau, presenilin, oxidative stress, and metal hypotheses. The amyloid hypothesis has do...
journal_title:Progress in neurobiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-08-01 00:00:00
abstract::The brain circuitry of saccadic eye movements, from brainstem to cortex, has been extensively studied during the last 30 years. The wealth of data gathered allowed the conception of numerous computational models. These models proposed descriptions of the putative mechanisms generating this data, and, in turn, made pre...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2005.11.001
更新日期:2005-11-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.08.002
更新日期:2018-10-01 00:00:00
abstract::Memorizing new facts and events means that entering information produces specific physical changes within the brain. According to the commonly accepted view, traces of memory are stored through the structural modifications of synaptic connections, which result in changes of synaptic efficiency and, therefore, in forma...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2006.09.004
更新日期:2006-10-01 00:00:00
abstract::The wide tissue distribution of butyrylcholinesterase (BChE) in organisms makes specific roles possible, although no clear physiologic function has yet been assigned to this enzyme. In vertebrates, it appears e.g. in serum, hemopoietic cells, liver, lung, heart, at cholinergic synapses, in the central nervous system. ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(99)00047-7
更新日期:2000-04-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2019.03.001
更新日期:2019-05-01 00:00:00
abstract::Brain lactate formation, intercellular exchange and utilization has been implicated in memory formation. However, the individual role of either neuronal or astroglial monocarboxylate transporters for the acquisition and consolidation of information remains incomplete. Using novel transgenic mice and a viral vector app...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101888
更新日期:2020-11-01 00:00:00
abstract::Recognition is the process by which a subject is aware that a stimulus has been previously experienced. It requires that the characteristics of events are perceived, discriminated, identified and then compared (matched) against a memory of the characteristics of previously experienced events. Understanding recognition...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(97)00060-9
更新日期:1998-02-01 00:00:00