Abstract:
:Recognition is the process by which a subject is aware that a stimulus has been previously experienced. It requires that the characteristics of events are perceived, discriminated, identified and then compared (matched) against a memory of the characteristics of previously experienced events. Understanding recognition memory, its underlying neuronal mechanisms, its dysfunction and alleviation of the latter by putative cognition enhancing drugs is a major research target and has triggered a wealth of animal studies. One of the most widely used animals for this purpose is the rat, and it is the rat's recognition memory which is the focus of this review. In this first part, concepts of recognition memory, stages of mnemonic processing and paradigms for the measurement of the rat's recognition memory will be discussed. In two subsequent articles (parts II and III) we will focus on the neuronal mechanisms underlying recognition memory in rats. Three major points arise from the comparison of paradigms that have in the past been used to assess recognition memory in rats. First, it should be realized that some tasks which, at face value, can all be considered to measure recognition memory in rats, may not assess recognition memory at all but may, for example, be based on recall rather than recognition. Second, it is evident that different types of recognition memory can be distinguished and that tasks differ in the type of recognition memory taxed. Some paradigms, for example, measure familiarity, whereas others assess recency. Furthermore, paradigms differ as to whether spatial stimuli or items are employed. Third, different processes, ranging from stimulus-response learning to the formation of concepts, may be involved to varying extent in different tasks. These are important considerations and question the predictive validity of the results obtained from studies examining, for example, the effects of putative cognition enhancing drugs.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Steckler T,Drinkenburg WH,Sahgal A,Aggleton JPdoi
10.1016/s0301-0082(97)00060-9subject
Has Abstractpub_date
1998-02-01 00:00:00pages
289-311issue
3eissn
0301-0082issn
1873-5118pii
S0301-0082(97)00060-9journal_volume
54pub_type
杂志文章,评审abstract::Not later than two synapses after their arrival in the cerebellar cortex all excitatory afferent signals are subsequently transformed into inhibitory ones. Guaranteed by the exceedingly ordered and stereotyped synaptic arrangement of its cellular elements, the cerebellar cortex transmits this inhibitory result of cere...
journal_title:Progress in neurobiology
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abstract::Any biological structure can be studied using mutations that interfere either with its emergence or its function. We investigate spontaneous and induced mutations in the mouse that affect neuromuscular development and function. The wobbler mouse (phenotype WR, genotype wr/wr) suffers from muscular atrophy because of t...
journal_title:Progress in neurobiology
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abstract::The Midline Glia of Drosophila are required for nervous system morphogenesis and midline axon guidance during embryogenesis. In origin, gene expression and function, this lineage is analogous to the floorplate of the vertebrate neural tube. The expression or function of over 50 genes, summarised here, has been linked ...
journal_title:Progress in neurobiology
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abstract::Japanese encephalitis (JE) is one of the most important endemic encephalitis in the world especially in Eastern and Southeastern Asia. JE affects over 50,000 patients and results in 15,000 deaths annually. JE virus is a single stranded positive sense RNA virus belonging to family flaviviridae. JE virus is transmitted ...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:1995-10-01 00:00:00
abstract::Microglia, macrophages that reside in the brain, can express at least 12 different ion channels, including voltage-gated proton channels. The properties of H+ currents in microglia are similar to those in other phagocytes. Proton currents are elicited by depolarizing the membrane potential, but activation also depends...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(00)00062-9
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2009-01-12 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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abstract::Following rapid methodological advances, ultra-high field (UHF) functional and anatomical magnetic resonance imaging (MRI) has been repeatedly and successfully used for the investigation of the human auditory system in recent years. Here, we review this work and argue that UHF MRI is uniquely suited to shed light on h...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101887
更新日期:2020-08-01 00:00:00
abstract::There has been an abundance of literature devoted to the involvement of noradrenaline in basic rapid eye movement (REM) sleep processes since the subject was first investigated in 1964. Nowadays, the great majority of studies highlight the need for silence in the locus coeruleus noradrenergic neurons as a condition fo...
journal_title:Progress in neurobiology
pub_type: 历史文章,杂志文章,评审
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更新日期:2008-07-01 00:00:00
abstract::Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust protection against subsequent lethal injuries. Preconditioning has been observed in multiple organisms and can occur in the brain as well as other tissues. Extensive animal studies suggest that the brain can be preconditioned t...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2013.11.005
更新日期:2014-03-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(97)00078-6
更新日期:1998-04-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2009.05.002
更新日期:2009-08-01 00:00:00
abstract::Sound communication is not unique to humans but rather is a trait shared with most non-mammalian vertebrates. A practical way to address questions of vocal signal encoding has been to identify mechanisms in non-mammalian model systems that use acoustic communication signals in their social behavior. Teleost fishes, th...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(03)00004-2
更新日期:2003-01-01 00:00:00
abstract::Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which affects about 0.3% of the general population. As the population in the developed world ages, this creates an escalating burden on society both in economic terms and in quality of life for these patients and for the families that supp...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2018.04.005
更新日期:2018-09-01 00:00:00
abstract::White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI) and myelination has been suggested as a possible mechanism. Here, we set out to identify molecular and cellular changes ass...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2020.101770
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abstract::Self-supervised models of how the brain represents and categorises the causes of its sensory input can be divided into two classes: those that minimise the mutual information (i.e. redundancy) among evoked responses and those that minimise the prediction error. Although these models have similar goals, the way they ar...
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pub_type: 杂志文章,评审
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journal_title:Progress in neurobiology
pub_type: 历史文章,杂志文章,评审
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abstract::Neuromuscular junctions (NMJs) have long been studied as particularly accessible examples of chemical synapses. Nonetheless, some important features of neuromuscular transmission are still poorly understood. One of these is the low statistical variability of the number of transmitter quanta released from motor nerve t...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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abstract::In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease due to loss of upper motor neurons in cerebral cortex and lower motor neurons in brainstem and spinal cord. Accumulating evidence from recent studies suggests that th...
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更新日期:2012-05-01 00:00:00
abstract::Noradrenaline release in areas within the forebrain occurs following activation of noradrenergic cells in the locus coeruleus (LoC). Release of noradrenaline by attentional/arousal/vigilance factors appears to be essential for learning and is responsible for the consolidation of memory. Noradrenaline can activate any ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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abstract::Neurologic disease is a major cause of disability in resource-poor countries and a substantial portion of this disease is due to infections of the CNS. A wide variety of emerging and re-emerging viruses contribute to this disease burden. New emerging infections are commonly due to RNA viruses that have expanded their ...
journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2009.12.003
更新日期:2010-06-01 00:00:00
abstract::Nervous system development, plasticity and regeneration require numerous, coordinated and finely tuned subcellular mechanisms. Phosphoproteins of the stathmin family, originally identified as intracellular signal relay proteins, are mostly or exclusively expressed in the nervous system with a high level of expression ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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abstract::As the genetics of neurodegenerative disease become better understood, opportunities for genetic susceptibility testing for at-risk individuals will increase. Such testing raises important ethical and practice issues related to test access, informed consent, risk estimation and communication, return of results, and po...
journal_title:Progress in neurobiology
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abstract::Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory or...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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abstract::Long-term consequences of anesthetic exposure in humans are not well understood. It is possible that alterations in brain function occur beyond the initial anesthetic administration. Research in children and adults has reported cognitive and/or behavioral changes after surgery and general anesthesia that may be short ...
journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00