Abstract：
:Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which affects about 0.3% of the general population. As the population in the developed world ages, this creates an escalating burden on society both in economic terms and in quality of life for these patients and for the families that support them. Although currently available pharmacological or surgical treatments may significantly improve the quality of life of many patients with PD, these are symptomatic treatments that do not slow or stop the progressive course of the disease. Because motor impairments in PD largely result from loss of midbrain dopamine neurons in the substantia nigra pars compacta, PD has long been considered to be one of the most promising target diseases for cell-based therapy. Indeed, numerous clinical and preclinical studies using fetal cell transplantation have provided proof of concept that cell replacement therapy may be a viable therapeutic approach for PD. However, the use of human fetal cells as a standardized therapeutic regimen has been fraught with fundamental ethical, practical, and clinical issues, prompting scientists to explore alternative cell sources. Based on groundbreaking establishments of human embryonic stem cells and induced pluripotent stem cells, these human pluripotent stem cells have been the subject of extensive research, leading to tremendous advancement in our understanding of these novel classes of stem cells and promising great potential for regenerative medicine. In this review, we discuss the prospects and challenges of human pluripotent stem cell-based cell therapy for PD.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Sonntag KC,Song B,Lee N,Jung JH,Cha Y,Leblanc P,Neff C,Kong SW,Carter BS,Schweitzer J,Kim KSdoi
10.1016/j.pneurobio.2018.04.005subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1-20eissn
0301-0082issn
1873-5118pii
S0301-0082(17)30104-1journal_volume
168pub_type
杂志文章,评审abstract：:Recent evidence has shown that neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD). However, different components of the brain's immune system may exert diverse effects on neuroinflammatory events in PD. The adaptive immune response, especially the T cell response, can trigger type 1 pro...
journal_title：Progress in neurobiology
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pub_type： 历史文章,杂志文章,评审
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2013.02.005
更新日期：2013-11-01 00:00:00
abstract：:Parkinson's disease is the second most common neurodegenerative disorder, characterized by the manifestation of motor symptoms, which are mainly attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra. Based on advancements in the understanding of the pathophysiology of the disease,...
journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2016.07.003
更新日期：2017-04-01 00:00:00
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.pneurobio.2013.04.003
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doi：10.1016/s0301-0082(96)00057-3
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pub_type： 杂志文章,评审
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journal_title：Progress in neurobiology
pub_type： 杂志文章,评审
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