Cysteine string proteins.


:Cysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory organelles. Knockout of the csp gene in Drosophila produced temperature-sensitive paralysis reflecting a loss of evoked (but not spontaneous) transmitter release. However, CSP's role in regulated exocytosis remains ambiguous. Fruit flies lacking the csp gene also exhibited nerve terminal degeneration as did mice deficient in the csp-α gene. This phenotype has been ascribed to the depletion of a functional pool of the t-SNARE, SNAP-25. However, recent studies showing that an endosomal pool of CSP-α contributes to a novel, protein-export pathway argues that CSP's role in neurodegeneration is more complex. Clients of this later pathway include tau and α-synuclein, proteins linked to neurodegeneration. Additionally, mutations in the csp-α gene cause an adult-onset, neuronal ceroid lipofuscinosis and diminished CSP-α expression is an early event in Alzheimer's disease. Collectively, these findings indicate that much remains to be learned about the role of CSPs in cellular secretory pathways and human disease.


Prog Neurobiol


Progress in neurobiology


Gundersen CB




Has Abstract


2020-05-01 00:00:00












  • The subiculum: a review of form, physiology and function.

    abstract::We review the neuroanatomical, neurophysiological and functional properties of the mammalian subiculum in this paper. The subiculum is a pivotal structure positioned between the hippocampus proper and entorhinal and other cortices, as well as a range of subcortical structures. It is an under-investigated region that p...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: O'Mara SM,Commins S,Anderson M,Gigg J

    更新日期:2001-06-01 00:00:00

  • Covert cognition in the persistent vegetative state.

    abstract::Brain damage can sometimes render a patient persistently unresponsive and yet apparently awake, admitting the possibility that the absence of overt voluntary behaviour might conceal a retained capacity for covert cognition. When given instructions to perform a cognitive task, a minority of patients in such a so-called...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Nachev P,Hacker PM

    更新日期:2010-05-01 00:00:00

  • The origin and differentiation of microglial cells during development.

    abstract::Some authors claim that microglia originate from the neuroepithelium, although most now believe that microglial cells are of mesodermal origin, and probably belong to the monocyte/macrophage cell line. These cells must enter the developing central nervous system (CNS) from the blood stream, the ventricular space or th...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Cuadros MA,Navascués J

    更新日期:1998-10-01 00:00:00

  • Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND.

    abstract::Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, hallmarks of aging and...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Vartak-Sharma N,Nooka S,Ghorpade A

    更新日期:2017-10-01 00:00:00

  • ACTH modulation of nerve development and regeneration.

    abstract::(1) The availability of short amino acid sequences of the naturally occurring ACTH 1-39 molecule has made it possible to separate the corticotropic characteristics of the parent molecule from its neurotrophic effects. Potent neurotrophic fragments are ACTH 4-10, an analog of ACTH 4-9 (Org 2766), and alpha-MSH (ACTH 1-...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Strand FL,Rose KJ,King JA,Segarra AC,Zuccarelli LA

    更新日期:1989-01-01 00:00:00

  • Thinking globally, acting locally: steroid hormone regulation of the dendritic architecture, synaptic connectivity and death of an individual neuron.

    abstract::Steroid hormones act via evolutionarily conserved nuclear receptors to regulate neuronal phenotype during development, maturity and disease. Steroid hormones exert 'global' effects in organisms to produce coordinated physiological responses whereas, at the 'local' level, individual neurons can respond to a steroidal s...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Weeks JC

    更新日期:2003-08-01 00:00:00

  • Nanotechnological applications for the treatment of neurodegenerative disorders.

    abstract::Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of neurodegenerative disorders (NDs) by stimulating, responding to and interacting with target sites to induce physiological responses while minimizing side-effects. C...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Modi G,Pillay V,Choonara YE,Ndesendo VM,du Toit LC,Naidoo D

    更新日期:2009-08-01 00:00:00

  • Voltage-gated proton channels in microglia.

    abstract::Microglia, macrophages that reside in the brain, can express at least 12 different ion channels, including voltage-gated proton channels. The properties of H+ currents in microglia are similar to those in other phagocytes. Proton currents are elicited by depolarizing the membrane potential, but activation also depends...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Eder C,DeCoursey TE

    更新日期:2001-06-01 00:00:00

  • Effects of estrogens and androgens on mitochondria under normal and pathological conditions.

    abstract::Several lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated ...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Mohajeri M,Martín-Jiménez C,Barreto GE,Sahebkar A

    更新日期:2019-05-01 00:00:00

  • Neuronal stathmins: a family of phosphoproteins cooperating for neuronal development, plasticity and regeneration.

    abstract::Nervous system development, plasticity and regeneration require numerous, coordinated and finely tuned subcellular mechanisms. Phosphoproteins of the stathmin family, originally identified as intracellular signal relay proteins, are mostly or exclusively expressed in the nervous system with a high level of expression ...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Chauvin S,Sobel A

    更新日期:2015-03-01 00:00:00

  • Molecular and systems mechanisms of memory consolidation and storage.

    abstract::Until recently, memory consolidation and storage had been traditionally viewed as a permissive process derived from learning-activated molecular signaling cascades which include activations of the NMDA receptors, CaMKII, PKC, PKA and other kinases, new protein synthesis and CREB-mediated gene expression, and subsequen...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Wang H,Hu Y,Tsien JZ

    更新日期:2006-06-01 00:00:00

  • Nano- and neurotoxicology: An emerging discipline.

    abstract::The present critical review analyzes the question of how nanoparticles from continuously growing industrial production and use of nanomaterials may impact human brain health. Available evidence suggests incomplete effectiveness of protective barriers of the brain against nanoparticles translocation to the brain. This ...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Bencsik A,Lestaevel P,Guseva Canu I

    更新日期:2018-01-01 00:00:00

  • Mitochondrial dysfunction and oxidative stress in Parkinson's disease.

    abstract::Parkinson's disease (PD) is a movement disorder that is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. Although majority of the PD cases are sporadic several genetic mutations have also been linked to the disease...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Subramaniam SR,Chesselet MF

    更新日期:2013-07-01 00:00:00

  • Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology.

    abstract::Obsessive-compulsive disorder (OCD) is characterized by repetitive intrusive thoughts and compulsive time-consuming behaviors classified into three to five distinct symptom dimensions including: (1) aggressive/somatic obsessions with checking compulsions; (2) contamination concerns with washing compulsions; (3) symmet...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Aouizerate B,Guehl D,Cuny E,Rougier A,Bioulac B,Tignol J,Burbaud P

    更新日期:2004-02-01 00:00:00

  • The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair.

    abstract::Neural stem and progenitor cells (NSPCs) are the primary source of new neurons in the brain and serve critical roles in tissue homeostasis and plasticity throughout life. Within the vertebrate brain, NSPCs are located within distinct neurogenic niches differing in their location, cellular composition, and proliferativ...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Lindsey BW,Hall ZJ,Heuzé A,Joly JS,Tropepe V,Kaslin J

    更新日期:2018-11-01 00:00:00

  • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases.

    abstract::The blood-brain barrier (BBB) serves as a protective mechanism for the brain by preventing entry of potentially harmful substances from free access to the central nervous system (CNS). Tight junctions present between the brain microvessel endothelial cells form a diffusion barrier, which selectively excludes most bloo...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Löscher W,Potschka H

    更新日期:2005-05-01 00:00:00

  • Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: a potent tool for expanding functional information.

    abstract::Despite huge improvements in neurobiological approaches for investigating the functional properties of neurotransmitter receptors and ion channels, many difficulties are still encountered when focusing on the human brain. Electrophysiological studies aimed at performing direct determinations on human nervous tissue ar...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章


    authors: Eusebi F,Palma E,Amici M,Miledi R

    更新日期:2009-05-01 00:00:00

  • Intrinsic primary afferent neurons of the intestine.

    abstract::After a long period of inconclusive observations, the intrinsic primary afferent neurons of the intestine have been identified. The intestine is thus equipped with two groups of afferent neurons, those with cell bodies in cranial and dorsal root ganglia, and these recently identified afferent neurons with cell bodies ...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Furness JB,Kunze WA,Bertrand PP,Clerc N,Bornstein JC

    更新日期:1998-01-01 00:00:00

  • The art of lineage tracing: From worm to human.

    abstract::Reconstructing the genealogy of every cell that makes up an organism remains a long-standing challenge in developmental biology. Besides its relevance for understanding the mechanisms underlying normal and pathological development, resolving the lineage origin of cell types will be crucial to create these types on-dem...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Garcia-Marques J,Espinosa-Medina I,Lee T

    更新日期:2020-11-26 00:00:00

  • Controversies and evolving new mechanisms in subarachnoid hemorrhage.

    abstract::Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and significant health problem in the United States and worldwide. The mechanisms contributing to brain injury after SAH remain unclear. Traditionally, most in vivo research has heavily emphasized the basic mechanisms of SAH over the pat...

    journal_title:Progress in neurobiology

    pub_type: 历史文章,杂志文章


    authors: Chen S,Feng H,Sherchan P,Klebe D,Zhao G,Sun X,Zhang J,Tang J,Zhang JH

    更新日期:2014-04-01 00:00:00

  • Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: From history to the interaction with the monoaminergic systems.

    abstract::Parkinson's disease is the second most common neurodegenerative disorder, characterized by the manifestation of motor symptoms, which are mainly attributed to the degeneration of dopamine neurons in the pars compacta of substantia nigra. Based on advancements in the understanding of the pathophysiology of the disease,...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Faggiani E,Benazzouz A

    更新日期:2017-04-01 00:00:00

  • Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue.

    abstract::This paper provides the first review of the memory-enhancing and neuroprotective metabolic mechanisms of action of methylene blue in vivo. These mechanisms have important implications as a new neurobiological approach to improve normal memory and to treat memory impairment and neurodegeneration associated with mitocho...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Rojas JC,Bruchey AK,Gonzalez-Lima F

    更新日期:2012-01-01 00:00:00

  • "The seven sins" of the Hebbian synapse: can the hypothesis of synaptic plasticity explain long-term memory consolidation?

    abstract::Memorizing new facts and events means that entering information produces specific physical changes within the brain. According to the commonly accepted view, traces of memory are stored through the structural modifications of synaptic connections, which result in changes of synaptic efficiency and, therefore, in forma...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Arshavsky YI

    更新日期:2006-10-01 00:00:00

  • The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features.

    abstract::As the population ages, the economic and societal impacts of neurodegenerative and neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive disorders are common and are linked to increased disability, high healthcare utilisation, cognitive decline and premature mortality. Considerab...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Naismith SL,Norrie LM,Mowszowski L,Hickie IB

    更新日期:2012-07-01 00:00:00

  • Proteomics in brain research: potentials and limitations.

    abstract::The advent of proteomics techniques has been enthusiastically accepted in most areas of biology and medicine. In neuroscience, a host of applications was proposed ranging from neurotoxicology, neurometabolism, determination of the proteome of the individual brain areas in health and disease, to name a few. Only recent...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Lubec G,Krapfenbauer K,Fountoulakis M

    更新日期:2003-02-01 00:00:00

  • Bioenergetics and glutamate excitotoxicity.

    abstract::Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationship between these two systems. Metabolic inhibition predisposes neuron...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Greene JG,Greenamyre JT

    更新日期:1996-04-01 00:00:00

  • Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease.

    abstract::Dementia encapsulates a set of symptoms that include loss of mental abilities such as memory, problem solving or language, and reduces a person's ability to perform daily activities. Alzheimer's disease is the most common form of dementia, however dementia can also occur in other neurological disorders such as Hunting...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Tyebji S,Hannan AJ

    更新日期:2017-06-01 00:00:00

  • Inhibitory learning and memory in newborn rats.

    abstract::Firstly, the noetic value of the ontogenetic approach to the problems of learning and memory is emphasized; then the heterochrony and uneven time course of the development of neural systems are accentuated, which fully holds for the basic cognitive functions. Contrary to a broadly accepted opinion, that inhibitory lea...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Myslivecek J

    更新日期:1997-11-01 00:00:00

  • Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon.

    abstract::Most spiking neurons are divided into functional compartments: a dendritic input region, a soma, a site of action potential initiation, an axon trunk and its collaterals for propagation of action potentials, and distal arborizations and terminals carrying the output synapses. The axon trunk and lower order branches ar...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章,评审


    authors: Bucher D,Goaillard JM

    更新日期:2011-09-01 00:00:00

  • Neurotrophic activity of a homeobox peptide.

    abstract::Homeoproteins are well known for their role in defining the shape of organs during early development. The late expression of some homeogenes in the nervous system suggests that they might have other, additional functions, possibly in neurite growth and target recognition. The 60 amino acid-long peptide corresponding t...

    journal_title:Progress in neurobiology

    pub_type: 杂志文章


    authors: Joliot A,Le Roux I,Volovitch M,Bloch-Gallego E,Prochiantz A

    更新日期:1994-02-01 00:00:00