Abstract：
:White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI) and myelination has been suggested as a possible mechanism. Here, we set out to identify molecular and cellular changes associated with WM plasticity measured by DTI. We combined DTI, immunohistochemistry and mRNA expression analysis and examined the effects of somatosensory experience in adult rats. First, we observed experience-induced DTI differences in WM and in grey matter structure. C-Fos mRNA expression, a marker of cortical activity, in the barrel cortex correlated with the MRI WM metrics, indicating that molecular correlates of cortical activity relate to macroscale measures of WM structure. Analysis of myelin-related genes revealed higher myelin basic protein (MBP) mRNA expression. Higher MBP protein expression was also found via immunohistochemistry in WM. Finally, unbiased RNA sequencing analysis identified 134 differentially expressed genes encoding proteins involved in functions related to cell proliferation and differentiation, regulation of myelination and neuronal activity modulation. In conclusion, macroscale measures of WM plasticity are supported by both molecular and cellular evidence and confirm that myelination is one of the underlying mechanisms.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Sampaio-Baptista C,Vallès A,Khrapitchev AA,Akkermans G,Winkler AM,Foxley S,Sibson NR,Roberts M,Miller K,Diamond ME,Martens GJM,De Weerd P,Johansen-Berg Hdoi
10.1016/j.pneurobio.2020.101770subject
Has Abstractpub_date
2020-04-01 00:00:00pages
101770eissn
0301-0082issn
1873-5118pii
S0301-0082(20)30025-3journal_volume
187pub_type
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