Abstract:
:Parkinson's disease (PD) is a movement disorder that is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in dopamine deficiency in the striatum. Although majority of the PD cases are sporadic several genetic mutations have also been linked to the disease thus providing new opportunities to study the pathology of the illness. Studies in humans and various animal models of PD reveal that mitochondrial dysfunction might be a defect that occurs early in PD pathogenesis and appears to be a widespread feature in both sporadic and monogenic forms of PD. The general mitochondrial abnormalities linked with the disease include mitochondrial electron transport chain impairment, alterations in mitochondrial morphology and dynamics, mitochondrial DNA mutations and anomaly in calcium homeostasis. Mitochondria are vital organelles with multiple functions and their dysfunction can lead to a decline in energy production, generation of reactive oxygen species and induction of stress-induced apoptosis. In this review, we give an outline of mitochondrial functions that are affected in the pathogenesis of sporadic and familial PD, and hence provide insights that might be valuable for focused future research to exploit possible mitochondrial targets for neuroprotective interventions in PD.
journal_name
Prog Neurobioljournal_title
Progress in neurobiologyauthors
Subramaniam SR,Chesselet MFdoi
10.1016/j.pneurobio.2013.04.004subject
Has Abstractpub_date
2013-07-01 00:00:00pages
17-32eissn
0301-0082issn
1873-5118pii
S0301-0082(13)00040-3journal_volume
106-107pub_type
杂志文章,评审abstract::Noradrenaline release in areas within the forebrain occurs following activation of noradrenergic cells in the locus coeruleus (LoC). Release of noradrenaline by attentional/arousal/vigilance factors appears to be essential for learning and is responsible for the consolidation of memory. Noradrenaline can activate any ...
journal_title:Progress in neurobiology
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abstract::Cognitive neuroscientists in the late 20th century began the task of identifying the part(s) of the brain concerned with normal behavior as manifest in the psychological capacities as affective powers, reasoning, behaving purposively and the pursuit of goals, following introduction of the 'functional magnetic resonanc...
journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
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更新日期:1998-10-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章
doi:10.1016/j.pneurobio.2009.12.003
更新日期:2010-06-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2008.01.002
更新日期:2008-04-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2003.12.004
更新日期:2004-02-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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更新日期:2010-02-09 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2017.10.003
更新日期:2018-01-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0301-0082(00)00013-7
更新日期:2000-11-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0301-0082(95)00011-j
更新日期:1995-08-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Progress in neurobiology
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journal_title:Progress in neurobiology
pub_type: 传,历史文章,杂志文章
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Progress in neurobiology
pub_type: 历史文章,杂志文章
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更新日期:2014-04-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/s0301-0082(98)00092-6
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abstract::Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila due to rapid developments in molecular genetics approaches that overcome the difficulties caused by the small size of the fly. In addition we have genome-wide information on genes involved in peptide signaling, and growing pools of p...
journal_title:Progress in neurobiology
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Progress in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.pneurobio.2016.05.004
更新日期:2016-07-01 00:00:00
abstract::Following rapid methodological advances, ultra-high field (UHF) functional and anatomical magnetic resonance imaging (MRI) has been repeatedly and successfully used for the investigation of the human auditory system in recent years. Here, we review this work and argue that UHF MRI is uniquely suited to shed light on h...
journal_title:Progress in neurobiology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00