Abstract：
PURPOSE:To investigate effects of alertness on three-dimensional (3D) eye movements. METHODS:During drowsy and alert periods, 3D eye movements were recorded with dual search coils in three normal rhesus monkeys, and in two of these monkeys after placement of bilateral kainic acid lesions of the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF). RESULTS:When the three monkeys were in the normal state, the average plane thickness (standard deviation of all rotation vectors from the regressed plane) during drowsy periods (range, 1.2-1.9 degrees ) increased significantly compared with the plane thickness during alert periods (range, 0.7-0.9 degrees ) in the light (P <.05). The plane thickness increased significantly in the monkey with asymmetric bilateral riMLF-lesions (P <.05); however, the increase was not significant in the monkey with more symmetric bilateral riMLF-lesions. After the bilateral riMLF-lesions, the plane thickness also increased with drowsiness in both monkeys (P <.02), as it had in the normal state. CONCLUSION:The implementation of Listing's law is independent of the presence of vertical-torsional burst neurons in the riMLF. The increase in thickness of Listing's plane during drowsy periods is not due to an imprecise signal from saccadic burst neurons to the 3D velocity-to-position integrator. It is possible that this integrator itself controls Listing's law, depending on the state of alertness.
journal_name
Jpn J Ophthalmoljournal_title
Japanese journal of ophthalmologyauthors
Suzuki Y,Straumann D,Henn Vdoi
10.1016/s0021-5155(00)00211-2keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
457-62issue
5eissn
0021-5155issn
1613-2246pii
S0021-5155(00)00211-2journal_volume
44pub_type
杂志文章abstract：:The purpose of this study is to elucidate the extension of the corneal endothelium onto the iris surface, a condition which has been found in the eyes with rubeosis iridis in various ocular disorders. Histopathology of the anterior chamber angle was studied by electron microscopy in 6 eyes with neovascular glaucoma oc...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:This is a clinical and laboratory report on 98 patients with acute viral conjunctivitis who were referred to the Eye Clinic of the Escola Paulista de Medicina of Sao Paulo, Brazil, from February 1983 to February 1984. It was planned with the objective of confirming the importance of adenovirus and enterovirus 70 as et...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:To test the hypothesis that ischemia of the Schlemm's canal endothelium is involved in the control of intraocular pressure (IOP). METHODS:Experiments were conducted on pigeons. The course of the aqueous sinus and the aqueous sinus artery was determined by examining serial sections and the distribution of polym...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(99)00017-9
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS:We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly define...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1007/s10384-017-0517-x
更新日期：2017-07-01 00:00:00
abstract：:Medical histories with emphasis on malignant disease were obtained on 1,269 first and second degree relatives of 93 probands with retinoblastoma and on 671 first and second degree relatives of 50 age-matched control children. The number of nonocular malignancies expected to occur in first and second degree relatives o...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:To investigate global protein expression profiles in the retinas of normal and glucocorticoid-induced ocular hypertensive rats by proteomic analysis. METHODS:Ocular hypertension was induced by topical application of dexamethasone (DEX) for 4 weeks. Age-matched untreated rats served as controls. Intraocular pre...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-007-0507-5
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:It is well-known that patients with psychogenic visual disturbances (PVD) exhibit characteristic kinetic visual fields. Even when the kinetic fields are normalized, the static fields of PVD children frequently remain abnormal. To verify this finding, we performed static perimetry on those children whose kinetic...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(00)00215-x
更新日期：2000-09-01 00:00:00
abstract：PURPOSE:To clarify the redox states of the aqueous humor and serum in senile cataract patients. METHODS:We analyzed the reduced and oxidized albumin fractions in 58 patients. The patients had no detectable evidence of other eye or systemic diseases and were divided into two age groups (53-75 and 76-96 years). Analysis...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-010-0877-y
更新日期：2010-11-01 00:00:00
abstract：PURPOSE:The new microemulsion preconcentrate (MEPC) formulation of ciclosporin has been developed to reduce problems in intestinal absorption and to stabilize fluctuations in blood levels. A multicenter, open-label clinical trial of MEPC was conducted to assess its efficacy and safety in Behçet's disease patients with ...
journal_title：Japanese journal of ophthalmology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0021-5155(99)00025-8
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the usefulness of laser speckle flowgraphy (LSFG) for the differentiation of acute nonarteritic ischemic optic neuropathy (NAION) from anterior optic neuritis (ON). METHODS:To investigate blood flow in the optic disc under normal conditions, NAION, and anterior ON, we c...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-013-0246-8
更新日期：2013-07-01 00:00:00
abstract：:In this report, membranes removed during vitrectomy were observed by various methods of electron microscopy to determine their three-dimensional structure and the mechanism of the contraction of preretinal membranes. The vitreous side surface of the preretinal membranes was covered by two types of flat cells, cells wi...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Human lens epithelial cells (HLECs) with lens capsules were cultured to investigate the morphology and outgrowth potential of the cultured cells. Anterior lens capsules obtained during cataract surgery were placed cell side down in a medium in culture wells. Cultivation was successful with 24 of 36 specimens from seni...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The exfoliation syndrome is thought to be a very rare disease in China. The clinical features of 11 patients with pseudoexfoliation (PE) and the histopathologic changes in specimens affected by PE were studied. The loss of pigment at the pupillary ruff and the dense pigmentation on the trabecular meshwork were the ear...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:From the study of 18 pregnancies in 10 patients with toxoplasmic retinochoroiditis, it was concluded that the most important factor to be considered in advising pregnant patients with this disease is whether or not the antibody titer increases during pregnancy rather than the clinical pictures or the absolute values o...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：PURPOSE:To investigate the expression of beta-defensin in the ocular surface of a mouse experimental allergic conjunctivitis (EAC) model. METHODS:Mouse beta-defensin (mBD)-1 and -2 mRNA expressed in conjunctival tissue of both the EAC and the control group were analyzed by real-time reverse transcriptase-polymerase ch...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-005-0262-4
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To evaluate aqueous flare change patterns following anti-vascular endothelial growth factor therapy for diabetic macular edema (DME) and investigate the relationship between changes in flare values and central macular thickness (CMT). STUDY DESIGN:Retrospective, interventional case series METHODS: A total of 8...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-019-00698-z
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:We report a patient with a limited form of Wegener's granulomatosis (WG) who presented with ocular changes and an eyelid ulcer in her left eye. CASE:A 56-year-old woman complained of ocular pain and discharge. Upon examination, we found evidence of ulcerative keratitis, a mass in the orbit, and an eyelid sk...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(03)00078-9
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:To determine the pharmacological response when dysiherbaine acts on cultured Müller cells, considering the glutamate receptor functions. Dysiherbaine is a new excitotoxic amino acid, which was recently isolated from the liquid extract of a certain sponge. METHODS:Retinas of adult rabbits were used to culture t...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(01)00488-9
更新日期：2002-03-01 00:00:00
abstract：:The ocular penetration of two beta-adrenergic blockers, befunolol and timolol, was studied using albino and pigmented rabbits. A 1% ophthalmic solution of 14C-befunolol hydrochloride or 14C-timolol maleate was instilled in one eye of nonsedated rabbits, and the concentrations of radioactive material in the ocular tiss...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：PURPOSE:To compare the progression of posterior vitreous detachment (PVD) during aging among eyes of diabetics with diabetic retinopathy (DR), eyes of diabetics without DR, and eyes of nondiabetics. STUDY DESIGN:Prospective cross-sectional study. METHODS:One-hundred thirty-three diabetic eyes with DR (DR group), 254 ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-020-00720-9
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:To determine whether photoreceptor degeneration in transgenic (Tg) rabbits carrying the Pro347Leu rhodopsin mutation alters the neural activity of the middle and inner retinal neurons. METHODS:Multifocal electroretinograms (mfERGs) were recorded from eight 12-week-old Tg rabbits both before and after intravitr...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-010-0842-9
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To assess whether the outcomes of toric intraocular lens (IOL) implantation in eyes with oblique astigmatism can be improved by direct measurements of posterior corneal astigmatism using anterior segment optical coherence tomography (AS-OCT) instead of by using anterior corneal measurements alone. STUDY DESIGN...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-021-00812-0
更新日期：2021-01-28 00:00:00
abstract：:Purpose: To confirm the intraocular dynamics of 1% deuterium (D) labeled alpha-tocopheral acetate (VEA) solution.Methods: The concentrations of D(3)-VEA and D(3)-alpha-tocopherol (VE) derived from D(3)-VEA in the aqueous humor and lens were measured after instilling 1% D(3)-VEA continuously into the cul-de-sac of rat ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(00)00315-4
更新日期：2001-01-01 00:00:00
abstract：: ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1007/s10384-018-0627-0
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To determine the efficacy of real-time PCR for the diagnosis and prognosis of varicella-zoster virus (VZV) keratitis. STUDY DESIGN:Retrospective case series. METHODS:Patients: 545 consecutive patients with keratitis were examined to quantify copy numbers of VZV DNA by real-time PCR. Association of copy number...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-018-0604-7
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between visual disability and visual scores in patients with retinitis pigmentosa. METHODS:The relationship between visual disability and visual scores (visual acuity and visual field) was investigated in 93 patients with retinitis pigmentosa. The visual disability of each patient ...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(99)00171-9
更新日期：2000-01-01 00:00:00
abstract：:We assessed the function of Endothelin-1 (ET-1) in the development of anterior chamber inflammation in pigmented rabbit eyes. After the injection of ET-1 solution (10(-13), 10(-11), 10(-9), or 10(-7) M, diluted with 300 microL of artificial aqueous humor) into the anterior chamber, the aqueous protein concentration (A...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0021-5155(97)00032-4
更新日期：1997-05-01 00:00:00
abstract：PURPOSE:To describe baseline measures of refraction, accommodation, and heterophoria in Japanese schoolchildren enrolled in a randomized clinical trial that examines whether progressive addition lenses slow myopic progression compared with single-focus lenses. METHODS:Ninety-five children with myopia between -1.25 and...
journal_title：Japanese journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10384-004-0131-6
更新日期：2005-01-01 00:00:00
abstract：:We evaluated the clinical statistics of a total of 186 patients (101 men and 85 women) with Vogt-Koyanagi-Harada's disease seen in the Uveitis Survey Clinic of the Hokkaido University Hospital during the 18-year period from 1966 to 1983. The annual number of new cases showed some change. More new patients were seen in...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:To evaluate the functional surgical success, complications, and degree of satisfaction after endoscopy-guided transcaruncular Jones tube intubation without dacryocystorhinostomy (DCR). METHODS:A pair of Westcott scissors was passed into the nose from the side of the caruncle, and the lacrimal bone was penetrat...
journal_title：Japanese journal of ophthalmology
pub_type： 杂志文章
doi：10.1007/s10384-005-0284-y
更新日期：2006-03-01 00:00:00
