UDS induction by an array of standard carcinogens in human and rodent hepatocytes: effect of cryopreservation.

abstract：:The mechanism of delta-aminolevulinate dehydratase (delta-ALA-D) inhibition by phenyl selenoacetylene in vitro was investigated in this study. Phenyl selenoacetylene (40-400 microM) inhibition of delta-aminolevulinate dehydratase from rat liver (low speed supernatant fraction, S1 fraction) was partially prevented by i...

journal_title：Toxicology

authors： Folmer V,Bolzan RC,Farina M,Zeni G,Nogueira CW,Emanuelli T,Rocha JB

更新日期：2005-01-31 00:00:00

abstract：:Static and rotary cultures of adult rabbit hepatocytes can be produced reproducibly following their isolation by means of a simplified, inexpensive recycling perfusion system. Light and electron microscopic examination of the cultures showed that these hepatocytes retained the morphological characteristics of fully di...

journal_title：Toxicology

authors： Poole A,Chasseaud LF,Bridges JW

更新日期：1982-01-01 00:00:00

abstract：:Diesel exhaust particles (DEP) affect health adversely. Our previous studies revealed that DEP extracts up-regulated expression of genes related to drug metabolism, antioxidant enzymes, cell cycle/apoptosis and coagulation, and in addition, n-hexane soluble fraction (n-HSF) of DEP extracts contains aliphatic and polyc...

journal_title：Toxicology

authors： Omura S,Koike E,Kobayashi T

更新日期：2009-07-28 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) is a cellular process during which epithelial polarized cells become motile mesenchymal-appearing cells, which in turn promotes carcinoma invasion and metastasis. Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural polyphenolic compound found in grapes, red wine and se...

journal_title：Toxicology

authors： Wang H,Zhang H,Tang L,Chen H,Wu C,Zhao M,Yang Y,Chen X,Liu G

更新日期：2013-01-07 00:00:00

abstract：:Chronic beryllium disease (CBD) results from exposure to the light-weight metal beryllium (Be). In vitro stimulation of bronchoalveolar lavage cells from CBD subjects causes the production of high levels of TNF-alpha, IFN-gamma and IL-6. We tested the hypothesis that Be-stimulation might induce the production of TNF-a...

journal_title：Toxicology

authors： Sawyer RT,Kittle LA,Hamada H,Newman LS,Campbell PA

更新日期：2000-03-07 00:00:00

abstract：:Gambogic acid (GA), a major active component of gamboge, exhibits potent anticancer activity in many kinds of cancer cells. However, the anticancer mechanism of GA is not clearly understood. Here we showed that GA could cause growth inhibition, induce the G0/G1 phase cell cycle arrest and apoptosis in human chronic my...

journal_title：Toxicology

authors： Li R,Chen Y,Zeng LL,Shu WX,Zhao F,Wen L,Liu Y

更新日期：2009-08-03 00:00:00

abstract：:Subchronic exposure to arsenic is associated with alteration of glucose homeostasis. Arsenic treatment (as sodium arsenite) of male Wistar rats (weighing 130-150 g) at a dose of 5.55 mg kg(-1) body weight (equivalent to 35% of LD(50)) (i.p.) per day for a period of 30 days produced hypoglycemia, with associated increa...

journal_title：Toxicology

authors： Pal S,Chatterjee AK

更新日期：2005-03-01 00:00:00

abstract：:For the first time, kinetic parameters of the effect of tacrine, an anti-cholinesterase inhibitor of therapeutic potential in Alzheimer's disease has been studied on human retinal acetyl-cholinesterase (AChE). Tacrine inhibited the AChE activity in a concentration dependent manner, the IC(50) being about 45 nM. The Mi...

journal_title：Toxicology

authors： Alhomida AS,Al-Rajhi AA,Kamal MA,Al-Jafari AA

更新日期：2000-05-19 00:00:00

abstract：:Although several specific micronutrient deficiencies are associated with disease progression and increased mortality risk in HIV/AIDS, and even a simple multivitamin/mineral supplement can prolong survival, this is typically viewed merely as nutritional support of the immune system, and only necessary if there are def...

journal_title：Toxicology

authors： Taylor EW

更新日期：2010-11-28 00:00:00

abstract：:Dioxins, including the most toxic congener, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), exert diverse biological effects in humans and animals. Host resistance, especially to virus infections, is considered one of the most sensitive targets of TCDD-toxicity, while a recent study showed that the vulnerability to TCDD o...

journal_title：Toxicology

authors： Nohara K,Izumi H,Tamura Si,Nagata R,Tohyama C

更新日期：2002-01-15 00:00:00

abstract：:Food labels are an important educational tool to assist consumers in making healthy food choices. In addition to mandatory nutritional labeling information, manufacturers have a variety of options on the food/supplement packages to communicate the nutrition/health benefits of their products. This paper describes the d...

journal_title：Toxicology

authors： Agarwal S,Hordvik S,Morar S

更新日期：2006-04-03 00:00:00

abstract：:Heavy metal environmental pollutants increase susceptibility of affected individuals to bacterial and viral infections, but the mechanisms responsible for this effect are not known. We established cellular in vitro systems to identify molecular targets for the action of heavy metal ions. We used two model systems to d...

journal_title：Toxicology

authors： Shen X,Lee K,König R

更新日期：2001-12-01 00:00:00

abstract：:The toxicity of two new monofunctional sulfur mustard derivatives was tested. The compound (4-carboxybutyl 2-chloroethyl sulfide, CBCS; 10-carboxydecyl 2-chloroethyl sulfide, CDCS) possess the 2-chloroethyl sulfide moiety present in mustard gas. Exposure of guinea pig skin to CBCS resulted in a dose-related ulcerative...

journal_title：Toxicology

authors： Wormser U,Green BS,Arad-Yellin R,Brodsky B,Shatz I,Nyska A

更新日期：1996-04-15 00:00:00

abstract：:In the current study, we used pathway-specific cDNA arrays to detect the transcriptional signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vivo by studying simultaneously the expression profiles of 83 genes involved in apoptosis, cytokine production and angiogenesis. To this end, C57BL/6 mice were inj...

journal_title：Toxicology

authors： Zeytun A,McKallip RJ,Fisher M,Camacho I,Nagarkatti M,Nagarkatti PS

更新日期：2002-09-16 00:00:00

abstract：:Among exocyclic DNA adducts, etheno (epsilon) bases (epsilond A, epsilond C, N(2),3-epsilond G) are generated by reactions of DNA bases with lipid peroxidation (LPO) products derived from endogenous sources and from the carcinogens vinyl chloride or urethane. The recent development of ultrasensitive methods has made i...

journal_title：Toxicology

authors： Bartsch H,Nair J

更新日期：2000-11-16 00:00:00

abstract：:There has been an intensive debate whether dietary exposure to acrylamide could increase the risk of human cancer since the first description of the presence of acrylamide in food in 2002. As the intestinal mechanisms of acrylamide absorption are poorly investigated we studied the transport of acrylamide in differenti...

journal_title：Toxicology

authors： Zödl B,Schmid D,Wassler G,Gundacker C,Leibetseder V,Thalhammer T,Ekmekcioglu C

更新日期：2007-03-22 00:00:00

abstract：:Previous work has indicated that testosterone pretreatment protects against cadmium-induced toxicity in male rats while other data indicate that pretreatment of mice with testosterone offers no such protection against cadmium. Since cadmium toxicity may vary widely with species and strain, we examined the effect of te...

journal_title：Toxicology

authors： Shimada H,Bare RM,Hochadel JF,Waalkes MP

更新日期：1997-01-15 00:00:00

abstract：:Pilinskaya showed that the fungicide ziram induced chrocosome aberrations in the lymphocytes of exposed industrial workers and also in lymphocyte cultures treated in vitro. Ziram is chemically similar to the drug Antabuse (disulfirm) which is used in the treatment of alcoholics. To establish whether disulfirm can also...

journal_title：Toxicology

authors： Lilly LJ

更新日期：1975-07-01 00:00:00

abstract：:Drug-induced hypersensitivity syndrome (DIHS) is a severe multi-organ system reaction caused by specific drugs. Many reports have revealed that human herpesvirus 6 (HHV-6) reactivation contributes to the development of DIHS. In addition, recent articles have shown that reactivation of other herpesviruses such as human...

journal_title：Toxicology

authors： Kano Y,Inaoka M,Sakuma K,Shiohara T

更新日期：2005-04-15 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) and N-nitrosamines (NNA) are mainly activated by cytochrome P450s, and their associated enzyme activities such as aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH), N-nitrosdimethylamine N-demethylase I (NDMA-dI), NADPH-cytochrome C reductase, and detoxified by glutathione S-t...

journal_title：Toxicology

authors： Sheweita SA,Newairy AA,Mansour HA,Yousef MI

更新日期：2002-05-24 00:00:00

abstract：:To evaluate the developmental toxicity of uranium, 5 groups of 20 pregnant Swiss mice were given by gavage daily doses of 0, 5, 10, 25 and 50 mg/kg of uranyl acetate dihydrate on gestational days 6-15. Cesarean sections were performed on all females on gestation day 18. Fetuses were examined for external, visceral, an...

journal_title：Toxicology

authors： Domingo JL,Paternain JL,Llobet JM,Corbella J

更新日期：1989-04-01 00:00:00

abstract：:The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and ...

journal_title：Toxicology

authors： Kennedy GL Jr,Fancher OE,Calandra JC

更新日期：1976-08-01 00:00:00

abstract：:Immunohistochemical methods have been widely used to determine the histogenesis of spontaneous and chemically-induced mouse lung tumors. Typically, antigens for either alveolar Type II cells or bronchiolar epithelial Clara cells are studied. In the present work, the morphological and immunohistochemical phenotype of a...

journal_title：Toxicology

authors： Hicks SM,Vassallo JD,Dieter MZ,Lewis CL,Whiteley LO,Fix AS,Lehman-McKeeman LD

更新日期：2003-05-03 00:00:00

abstract：:The ligand-activated nuclear receptor AhR (aryl hydrocarbon receptor) mediates the response of hepatocytes to various exogenous compounds. AhR is classically activated by planar, aromatic hydrocarbons, but also by other, structurally rather unrelated compounds. Recent data show that the canonical Wnt/β-catenin signali...

journal_title：Toxicology

authors： Vaas S,Kreft L,Schwarz M,Braeuning A

更新日期：2014-11-05 00:00:00

abstract：:The intravenous LD50 of cefuroxime sodium for mice was 10.4 g/kg. The maximum dosage administered in other acute toxicity tests was well tolerated by mice (10 g/kg, subcutaneous), by rats (4 g/kg, intravenous, 5 g/kg, subcutaneous) and by cats, dogs and monkeys (2 g/kg, intramuscularly). Cefuroxime sodium was administ...

journal_title：Toxicology

authors： Capel-Edwards K,Atkinson RM,Pratt DA

更新日期：1979-05-01 00:00:00

abstract：:To elucidate factors responsible for altered proliferation of preneoplastic hepatocytes in rat hepatocarcinogenesis in vivo, EGF-stimulated DNA synthesis of normal and nodular hepatocytes in primary culture was studied. In addition, the influence of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated to clari...

journal_title：Toxicology

authors： Bock KW,Gschaidmeier H,Bock-Hennig BS,Eriksson LC

更新日期：2000-04-03 00:00:00

abstract：:A qualitative assessment of developmental toxicity within a series of 12 structurally related compounds, 11 of which were active dopamine mimetics and one was inactive, was conducted in rats treated orally by gavage during the major period of organogenesis. Doses were chosen where possible to be equipotent in terms of...

journal_title：Toxicology

authors： Ridings JE,Baldwin JA

更新日期：1992-12-04 00:00:00

abstract：:Transferrin, as the major iron-transport protein in serum and other body fluids, has a central role in managing iron the body receives. Liver is a major site of transferrin synthesis, and in this study we present evidence that liver synthesis of human transferrin is suppressed by both the toxic metal lead and bacteria...

journal_title：Toxicology

authors： Barnum-Huckins KM,Martinez AO,Rivera EV,Adrian EK Jr,Herbert DC,Weaker FJ,Walter CA,Adrian GS

更新日期：1997-03-14 00:00:00

abstract：:Lead-exposed mice were found to show a significantly increased frequency of acrosome-reacted spermatozoa. The number of spermatozoa bound to the zona pellucida of denuded mouse eggs was also significant increased, probably as a result of an acceleration of the processes involved in the capacitation of the spermatozoa ...

journal_title：Toxicology

authors： Johansson L

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:The environmental endocrine disruptors, bisphenol A (BPA) and bisphenol S (BPS) are associated with the development of type 2 diabetes. We aim to study the effects of BPA or BPS exposure on adipokine expression in human adipose tissue and on adipocyte glucose uptake. METHODS:Human subcutaneous adipose tissue w...

journal_title：Toxicology

authors： Ahmed F,Sarsenbayeva A,Katsogiannos P,Aguer C,Pereira MJ

更新日期：2020-12-01 00:00:00