Abstract:
:Drug-induced hypersensitivity syndrome (DIHS) is a severe multi-organ system reaction caused by specific drugs. Many reports have revealed that human herpesvirus 6 (HHV-6) reactivation contributes to the development of DIHS. In addition, recent articles have shown that reactivation of other herpesviruses such as human herpesvirus 7 (HHV-7), Epstein-Barr virus (EBV), cytomegalovirus (CMV) might be also implicated in the development of DIHS. These observations suggest that not only HHV-6 but also other herpesvirses might reactivate from the latency and play an important role in the appearance of clinical manifestations of DIHS. Several patients with DIHS were treated with intravenous immunoglobulin (IVIG) in addition to systemic corticosteroids. The results have been encouraging although virus reactivation could not be suppressed. Although the pathomechanism of IVIG treatment in patients with DIHS remains unknown, the therapeutic effects of IVIG could be dependent, in part, on functional capabilities of anti-virus IgG contained in IVIG.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Kano Y,Inaoka M,Sakuma K,Shiohara Tdoi
10.1016/j.tox.2004.12.013keywords:
subject
Has Abstractpub_date
2005-04-15 00:00:00pages
165-7issue
2eissn
0300-483Xissn
1879-3185pii
S0300-483X(04)00713-9journal_volume
209pub_type
杂志文章,评审相关文献
TOXICOLOGY文献大全abstract::We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) pro...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.02.014
更新日期:2017-04-15 00:00:00
abstract::This study investigated the effect of astaxanthin (ASX; 3,3-dihydroxybeta, beta-carotene-4,4-dione), a water-dispersible synthetic carotenoid, on liver ischemia-reperfusion (IR) injury. Astaxanthin (5 mg/kg/day) or olive oil was administered to rats via intragastric intubation for 14 consecutive days before the induct...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2009.11.003
更新日期:2010-01-12 00:00:00
abstract::Exposure of cultured rat mesangial cells to CdCl2 caused a dose- and time-dependent increase in intracellular glutathione that was significant at 0.5 microM and maximal at 1 microM Cd2+. The effect depended on glutathione synthesis and was masked by inhibiting synthesis with buthionine sulfoximine. The cells responded...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(93)90145-i
更新日期:1993-01-29 00:00:00
abstract::Studies showed that certain cytotoxicity assays were not suitable for assessing nanoparticle (NP) toxicity. We evaluated a lactate dehydrogenase (LDH) assay for assessing copper (Cu-40, 40nm), silver (Ag-35, 35nm; Ag-40, 40nm), and titanium dioxide (TiO(2)-25, 25nm) NPs by examining their potential to inactivate LDH a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.06.011
更新日期:2011-09-05 00:00:00
abstract::We have investigated in the current study, the possible modulatory effects of dexamethasone on cisplatin cytotoxicity in Ehrlich ascites carcinoma (EAC)-bearing female Swiss albino mice. Cisplatin (3.5mg/kg) was injected IP for 3 consecutive days in mice previously inoculated SC with EAC cells in the right flank. Dexa...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.02.007
更新日期:2006-05-01 00:00:00
abstract::Double-stranded RNA-dependent protein kinase (PKR) is a component of signal transduction pathways mediating various stress signals including oxidative stress and endoplasmic reticulum (ER) stress and is suggested to be implicated in several neurodegenerative diseases. Cell death in neurodegenerative conditions has bee...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2019.02.012
更新日期:2019-04-15 00:00:00
abstract::Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This ...
journal_title:Toxicology
pub_type:
doi:10.1016/j.tox.2020.152421
更新日期:2020-04-30 00:00:00
abstract::Choice behavior of rats in a radially symmetrical 6-arm maze, without food reward, was validated for assessing changes in learning and memory following treatment with 4 psychoactive agents. The test is designed for future use in routine toxicity studies with laboratory rodents. Each radial main arm of the maze leads t...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90028-5
更新日期:1988-05-01 00:00:00
abstract::The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v. bolus doses of Al-H...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(94)90177-5
更新日期:1994-09-06 00:00:00
abstract::Testicular injury is often observed in drug development. Serum hormones are usually used as noninvasive biomarkers for testicular injury; however, their sensitivities are low. Therefore, it is difficult to monitor testicular injury in drug development. In recent years, molecules in body fluid exosomes have attracted a...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2020.152490
更新日期:2020-07-01 00:00:00
abstract::The present study was undertaken to examine the effects of iodoacetic acid, a non-phorbol tumor promoter, on metabolic cooperation between mutant human fibroblasts as measured by [14C]citrulline incorporation. Other thiol-reactive polyphenolic compounds such as hydroquinone and 2-hydroxyestrone were also examined. 12-...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(87)90047-3
更新日期:1987-04-01 00:00:00
abstract::Cadmium, an environmental neurotoxic compound, produces cognitive disorders, although the mechanism remains unknown. Previously, we described that cadmium induces a more pronounced cell death on cholinergic neurons from basal forebrain (BF). This effect, partially mediated by M1 receptor blockade, triggering it throug...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2017.12.006
更新日期:2018-02-01 00:00:00
abstract::Several dicationic amphiphilic compounds, such as the immunomodulator tilorone and analogues, impair the lysosomal catabolism of sulphated glycosaminoglycans (GAGs). Thereby they cause lysosomal GAG storage in rats and in cultured fibroblasts of several species including man. The GAG storage is rather slowly reversibl...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(98)00052-3
更新日期:1998-07-03 00:00:00
abstract::Hyperbilirubinemia is one of the most common clinical phenomena observed in human newborns. To achieve effective therapeutic treatment, numerous studies have been done to determine the molecular mechanisms of bilirubin-induced neuronal excitotoxicity. However, there is no conclusive evidence for the involvement of glu...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2011.03.010
更新日期:2011-06-18 00:00:00
abstract::The effects of low doses of (S)-alpha-cyano-3-phenoxybenzyl (1R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate (Roussel UCLAF, Paris, France), (deltamethrin) upon sympathetic-adrenomedullary and pituitary-adrenocortical activity were investigated in rats by measuring plasma noradrenaline (NA), adrenalin...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90007-8
更新日期:1988-05-01 00:00:00
abstract::The zebrafish Danio rerio embryo test with metabolic activation (mDarT) was developed to assess the teratogenic effects of proteratogens. In this study induced rat liver microsomes (RLM) were used as a mammalian metabolic activation system (MAS), since they contain various cytochrome P450 (CYP) isoforms at high concen...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2010.05.012
更新日期:2010-09-10 00:00:00
abstract::Maintenance of health is dependent on numerous regulatory interactions between organ systems. This review discusses interorgan communication between the nervous, endocrine, and immune systems and environmental and genetic influences on this neuroendocrine immune circuitry. Stresses of multiple types, including psychol...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/s0300-483x(99)00144-4
更新日期:2000-01-17 00:00:00
abstract::Induction of hepatic metallothionein (MT) by acetaminophen was characterized in the rat and mouse. Treatment of rats with the hepatotoxin resulted in increase of liver MT in a dose-dependent manner. MT concentration was elevated by 41%, 140% and 260% following acetaminophen injection at doses of 250, 500 and 1000 mg/k...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(88)90224-7
更新日期:1988-12-30 00:00:00
abstract::Neonatal rat hearts were separated into separate cultures of beating myocytes (M cells), endothelial cells (E cells) and fibroblasts (F cells). Their susceptibilities to the toxic effects of emetine, chloroquine and metronidazole were then compared using a quantitative metabolic inhibition test (QMIT) and morphologic ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90066-0
更新日期:1984-11-01 00:00:00
abstract::This review deals with some of our contributions to the use of chemotaxis, as a tool in evaluating effects of industrial xenobiotics on PMN, either in vitro or ex vivo. In vitro experiments have shown that lead, arsenic, styrene and 2,5-hexanedione, a major neurotoxicant metabolite of n-hexane, reduce chemotaxis. The ...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/0300-483x(94)90142-2
更新日期:1994-07-01 00:00:00
abstract::The overall purpose of this study was to investigate how airborne house dust particles may contribute to an allergic immune response, and thereby also to asthma and other respiratory symptoms. The following aims were set: first, to quantify and characterize indoor suspended particulate matter (SPM) with regard to amou...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/s0300-483x(00)00292-4
更新日期:2000-11-02 00:00:00
abstract::Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we prese...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2018.11.008
更新日期:2019-01-15 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) with molecular weight 278 are a group of PAHs that are mostly not covered by the current monitoring programs, despite their relative abundance in environmental samples and possible carcinogenicity. Although benzo[g]chrysene (BgChry) and dibenz[a,h]anthracene (DBahA) have been fo...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2006.12.024
更新日期:2007-03-22 00:00:00
abstract::Many studies have demonstrated that polycyclic aromatic hydrocarbons adversely affect mature mammalian immune systems. However, little is known about the cellular mechanism(s) mediating this immunosuppression or the potential for these ubiquitous environmental chemicals to similarly compromise lymphocyte development (...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90103-l
更新日期:1992-01-01 00:00:00
abstract::Subacute exposure of male rats to various concentrations (70-1000 ppm) of dichloromethane (DCM) produces a selective reduction of dopamine (DA) levels without a change of DA turnover in certain types of forebrain DA nerve terminal systems. In the low concentration (70 ppm) a selective reduction of DA turnover was obse...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(84)90161-6
更新日期:1984-02-01 00:00:00
abstract::We had previously demonstrated that 1 mM 2,4-D inhibited cell growth, nucleic acid synthesis and protein synthesis (at the ribosomal level) of Azospirillum brasilense. These alterations were prevented by the presence of polyamines in the culture medium. On the other hand, polyamines did not affect the 2,4-D uptake. In...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(95)02952-5
更新日期:1995-04-12 00:00:00
abstract::Oxalate is a minor, but important metabolite of ethylene glycol and has been directly linked with acute and subchronic renal toxicity in ethylene glycol poisoning. Numerous studies have characterized the cytotoxicity of oxalate as including plasma membrane damage and organelle injury. Oxalate has two forms in vivo: ox...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2004.11.029
更新日期:2005-03-30 00:00:00
abstract::Haptens are classified as low molecular chemicals with an intrinsic potential to covalently modify proteins, and many of them are strong inducers of contact hypersensitivity (CHS). CHS is T cell mediated, and hapten-specific T cells have been shown to interact with hapten-modified, MHC-associated peptides. However, th...
journal_title:Toxicology
pub_type: 杂志文章,评审
doi:10.1016/j.tox.2004.12.015
更新日期:2005-04-15 00:00:00
abstract::Five male and female rats per dose-group received 2,3,7,8-tetrabromodibenzo-p-dioxin (2,3,7,8-TBDD) once on the first day of the study. Doses of 10, 33, 100, or 300 micrograms 2,3,7,8-TBDD/kg body wt. and the vehicle control were administered by gavage. About 20% of 2,3,7,8-TBDD was excreted via feces. Severe body wei...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/0300-483x(92)90170-j
更新日期:1992-01-01 00:00:00
abstract::The present study was examined whether or not 2-bromoethyamine, a semicarbazide-sensitive amine oxidase (SSAO, EC; 1.4.3.6) inhibitor, would increase an active dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical ((*)OH) generation in the rat striatum. Rats were anesthetized, and ...
journal_title:Toxicology
pub_type: 杂志文章
doi:10.1016/j.tox.2005.09.012
更新日期:2006-01-20 00:00:00