Abstract:
BACKGROUND:To examine whether induced abortion increases the risk of low birthweight in subsequent singleton live births. METHODS:Cohort study using the Danish Medical Birth Registry (MBR), the Hospital Discharge Registry (HDR), and the Induced Abortion Registry (IAR). All women who had their first pregnancy during 1980-1982 were identified in the MBR, the HDR, and the IAR. We included all 15,727 women whose pregnancy was terminated by a first trimester induced abortion in the induced abortion cohort and 46,026 women whose pregnancy was not terminated by an induced abortion were selected for the control cohort. All subsequent pregnancies until 1994 were identified by register record linkage. RESULTS:Low birthweight (<2500 g) in singleton term live births occurred more frequently in women with one, two, three or more previous induced abortions, compared with women without any previous induced abortion of similar gravidity, 2.2% versus 1.5%, 2.4% versus 1.7%, and 1.8% versus 1.6%, respectively. Adjusting for maternal age and residence at time of pregnancy, interpregnancy interval, gender of newborn, number of previous spontaneous abortions and number of previous low birthweight infants (control cohort only), the odds ratios (OR) of low birthweight in singleton term live births in women with one, two or more previous first trimester induced abortions were 1.9 (95% CI: 1.6, 2.3), and 1.9 (95% CI: 1.3, 2.7), respectively, compared with the control cohort of similar gravidity. High risks were mainly seen in women with an interpregnancy interval of more than 6 months. CONCLUSIONS:The findings suggest a positive association between one or more first trimester induced abortions and the risk of low birthweight in subsequent singleton term live births when the interpregnancy interval is longer than 6 months. This result was unexpected and confounding cannot be ruled out.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Zhou W,Sørensen HT,Olsen Jdoi
10.1093/ije/29.1.100keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
100-6issue
1eissn
0300-5771issn
1464-3685journal_volume
29pub_type
杂志文章abstract:BACKGROUND:The incidence of hepatitis C (HCV) infection among injecting drug users (IDUs) in Dublin is particularly high by international standards. The most robust predictor of an IDU's HCV status is his or her total number of lifetime injecting episodes. It has been proposed that participation in specific unsafe inje...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh347
更新日期:2005-02-01 00:00:00
abstract::Methodological issues concerning the collection and analysis of daily morbidity data in community studies in developing countries are discussed. The effects of recall period and inter-observer variation on symptom prevalence are considered in the context of a longitudinal study in The Gambia, in which prevalence fell ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.4.757
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:In sub-Saharan Africa, the prevalence of orphanhood among children has been greatly exacerbated by the HIV/AIDS pandemic. If orphanhood harms a child's development and these effects perpetuate into adult life, then the African orphan crisis could seriously jeopardize the continent's future generations. Wheth...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyn197
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:A growing body of evidence supports the role of type 2 diabetes as an individual-level risk factor for tuberculosis (TB), though evidence from developing countries with the highest TB burdens is lacking. In developing countries, TB is most common among the poor, in whom diabetes may be less common. We assess...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq238
更新日期:2011-04-01 00:00:00
abstract::Several conditions, whose timely and appropriate therapy should decrease case fatality, have been proposed as indicators of medical care quality for the National Health Service. Mortality rates for these diseases vary widely within the UK. To evaluate the contribution of varying incidence rates to these mortality diff...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.3.408
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years. METHODS:We reviewed all literature repo...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyq024
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Aetiological profiles of non-Hodgkin's lymphoma (NHL) may differ depending upon whether the disease is inheritance-related or sporadic. Because familial risk (a probable surrogate of inheritance-relatedness) of NHL is influenced by haematolymphoproliferative malignancies (HLPM), we evaluated whether non-fami...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.4.818
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Increases in measles antibodies without rash-illnesses have been documented in previously vaccinated children exposed to measles cases. The phenomenon has been incompletely evaluated in young unvaccinated infants with immunity of maternal origin. METHODS:Monthly cohorts of newborns were prospectively random...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/28.1.147
更新日期:1999-02-01 00:00:00
abstract::A 10-year prospective study of Hawaii Japanese males with partial gastrectomy shows that the age-adjusted mortality rates in men with partial gastrectomy were slightly higher than in those with an intact stomach, but the difference failed to achieve statistical significance. This excess of mortality is due, in part, t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.3.299
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) incidence and prevalence are increasing in many countries worldwide. Due to the high cost of therapy, predicting future numbers of patients requiring dialysis and transplantation is necessary for health care planners. Projecting therapy-specific chronic disease prevalence is in...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.2.274
更新日期:1998-04-01 00:00:00
abstract::Quantitative bias analysis serves several objectives in epidemiological research. First, it provides a quantitative estimate of the direction, magnitude and uncertainty arising from systematic errors. Second, the acts of identifying sources of systematic error, writing down models to quantify them, assigning values to...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu149
更新日期:2014-12-01 00:00:00
abstract::A random population sample from Eastern Finland was studied. Altogether approximately 12 000 persons aged 25 to 59 years were examined with participation rate of 92%. Smoking, high saturated fat diet, increased serum cholesterol and elevated blood pressure showed clustering among men but not among women. Smoking tende...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/10.3.203
更新日期:1981-09-01 00:00:00
abstract:BACKGROUND:The wide use of highly active antiretroviral therapy has led to an impressive improvement in AIDS survival after the mid-1990s in cities and countries with a high access to these medications. Notwithstanding its beneficial overall effect, antiretroviral therapy was also reported as a factor for the increase ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi022
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:The objective of this retrospective cohort study was to assess the effect of hysterectomy on subsequent risk of cancer among 25,382 hysterectomized and a similar number of non-hysterectomized control women, registered in 1963-1976 in the Mass Screening Registry (MSR). METHODS:Cancer cases were obtained from...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.3.476
更新日期:1997-06-01 00:00:00
abstract::Samples of East African tribesmen from two separate locations were compared with respect to a number of anthropometric, cardiovascular and biochemical variables. The major finding was a large, significant difference in mean triglyceride levels between the groups (0.97 vs. 0.67 mmol/l; p less than 0.001), the mean plas...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.2.183
更新日期:1986-06-01 00:00:00
abstract::Aboriginal communities have a high prevalence of upper and lower respiratory tract disease. One thousand two hundred and eighty seven West Australian Aborigines and 265 non-Aborigines were examined. Twenty nine per cent of Aborigines had lower respiratory tract abnormalities. Amongst 635 Aboriginal children less than ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.1.105
更新日期:1983-03-01 00:00:00
abstract::A serological survey of 300 Israeli intravenous drug addicts in 1988-1989, showed a 2.3% prevalence of antibodies to human immunodeficiency virus (HIV), very similar to the finding of a previous study (2%) performed in the same population in 1986. Travel and drug injection abroad continue to be the most significant pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.3.561
更新日期:1992-06-01 00:00:00
abstract::Blood pressure levels were measured in 626 children (138 Japanese, 477 Bolivian and 11 of mixed blood) in a Japanese agricultural settlement in Bolivia. Systolic (SBP) and diastolic (DBP) blood pressure was higher in Japanese children than in Bolivian children at each measured age by 4.09 mmHg (P = 0.0001) and 2.25 mm...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.1.100
更新日期:1989-03-01 00:00:00
abstract:Background:Children with a diagnosis of attention-deficit hyperactivity disorder ADHD) have lower cognitive ability and are at risk of adverse educational outcomes; ADHD genetic risks have been found to predict childhood cognitive ability and other neurodevelopmental traits in the general population; thus genetic risks...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyw216
更新日期:2017-04-01 00:00:00
abstract::The relationship between body fat and different aspects of glucose tolerance was examined within the Zutphen Study. In 1970 an oral glucose tolerance test (OGTT) was carried out in 404 non-diabetic men aged 50-70. None of the subjects could be classified as having impaired glucose tolerance. Body mass index (BMI), sub...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.2.368
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:We assessed the risk of tubal pregnancy among women who (1) were currently using an intrauterine device (IUD) and (2) had discontinued IUD use while still sexually active and at risk of pregnancy using data from a multicentre case-control study of married women conducted in Indonesia. METHODS:Cases were 560...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/23.5.1000
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Exposure to a pre-natal famine environment has been associated with a persistent decrease in DNA methylation of the IGF2 gene, although study findings on other loci have been highly variable. There have been no studies to date of the relation between pre-natal famine and overall global DNA methylation in adu...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyr137
更新日期:2012-02-01 00:00:00
abstract::Corporate influences on epidemiology have become stronger and more pervasive in the last few decades, particularly in the contentious fields of pharmacoepidemiology and occupational epidemiology. For every independent epidemiologist studying the side effects of medicines and the hazardous effects of industrial chemica...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dym270
更新日期:2008-02-01 00:00:00
abstract::We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples po...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/30.2.400
更新日期:2001-04-01 00:00:00
abstract::This article investigates the interrelationship of socioeconemic status, anthropometric status and mortality of young children in rural Bangladesh. Data for this study come from Matlab, the vital registration area of the International Centre for Diarrhoeal Disease Research, Bangladesh, where anthropometric and socioec...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.6.1179
更新日期:1994-12-01 00:00:00
abstract::In a population-based cohort study in Southern Brazil, 87.3% of 5914 liveborn infants were followed for over 12 months. The 215 infant deaths occurring in this cohort were studied in relation to birthweight, gestational age and socioeconomic status. Causes of death were ascertained through the review of case notes and...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.2.239
更新日期:1987-06-01 00:00:00
abstract::One task faced by public health surveillance practitioners is the timely identification of data patterns that might suggest the onset of an epidemic period. Many available techniques for analysis of surveillance data are based on sequential procedures, which predict expected numbers of cases and compare this estimate ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.2.408
更新日期:1994-04-01 00:00:00
abstract::The proportional relationships of the four numbers in a 2 x 2 table can be displayed using two types of box graphs. In one approach, a 'unitary square' is first divided according to the denominator proportions of the two groups formed in a cohort or case-control study, and then re-divided according to the numerator pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.1.222
更新日期:1988-03-01 00:00:00
abstract::Studies of diet in relation to disease raise methodological challenges considerably more complicated than in most epidemiological investigations. Diet is not a single exposure, but rather a complex set of many intercorrelated continuous variables. Moreover, these variables are likely to have non-linear relationships w...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.2.312
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is causal. METHODS:We performed two-sample Mendelian randomization (MR) using summary data on associati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa256
更新日期:2020-12-21 00:00:00