Characteristics of ectopic discharges in a rat neuropathic pain model.


:Injured afferent neurons produce spontaneous activity that is generated away from the normal impulse generation site. Since this activity, referred to as ectopic discharges, may play a significant role in neuropathic pain, it is important to systematically analyze the activity in various pain states. The present study used the segmental spinal nerve injury model of neuropathic pain to quantify the ectopic discharges from injured afferents in the neuropathic rat under various conditions. All aspects of measured ectopic discharges declined as postoperative time lengthened. Neuropathic pain behaviors declined in a similar fashion over the same time period. Surgical sympathectomy on neuropathic animals lowered the level of ectopic discharges along with neuropathic pain behaviors. The data indicate that the level of ectopic discharges is well correlated with that of pain behaviors in a rat neuropathic pain model, and this reinforces the supposition that ectopic discharges are important to the maintenance of neuropathic pain behaviors. The data suggest that there are two components of ectopic discharge generator mechanisms: sympathetically dependent and sympathetically independent components.






Han HC,Lee DH,Chung JM





Has Abstract


2000-02-01 00:00:00
















  • Cutaneous pain threshold changes after sympathetic block in reflex dystrophies.

    abstract::In a group of 30 subjects suffering from sympathetic reflex dystrophies of the limbs, the sympathetic ganglia of the affected side were blocked with a local anesthetic. Using an original method, we measured the cutaneous pain threshold before the block and at prefixed intervals after the block during a period of 2 day...


    pub_type: 杂志文章


    authors: Procacci P,Francini F,Zoppi M,Maresca M

    更新日期:1975-06-01 00:00:00

  • Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain.

    abstract::Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal h...


    pub_type: 杂志文章


    authors: Gao X,Kim HK,Mo Chung J,Chung K

    更新日期:2007-10-01 00:00:00

  • Tolerance to repeated microinjection of morphine into the periaqueductal gray is associated with changes in the behavior of off- and on-cells in the rostral ventromedial medulla of rats.

    abstract::Although the administration of opioids is the most effective treatment for pain, their efficacy is limited by the development of tolerance. The midbrain periaqueductal gray matter (PAG) participates in opioid analgesia and tolerance. Microinjection of morphine into PAG produces antinociception, probably through neuron...


    pub_type: 杂志文章


    authors: Tortorici V,Morgan MM,Vanegas H

    更新日期:2001-01-01 00:00:00

  • The influence of children's vocal expressions, age, medical diagnosis and information obtained from parents on nurses' pain assessments and decisions regarding interventions.

    abstract::This article reports on a study that examines the influence of task-related factors on nurses' pain assessments and decision regarding interventions. In an experimental design pediatric nurses (n = 202), were exposed to different cases, each case being a combination of a vignette and a videotape. For every case subjec...


    pub_type: 杂志文章


    authors: Hamers JPH,Abu-Saad HH,van den Hout MA,Halfens RJG,Kester ADM

    更新日期:1996-04-01 00:00:00

  • Chronic secondary hypersensitivity of dorsal horn neurones following inflammation of the knee joint.

    abstract::Intra-articular injection of Freund's complete adjuvant (FCA) into the rat knee joint produces a swelling of the joint and long lasting hypersensitivity. In this study we have used this model and in vivo electrophysiology to investigate the time course of spinal changes underlying chronic secondary hypersensitivity, b...


    pub_type: 杂志文章


    authors: Martindale JC,Wilson AW,Reeve AJ,Chessell IP,Headley PM

    更新日期:2007-12-15 00:00:00

  • The development of pain-related behaviour and opioid tolerance after neuropathy-inducing surgery and sham surgery.

    abstract::The inability of opioids to control pain over time may be influenced by different factors such as drug tolerance, hyperalgesia due to repeated morphine administration or progression of the original disease. In addition, chronic pain may alter morphine tolerance development. This study examined whether chronic morphine...


    pub_type: 杂志文章


    authors: Christensen D,Kayser V

    更新日期:2000-12-01 00:00:00

  • Stress-related pain behavior in rats with peripheral nerve injuries.

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    pub_type: 杂志文章


    authors: Wiesenfeld Z,Hallin RG

    更新日期:1980-06-01 00:00:00

  • Cooperation of NMDA and tachykinin NK(1) and NK(2) receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach.

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    pub_type: 杂志文章


    authors: Jocic M,Schuligoi R,Schöninkle E,Pabst MA,Holzer P

    更新日期:2001-01-01 00:00:00

  • Effects of doxepin on perception of laboratory-induced pain in man.

    abstract::Beneficial effects have been observed in University of Washington Pain Clinic patients treated with tricyclic antidepressants, but such effects occur much earlier than predicted mood elevation. A laboratory investigation of pain perception was employed to test the hypothesis that doxepin, a tricyclic antidepressant, h...


    pub_type: 临床试验,杂志文章


    authors: Chapman RC,Butler SH

    更新日期:1978-10-01 00:00:00

  • Functional and anatomical deficits in visceral nociception with age: a mechanism of silent appendicitis in the elderly?

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    pub_type: 杂志文章


    authors: Cibert-Goton V,Kung VWS,McGuire C,Hockley JRF,Tranter MM,Dogra H,Belai A,Blackshaw LA,Sanger GJ,Knowles CH,Araujo EJA,Winchester WJ,Bulmer DC

    更新日期:2020-04-01 00:00:00

  • Self-administration of midazolam for postoperative anxiety: a double blinded study.

    abstract::Anxiety is almost inevitably present in patients facing surgery. The optimal management of postoperative pain requires the acknowledgement of perioperative anxiety and the inclusion of pharmacological and/or non-pharmacological means of alleviating the fear and worry inherent in the surgical experience. In a double-bl...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Egan KJ,Ready LB,Nessly M,Greer BE

    更新日期:1992-04-01 00:00:00

  • Psychological aspects of reflex sympathetic dystrophy: a review of the adult and paediatric literature.

    abstract::In 1864, W. Mitchell and colleagues first described the clinical syndrome which came to be known as 'causalgia'. Since that time, the concept of sympathetically related pain has evolved. There is general agreement that profound emotional and behavioural changes can follow these types of pain. Opinions have varied wide...


    pub_type: 杂志文章,评审


    authors: Lynch ME

    更新日期:1992-06-01 00:00:00

  • Sex- and age-specific genetic analysis of chronic back pain.

    abstract::Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide assoc...


    pub_type: 杂志文章


    authors: Freidin MB,Tsepilov YA,Stanaway IB,Meng W,Hayward C,Smith BH,Khoury S,Parisien M,Bortsov A,Diatchenko L,Børte S,Winsvold BS,Brumpton BM,Zwart JA,Aulchenko YS,Suri P,Williams FMK,HUNT All-In Pain.

    更新日期:2020-09-30 00:00:00

  • Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.

    abstract::Pro-inflammatory cytokine production after nociceptive stimuli is pivotal for hyperalgesia. As macrophage migration inhibitory factor (MIF), a pleiotropic cytokine produced mainly by nonneuronal tissue, has been involved in the regulation of neuronal functions, herein we examined the role for MIF in formalin-induced i...


    pub_type: 杂志文章


    authors: Wang F,Shen X,Guo X,Peng Y,Liu Y,Xu S,Yang J

    更新日期:2010-02-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scudds RA,Janzen V,Delaney G,Heck C,McCain GA,Russell AL,Teasell RW,Varkey G,Woodbury GM

    更新日期:1995-07-01 00:00:00

  • The evaluation of acute pain in individuals with cognitive impairment: a differential effect of the level of impairment.

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    pub_type: 临床试验,杂志文章


    authors: Defrin R,Lotan M,Pick CG

    更新日期:2006-10-01 00:00:00

  • Severity of chronic pain in an elderly population in Sweden--impact on costs and quality of life.

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    pub_type: 杂志文章


    authors: Bernfort L,Gerdle B,Rahmqvist M,Husberg M,Levin LÅ

    更新日期:2015-03-01 00:00:00

  • Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling.

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    pub_type: 杂志文章


    authors: Russell FA,Fernandes ES,Courade JP,Keeble JE,Brain SD

    更新日期:2009-04-01 00:00:00

  • Catastrophizing, pain, and disability in patients with soft-tissue injuries.

    abstract::The present study examined the role of catastrophizing in predicting levels of pain and disability in a sample of individuals who had sustained soft-tissue injuries to the neck, shoulders or back following work or motor vehicle accidents. Participants were 86 (27 men, 59 women) consecutive referrals to the Atlantic Pa...


    pub_type: 杂志文章


    authors: Sullivan MJL,Stanish W,Waite H,Sullivan M,Tripp DA

    更新日期:1998-09-01 00:00:00

  • Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia.

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    pub_type: 杂志文章


    authors: Godínez-Chaparro B,Barragán-Iglesias P,Castañeda-Corral G,Rocha-González HI,Granados-Soto V

    更新日期:2011-03-01 00:00:00

  • Arabic pain words.

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    pub_type: 杂志文章


    authors: Harrison A

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  • Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia.

    abstract::Monoclonal antibodies against GD(2) ganglioside, such as ch14.18, the human-mouse chimeric antibody, have been shown to be effective for the treatment of neuroblastoma. However, treatment is associated with generalized, relatively opiate-resistant pain. We investigated if a point mutation in ch14.18 antibody (hu14.18K...


    pub_type: 杂志文章


    authors: Sorkin LS,Otto M,Baldwin WM 3rd,Vail E,Gillies SD,Handgretinger R,Barfield RC,Yu HM,Yu AL

    更新日期:2010-04-01 00:00:00

  • Thermoreceptive innervation of human glabrous and hairy skin: a contact heat evoked potential analysis.

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    pub_type: 杂志文章


    authors: Granovsky Y,Matre D,Sokolik A,Lorenz J,Casey KL

    更新日期:2005-06-01 00:00:00

  • Extent of sympathetic blockade after stellate ganglion block with bupivacaine.

    abstract::A study of the extent of sympathetic blockade after stellate ganglion block was assessed using liquid crystal thermography. Two volumes (10 and 20 ml) of bupivacaine 0.5% plain were used. Irrespective of the volume used cranial sympathetic block always occurred and thoracic sympathetic block never occurred. While uppe...


    pub_type: 杂志文章


    authors: Hardy PAJ,Wells JCD

    更新日期:1989-02-01 00:00:00

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    abstract::Tri-cyclic antidepressants (TCAs) have been widely used in treating major depressive disorders. Recent studies further demonstrated that TCAs have potent sodium channel blocking effect, and amitriptyline, one of the TCAs, has a potent spinal anesthetic effect. The aim of the study was to evaluate the spinal anesthetic...


    pub_type: 杂志文章


    authors: Chen YW,Huang KL,Liu SY,Tzeng JI,Chu KS,Lin MT,Wang JJ

    更新日期:2004-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Nicholas MK,Wilson PH,Goyen J

    更新日期:1992-03-01 00:00:00

  • Racial/ethnic differences in the experience of chronic pain.

    abstract::The purpose of this study was to examine racial/ethnic-related differences in a four-stage model of the processing of chronic pain. The subjects were 1557 chronic pain patients (White=1084, African American=473) evaluated at a pain management clinic at a large southeastern university medical center. Using an analysis ...


    pub_type: 杂志文章


    authors: Riley JL 3rd,Wade JB,Myers CD,Sheffield D,Papas RK,Price DD

    更新日期:2002-12-01 00:00:00

  • Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury.

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    pub_type: 杂志文章


    authors: Pan B,Guo Y,Wu HE,Park J,Trinh VN,Luo ZD,Hogan QH

    更新日期:2016-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Langer SL,Romano J,Brown JD,Nielson H,Ou B,Rauch C,Zullo L,Levy RL

    更新日期:2017-09-01 00:00:00

  • A cross-national study of the course of persistent pain in primary care.

    abstract::Data from the World Health Organization's study of psychological problems in general health care were used to examine the course of persistent pain syndromes among primary care patients. Across 15 sites in 14 countries, 3197 randomly selected primary care patients completed baseline and 12-month follow-up assessments ...


    pub_type: 杂志文章


    authors: Gureje O,Simon GE,Von Korff M

    更新日期:2001-05-01 00:00:00