Characteristics of ectopic discharges in a rat neuropathic pain model.

Abstract:

:Injured afferent neurons produce spontaneous activity that is generated away from the normal impulse generation site. Since this activity, referred to as ectopic discharges, may play a significant role in neuropathic pain, it is important to systematically analyze the activity in various pain states. The present study used the segmental spinal nerve injury model of neuropathic pain to quantify the ectopic discharges from injured afferents in the neuropathic rat under various conditions. All aspects of measured ectopic discharges declined as postoperative time lengthened. Neuropathic pain behaviors declined in a similar fashion over the same time period. Surgical sympathectomy on neuropathic animals lowered the level of ectopic discharges along with neuropathic pain behaviors. The data indicate that the level of ectopic discharges is well correlated with that of pain behaviors in a rat neuropathic pain model, and this reinforces the supposition that ectopic discharges are important to the maintenance of neuropathic pain behaviors. The data suggest that there are two components of ectopic discharge generator mechanisms: sympathetically dependent and sympathetically independent components.

journal_name

Pain

journal_title

Pain

authors

Han HC,Lee DH,Chung JM

doi

10.1016/s0304-3959(99)00219-5

keywords:

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

253-61

issue

2-3

eissn

0304-3959

issn

1872-6623

pii

S0304395999002195

journal_volume

84

pub_type

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