A comprehensive categorical and bibliometric analysis of published research articles on pediatric pain from 1975 to 2010.


:The field of pediatric pain research began in the mid-1970s and has undergone significant growth and development in recent years as evidenced by the variety of books, conferences, and journals on the topic and also the number of disciplines engaged in work in this area. Using categorical and bibliometric meta-trend analysis, this study offers a synthesis of research on pediatric pain published between 1975 and 2010 in peer-reviewed journals. Abstracts from 4256 articles, retrieved from Web of Science, were coded across 4 categories: article type, article topic, type and age of participants, and pain stimulus. The affiliation of the first author and number of citations were also gathered. The results suggest a significant increase in the number of publications over the time period investigated, with 96% of the included articles published since 1990 and most research being multiauthored publications in pain-focused journals. First authors were most often from the United States and affiliated with a medical department. Most studies were original research articles; the most frequent topics were pain characterization (39.86%), pain intervention (37.49%), and pain assessment (25.00%). Clinical samples were most frequent, with participants most often characterized as children (6-12 years) or adolescents (13-18 years) experiencing chronic or acute pain. The findings provide a comprehensive overview of contributions in the field of pediatric pain research over 35 years and offers recommendations for future research in the area.






Caes L,Boerner KE,Chambers CT,Campbell-Yeo M,Stinson J,Birnie KA,Parker JA,Huguet A,Jordan A,MacLaren Chorney J,Schinkel M,Dol J




Has Abstract


2016-02-01 00:00:00
















  • A randomized controlled efficacy trial of mindfulness-based stress reduction compared with an active control group and usual care for fibromyalgia: the EUDAIMON study.

    abstract::Fibromyalgia (FM) syndrome represents a great challenge for clinicians and researchers because the efficacy of currently available treatments is limited. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for reducing functional impairment as well as the role of mindfulness-related construct...


    pub_type: 杂志文章,随机对照试验


    authors: Pérez-Aranda A,Feliu-Soler A,Montero-Marín J,García-Campayo J,Andrés-Rodríguez L,Borràs X,Rozadilla-Sacanell A,Peñarrubia-Maria MT,Angarita-Osorio N,McCracken LM,Luciano JV

    更新日期:2019-11-01 00:00:00

  • Personalized evaluation of self-hypnosis as a treatment of chronic pain: a repertory grid analysis.

    abstract::Self-hypnosis was taught to 5 highly hypnotisable patients referred to Auckland Hospital Pain Clinic. Evaluation included the Illness Self-Concept Repertory Grid (ISCRG) and follow-up was at 1 and 6 months post treatment. Consensus grids indicated the subjects initially identified with physical illness but this associ...


    pub_type: 杂志文章


    authors: Large RG,James FR

    更新日期:1988-11-01 00:00:00

  • Cross-sex hormone administration changes pain in transsexual women and men.

    abstract::Chronic pain is gender-related, since there is a clear predominance of one sex with respect to the other in most pain syndromes. Gonadal hormones are known to affect the occurrence and incidence of pain. Transsexuals receive cross-sex hormones to develop and maintain somatic characteristics of the opposite sex: male t...


    pub_type: 杂志文章


    authors: Aloisi AM,Bachiocco V,Costantino A,Stefani R,Ceccarelli I,Bertaccini A,Meriggiola MC

    更新日期:2007-11-01 00:00:00

  • The analgesic effects of caffeine in headache.

    abstract::Caffeine is frequently added to mild analgesic preparations but its effect when used alone on pain has never been studied in humans. Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were given placebo, acetaminophen, 2 doses of caffeine and 2 combinations of ...


    pub_type: 临床试验,杂志文章


    authors: Ward N,Whitney C,Avery D,Dunner D

    更新日期:1991-02-01 00:00:00

  • Chronic stress exacerbates neuropathic pain via the integration of stress-affect-related information with nociceptive information in the central nucleus of the amygdala.

    abstract::Exacerbation of pain by chronic stress and comorbidity of pain with stress-related psychiatric disorders, including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim stress (CFSS)-induced exacerb...


    pub_type: 杂志文章


    authors: Li MJ,Liu LY,Chen L,Cai J,Wan Y,Xing GG

    更新日期:2017-04-01 00:00:00

  • Receptive properties of pial afferents.

    abstract::The blood vessels and the pial surface of the brain, spinal cord and its roots are innervated by primary afferent neurones. Here, we have electrophysiologically characterized the functional properties of a subpopulation of these afferent fibres that supply the ventral roots of the cat sacral spinal cord. We have taken...


    pub_type: 杂志文章


    authors: Jänig W,Koltzenburg M

    更新日期:1991-04-01 00:00:00

  • Intrathecal delivery of hydromorphone vs morphine for refractory cancer pain: a multicenter, randomized, single-blind, controlled noninferiority trial.

    abstract::Hydromorphone is an alternative to morphine for intrathecal drug delivery system to treat refractory cancer pain; however, there is not enough clinical evidence to prove it. In our study, 233 patients from 12 different pain management centers across China were enrolled, 121 and 112 in the intrathecal hydromorphone (IT...


    pub_type: 杂志文章


    authors: Ma K,Jin Y,Wang L,Feng ZY,Song T,Yang XQ,Chen FQ,Duan BL,Huang YQ,Xie GL,Bao HG,Wang K,Xu JT,Lu Y,Liu YQ

    更新日期:2020-11-01 00:00:00

  • Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.

    abstract::Glutamate is a major excitatory neurotransmitter in primary afferent terminals and is critical for normal spinal excitatory synaptic transmission. However, little is known about the regulation of synaptically released glutamate in the spinal cord under physiologic conditions. The sodium-dependent, high-affinity glutam...


    pub_type: 杂志文章


    authors: Liaw WJ,Stephens RL Jr,Binns BC,Chu Y,Sepkuty JP,Johns RA,Rothstein JD,Tao YX

    更新日期:2005-05-01 00:00:00

  • The behavioral management of pain: a criticism of a response.

    abstract::In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pai...


    pub_type: 杂志文章,评审


    authors: Schmidt AJM

    更新日期:1987-09-01 00:00:00

  • Reference values for quantitative sensory testing in children and adolescents: developmental and gender differences of somatosensory perception.

    abstract::The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (...


    pub_type: 杂志文章


    authors: Blankenburg M,Boekens H,Hechler T,Maier C,Krumova E,Scherens A,Magerl W,Aksu F,Zernikow B

    更新日期:2010-04-01 00:00:00

  • Recognition and discrimination of prototypical dynamic expressions of pain and emotions.

    abstract::Facial expressions of pain and emotions provide powerful social signals, which impart information about a person's state. Unfortunately, research on pain and emotion expression has been conducted largely in parallel with few bridges allowing for direct comparison of the expressive displays and their impact on observer...


    pub_type: 杂志文章


    authors: Simon D,Craig KD,Gosselin F,Belin P,Rainville P

    更新日期:2008-03-01 00:00:00

  • The characteristics of chronic central pain after traumatic brain injury.

    abstract::Central pain following traumatic brain injury (TBI) has not been studied in depth. Our purpose was to conduct a systematic study of patients with TBI suffering from chronic central pain, and to describe the characteristics of the central pain. Groups were TBI patients with (TBIP) and without central pain (TBINP) and h...


    pub_type: 杂志文章


    authors: Ofek H,Defrin R

    更新日期:2007-10-01 00:00:00

  • Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat.

    abstract::A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from formerly compressed neurons in the intact dorsal root ganglion (DRG) reveal lower than normal current thresholds (CTs) and abnormal spontaneous a...


    pub_type: 杂志文章


    authors: Ma C,LaMotte RH

    更新日期:2005-01-01 00:00:00

  • Vibratory stimulation for the relief of pain of dental origin.

    abstract::The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 day...


    pub_type: 杂志文章


    authors: Ottoson D,Ekblom A,Hansson P

    更新日期:1981-02-01 00:00:00

  • Electrical stimulation of tooth pulp in humans. I. Relationships among physical stimulus intensities, psychological magnitude estimates and cerebral evoked potentials.

    abstract::Brief electrical pulses were applied to the pulp of individual pre-molar teeth of 14 healthy, adult volunteers via wire electrodes implanted and sealed in dentine. The sensation threshold was estimated in each individual by the Two-Alternative Forced-Choice Staircase (2AFCS) method. Seven, 5 or 4 stimulus intensities ...


    pub_type: 杂志文章


    authors: Fernandes de Lima VM,Chatrian GE,Lettich E,Canfield RC,Miller CR,Soso MJ

    更新日期:1982-11-01 00:00:00

  • Ventrolateral medullary lesions block the antinociceptive and cardiovascular responses elicited by stimulating the dorsal periaqueductal grey matter in rats.

    abstract::In rats anaesthetised with Saffan (Glaxovet), inhibition of the tail flick reflex evoked by electrical stimulation in the dorsal periaqueductal grey matter (PAG) was accompanied by an increase in blood pressure, tachycardia, vasodilatation in hind limb muscle, an increase in respiration, pupillodilatation and widening...


    pub_type: 杂志文章


    authors: Lovick TA

    更新日期:1985-03-01 00:00:00

  • Substance dependence and chronic pain: profile of 50 patients treated in an alcohol and drug dependence unit.

    abstract::Fifty adult patients with chronic pain and substance dependence were admitted to an inpatient unit for treatment of addiction without primary emphasis on treatment of pain. As a group they had received considerable medical attention for their pain, but relatively little for their addictions. When compared with a group...


    pub_type: 杂志文章


    authors: Finlayson RE,Maruta T,Morse RM,Swenson WM,Martin MA

    更新日期:1986-08-01 00:00:00

  • Tonic cholinergic inhibition of spinal mechanical transmission.

    abstract::The present study examined the role of spinal cholinergic modulation of spinal mechanical and thermal transmission. Intrathecal administration of the cholinergic muscarinic receptor antagonists atropine or scopolamine in awake rats produced a dose-dependent decrease in the nociceptive mechanical withdrawal threshold o...


    pub_type: 杂志文章


    authors: Zhuo M,Gebhart GF

    更新日期:1991-08-01 00:00:00

  • Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center.

    abstract::This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...


    pub_type: 临床试验,杂志文章


    authors: Becker N,Thomsen AB,Olsen AK,Sjøgren P,Bech P,Eriksen J

    更新日期:1997-12-01 00:00:00

  • P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice.

    abstract::Growing evidence suggests that leukocyte extravasation is initiated by the interaction of selectins with their ligands; as well as an essential role for P-selectin in the initial recruitment of inflammatory cells to sites of inflammation. In this study, P-selectin-deficient (P-sel-/-) mice were used to test the hypoth...


    pub_type: 杂志文章


    authors: Liou JT,Lee CM,Lin YC,Chen CY,Liao CC,Lee HC,Day YJ

    更新日期:2013-10-01 00:00:00

  • Effects of morphine on immune response in rats with sciatic constriction injury.

    abstract::We investigated the effects of acute and of chronic morphine treatment on T-lymphocyte function and natural killer (NK) cell activity in rats receiving chronic constriction injury (CCI) of the sciatic nerve. T-Lymphocyte function was evaluated based on concanavalin-A (ConA)- and phytohemagglutinin (PHA)-induced spleno...


    pub_type: 杂志文章


    authors: Tsai YC,Won SJ,Lin MT

    更新日期:2000-11-01 00:00:00

  • Determination of mild, moderate, and severe pain interference in patients with cancer.

    abstract::Effective assessment and management of pain in patients with cancer is strengthened by the patient's report of how much pain interferes with daily functioning. This requires a clear delineation of different levels of pain interference. We derived optimal cutpoints for differentiating between mild, moderate, and severe...


    pub_type: 杂志文章


    authors: Shi Q,Mendoza TR,Dueck AC,Ma H,Zhang J,Qian Y,Bhowmik D,Cleeland CS

    更新日期:2017-06-01 00:00:00

  • Chronic effects of topical application of capsaicin to the sciatic nerve on responses of primate spinothalamic neurons.

    abstract::The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...


    pub_type: 杂志文章


    authors: Chung JM,Paik KS,Kim JS,Nam SC,Kim KJ,Oh UT,Hasegawa T,Chung K,Willis WD

    更新日期:1993-06-01 00:00:00

  • Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain.

    abstract::Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and noci...


    pub_type: 杂志文章


    authors: Ichihara K,Aizawa N,Akiyama Y,Kamei J,Masumori N,Andersson KE,Homma Y,Igawa Y

    更新日期:2017-08-01 00:00:00

  • Sleep pattern in an experimental model of osteoarthritis.

    abstract::Osteoarthritis (OA) is a major healthcare burden of increasing prevalence. It has been demonstrated that the relationship between pain and sleep produces changes in sleep patterns and pain perception. However, electrophysiological studies in animal models of pain are limited. The current study examined the effect of c...


    pub_type: 杂志文章


    authors: Silva A,Andersen ML,Tufik S

    更新日期:2008-12-01 00:00:00

  • Are both the sensory and the affective dimensions of pain encoded in the face?

    abstract::The facial expression of pain plays a crucial role in pain communication and pain diagnostics. Despite its importance, it has remained unknown which dimensions of pain (sensory and/or affective) are encoded in the face. To answer this question, we used a well-established cognitive strategy (suggestions) to differentia...


    pub_type: 杂志文章


    authors: Kunz M,Lautenbacher S,LeBlanc N,Rainville P

    更新日期:2012-02-01 00:00:00

  • Effectiveness of group acceptance and commitment therapy for fibromyalgia: a 6-month randomized controlled trial (EFFIGACT study).

    abstract::In the last decade, there has been burgeoning interest in the effectiveness of third-generation psychological therapies for managing fibromyalgia (FM) symptoms. The present study examined the effectiveness of acceptance and commitment therapy (ACT) on functional status as well as the role of pain acceptance as a media...


    pub_type: 杂志文章,随机对照试验


    authors: Luciano JV,Guallar JA,Aguado J,López-Del-Hoyo Y,Olivan B,Magallón R,Alda M,Serrano-Blanco A,Gili M,Garcia-Campayo J

    更新日期:2014-04-01 00:00:00

  • Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain.

    abstract::Cyclooxygenase-2 (COX-2) activity in the spinal cord plays a key role in sensitization to sensory stimuli during acute inflammation. In contrast, intrathecal administration of COX-2 specific inhibitors has minimal analgesic effects in an incisional model of postoperative pain. We investigated the role of COX isoforms ...


    pub_type: 杂志文章


    authors: Zhu X,Conklin D,Eisenach JC

    更新日期:2003-07-01 00:00:00

  • Cytokine involvement in dynorphin-induced allodynia.

    abstract::Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. This dynorphin-induced allodynia was used as a pharmacological, central model of neuropathic pain. ...


    pub_type: 杂志文章


    authors: Laughlin TM,Bethea JR,Yezierski RP,Wilcox GL

    更新日期:2000-02-01 00:00:00

  • Pain and the marital relationship: psychiatric distress.

    abstract::Psychologic assessment and treatment of the family of the chronic pain patient has been thought to be of benefit in the outcome of pain therapy. The present study was designed to determine the presence of psychologic symptoms in the spouses of pain patients and the relationship of distress levels between the marital p...


    pub_type: 杂志文章


    authors: Shanfield SB,Heiman EM,Cope N,Jones JR

    更新日期:1979-12-01 00:00:00