A different mode of entry by dengue-2 neutralisation escape mutant virus.

Abstract:

:Entry processes were compared between dengue-2 (DEN-2) virus and a DEN-2 neutralisation escape mutant virus in baby hamster kidney (BHK) cells. The mutant virus (mu6B2) was resistant to neutralisation by a monoclonal antibody, MAb 6B2. Infection of BHK cells by the wild-type DEN-2 virus resulted in direct penetration of the virions into the cytoplasm whereas the mutant virus entered cells by endocytosis. The continual presence of the monoclonal antibody might have asserted some pressure for the mutant to adopt a different mode of entry.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Lim HY,Ng ML

doi

10.1007/s007050050561

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

989-95

issue

5

eissn

0304-8608

issn

1432-8798

journal_volume

144

pub_type

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