The cytochrome b5 tail anchors and stabilizes subdomains of human DNA topoisomerase II alpha in the cytoplasm of retrovirally infected mammalian cells.

abstract：:The specific activities of pyruvate kinase and phosphofructokinase but not lactate dehydrogenase increase as P-815 mastocytoma cells approach the stationary phase. During this growth period, the rates of uptake of labelled precursors into DNA, RNA and total protein decreases. On the other hand, the pyruvate kinase pro...

journal_title：Experimental cell research

authors： Ngo JL,Chute H,Sanders DA,Orlando RA,Ibsen KH

更新日期：1983-12-01 00:00:00

abstract：:CUB domains are most exclusively found in secreted proteins and in a few transmembrane proteins. These domains are approximately 110 amino acids long and have four conserved cysteines that form a β-sandwich fold. CUB domains proteins are involved in a wide range of biological functions. We have shown that CUB domains ...

journal_title：Experimental cell research

authors： Predes D,Cruz JVR,Abreu JG,Mendes FA

更新日期：2019-10-01 00:00:00

abstract：:The p53-regulated stress-inducible gene GADD45 has been shown to participate in cellular response to DNA damage, including cell cycle checkpoint, apoptosis, and DNA repair. However, the regulation of GADD45 expression is complex and may involve both p53-dependent and -independent pathways. Recent findings have demonst...

journal_title：Experimental cell research

authors： Tong T,Fan W,Zhao H,Jin S,Fan F,Blanck P,Alomo I,Rajasekaran B,Liu Y,Holbrook NJ,Zhan Q

更新日期：2001-09-10 00:00:00

abstract：:Microparticles are small membrane-bound vesicles that are released from apoptotic cells during blebbing. These particles contain DNA and RNA and display important functional activities, including immune system activation. Furthermore, nucleic acids inside the particle can be analyzed as biomarkers in a variety of dise...

journal_title：Experimental cell research

authors： Reich CF 3rd,Pisetsky DS

更新日期：2009-03-10 00:00:00

abstract：:Cytostatic factor (CSF), found in the cytoplasm of unfertilized eggs of amphibians, causes metaphase arrest when microinjected into cleaving blastomeres. Although CSF from Rana pipiens eggs has been extracted and characterized, little is known about CSF extracted from eggs of other species. We investigated the conditi...

journal_title：Experimental cell research

authors： Moses RM,Masui Y

更新日期：1990-01-01 00:00:00

abstract：:Germ cells were isolated from mouse fetal gonads 11 1/2-16 1/2 days post coitum (dpc), and exposed to various methods of in vitro culture. From 13 1/2 dpc onwards, both male and female germ cells survived well at 37 degrees C for several days. During the culture period the proportion of female germ cells in meiosis in...

journal_title：Experimental cell research

authors： De Felici M,McLaren A

更新日期：1983-04-01 00:00:00

abstract：:Binding of integrins to the extracellular matrix (ECM) activates various signal transduction pathways and regulates gene expression in many cell types. Integrin-dependent cytoplasmic protein/protein interactions are necessary for activation of those signal transduction cascades. In our studies we investigated a possib...

journal_title：Experimental cell research

authors： Danker K,Gabriel B,Heidrich C,Reutter W

更新日期：1998-03-15 00:00:00

abstract：:The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The nucleolus is partially enveloped by a layer of condensed chromatin which, at several places, penetrates into the nucleola...

journal_title：Experimental cell research

authors： Vandelaer M,Thiry M,Goessens G

更新日期：1993-04-01 00:00:00

abstract：:With multiple divisions in culture, normal diploid cells suffer a loss of growth potential that leads to replicative senescence and a finite replicative capacity. Using quantitative RT-PCR, we have monitored mRNA expression levels of c-fos, c-jun, JunB, c-myc, p53, H-ras, and histone H4 during the replicative senescen...

journal_title：Experimental cell research

authors： Irving J,Feng J,Wistrom C,Pikaart M,Villeponteau B

更新日期：1992-09-01 00:00:00

abstract：:The first angiogenesis inhibitors for cancer have now been approved by the F.D.A. in the U.S. and in 28 other countries, including China. The majority of these are monotherapies that block VEGF. However, mutant tumor cells may over time produce redundant angiogenic factors. Therefore, for long-term use in cancer, comb...

journal_title：Experimental cell research

authors： Folkman J

更新日期：2006-03-10 00:00:00

abstract：:Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biologic...

journal_title：Experimental cell research

authors： Haase VH

更新日期：2012-05-15 00:00:00

abstract：:The role of the F-actin cytoskeleton in cell volume regulation was studied in Ehrlich ascites tumor cells, using a quantitative rhodamine-phalloidin assay, confocal laser scanning microscopy, and electronic cell sizing. A hypotonic challenge (160 mOsm) was associated with a decrease in cellular F-actin content at 1 an...

journal_title：Experimental cell research

authors： Pedersen SF,Mills JW,Hoffmann EK

更新日期：1999-10-10 00:00:00

abstract：:Fenretinide is an effective inducer of apoptosis in many malignancies but its precise mechanism(s) of action in the induction of apoptosis in neuroblastoma is unclear. To characterize fenretinide-induced apoptosis, neuroblastoma cell lines were treated with fenretinide and flow cytometry was used to measure apoptosis,...

journal_title：Experimental cell research

authors： Lovat PE,Ranalli M,Annichiarrico-Petruzzelli M,Bernassola F,Piacentini M,Malcolm AJ,Pearson AD,Melino G,Redfern CP

更新日期：2000-10-10 00:00:00

abstract：:Tubular epithelial-to-mesenchymal transition (EMT) plays a crucial role in the progression of renal tubular interstitial fibrosis (TIF), which subsequently leads to chronic kidney disease (CKD) and eventually, end-stage renal disease (ESRD). We propose that augmenter of liver regeneration (ALR), a member of the newly ...

journal_title：Experimental cell research

authors： Liao XH,Zhang L,Chen GT,Yan RY,Sun H,Guo H,Liu Q

更新日期：2014-10-01 00:00:00

abstract：:The differential activation of cyclin and cyclin-dependent kinase genes by the adenovirus E1A gene product (E1A) or serum factors was studied with a rat 3Y1 derivative cell line, g12-21, in which the E1A12S cDNA can be expressed in response to dexamethasone (dex). The induction of DNA synthesis in quiescent g12-21 cel...

journal_title：Experimental cell research

authors： Ishii T,Shimizu M,Kanayama Y,Nakada S,Nojima H,Oda K

更新日期：1993-10-01 00:00:00

abstract：:Hereditary transthyretin amyloidosis (ATTR) is caused by amyloid deposition of misfolded transthyretin (TTR) in various tissues. Recently, reduction of circulating serum TTR, achieved via silencing oligonucleotides, was introduced as therapy of ATTR amyloidosis. We explored the impact of Serpin Family A Member 1 (SERP...

journal_title：Experimental cell research

authors： Niemietz C,Bezerra F,Almeida MR,Guo S,Monia BP,Saraiva MJ,Schütz P,Schmidt HH,Zibert A

更新日期：2020-10-15 00:00:00

abstract：:We have investigated the role played by the growth and differentiation factor (GDF)-induced calcium ion second messenger signal in the control of cellular differentiation and proliferation in Syrian hamster embryo (SHE) cells. Blocking the platelet-derived growth factor (PDGF)-induced calcium ion signal with either ex...

journal_title：Experimental cell research

authors： Isfort RJ,Cody DB,Stuard SB,Ridder GM,LeBoeuf RA

更新日期：1996-08-01 00:00:00

abstract：:It has previously been shown by immunocytochemistry that the inactive X chromosome (Xi) in somatic cells of human and mouse females is marked by underacetylation of histone H4. It has been suggested that this may be important for transcriptional silencing of genes on Xi. We have now investigated X-inactivation in meio...

journal_title：Experimental cell research

authors： Armstrong SJ,Hultén MA,Keohane AM,Turner BM

更新日期：1997-02-01 00:00:00

abstract：:Ubiquitin-specific peptidase 18 (USP18) is closely related with hepatitis B virus (HBV), which has been involved in tumourigenesis. However, there has been little research into the role of USP18 on the progression of hepatocellular carcinoma (HCC), especially in HBV-related HCC. In present study, we found that USP18 e...

journal_title：Experimental cell research

authors： Cai J,Liu T,Jiang X,Guo C,Liu A,Xiao X

更新日期：2017-09-15 00:00:00

abstract：:Pure melanophore populations isolated from the tail skin of the tadpole, Rana catesbeiana, were mass cultured for a period of 2-3 years. All cell lines of amphibian melanophores studied exhibited growth crisis (in vitro ageing) followed by spontaneous transformation to a continuous cell line, as shown by changes in gr...

journal_title：Experimental cell research

authors： Kondo H,Ide H

更新日期：1983-11-01 00:00:00

abstract：:Fibronectin and alpha 1(I) and alpha 2(I) collagen proteins and RNAs are highly expressed during the growth phase of the non-transformed L6 alpha 1 rat myoblasts. When L6 alpha 1 cells from myotubes following transfer to low serum medium, the levels of fibronectin RNA decrease 8-fold, those of both alpha 2(I) transcri...

journal_title：Experimental cell research

authors： Leibovitch SA,Hillion J,Leibovitch MP,Guillier M,Schmitz A,Harel J

更新日期：1986-10-01 00:00:00

abstract：:The laminins consist of at least 11 polypeptides (5 alpha-chains, 3 beta-chains, and 3 gamma-chains) specific to basement membranes. Here we investigate the biological activity associated with the G domain of the newly identified laminin alpha5-chain using 113 overlapping synthetic peptides (positions 2679-3635). Usin...

journal_title：Experimental cell research

authors： Makino M,Okazaki I,Kasai S,Nishi N,Bougaeva M,Weeks BS,Otaka A,Nielsen PK,Yamada Y,Nomizu M

更新日期：2002-07-01 00:00:00

abstract：:Melanotransferrin is a glycoprotein expressed at the cell membrane and secreted in the extracellular environment. Recombinant truncated form of membrane-bound melanotransferrin (sMTf) was reported to exert in vitro anti-angiogenic properties. Here we show that sMTf treatment leads to a 50% inhibition of neovasculariza...

journal_title：Experimental cell research

authors： Rolland Y,Demeule M,Michaud-Levesque J,Béliveau R

更新日期：2007-08-01 00:00:00

abstract：:In confluent keratinocyte monolayers, desmosomal adhesion gradually becomes calcium-independent and this is associated with an increase in the strength of intercellular adhesion (hyper-adhesion). In this study, we investigated the functional and molecular significance of hyper-adhesion in a system challenged by autoim...

journal_title：Experimental cell research

authors： Cirillo N,Lanza A,Prime SS

更新日期：2010-02-15 00:00:00

abstract：:Thyroid hormone (T3) and estradiol (Est) modulate biological processes by binding to nuclear receptor proteins that, through interactions with specific response elements in the regulatory regions of genes, modulate gene transcription. Est stimulation of estrogen receptor (ER)-positive breast carcinoma cell growth occu...

journal_title：Experimental cell research

authors： Shao ZM,Sheikh MS,Rishi AK,Dawson MI,Li XS,Wilber JF,Feng P,Fontana JA

更新日期：1995-05-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors in China with a poor prognosis. Most ESCC patients were diagnosed at advanced stages, losing the opportunity for surgical excision. Hence, it remains a pressing work to identify biomarkers for early detection, prognosis prediction and target...

journal_title：Experimental cell research

authors： Yuan H,Zhou W,Yang Y,Xue L,Liu L,Song Y

更新日期：2018-06-01 00:00:00

abstract：:Several cell division cycle (cdc) mutants of Saccharomyces cerevisiae (cdc28, cdc35, cdc19, cdc21, and cdc17) at the restrictive temperature (37 degrees C) in the presence of 1% glucose and defined medium divert most of the carbon (approximately 50%) to ethanol production with low biomass growth yields (Yglc) that cor...

journal_title：Experimental cell research

authors： Mónaco ME,Valdecantos PA,Aon MA

更新日期：1995-03-01 00:00:00

abstract：:Lamin-associated polypeptides (LAPs) comprise inner nuclear membrane proteins tightly associated with the peripheral lamin scaffold as well as proteins forming stable complexes with lamins in the nucleoplasm. The involvement of LAPs in a wide range of human diseases may be linked to an equally bewildering range of the...

journal_title：Experimental cell research

authors： Schirmer EC,Foisner R

更新日期：2007-06-10 00:00:00

abstract：:The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulato...

journal_title：Experimental cell research

authors： Serrano M

更新日期：1997-11-25 00:00:00

abstract：:We recently observed a 25-fold increase in the activity of ornithine decarboxylase (ODC) 6 h after treatment of G1-synchronized CTLL-2 cells with interleukin-2 (IL-2). Here we show that the ODC mRNA content increased in parallel with the ODC activity during the first hours of stimulation with IL-2, resulting in a 25-f...

journal_title：Experimental cell research

authors： Legraverend C,Potter A,Hölttä E,Alitalo K,Andersson LC

更新日期：1989-03-01 00:00:00