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Renal cancer: oxygen meets metabolism.

Abstract：

:Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biological impact and extend beyond renal cancer. This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Haase VH

doi

10.1016/j.yexcr.2012.02.026

subject

Has Abstract

pub_date

2012-05-15 00:00:00

pages

1057-67

issue

9

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(12)00102-4

journal_volume

318

pub_type

杂志文章,评审

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