The tumor suppressor protein p16INK4a.

abstract：:Ring finger protein 6 (RNF6), a RING-domain E3 ubiquitin Ligase, functions as a potential tumor promoter in several caners. However, the function and clinical significance of RNF6 in hepatocellular carcinoma (HCC) remains unclear. Here, we found that high RNF6 expression was detected frequently in primary HCC tissues,...

journal_title：Experimental cell research

authors： Cai J,Xiong Q,Jiang X,Zhou S,Liu T

更新日期：2019-01-01 00:00:00

abstract：:β-Catenin signaling plays a pivotal role in the genesis of a variety of malignant tumors, but its role in breast cancer has not been fully elucidated. Here, we examined whether deregulation of β-catenin signaling is related to the aggressive characteristics of certain types of breast cancers. Analysis of cytokine leve...

journal_title：Experimental cell research

authors： Yasuhara R,Irié T,Suzuki K,Sawada T,Miwa N,Sasaki A,Tsunoda Y,Nakamura S,Mishima K

更新日期：2015-10-15 00:00:00

abstract：:Polycystins 1 and 2, which are mutated in Autosomal Polycystic Kidney Disease, are involved in mechanotransduction through various mechanisms. In renal cells, polycystins not only have an important mechanotransductive role in primary cilia but are also present in intercellular contacts but their role there remains unc...

journal_title：Experimental cell research

authors： Bhoonderowa L,Hameurlaine F,Arbabian A,Faqir F,Amblard F,Coscoy S

更新日期：2016-10-15 00:00:00

abstract：:Our results showed that the expression of the src gene in chick embryo fibroblasts (CEF) released the density-dependent inhibition (DDI) of phosphate metabolism (phosphate uptake and phosphorylation of small organic compounds). With increasing cell density, phosphate metabolism decreased by 58% in normal CEF and, in c...

journal_title：Experimental cell research

authors： Jullien M,Harel L,Golde A,Villaudy J,Pugnet P

更新日期：1984-06-01 00:00:00

abstract：:This study shows the sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis without modifying intracellular free calcium concentrations. The culture of cells in the absence of serum during 6 h failed to produce spontaneous DNA fragmentation. However, when cultures were carried out in the presence of th...

journal_title：Experimental cell research

authors： Sánchez-Margalet V,Lucas M,Solano F,Goberna R

更新日期：1993-11-01 00:00:00

abstract：:Breast cancer is a common malignancy and a major cause of death in women worldwide. The immunomodulatory role of B cells is being increasingly recognized in autoimmune diseases and cancers. In recent years, immunotherapeutic strategies that upregulate the patient's own antitumor T cell responses have shown promise in ...

journal_title：Experimental cell research

authors： Zhu S,Wang X,Wang J,Lin J,Cong Y,Qiao G

更新日期：2017-12-01 00:00:00

abstract：:A two-site radio-immunoassay for beta NGF demonstrated 5-10 pg of NGF in the normal, adult rat iris. Ciliarectomy or sympathectomy did not significantly alter the amount of NGF after 10 days. However, denervation including all sensory axons (stereotactic lesion distal to the trigeminal ganglion) increased the level to...

journal_title：Experimental cell research

authors： Ebendal T,Olson L,Seiger A

更新日期：1983-10-15 00:00:00

abstract：:Reversible methylation of the protein phosphatase 2A catalytic subunit (PP2A(C)(1)) is an important regulatory mechanism playing a crucial role in the selective recruitment of regulatory B subunits. Here, we investigated the subcellular localization of leucine carboxyl methyltransferase (LCMT1) and protein phosphatase...

journal_title：Experimental cell research

authors： Longin S,Zwaenepoel K,Martens E,Louis JV,Rondelez E,Goris J,Janssens V

更新日期：2008-01-01 00:00:00

abstract：:A heterogeneous RNP structure has been isolated from rat liver nuclei by a method previously used for the isolation of 30S RNP complexes carrying heterogeneous RNA (hnRNA) [1]. The RNP sediments in sucrose gradients with s-values of 70-110S. Formaldehyde-fixed preparations band at Q = 1.40 in isopycnic CsCl gradients....

journal_title：Experimental cell research

authors： Hatzoglou M,Adamtziki E,Margaritis L,Sekeris CE

更新日期：1985-03-01 00:00:00

abstract：:We previously showed that clonable skeletal myogenic cells can be derived from the embryonic aorta but become very rare in the more mature and structured fetal aorta. The aim of this study was to investigate whether, during fetal and postnatal development, these myogenic progenitors progressively disappear or may rath...

journal_title：Experimental cell research

authors： Cusella De Angelis MG,Balconi G,Bernasconi S,Zanetta L,Boratto R,Galli D,Dejana E,Cossu G

更新日期：2003-11-01 00:00:00

abstract：:Oligomerization of Fas receptor by its ligand, FasL, activates a signaling cascade that leads to apoptosis of Fas bearing cells. Interestingly, many epithelia coexpress Fas and FasL, yet FasL does not trigger Fas present on the same or neighboring cells to induce spontaneous apoptosis. Here, we show that Fas and FasL ...

journal_title：Experimental cell research

authors： Tan KH,Hunziker W

更新日期：2003-04-01 00:00:00

abstract：:Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin A molecule and then processed into mature lamin A through sequential steps of posttranslational modifications and proteolytic cleavages. Remarkably, over 400 distinct point mutations have been so far identified throughout the LM...

journal_title：Experimental cell research

authors： Reddy S,Comai L

更新日期：2012-01-01 00:00:00

abstract：:The protein kinase mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and growth, with the ribosomal subunit S6 kinase 1 (S6K1) as one of the key downstream signaling effectors. A critical role of mTOR signaling in skeletal muscle differentiation has been identified recently, and an unus...

journal_title：Experimental cell research

authors： Park IH,Erbay E,Nuzzi P,Chen J

更新日期：2005-09-10 00:00:00

abstract：:With the aim of discovering new molecular interactions of the tight junction protein ZO-2, a two-hybrid screen was performed on a human kidney cDNA library using as bait the middle segment of ZO-2. Through this assay we identified a 24-kDa novel protein herein named ZASP for ZO-2 associated speckle protein. ZO-2/ZASP ...

journal_title：Experimental cell research

authors： Lechuga S,Alarcón L,Solano J,Huerta M,Lopez-Bayghen E,González-Mariscal L

更新日期：2010-11-15 00:00:00

abstract：UNLABELLED:The success of hepatocyte transplantation has been limited by the low efficiency of transplanted cell integration into liver parenchyma. Human fetal hepatic progenitor cells (hepatoblasts) engraft more effectively than adult hepatocytes in mouse livers. However, the signals required for their integration are...

journal_title：Experimental cell research

authors： Delgado JP,Vanneaux V,Branger J,Touboul T,Sentilhes L,Mainot S,Lainas P,Leclerc P,Uzan G,Mahieu-Caputo D,Weber A

更新日期：2009-11-15 00:00:00

abstract：:The distribution of rDNA and the uptake of tritiated uridine was investigated in nucleoli of human Sertoli cells. The nucleolar components in these cells are spatially arranged in a highly ordered and invariable way and can be recognized in both light and electron microscopy. The pattern of distribution of rDNA and th...

journal_title：Experimental cell research

authors： Wachtler F,Hartung M,Devictor M,Wiegant J,Stahl A,Schwarzacher HG

更新日期：1989-09-01 00:00:00

abstract：:Recent studies have provided evidence that apoptosis of pancreatic beta-cells is important in the early etiology of both type I and type II diabetes mellitus. The mechanisms responsible for induction of apoptosis are unknown, but we present evidence that the signal transduction pathway controlling the process in pancr...

journal_title：Experimental cell research

authors： Loweth AC,Williams GT,Scarpello JH,Morgan NG

更新日期：1996-11-25 00:00:00

abstract：:The pleiotropic cytokine interleukin (IL)-10 is best characterized by its ability to downregulate inflammation and promote peripheral tolerance. On the other hand, IL-10 was also found to maintain the effector response of CD8+ T cells and promote the expansion of tumor-resident CD8+ T cells. In diffuse large B cell ly...

journal_title：Experimental cell research

authors： Qiu H,Hu X,Gao L,Chen L,Chen J,Yuan J,Huang C,Xu X,Yang J

更新日期：2017-11-15 00:00:00

abstract：:Gap junctional intercellular communication (GJIC), desmosomes, and cell movement were evaluated in a rat ovarian epithelial cell model system which consisted of an immortalized clonal cell line (SIGC), a pSV3neotransfected clonal derivative (SV-SIGC), and a nude mouse SV-SIGC-tumor-derived cell line (T-SV-SIGC). Compl...

journal_title：Experimental cell research

authors： Stein LS,Stein DW,Echols J,Burghardt RC

更新日期：1993-07-01 00:00:00

abstract：:In preparation for studies on the growth factor requirements of normal and transformed human fibroblasts, we have developed a serum-free medium that supports vigorous long-term serial subculture of diploid human fibroblasts and allows them to form large-sized colonies with high efficiency (40 to 60%) when plated at cl...

journal_title：Experimental cell research

authors： Ryan PA,Maher VM,McCormick JJ

更新日期：1987-10-01 00:00:00

abstract：:Bullous pemphigoid antigen 1 (BPAG1) is a member of the plakin family of proteins that is involved in cross-linking the cytoskeletal elements and attaching them to cell junctions. BPAG1 null mice develop severe degeneration of sensory neurons that was attributed in part due to the absence of a splice variant called BP...

journal_title：Experimental cell research

authors： Jefferson JJ,Leung CL,Liem RK

更新日期：2006-09-10 00:00:00

abstract：:Cross-linking of CD44 in vitro promotes chemokinesis and actin-based dendrite formation in T and B cells. However, the mechanisms by which the adhesion molecule CD44 induces cytoskeleton activation in lymphocytes are still poorly understood. In this study, we have investigated whether myosin isoforms are involved in C...

journal_title：Experimental cell research

authors： Sumoza-Toledo A,Gillespie PG,Romero-Ramirez H,Ferreira-Ishikawa HC,Larson RE,Santos-Argumedo L

更新日期：2006-10-15 00:00:00

abstract：:In many systems, events participating in cell division are controlled by intracellular pH (pHi). In Xenopus eggs, fertilization is accompanied by an increase in pHi which occurs concomitantly with an increase in protein synthesis and a reinitiation of DNA synthesis, leading the embryo to cell division. In this paper, ...

journal_title：Experimental cell research

authors： Grandin N,Charbonneau M

更新日期：1989-12-01 00:00:00

abstract：:In DNA isolated from proliferating human lymphoblastoid CCRF-CEM cells which had been pulse-labeled by exposure to [3H]thymidine for periods from 30 s to 10 min, single-stranded regions were analyzed by caffeine-gradient elution from benzoylated DEAE-cellulose. Two classes of structural defect were evident. Some repli...

journal_title：Experimental cell research

authors： Stewart BW,Kavallaris M,Catchpoole D,Norris MD

更新日期：1991-02-01 00:00:00

abstract：:We have shown previously that there is a good correlation between the degree of microtubule disassembly by methylmercury (MeHg) and the extent of inhibition of DNA replication in Concanavalin A (Con A)-stimulated mouse splenic lymphocytes. The purpose of this study was to determine if these two events are causally rel...

journal_title：Experimental cell research

authors： Roy C,Prasad KV,Reuhl KR,Little JE,Valentine BK,Brown DL

更新日期：1991-08-01 00:00:00

abstract：:The correct functioning of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is required for normal skin development and homeostasis. Cellular hyperproliferation induced by dysregulation of EGFR is tightly associated with structural and functional defects of hair follicles, skin lesions, and tumorig...

journal_title：Experimental cell research

authors： Chen L,Wang T,Ji X,Ding C,Liang T,Liu X,Lu J,Guo X,Kang Q,Ji Z

更新日期：2019-11-15 00:00:00

abstract：:The Chinese hamster dihydrofolate reductase (DHFR) origin consists of many inefficient initiation sites scattered throughout a 55-kb intergenic spacer, with the ori-beta, ori-beta', and ori-gamma subregions being preferred. To test for the presence of genetic replicators within these subregions, fragments containing o...

journal_title：Experimental cell research

authors： Lin HB,Dijkwel PA,Hamlin JL

更新日期：2005-08-01 00:00:00

abstract：:Two HL60 clones (C12 and C13) totally insensitive to differentiation induction by dimethylsulfoxide (Me2SO) are described. They have been growing continuously in the presence of the inducer for more than 6 months. The morphological and cytochemical features of the two populations are quite similar to those of the orig...

journal_title：Experimental cell research

authors： Ferrero D,Gallo E,Lanfrancone L,Tarella C

更新日期：1983-08-01 00:00:00

abstract：:Prior studies have shown that synthetic peptides representing the domain of thrombin responsible for high-affinity binding to fibroblasts stimulate chemotactic and cell proliferative signals through a nonproteolytic mechanism. One of these peptides, TP508, has recently been shown to be chemotactic for neutrophils, to ...

journal_title：Experimental cell research

authors： Sower LE,Payne DA,Meyers R,Carney DH

更新日期：1999-03-15 00:00:00

abstract：:Protein C23 (also called nucleolin or 100-kDa nucleolar protein) is a major nucleolar phosphoprotein involved in ribosome biogenesis. To determine the effects of protein C23 on preribosomal RNA (pre-rRNA) synthesis anti-C23 antiserum was microinjected into nuclei of Chironomus tentans salivary glands. Transcription wa...

journal_title：Experimental cell research

authors： Egyhazi E,Pigon A,Chang JH,Ghaffari SH,Dreesen TD,Wellman SE,Case ST,Olson MO

更新日期：1988-10-01 00:00:00