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Compartmentalization of Fas and Fas ligand may prevent auto- or paracrine apoptosis in epithelial cells.

Abstract：

:Oligomerization of Fas receptor by its ligand, FasL, activates a signaling cascade that leads to apoptosis of Fas bearing cells. Interestingly, many epithelia coexpress Fas and FasL, yet FasL does not trigger Fas present on the same or neighboring cells to induce spontaneous apoptosis. Here, we show that Fas and FasL are segregated from each other to different cellular compartments in kidney epithelial MDCK cells. While Fas is restricted to the basolateral surface, FasL is sequestered to an intracellular compartment and, a lesser extent, the apical surface. This spatial segregation of Fas and FasL may explain how epithelial cells can constitutively express a functional Fas pathway but avoid auto- or paracrine cell death. Compromising this spatial segregation in physiological or pathological situations may play a so far underestimated role in initiating apoptosis of epithelial cells.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Tan KH,Hunziker W

doi

10.1016/s0014-4827(02)00056-3

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

283-90

issue

2

eissn

0014-4827

issn

1090-2422

pii

S0014482702000563

journal_volume

284

pub_type

杂志文章

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