Pharmacogenetics in Psychiatry: An Update on Clinical Usability.

abstract：:Traditionally, the solution to reduce parameter dimensionality in a physiologically-based pharmacokinetic (PBPK) model is through expert judgment. However, this approach may lead to bias in parameter estimates and model predictions if important parameters are fixed at uncertain or inappropriate values. The purpose of ...

journal_title：Frontiers in pharmacology

authors： Hsieh NH,Reisfeld B,Bois FY,Chiu WA

更新日期：2018-06-08 00:00:00

abstract：:Neutrophil killing of bacteria is mediated by oxidative and non-oxidative mechanisms. Oxidants are generated through the NADPH oxidase complex, whereas antimicrobial proteins and peptides rank amongst non-oxidative host defenses. Mucus hypersecretion, deficient hydration and poor clearance from the airways are promine...

journal_title：Frontiers in pharmacology

authors： Cantin AM,Ouellet C,Cloutier A,McDonald PP

更新日期：2020-09-30 00:00:00

abstract：:The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles a...

journal_title：Frontiers in pharmacology

authors： Coricovac DE,Moacă EA,Pinzaru I,Cîtu C,Soica C,Mihali CV,Păcurariu C,Tutelyan VA,Tsatsakis A,Dehelean CA

更新日期：2017-03-28 00:00:00

abstract：:Selective estrogen receptor modulators (SERMs) are used to treat estrogen receptor (ER)-positive breast cancer and osteoporosis. Interestingly, tamoxifen and newer classes of SERMs also exhibit cytotoxic effects in cancers devoid of ERs, indicating a non-estrogenic mechanism of action. Indicative of a potential ER-ind...

journal_title：Frontiers in pharmacology

authors： Franks LN,Ford BM,Prather PL

更新日期：2016-12-22 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that exerts actions and effectiveness in PD through its conversion to dopamine. In contrast to this generally accepted idea, l-DOPA is proposed to be a ...

journal_title：Frontiers in pharmacology

authors： Goshima Y,Masukawa D,Kasahara Y,Hashimoto T,Aladeokin AC

更新日期：2019-10-03 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its cont...

journal_title：Frontiers in pharmacology

authors： Guo Y,Sun L,Xiao L,Gou R,Fang Y,Liang Y,Wang R,Li N,Liu F,Tang L

更新日期：2017-10-30 00:00:00

abstract：:Cancer stem cells are involved in cancer establishment, progression, and resistance to current treatments. We demonstrated the in vitro and in vivo anti-breast cancer effect of bakuchiol in a previous study. However, the ability of bakuchiol to target breast cancer stem cells (BCSCs) and inhibit breast cancer metastas...

journal_title：Frontiers in pharmacology

authors： Li L,Liu CC,Chen X,Xu S,Hernandez Cortes-Manno S,Cheng SH

更新日期：2017-10-18 00:00:00

abstract：:Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanop...

journal_title：Frontiers in pharmacology

authors： Rezvantalab S,Drude NI,Moraveji MK,Güvener N,Koons EK,Shi Y,Lammers T,Kiessling F

更新日期：2018-11-02 00:00:00

abstract：:Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, histone post-translational modifications, and non-coding RNAs. Emergin...

journal_title：Frontiers in pharmacology

authors： Akone SH,Ntie-Kang F,Stuhldreier F,Ewonkem MB,Noah AM,Mouelle SEM,Müller R

更新日期：2020-08-13 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：:Objectives: This study aimed to elucidate the contribution of candidate single nucleotide polymorphisms (SNPs) related to pharmacokinetics on the recovery of platelet function after single dose of ticagrelor was orally administered to healthy Chinese subjects. Methods: The pharmacokinetic profiles of ticagrelor and it...

journal_title：Frontiers in pharmacology

authors： Zhu Q,Zhong W,Wang X,Mai L,He G,Chen J,Tang L,Liu S,Lai W,Zhong S

更新日期：2019-03-18 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy (CIPN) is a severe, toxic side effect that frequently occurs in anticancer treatment and may result in discontinuation of treatment as well as a serious reduction in life quality. The CIPN incidence rate is as high as 85-90%. Unfortunately, there is currently no standard evid...

journal_title：Frontiers in pharmacology

authors： Meng J,Zhang Q,Yang C,Xiao L,Xue Z,Zhu J

更新日期：2019-04-09 00:00:00

abstract：:The Glp-1 analog, liraglutide (Lir), has been shown to reduce infarct size and improve cardiac function after myocardial ischemia in rodents with or without diabetes. However, the effect of Lir on angiotensin II (AngII) and pressure overload induced cardiac hypertrophy in nondiabetic mice and the underlying mechanisms...

journal_title：Frontiers in pharmacology

authors： Li R,Shan Y,Gao L,Wang X,Wang X,Wang F

更新日期：2019-06-05 00:00:00

abstract：Ethnopharmacological Relevance:Diarrhea is a major medical problem in clinical practice. According to the theory of traditional Chinese medicine (TCM), different types of diarrhea should be treated with different TCM formulations based on the targeted medical condition. Dampness-heat diarrhea (DHD) is a serious diarrhe...

journal_title：Frontiers in pharmacology

authors： Hua YL,Ma Q,Zhang XS,Jia YQ,Peng XT,Yao WL,Ji P,Hu JJ,Wei YM

更新日期：2020-03-03 00:00:00

abstract：:This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell proliferation was assessed...

journal_title：Frontiers in pharmacology

authors： Wang C,Liu E,Li W,Cui J,Li T

更新日期：2018-12-11 00:00:00

abstract：:The clinical benefit of therapies using Mesenchymal Stem Cells (MSCs) is attributable to their pleiotropic effect over cells and tissues, mainly through their secretome. This paracrine effect is mediated by secreted growth factors and extracellular vesicles (EV) including small EV (sEV). sEV are extra-cellular, membra...

journal_title：Frontiers in pharmacology

authors： Zavala G,Ramos MP,Figueroa-Valdés AI,Cisternas P,Wyneken U,Hernández M,Toa P,Salmons B,Dangerfield J,Gunzburg WH,Khoury M

更新日期：2020-05-21 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. ...

journal_title：Frontiers in pharmacology

authors： Michalak A,Mosińska P,Fichna J

更新日期：2016-12-01 00:00:00

abstract：:Fibrosis is a common, persistent and potentially debilitating complication of chemotherapy and radiation regimens used for the treatment of cancer. The molecular mechanisms underlying fibrosis have been well studied and reveal overall processes that are largely ubiquitous. However, it is important to note that althoug...

journal_title：Frontiers in pharmacology

authors： Mancini ML,Sonis ST

更新日期：2014-03-27 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury remains the leading risk factor of disability and mortality worldwide. In this study, the myocardial protective effect of eriodictyol (EDT) and the underlying mechanism in an ex vivo model of global myocardial I/R was investigated. After treatment with different concentrati...

journal_title：Frontiers in pharmacology

authors： Li D,Lu N,Han J,Chen X,Hao W,Xu W,Liu X,Ye L,Zheng Q

更新日期：2018-01-30 00:00:00

abstract：:Zingiber zerumbet (L) Smith is part of the Zingiberaceae family, one of the largest families of the plant kingdom. Z. zerumbet is a perennial, aromatic and tuberose plant that grows in humid locations where its center of distribution is located in the South-East Asia region. This plant has been traditionally used in f...

journal_title：Frontiers in pharmacology

authors： Tan JW,Israf DA,Tham CL

更新日期：2018-06-20 00:00:00

abstract：:Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiologica...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Yu T,Peng L,Sun Q,Wei Y,Han B

更新日期：2020-05-06 00:00:00

abstract：:Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a significant pathophysiological process involved in almost all forms of heart diseases. MicroRNAs (miRNAs) are a group of non-coding RNAs of 20-25 nucleotides in length that primarily regulate gene expression by promoting mRNA degr...

journal_title：Frontiers in pharmacology

authors： Li N,Zhou H,Tang Q

更新日期：2018-08-17 00:00:00

abstract：:Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. In the pres...

journal_title：Frontiers in pharmacology

authors： Li J,Bao G,ALyafeai E,Ding J,Li S,Sheng S,Shen Z,Jia Z,Lin C,Zhang C,Lou Z,Xu H,Gao W,Zhou K

更新日期：2019-09-13 00:00:00

abstract：:This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities. A retrospective study of 42 cases on paraffin-embedded tissue specimens diagnosed with DLBCL was performed using immunohistochemistry (IHC) and fluoresce...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Wang H,Ren C,Yu H,Fang W,Zhang N,Gao S,Hou Q

更新日期：2019-01-07 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization. On the other hand, blockade of mGlu5 receptor results in inhibition of microglia activation. To dissect this controversy, we investigated ...

journal_title：Frontiers in pharmacology

authors： Beneventano M,Spampinato SF,Merlo S,Chisari M,Platania P,Ragusa M,Purrello M,Nicoletti F,Sortino MA

更新日期：2017-11-09 00:00:00

abstract：Background:Pancreatic cancer is one of the most aggressive malignancies. Bufalin, a traditional Chinese medicine, has been used to treat pancreatic cancer as an antitumor agent although the mechanism by which it exerts its effects is still unclear. c-Myc has been found to be overexpressed in more than half of human can...

journal_title：Frontiers in pharmacology

authors： Liu X,Zhou Y,Peng J,Xie B,Shou Q,Wang J

更新日期：2020-04-17 00:00:00

abstract：:Drug scheduling within the international system of drug control and national legislation has been recently criticized as having insufficient footing in scientific evidence. The legal harms related to non-medical uses of certain drugs (e.g., cannabis) have arguably exceeded their physiological and social harmfulness co...

journal_title：Frontiers in pharmacology

authors： Dubljević V

更新日期：2018-08-20 00:00:00

abstract：:Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective endocrine drugs that block the growth of tumors and have no severe side effects is a challenge. Thereupon, synthetic steroids are promising therapeutic drugs for the t...

journal_title：Frontiers in pharmacology

authors： Scherbakov AM,Komkov AV,Komendantova AS,Yastrebova MA,Andreeva OE,Shirinian VZ,Hajra A,Zavarzin IV,Volkova YA

更新日期：2018-01-10 00:00:00

abstract：:As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have neuroprotective effects in patients with Parkinson's disease (PD), particularly by ameliorating mitochondrial dysfunction and regulating expression of the parkin protein. However, the underlying mechanisms by which BYQZ...

journal_title：Frontiers in pharmacology

authors： Ma HJ,Gai C,Chai Y,Feng WD,Cheng CC,Zhang JK,Zhang YX,Yang LP,Guo ZY,Gao YS,Sun HM

更新日期：2020-12-18 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2019.01370.]. ...

journal_title：Frontiers in pharmacology

authors： Wang H,Liu B,Tang Y,Chang P,Yao L,Huang B,Lodato RF,Liu Z

更新日期：2020-02-21 00:00:00