MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway.


:This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell proliferation was assessed by immunohistochemical staining of Ki67 and PCNA, Edu incorporation, and colony formation assay. Western blotting was used to examine expression of FOXO1, mTOR, p-mTOR, CCND1, p21, c-JUN, AKT, pAKT, PI3K, p-PI3K, and p27 proteins. It was found that miR-3188 reduced cell proliferation in NSCLC cells. Molecular analyses indicated that the effect of mammalian target of rapamycin (mTOR) was directly mediated by miR-3188, leading to p-PI3K/p-AKT/c-JUN inactivation. The inhibition of this signaling pathway further caused cell-cycle suppression. Moreover, FOXO1 was found to be involved in regulating the interaction of miR-3188 and mTOR through p-PI3K/p-AKT/c-JUN signaling pathway. Taken together, our study demonstrated that miR-3188 interacts with mTOR and FOXO1 to inhibit NSCLC cell proliferation through a mTOR-p-PI3K/AKT-c-JUN signaling pathway. Therefore, miR-3188 might be a potential target for the treatment of NSCLC.


Front Pharmacol


Wang C,Liu E,Li W,Cui J,Li T




Has Abstract


2018-12-11 00:00:00








  • Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naïve Rats and Rats With Inflammatory Pain.

    abstract::It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. The present study explored the role and mechanisms of CGRP and CGRP recepto...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Hou KS,Wang LL,Wang HB,Fu FH,Yu LC

    更新日期:2020-06-26 00:00:00

  • Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook.

    abstract::Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Singh L,Joshi T,Tewari D,Echeverría J,Mocan A,Sah AN,Parvanov E,Tzvetkov NT,Ma ZF,Lee YY,Poznański P,Huminiecki L,Sacharczuk M,Jóźwik A,Horbańczuk JO,Feder-Kubis J,Atanasov AG

    更新日期:2020-02-14 00:00:00

  • Digoxin and Amiodarone on the Risk of Ischemic Stroke in Atrial Fibrillation: An Observational Study.

    abstract::Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

    更新日期:2018-05-07 00:00:00

  • UVA Induced Oxidative Stress Was Inhibited by Paeoniflorin/Nrf2 Signaling or PLIN2.

    abstract::Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported to be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, has been previously involved in...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lu YS,Jiang Y,Yuan JP,Jiang SB,Yang Y,Zhu PY,Sun YZ,Qi RQ,Liu T,Wang HX,Wu Y,Gao XH,Chen HD

    更新日期:2020-05-15 00:00:00

  • Mifepristone for Treatment of Metabolic Syndrome: Beyond Cushing's Syndrome.

    abstract::A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Díaz-Castro F,Monsalves-Álvarez M,Rojo LE,Del Campo A,Troncoso R

    更新日期:2020-04-24 00:00:00

  • The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators.

    abstract::Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain (CaM-BD) of ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Shim H,Brown BM,Singh L,Singh V,Fettinger JC,Yarov-Yarovoy V,Wulff H

    更新日期:2019-09-20 00:00:00

  • Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis.

    abstract::Introduction: Chronic hepatitis B (HBV) and C (HCV) virus infection is associated with the activation of hepatic stellate cells (HSCs) toward a myofibroblastic phenotype, resulting in excessive deposition of extracellular matrix, the development of liver fibrosis, and its progression toward cirrhosis. The gold standar...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Lambrecht J,Jan Poortmans P,Verhulst S,Reynaert H,Mannaerts I,van Grunsven LA

    更新日期:2017-02-09 00:00:00

  • Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice.

    abstract::Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allody...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Silva RV,Oliveira JT,Santos BLR,Dias FC,Martinez AMB,Lima CKF,Miranda ALP

    更新日期:2017-10-17 00:00:00

  • UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic.

    abstract::Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

    更新日期:2018-06-15 00:00:00

  • Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases.

    abstract::Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for effective drugs an urgent need. Neurodegeneration is triggered by the activation of several cellular processes, including oxidative stress, mitochondrial impairme...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: de Souza JM,Goncalves BDC,Gomez MV,Vieira LB,Ribeiro FM

    更新日期:2018-02-23 00:00:00

  • Analysis of biomarker utility using a PBPK/PD model for carbaryl.

    abstract::There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on the strength of the correlation between biomarker concentrations and exposure/effects. In the current study, a combined exposur...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Phillips MB,Yoon M,Young B,Tan YM

    更新日期:2014-11-18 00:00:00

  • Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases.

    abstract::Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patte...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Wu L,Tai Y,Hu S,Zhang M,Wang R,Zhou W,Tao J,Han Y,Wang Q,Wei W

    更新日期:2018-11-27 00:00:00

  • Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes.

    abstract::The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situa...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Saha P,Talukdar AD,Nath R,Sarker SD,Nahar L,Sahu J,Choudhury MD

    更新日期:2019-05-24 00:00:00

  • Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions.

    abstract::Dermaseptins are a group of α-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Bartels EJH,Dekker D,Amiche M

    更新日期:2019-11-26 00:00:00

  • A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.

    abstract::Danggui Sini Decoction (DSD), a classic Chinese herb medicine (CHM) formula, has been used to treat various diseases in China for centuries. However, it remains challenging to reveal its mechanism of action through conventional pharmacological methods. Here, we first explored the mechanism of action of DSD with the as...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Pan B,Wang Y,Wu C,Jia J,Huang C,Fang S,Liu L

    更新日期:2021-01-11 00:00:00

  • Managing the complexity of communication: regulation of gap junctions by post-translational modification.

    abstract::Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcriptio...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Axelsen LN,Calloe K,Holstein-Rathlou NH,Nielsen MS

    更新日期:2013-10-22 00:00:00

  • Retraction: Baicalin induced dendritic cell apoptosis in vitro.

    abstract::[This retracts the article on p. 15 in vol. 2, PMID: 21687510.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 撤回出版物


    authors: Frontiers in Pharmacology Editorial Office.

    更新日期:2014-12-17 00:00:00

  • Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications.

    abstract::Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical a...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Sadu Singh BK,Narayanan SS,Khor BH,Sahathevan S,Abdul Gafor AH,Fiaccadori E,Sundram K,Karupaiah T

    更新日期:2020-04-29 00:00:00

  • Administrative Data Linkage in Brazil: Potentials for Health Technology Assessment.

    abstract::Health technology assessment (HTA) is the systematic evaluation of the properties and impacts of health technologies and interventions. In this article, we presented a discussion of HTA and its evolution in Brazil, as well as a description of secondary data sources available in Brazil with potential applications to ge...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Ali MS,Ichihara MY,Lopes LC,Barbosa GCG,Pita R,Carreiro RP,Dos Santos DB,Ramos D,Bispo N,Raynal F,Canuto V,de Araujo Almeida B,Fiaccone RL,Barreto ME,Smeeth L,Barreto ML

    更新日期:2019-09-23 00:00:00

  • Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways.

    abstract::Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

    更新日期:2018-02-13 00:00:00

  • A practical approach to communicating benefit-risk decisions of medicines to stakeholders.

    abstract:PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Leong J,Walker S,Salek S

    更新日期:2015-06-11 00:00:00

  • Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation.

    abstract::Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders. Three classes of kappa antagonists have been distinguished: non-selectiv...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Chavkin C,Cohen JH,Land BB

    更新日期:2019-02-06 00:00:00

  • In Vivo Pharmacokinetic/Pharmacodynamic Profiles of Danofloxacin in Rabbits Infected With Salmonella typhimurium After Oral Administration.

    abstract::Salmonella typhimurium is a highly transmissible pathogen in rabbits that causes significant losses. Danofloxacin shows excellent efficacy against S. typhimurium infections. However, there are few reports of the pharmacokinetic/pharmacodynamic (PK/PD) modeling of danofloxacin against this pathogen. The aim of this stu...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Xiao X,Pei L,Jiang LJ,Lan WX,Xiao JY,Jiang YJ,Wang ZQ

    更新日期:2018-04-17 00:00:00

  • The use of lipid-based nanocarriers for targeted pain therapies.

    abstract::Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric car...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Hua S,Wu SY

    更新日期:2013-11-21 00:00:00

  • Particulate Matter 2.5 Induced Developmental Cardiotoxicity in Chicken Embryo and Hatchling.

    abstract::Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

    更新日期:2020-06-05 00:00:00

  • Actinidia chinensis Planch.: A Review of Chemistry and Pharmacology.

    abstract::Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or add...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: He X,Fang J,Chen X,Zhao Z,Li Y,Meng Y,Huang L

    更新日期:2019-10-30 00:00:00

  • Apatinib Combined With SOX Regimen in Conversion Treatment of Advanced Gastric Cancer: A Case Series and Literature Review.

    abstract::Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

    journal_title:Frontiers in pharmacology



    authors: Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

    更新日期:2020-07-14 00:00:00

  • Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines.

    abstract::Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described - OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2), and OAT2 transcript variant 3 (OAT2-tv3). Early studies helping to define the liga...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章


    authors: Hotchkiss AG,Berrigan L,Pelis RM

    更新日期:2015-10-06 00:00:00

  • Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.

    abstract::In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Zhou S,Skaar DJ,Jacobson PA,Huang RS

    更新日期:2018-12-04 00:00:00

  • Endocannabinoids: A Promising Impact for Traumatic Brain Injury.

    abstract::The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous liga...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审


    authors: Schurman LD,Lichtman AH

    更新日期:2017-02-17 00:00:00