PLGA-Based Nanoparticles in Cancer Treatment.

abstract：Objective:Current prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV season. Here we present proof-of-concept data using nebulized palivizu...

journal_title：Frontiers in pharmacology

authors： Rajapaksa AE,Do LAH,Suryawijaya Ong D,Sourial M,Veysey D,Beare R,Hughes W,Yang W,Bischof RJ,McDonnell A,Eu P,Yeo LY,Licciardi PV,Mulholland EK

更新日期：2020-08-19 00:00:00

abstract：:The root of Aconitum kusnezoffii (Caowu in Chinese, CW) is not only commonly used as a traditional Chinese medicine (TCM), but also served as a tonic in China. Due to its high toxicity, clinical poisoning cases induced by CW have frequently been reported. However, the mechanism is still unclear. In this study, Aconitu...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Bian X,Yang J,Wu H,Wu JL,Li N

更新日期：2019-03-22 00:00:00

abstract：:The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables...

journal_title：Frontiers in pharmacology

authors： Sercombe L,Veerati T,Moheimani F,Wu SY,Sood AK,Hua S

更新日期：2015-12-01 00:00:00

abstract：:The present paper continues a more complex research related to the increased synergism in terms of both anti-inflammatory and analgesic effect obtained by the addition of chlorpheniramine (CLF) to the common acetylsalicylic acid (ASA), acetaminophen (PAR), and caffeine (CAF) combination. This synergistic effect was pr...

journal_title：Frontiers in pharmacology

authors： Voicu VA,Mircioiu C,Plesa C,Jinga M,Balaban V,Sandulovici R,Costache AM,Anuta V,Mircioiu I

更新日期：2019-06-20 00:00:00

abstract：:Positive links have been found between periodontitis and numerous diseases in humans via persistent inflammation throughout the body. However, the main factors responsible for maintaining this pro-inflammatory condition are poorly understood. The spleen, the largest secondary immune organ, is a central hub regulating ...

journal_title：Frontiers in pharmacology

authors： Dekita M,Wu Z,Ni J,Zhang X,Liu Y,Yan X,Nakanishi H,Takahashi I

更新日期：2017-07-17 00:00:00

abstract：:Extracellular vesicles (EVs) are currently being considered as promising drug delivery vehicles. EVs are naturally occurring vesicles that exhibit many characteristics favorable to serve as drug delivery vehicles. In addition, EVs have inherent properties for treatment of cancers and other diseases. For research and c...

journal_title：Frontiers in pharmacology

authors： Gangadaran P,Hong CM,Ahn BC

更新日期：2018-02-28 00:00:00

abstract：:Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to occur in AT during ob...

journal_title：Frontiers in pharmacology

authors： Wang L,Chen L,Liu Z,Liu Y,Luo M,Chen N,Deng X,Luo Y,He J,Zhang L,Hill MA,Li R,Wu J

更新日期：2018-09-26 00:00:00

abstract：:Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allodynic activity of two novel sigma receptor antagonists, the S1R-selecti...

journal_title：Frontiers in pharmacology

authors： Cirino TJ,Eans SO,Medina JM,Wilson LL,Mottinelli M,Intagliata S,McCurdy CR,McLaughlin JP

更新日期：2019-06-14 00:00:00

abstract：:Calcium-calmodulin/dependent protein kinase II (CaMKII) plays an essential role in LTP induction, but since it has the capacity to remain persistently activated even after the decay of external stimuli it has been proposed that it can also be necessary for LTP maintenance and therefore for memory persistence. It has b...

journal_title：Frontiers in pharmacology

authors： Juárez-Muñoz Y,Ramos-Languren LE,Escobar ML

更新日期：2017-11-14 00:00:00

abstract：:The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 ...

journal_title：Frontiers in pharmacology

authors： Barlow N,Thompson PE

更新日期：2020-09-25 00:00:00

abstract：:Chronic kidney disease (CKD) is characterized by renal dysfunction, which is a common feature of other major diseases, such as hypertension and diabetes. Unilateral ureteral obstruction (UUO) has been used as a model of CKD in experimental animals and consists of total obstruction of one kidney ureter. The UUO decreas...

journal_title：Frontiers in pharmacology

authors： Figueroa SM,Lozano M,Lobos C,Hennrikus MT,Gonzalez AA,Amador CA

更新日期：2019-11-14 00:00:00

abstract：:Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface. Fibroblast growth factor (FGF) family members play an important role in angiogenesis to induce corneal neovascularization, which significantly a...

journal_title：Frontiers in pharmacology

authors： Chen M,Bao L,Zhao M,Cao J,Zheng H

更新日期：2020-02-25 00:00:00

abstract：Aim:To investigate the variations and the frequencies of the SLCO1B1 gene in the Thai population. Methods:Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the SLCO1B1, using TaqMan® real-time PCR. Results:The minor allele frequenci...

journal_title：Frontiers in pharmacology

authors： Na Nakorn C,Waisayarat J,Dejthevaporn C,Srisawasdi P,Wongwaisayawan S,Sukasem C

更新日期：2020-06-05 00:00:00

abstract：:Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

journal_title：Frontiers in pharmacology

authors： Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

更新日期：2020-07-14 00:00:00

abstract：:Purpose: Asian populations have around 40-60% frequency of reduced function allele CYP2D6∗10 compared to 1-2% in Caucasian populations. The wide range of CYP2D6 enzyme activities in subjects with the CYP2D6∗10 variant is a big concern for clinical practice. The quantitative analysis measuring the impact of CYP2D6 enzy...

journal_title：Frontiers in pharmacology

authors： Chen R,Zheng X,Hu P

更新日期：2017-05-02 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Ther...

journal_title：Frontiers in pharmacology

authors： Lewenhofer V,Schweighofer L,Ledermüller T,Eichsteininger J,Kählig H,Zehl M,Nguyen CH,Krupitza G,Özmen A,Krenn L

更新日期：2018-04-03 00:00:00

abstract：:The ecto-5'-nucleotidase (ecto-5'NT/CD73) represents a crucial enzyme for endogenous adenosine generation. Several findings have shown that CD73 plays an important role in regulating vascular permeability and immune cell function. Adenosine 5'-(α,β-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharm...

journal_title：Frontiers in pharmacology

authors： Caiazzo E,Morello S,Carnuccio R,Ialenti A,Cicala C

更新日期：2019-07-11 00:00:00

abstract：:In studies comparing regular versus on-demand treatment for patients with mild persistent asthma, on-demand treatment seems to have a similar efficacy on clinical and functional outcomes, but it does not suppress chronic airway inflammation or airway hyper-responsiveness (AHR) associated with asthma. Data on the effic...

journal_title：Frontiers in pharmacology

authors： Montuschi P

更新日期：2011-07-14 00:00:00

abstract：:Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guidelines based on these do...

journal_title：Frontiers in pharmacology

authors： Hartman SJF,Swaving JGE,van Beek SW,van Groen BD,de Hoop M,van der Zanden TM,Ter Heine R,de Wildt SN

更新日期：2020-12-16 00:00:00

abstract：:Lipopolysaccharide (LPS) can induce bone loss by stimulating bone resorption. Natural compounds have great potential for the treatment of osteolytic bone diseases. Magnesium lithospermate B (MLB) plays an important role in protecting against oxidative damage and also has potential anti-inflammatory pharmacological pro...

journal_title：Frontiers in pharmacology

authors： Wang J,Wu X,Duan Y

更新日期：2018-02-06 00:00:00

abstract：:Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

journal_title：Frontiers in pharmacology

authors： Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

更新日期：2018-05-07 00:00:00

abstract：:Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. Taking an integrated approach of RNA-seq and network pha...

journal_title：Frontiers in pharmacology

authors： Lyu M,Cui Y,Zhao T,Ning Z,Ren J,Jin X,Fan G,Zhu Y

更新日期：2018-04-06 00:00:00

abstract：:In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtuall...

journal_title：Frontiers in pharmacology

authors： Issa ME,Wijeratne EMK,Gunatilaka AAL,Cuendet M

更新日期：2017-09-08 00:00:00

abstract：:The Kinin B2 receptor (B2R) is classically involved in vasodilation and inflammatory responses. However, through the observation of hypoglycemic effects of Angiotensin-I-Converting Enzyme (ACE) inhibitors, this protein has been related to metabolic glucose modulation in physiological and pathophysiological contexts. A...

journal_title：Frontiers in pharmacology

authors： Gregnani MF,Hungaro TG,Martins-Silva L,Bader M,Araujo RC

更新日期：2020-08-04 00:00:00

abstract：Objective:Patient satisfaction is an indicator for quality of healthcare service and is sometimes linked to patients' willingness to pay. Willingness to pay is an economic method for estimating patient's inclination for a service in monetary terms. This study assessed satisfaction of patients from pharmacist counseling...

journal_title：Frontiers in pharmacology

authors： AlShayban DM,Naqvi AA,Islam MA,Almaskeen M,Almulla A,Alali M,AlQaroos A,Raafat M,Iqbal MS,Haseeb A

更新日期：2020-03-02 00:00:00

abstract：:Background: Sorafenib (Nexavar®) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, the low efficacy and adverse effects at high doses limit the clinical application of sorafenib and strongly recommend its combination with other agents aiming at ameliorating its drawbacks. OSU-2S...

journal_title：Frontiers in pharmacology

authors： Omar HA,Tolba MF,Hung JH,Al-Tel TH

更新日期：2016-11-30 00:00:00

abstract：:It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. The present study explored the role and mechanisms of CGRP and CGRP recepto...

journal_title：Frontiers in pharmacology

authors： Hou KS,Wang LL,Wang HB,Fu FH,Yu LC

更新日期：2020-06-26 00:00:00

abstract：:Type III and IV Bartter syndromes (BS) are rare kidney tubulopathies caused by loss-of-function mutations in the CLCNKB and BSND genes coding respectively for the ClC-Kb chloride channels and accessory subunit barttin. ClC-K channels are expressed in the Henle's loop, distal convoluted tubule, and cortical collecting ...

journal_title：Frontiers in pharmacology

authors： Sahbani D,Strumbo B,Tedeschi S,Conte E,Camerino GM,Benetti E,Montini G,Aceto G,Procino G,Imbrici P,Liantonio A

更新日期：2020-03-17 00:00:00

abstract：:Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against ...

journal_title：Frontiers in pharmacology

authors： Ansari A,Bose S,Patra JK,Shin NR,Lim DW,Kim KW,Wang JH,Kim YM,Chin YW,Kim H

更新日期：2018-06-19 00:00:00