The Ecto-5'-Nucleotidase/CD73 Inhibitor, α,β-Methylene Adenosine 5'-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat.

abstract：:Glucocorticoid (GC) therapy is the leading cause of secondary osteoporosis and the therapeutic and preventative drugs for GC-induced osteoporosis are limited. In this study, we investigated the protective effects of geniposide on dexamethasone (DEX)-induced osteogenic inhibition in MC3T3-E1 cells. The results showed t...

journal_title：Frontiers in pharmacology

authors： Xie B,Wu J,Li Y,Wu X,Zeng Z,Zhou C,Xu D,Wu L

更新日期：2019-04-18 00:00:00

abstract：:We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combina...

journal_title：Frontiers in pharmacology

authors： Tai YH,Tai YJ,Hsu HC,Lee SP,Chen YY,Chiang YC,Chen YL,Chen CA,Cheng WF

更新日期：2017-11-06 00:00:00

abstract：:Fasudil, a Rho-kinase inhibitor, has shown outstanding therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH) in humans. Studies show various biological effects of fasudil in the cardiovascular system. We conducted a preclinical systematic review to determine the efficacy and possible mecha...

journal_title：Frontiers in pharmacology

authors： Huang YY,Wu JM,Su T,Zhang SY,Lin XJ

更新日期：2018-10-01 00:00:00

abstract：Background:Among factors influencing the higher risk of developing unknown or rare adverse drug reactions (ADRs) among children and adolescents, there is the frequent off-label use of drugs that seems to be very common in pediatric oncological patients. Our study aim to collect and evaluate data on the safety profile o...

journal_title：Frontiers in pharmacology

authors： Mascolo A,Scavone C,Bertini M,Brusco S,Punzo F,Pota E,Di Martino M,Di Pinto D,Rossi F

更新日期：2020-05-07 00:00:00

abstract：:Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 axis in proliferatio...

journal_title：Frontiers in pharmacology

authors： Liu G,An L,Zhang H,Du P,Sheng Y

更新日期：2019-03-28 00:00:00

abstract：:Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system. Recently it has been demonstrated that Salvinorin A inhibits acute inflammatory response affecting leukotriene (LT) production. Since LTs are pot...

journal_title：Frontiers in pharmacology

authors： Rossi A,Caiazzo E,Bilancia R,Riemma MA,Pagano E,Cicala C,Ialenti A,Zjawiony JK,Izzo AA,Capasso R,Roviezzo F

更新日期：2017-01-13 00:00:00

abstract：:Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to occur in AT during ob...

journal_title：Frontiers in pharmacology

authors： Wang L,Chen L,Liu Z,Liu Y,Luo M,Chen N,Deng X,Luo Y,He J,Zhang L,Hill MA,Li R,Wu J

更新日期：2018-09-26 00:00:00

abstract：:In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack ...

journal_title：Frontiers in pharmacology

authors： Zhou S,Skaar DJ,Jacobson PA,Huang RS

更新日期：2018-12-04 00:00:00

abstract：:In Mexico, the Adenophyllum aurantium (L.) Strother plant is consumed as an infusion to treat intestinal diseases such as amoebiasis, which is an endemic health problem in Mexico and other countries. However, the effect of A. aurantium on Entamoeba histolytica, the causative agent of amoebiasis, is unknown. An aerial ...

journal_title：Frontiers in pharmacology

authors： Herrera-Martínez M,Hernández-Ramírez VI,Hernández-Carlos B,Chávez-Munguía B,Calderón-Oropeza MA,Talamás-Rohana P

更新日期：2016-06-27 00:00:00

abstract：:Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhi...

journal_title：Frontiers in pharmacology

authors： Li X,Tang S,Wang QQ,Leung EL,Jin H,Huang Y,Liu J,Geng M,Huang M,Yuan S,Yao XJ,Ding J

更新日期：2017-05-30 00:00:00

abstract：:Pharmacogenomics is moving from a candidate gene strategy to large scale approaches. This is in line with the new paradigm of linking a trait to (a) pathway(s) rather than to single genes. In addition, breakthroughs in genomics offer a non-a priori assessment of implicated genes, expanding the possibilities in pharmac...

journal_title：Frontiers in pharmacology

authors： di Iulio J,Rotger M

更新日期：2012-01-13 00:00:00

abstract：:Objectives: The aim of this study was to review the requirements for the reimbursement of biosimilars and to compare the reimbursement status, market share, and reimbursement costs of biosimilars in selected Central and Eastern European (CEE) countries. Methods: A questionnaire-based survey was conducted between Novem...

journal_title：Frontiers in pharmacology

authors： Kawalec P,Stawowczyk E,Tesar T,Skoupa J,Turcu-Stiolica A,Dimitrova M,Petrova GI,Rugaja Z,Männik A,Harsanyi A,Draganic P

更新日期：2017-06-08 00:00:00

abstract：:Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases. Tanshinones are the main active ingredients in S. miltiorrhiza and exhi...

journal_title：Frontiers in pharmacology

authors： Jiang Z,Gao W,Huang L

更新日期：2019-03-14 00:00:00

abstract：:Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

journal_title：Frontiers in pharmacology

authors： Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

更新日期：2018-02-13 00:00:00

abstract：:Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio-informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeu...

journal_title：Frontiers in pharmacology

authors： Balasopoulou A,Patrinos GP,Katsila T

更新日期：2016-10-27 00:00:00

abstract：Background:Dose requirements of vitamin K antagonists are associated with CYP2C9 and VKORC1, but, compared to warfarin, less data is available about phenprocoumon. Furthermore, the effects on dose stability and anticoagulation quality are still unclear. Methods:Aim was to scrutinize phenprocoumon dose requirements, do...

journal_title：Frontiers in pharmacology

authors： Schneider KL,Kunst M,Leuchs AK,Böhme M,Weckbecker K,Kastenmüller K,Bleckwenn M,Holdenrieder S,Coch C,Hartmann G,Stingl JC

更新日期：2020-01-28 00:00:00

abstract：:The pathophysiology of inflammation and oxidative stress generated during different types of cancers and anticancer treatments is well documented. Traditionally, grape pomace is used for animal feed, organic fertilizers, ethanol production or is disposed as waste. Because grape pomace is a rich source of antioxidant c...

journal_title：Frontiers in pharmacology

authors： Balea ŞS,Pârvu AE,Pârvu M,Vlase L,Dehelean CA,Pop TI

更新日期：2020-07-03 00:00:00

abstract：:Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a significant pathophysiological process involved in almost all forms of heart diseases. MicroRNAs (miRNAs) are a group of non-coding RNAs of 20-25 nucleotides in length that primarily regulate gene expression by promoting mRNA degr...

journal_title：Frontiers in pharmacology

authors： Li N,Zhou H,Tang Q

更新日期：2018-08-17 00:00:00

abstract：BACKGROUND:Abiraterone Acetate (AA) is approved for the treatment of mCRPC after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated and for treatment of mCRPC progressed during or after docetaxel-based chemotherapy regimen. The aim of this study is to evaluate the role of early...

journal_title：Frontiers in pharmacology

authors： Facchini G,Caffo O,Ortega C,D'Aniello C,Di Napoli M,Cecere SC,Della Pepa C,Crispo A,Maines F,Ruatta F,Iovane G,Pisconti S,Montella M,Berretta M,Pignata S,Cavaliere C

更新日期：2016-05-18 00:00:00

abstract：:Urothelial cells, myofibroblasts, and smooth muscle cells are important cell types contributing to bladder function. Multiple receptors including muscarinic (M3/M5), tachykinin (NK1/NK2), and purinergic (P2X1/P2Y6) receptors are involved in bladder motor and sensory actions. Using female pig bladder, our aim was to di...

journal_title：Frontiers in pharmacology

authors： Bahadory F,Moore KH,Liu L,Burcher E

更新日期：2013-11-28 00:00:00

abstract：:This article highlights several refractory oral diseases, such as stomatitis, burning mouth syndrome (BMS), glossalgia, atypical facial pain (AFP), oral cancer, dry mouth, and Sjögren's syndrome (SJS), in which use of Japanese herbal medicines, Kampo medicines (KM), on the basis of Kampo theory could exert the maximum...

journal_title：Frontiers in pharmacology

authors： Yamaguchi K

更新日期：2015-08-28 00:00:00

abstract：:The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, amount of histamine r...

journal_title：Frontiers in pharmacology

authors： Kim M,Lee SH,Kim Y,Kwon Y,Park Y,Lee HK,Jung HS,Jeoung D

更新日期：2018-11-06 00:00:00

abstract：:Direct-to-consumer (DTC) DNA testing has grown from contentious beginnings into a global industry, by providing a wide range of personal genomic information directly to its clients. These companies, typified by the well-established 23andMe, generally carry out a gene-chip analysis of single-nucleotide polymorphisms (S...

journal_title：Frontiers in pharmacology

authors： Chua EW,Kennedy MA

更新日期：2012-08-20 00:00:00

abstract：:Background: Biomarkers that predict clinical outcomes in depression are essential for increasing the precision of treatments and clinical outcomes. The electroencephalogram (EEG) is a non-invasive neurophysiological test that has promise as a biomarker sensitive to treatment effects. The aim of our study was to invest...

journal_title：Frontiers in pharmacology

authors： Shalbaf R,Brenner C,Pang C,Blumberger DM,Downar J,Daskalakis ZJ,Tham J,Lam RW,Farzan F,Vila-Rodriguez F

更新日期：2018-10-30 00:00:00

abstract：:The dermis of human skin contains large numbers of fibroblasts that are responsible for the production of the extracellular matrix (ECM) that supporting skin integrity, elasticity and wound healing. Previously, an in vivo study demonstrated that dermal fibroblasts siting in the lower dermis are capable to convert into...

journal_title：Frontiers in pharmacology

authors： Fang CL,Wang Y,Tsai KH,Chang HI

更新日期：2018-03-06 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-α induced cPLA2 expression were not fully defined in human pulmonary alveolar epithelial cells (HPAEpiCs). W...

journal_title：Frontiers in pharmacology

authors： Lin CC,Lin WN,Cho RL,Wang CY,Hsiao LD,Yang CM

更新日期：2016-11-25 00:00:00

abstract：:Human peripheral-blood monocytes are used as an established in vitro system for generating macrophages. For several reasons, monocytic cell lines such as THP-1 have been considered as a possible alternative. In view of their distinct developmental origins and phenotypic attributes, we set out to assess the extent to w...

journal_title：Frontiers in pharmacology

authors： Tedesco S,De Majo F,Kim J,Trenti A,Trevisi L,Fadini GP,Bolego C,Zandstra PW,Cignarella A,Vitiello L

更新日期：2018-02-22 00:00:00

abstract：:Objectives: Indigenous Latin American populations have used extracts from Calophyllum brasiliense, a native hardwood, to treat gastrointestinal symptoms for generations. The hexane extract of Calophyllum brasiliense stem bark (HECb) protects against ethanol-mediated gastric ulceration in Swiss-Webster mice. We investi...

journal_title：Frontiers in pharmacology

authors： Lemos LM,Miyajima F,Castilho GR,Martins DT,Pritchard DM,Burkitt MD

更新日期：2017-02-27 00:00:00

abstract：:Since the clinical use of digitalis as the first pharmacological therapy for atrial fibrillation (AF) 235 years ago in 1785, antiarrhythmic drug therapy has advanced considerably and become a cornerstone of AF clinical management. Yet, a preventive or curative panacea for sustained AF does not exist despite the rise o...

journal_title：Frontiers in pharmacology

authors： Geng M,Lin A,Nguyen TP

更新日期：2020-11-09 00:00:00

abstract：:The increase of non-communicable diseases at all ages has fostered the general concern for sustaining population health worldwide. Unhealthy lifestyles and dietary habits impacting physical and psycho-social health are well known risk factors for developing life threatening diseases. Identifying the determinants of qu...

journal_title：Frontiers in pharmacology

authors： Ruano-Rodríguez C,Serra-Majem L,Dubois D

更新日期：2015-05-08 00:00:00