Propoxyphene Mediates Oxyhemoglobin-Induced Injury in Rat Cortical Neurons Through Up-Regulation of Active-β-Catenin.

Abstract:

:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute craniocerebral trauma. Opioids can activate the canonical Wnt/β-catenin signaling pathway. c-Myc, a downstream protein of Wnt/β-catenin signaling, contributes to the fusion of mitochondria. Here, we investigated the protective roles of Propoxyphene (Pro) against Oxyhemoglobin (OxyHb)-induced primary cultured neuron apoptosis. The data indicated that Pro rescued active-β-catenin from OxyHb-induced decline. Furthermore, Pro attenuated OxyHb-induced apoptosis and fission of mitochondria in primary cortical neurons. However, the protective effects were abrogated under active-β-catenin-deficient conditions. Together, the data presented here showed that Pro, a weak opioid analgesic drug, attenuates OxyHb-induced mitochondria-dependent apoptosis in an active-β-catenin-c-Myc-dependent manner.

journal_name

Front Pharmacol

authors

Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

doi

10.3389/fphar.2019.01616

subject

Has Abstract

pub_date

2020-01-30 00:00:00

pages

1616

issn

1663-9812

journal_volume

10

pub_type

杂志文章
  • Parecoxib Shortens the Duration of Acute Postoperative Pain After Laparoscopic-Assisted Vaginal Hysterectomy.

    abstract::The effect of parecoxib sodium on the duration and severity of acute postoperative pain after laparoscopic-assisted vaginal hysterectomy has been inadequately studied. This randomized, controlled trial compared the effects of parecoxib, methylprednisolone, and placebo on the duration of acute postoperative pain after ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00689

    authors: Yang S,Xiao W,Wang S,Meng L,Zhou L,Wan A,Liu Y,Feng S,Wang T

    更新日期:2019-06-18 00:00:00

  • Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF-Trkb-CREB Pathway.

    abstract::Panax ginseng C.A. Meyer (Araliaceae), a popular tonic and dietetic herbal medicine, has been traditionally prescribed in China and other countries to treat affective disorders. The medicinal parts of ginseng, the roots and flower buds, have become increasingly popular as dietary supplements due to the current holisti...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01034

    authors: Wang G,Lei C,Tian Y,Wang Y,Zhang L,Zhang R

    更新日期:2019-09-13 00:00:00

  • Personalized medicine for pathological circadian dysfunctions.

    abstract::The recent approval of a therapeutic for a circadian disorder has increased interest in developing additional medicines for disorders characterized by circadian disruption. However, previous experience demonstrates that drug development for central nervous system (CNS) disorders has a high failure rate. Personalized m...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2015.00125

    authors: Skelton RL,Kornhauser JM,Tate BA

    更新日期:2015-06-19 00:00:00

  • Human Umbilical Cord Blood Cell Transplantation in Neuroregenerative Strategies.

    abstract::At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC), which are potentially able to ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00628

    authors: Galieva LR,Mukhamedshina YO,Arkhipova SS,Rizvanov AA

    更新日期:2017-09-08 00:00:00

  • The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism.

    abstract::The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes o...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00351

    authors: Li S,Xu Y,Guo W,Chen F,Zhang C,Tan HY,Wang N,Feng Y

    更新日期:2020-03-24 00:00:00

  • Chijabyukpi-Tang Inhibits Pro-Inflammatory Cytokines and Chemokines via the Nrf2/HO-1 Signaling Pathway in TNF-α/IFN-γ-Stimulated HaCaT Cells and Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice.

    abstract::Chijabyukpi-tang (CBT) is an oriental herbal formula consisting of three herbs (Gardeniae Fructus (Gardenia jasminoides J.Ellis.), Phellodendri Cortex (Phellodendron amurense Rupr.), Glycyrrhizae Radix (Glycyrrhiza uralensis Fisch. ex DC.) at the ratio of 2: 2: 1. CBT has traditionally been used to treat eczema with i...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.01018

    authors: Lee JH,Lim JY,Jo EH,Noh HM,Park S,Park MC,Kim DK

    更新日期:2020-07-07 00:00:00

  • Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and Downregulated Nrf2/CBR1 Pathway in Offspring.

    abstract::Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlyi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00097

    authors: Zheng J,Liu X,Zheng B,Zheng Z,Zhang H,Zheng J,Sun C,Chen H,Yang J,Wang Z,Lin M,Chen J,Zhou Q,Zheng Z,Xu X,Ying H

    更新日期:2020-02-28 00:00:00

  • The Ultrasmall Biocompatible CuS@BSA Nanoparticle and Its Photothermal Effects.

    abstract::Nanomaterials with localized surface plasmon resonance (LSPR) have exquisite optical properties, which allow a wide range of applications. Non-stoichiometric copper sulfides with active LSPR have drawn great attention, because its LSPR peak falls in the NIR region that is suitable for deep bioimaging and photothermal ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00141

    authors: Wan X,Liu M,Ma M,Chen D,Wu N,Li L,Li Z,Lin G,Wang X,Xu G

    更新日期:2019-02-26 00:00:00

  • Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases.

    abstract::Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the progression of ADs due to factors including diverse expression patte...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.01313

    authors: Wu L,Tai Y,Hu S,Zhang M,Wang R,Zhou W,Tao J,Han Y,Wang Q,Wei W

    更新日期:2018-11-27 00:00:00

  • From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery.

    abstract::Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic tools, experimental molecules to validate postulated therapeutic t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.01132

    authors: Bordon KCF,Cologna CT,Fornari-Baldo EC,Pinheiro-Júnior EL,Cerni FA,Amorim FG,Anjolette FAP,Cordeiro FA,Wiezel GA,Cardoso IA,Ferreira IG,de Oliveira IS,Boldrini-França J,Pucca MB,Baldo MA,Arantes EC

    更新日期:2020-07-24 00:00:00

  • UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic.

    abstract::Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00633

    authors: Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

    更新日期:2018-06-15 00:00:00

  • Kinsenoside Ameliorates Oxidative Stress-Induced RPE Cell Apoptosis and Inhibits Angiogenesis via Erk/p38/NF-κB/VEGF Signaling.

    abstract::The pathological superoxidative condition that retinal pigment epithelium (RPE) cells experience contributed to the advancement of age-related macular degeneration (AMD), which was accompanied by significant neovascularization. Therefore, the discovery of novel pharmacological candidates to ameliorate oxidative damage...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00240

    authors: Luo X,Gu S,Zhang Y,Zhang J

    更新日期:2018-03-20 00:00:00

  • Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.

    abstract::In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.01436

    authors: Zhou S,Skaar DJ,Jacobson PA,Huang RS

    更新日期:2018-12-04 00:00:00

  • Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux.

    abstract:Aims:SUMOylation is a post-translational modification that plays a crucial role in the cellular stress response. We aimed to demonstrate whether and how the SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Methods and Results:Adenovirus expressing Ubc9 was administrated by multipoint inje...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.561306

    authors: Xiao Q,Chen XH,Jiang RC,Chen SY,Chen KF,Zhu X,Zhang XL,Huang JJ,Qin Y,Zhang GP,Yi Q,Luo JD

    更新日期:2020-09-15 00:00:00

  • Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice.

    abstract::Objectives: Indigenous Latin American populations have used extracts from Calophyllum brasiliense, a native hardwood, to treat gastrointestinal symptoms for generations. The hexane extract of Calophyllum brasiliense stem bark (HECb) protects against ethanol-mediated gastric ulceration in Swiss-Webster mice. We investi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00092

    authors: Lemos LM,Miyajima F,Castilho GR,Martins DT,Pritchard DM,Burkitt MD

    更新日期:2017-02-27 00:00:00

  • A practical approach to communicating benefit-risk decisions of medicines to stakeholders.

    abstract:PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2015.00099

    authors: Leong J,Walker S,Salek S

    更新日期:2015-06-11 00:00:00

  • BGP-15 Protects against Oxaliplatin-Induced Skeletal Myopathy and Mitochondrial Reactive Oxygen Species Production in Mice.

    abstract::Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has a multitude of deleterious side-effects including skeletal muscle wasting and fatigue, which considerably reduces patient quality of life and survivability. As such, a defense against chemotherapy-induced skeletal muscle d...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00137

    authors: Sorensen JC,Petersen AC,Timpani CA,Campelj DG,Cook J,Trewin AJ,Stojanovska V,Stewart M,Hayes A,Rybalka E

    更新日期:2017-04-10 00:00:00

  • Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer.

    abstract::The efficacy of lamotrigine in the treatment of focal epilepsies have already been reported in several case reports and open studies, which is thought to act by inhibiting glutamate release through voltage-sensitive sodium channels blockade and neuronal membrane stabilization. However, recent findings have also illust...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2015.00242

    authors: Prabhavalkar KS,Poovanpallil NB,Bhatt LK

    更新日期:2015-10-23 00:00:00

  • The Bone Extracellular Matrix in Bone Formation and Regeneration.

    abstract::Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, prolifer...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00757

    authors: Lin X,Patil S,Gao YG,Qian A

    更新日期:2020-05-26 00:00:00

  • The Top-100 Highly Cited Original Articles on Drug Therapy for Ventilator-Associated Pneumonia.

    abstract::Background: In recent decades, research on drug therapy for ventilator-associated pneumonia (VAP) remains one of the major hot-spots in the field of critical care medicine, but relevant data are not satisfactory. Our aim was to assess the status and trends of the most cited articles on drug therapy for VAP through bib...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00108

    authors: Wang CY,Li BH,Ma LL,Zhao MJ,Deng T,Jin YH,Ren XQ

    更新日期:2019-02-12 00:00:00

  • Anti-Methicillin-Resistant Staphylococcus aureus Nanoantibiotics.

    abstract::Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among t...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.01121

    authors: Labruère R,Sona AJ,Turos E

    更新日期:2019-10-04 00:00:00

  • PLGA-Based Nanoparticles in Cancer Treatment.

    abstract::Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanop...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.01260

    authors: Rezvantalab S,Drude NI,Moraveji MK,Güvener N,Koons EK,Shi Y,Lammers T,Kiessling F

    更新日期:2018-11-02 00:00:00

  • The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer's Disease Pathophysiology.

    abstract::Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00985

    authors: Belo RF,Martins MLF,Shvachiy L,Costa-Coelho T,de Almeida-Borlido C,Fonseca-Gomes J,Neves V,Vicente Miranda H,Outeiro TF,Coelho JE,Xapelli S,Valente CA,Heras M,Bardaji E,Castanho MARB,Diógenes MJ,Sebastião AM

    更新日期:2020-07-09 00:00:00

  • Elevated Pressure Changes the Purinergic System of Microglial Cells.

    abstract::Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00016

    authors: Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

    更新日期:2018-01-24 00:00:00

  • The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.

    abstract::Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.01195

    authors: Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

    更新日期:2020-08-12 00:00:00

  • Monocytes, Macrophages, and Metabolic Disease in Atherosclerosis.

    abstract::Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease, in which macrophages are responsible for taking up these lipids and driving disease progression. Over the years, we and others have uncovered key pathways that regulate macrophage number/function and identified how metabolic d...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.00666

    authors: Flynn MC,Pernes G,Lee MKS,Nagareddy PR,Murphy AJ

    更新日期:2019-06-13 00:00:00

  • Ontological and Non-Ontological Resources for Associating Medical Dictionary for Regulatory Activities Terms to SNOMED Clinical Terms With Semantic Properties.

    abstract::Background: Formal definitions allow selecting terms (e.g., identifying all terms related to "Infectious disease" using the query "has causative agent organism") and terminological reasoning (e.g., "hepatitis B" is a "hepatitis" and is an "infectious disease"). However, the standard international terminology Medical D...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00975

    authors: Bousquet C,Souvignet J,Sadou É,Jaulent MC,Declerck G

    更新日期:2019-09-10 00:00:00

  • Bu-Yin-Qian-Zheng Formula Ameliorates MPP+-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.

    abstract::As a typical traditional Chinese medicine, Bu-Yin-Qian-Zheng Formula (BYQZF) has been shown to have neuroprotective effects in patients with Parkinson's disease (PD), particularly by ameliorating mitochondrial dysfunction and regulating expression of the parkin protein. However, the underlying mechanisms by which BYQZ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.577017

    authors: Ma HJ,Gai C,Chai Y,Feng WD,Cheng CC,Zhang JK,Zhang YX,Yang LP,Guo ZY,Gao YS,Sun HM

    更新日期:2020-12-18 00:00:00

  • Gender differences in pharmacokinetics and pharmacodynamics of methadone substitution therapy.

    abstract:UNLABELLED:Gender-related differences in the pharmacological effects of drug are an emerging topic. This review examines gender differences in both pharmacokinetic and pharmacodynamic aspects of methadone, a long-acting opioid agonist that is prescribed as a treatment for opioid dependence and the management of chronic...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2015.00122

    authors: Graziani M,Nisticò R

    更新日期:2015-06-09 00:00:00

  • Efficacy and Safety of Multiple Dosages of Fostamatinib in Adult Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

    abstract::Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

    journal_title:Frontiers in pharmacology

    pub_type:

    doi:10.3389/fphar.2019.00897

    authors: Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

    更新日期:2019-08-14 00:00:00