Upregulation of Cortical Renin and Downregulation of Medullary (Pro)Renin Receptor in Unilateral Ureteral Obstruction.

abstract：:Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of altern...

journal_title：Frontiers in pharmacology

authors： Batke M,Gütlein M,Partosch F,Gundert-Remy U,Helma C,Kramer S,Maunz A,Seeland M,Bitsch A

更新日期：2016-09-21 00:00:00

abstract：:Ethanol-induced gastric mucosal injury is a common gastrointestinal disorder. Polysaccharides separated from herbs have been shown to be effective for ethanol-induced gastric mucosal injury, but whether the polysaccharides from Dendrobium officinale Kimura & Migo leaves (LDOP-1) protected mucosa from ethanol-induced i...

journal_title：Frontiers in pharmacology

authors： Ke Y,Zhan L,Lu T,Zhou C,Chen X,Dong Y,Lv G,Chen S

更新日期：2020-11-11 00:00:00

abstract：:Dermaseptins are a group of α-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. ...

journal_title：Frontiers in pharmacology

authors： Bartels EJH,Dekker D,Amiche M

更新日期：2019-11-26 00:00:00

abstract：:Inborn cardiac diseases are among the most frequent congenital anomalies and are the main cause of death in infants within the first year of age in industrialized countries when not adequately treated. They can be divided into simple and complex cardiac malformations. The former ones, for instance atrial and ventricul...

journal_title：Frontiers in pharmacology

authors： Salameh A,Blanke K,Daehnert I

更新日期：2013-06-03 00:00:00

abstract：:In angiotensin II (Ang II)-dependent hypertensive rats there is an increased expression of proximal tubule angiotensinogen (AGT), collecting duct renin and angiotensin converting enzyme (ACE), which contributes to intratubular Ang II formation. Ang II acts on Ang II type 1 receptors promoting sodium retention and vaso...

journal_title：Frontiers in pharmacology

authors： Gonzalez AA,Gallardo M,Cespedes C,Vio CP

更新日期：2019-10-15 00:00:00

abstract：:Asthma is a chronic inflammatory disease characterized by airflow limitation and variable respiratory symptoms. It is characterized by variable symptoms such as cough, wheeze, chest tightness, and shortness of breath which vary in intensity and time. In order to reach a comprehensive approach of disease management, th...

journal_title：Frontiers in pharmacology

authors： Zampogna E,Zappa M,Spanevello A,Visca D

更新日期：2020-05-06 00:00:00

abstract：:Neonatal epileptic encephalopathy (NEE), as a result of pyridoxine 5'-phosphate oxidase (PNPO) deficiency, is a rare neural disorder characterized by intractable seizures and usually leads to early infant death. The clinical phenotypes do not respond to antiepileptic drugs but are alleviated in most cases by giving la...

journal_title：Frontiers in pharmacology

authors： Chen PY,Tu HC,Schirch V,Safo MK,Fu TF

更新日期：2019-09-20 00:00:00

abstract：:Blockchain systems are a fast emerging and a currently widely discussed novel strategy for a decentralized cryptographically enhanced digital ledger recording transactions among stakeholders. This perspective paper looks at its potential uses in the context of high value and mostly low volume botanical material traded...

journal_title：Frontiers in pharmacology

authors： Heinrich M,Scotti F,Booker A,Fitzgerald M,Kum KY,Löbel K

更新日期：2019-04-24 00:00:00

abstract：:The pathophysiology of inflammation and oxidative stress generated during different types of cancers and anticancer treatments is well documented. Traditionally, grape pomace is used for animal feed, organic fertilizers, ethanol production or is disposed as waste. Because grape pomace is a rich source of antioxidant c...

journal_title：Frontiers in pharmacology

authors： Balea ŞS,Pârvu AE,Pârvu M,Vlase L,Dehelean CA,Pop TI

更新日期：2020-07-03 00:00:00

abstract：:Medication with neuroleptics has been associated with adipose tissue dysfunctions and, in particular, with increased visceral fat amount. However, several studies suggested that antipsychotic treatment might not be the main responsible of fat mass accumulation, as this has been also described in not treated psychotic ...

journal_title：Frontiers in pharmacology

authors： Schiavone S,Camerino GM,Mhillaj E,Zotti M,Colaianna M,De Giorgi A,Trotta A,Cantatore FP,Conte E,Bove M,Tucci P,Morgese MG,Trabace L

更新日期：2017-11-08 00:00:00

abstract：:β2-adrenoceptor agonists are commonly used as bronchodilators to treat obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), however, they induce severe side effects. Therefore, developing new bronchodilators is essential. Herbal plants were extracted and the extracts' effect on ai...

journal_title：Frontiers in pharmacology

authors： She YS,Ma LQ,Liu BB,Zhang WJ,Qiu JY,Chen YY,Li MY,Xue L,Luo X,Wang Q,Xu H,Zang DA,Zhao XX,Cao L,Shen J,Peng YB,Zhao P,Yu MF,Chen W,Nie X,Shen C,Chen S,Chen S,Qin G,Dai J,Chen J,Liu QH

更新日期：2018-12-04 00:00:00

abstract：:Background: Patients undergoing percutaneous coronary intervention (PCI) who require anticoagulant therapy are at increased risk of bleeding. The optimal regimen for these patients is uncertain. This study aimed to compare safety and efficacy of antithrombotic regimens used in patients undergoing PCI with concomitant ...

journal_title：Frontiers in pharmacology

authors： Bunmark W,Jinatongthai P,Vathesatogkit P,Thakkinstian A,Reid CM,Wongcharoen W,Chaiyakunapruk N,Nathisuwan S

更新日期：2018-11-19 00:00:00

abstract：:Arsenic is a toxic environmental contaminant. Long-term exposure to arsenic through drinking water induces human cancers. However, it is as yet uncertain about the mechanisms of arsenic induced carcinogenesis. Although the effects of low-dose arsenicals on proliferation and cell cycle have been revealed by short time ...

journal_title：Frontiers in pharmacology

authors： Chen Y,Liu X,Wang H,Liu S,Hu N,Li X

更新日期：2019-10-11 00:00:00

abstract：:Neonatal hypoxic/ischemic encephalopathy (NHIE) is a severe condition that leads to death or neurological disability in newborns. The underlying pathological mechanisms are unclear, and developing the target neuroprotective strategies are urgent. 2,7,2'-trihydroxy-4,4'7'-trimethoxy-1,1'-biphenanthrene (TTB) is a natur...

journal_title：Frontiers in pharmacology

authors： Liu L,Zhao Z,Yin Q,Zhang X

更新日期：2019-07-16 00:00:00

abstract：:[This corrects the article on p. 402 in vol. 7, PMID: 27877128.]. ...

journal_title：Frontiers in pharmacology

authors： Zhang C,Sun PP,Guo HT,Liu Y,Li J,He XJ,Lu AP

更新日期：2017-02-15 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A...

journal_title：Frontiers in pharmacology

authors： Chen YA,Shih HW,Lin YC,Hsu HY,Wu TF,Tsai CH,Wu CL,Wu HY,Hsieh JT,Tang CH,Lai CH

更新日期：2018-06-13 00:00:00

abstract：:For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising n...

journal_title：Frontiers in pharmacology

authors： Wang J,Li S,Han Y,Guan J,Chung S,Wang C,Li D

更新日期：2018-03-08 00:00:00

abstract：Background:Acetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia. They are widely used not only in Alzheimer's disease, but also in other forms of dementia. Efficacy of treatment might depend on serum concentration ...

journal_title：Frontiers in pharmacology

authors： Ortner M,Stange M,Schneider H,Schroeder C,Buerger K,Müller C,Dorn B,Goldhardt O,Diehl-Schmid J,Förstl H,Steimer W,Grimmer T

更新日期：2020-05-21 00:00:00

abstract：:Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlat...

journal_title：Frontiers in pharmacology

authors： Yu W,Cheng JD

更新日期：2020-11-16 00:00:00

abstract：:Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical a...

journal_title：Frontiers in pharmacology

authors： Sadu Singh BK,Narayanan SS,Khor BH,Sahathevan S,Abdul Gafor AH,Fiaccadori E,Sundram K,Karupaiah T

更新日期：2020-04-29 00:00:00

abstract：:Lung cancer is one of main causes of cancer mortality and 83% of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Patients with NSCLC usually have a poor prognosis and one of the leading causes is drug resistance. With the progress of drug therapy, the emergence and development of drug resistanc...

journal_title：Frontiers in pharmacology

authors： Sun R,Wang R,Chang S,Li K,Sun R,Wang M,Li Z

更新日期：2019-12-18 00:00:00

abstract：:Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer because of their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tiss...

journal_title：Frontiers in pharmacology

authors： Yu T,Li Y,Gu X,Li Q

更新日期：2020-08-28 00:00:00

abstract：:Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

journal_title：Frontiers in pharmacology

authors： McVicker BL,Bennett RG

更新日期：2017-05-31 00:00:00

abstract：:The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two protein families: the AT...

journal_title：Frontiers in pharmacology

authors： César-Razquin A,Girardi E,Yang M,Brehme M,Saez-Rodriguez J,Superti-Furga G

更新日期：2018-09-07 00:00:00

abstract：:Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases. Tanshinones are the main active ingredients in S. miltiorrhiza and exhi...

journal_title：Frontiers in pharmacology

authors： Jiang Z,Gao W,Huang L

更新日期：2019-03-14 00:00:00

abstract：:Cardiovascular disease (CVD) is a leading cause of mortality and morbidity among patients with diabetes. Endothelial dysfunction is an early physiological event in CVD. Metformin, a common oral antihyperglycemic agent, has been demonstrated to directly affect endothelial cell function. Brain-derived neurotrophic facto...

journal_title：Frontiers in pharmacology

authors： Han X,Wang B,Sun Y,Huang J,Wang X,Ma W,Zhu Y,Xu R,Jin H,Liu N

更新日期：2018-11-06 00:00:00

abstract：:The use of nanomaterials to modulate the tumor microenvironment has great potential to advance outcomes in patients with lung cancer. Nanomaterials can be used to prolong the delivery time of therapeutics enabling their specific targeting to tumors while minimizing and potentially eliminating cytotoxic effects. Using ...

journal_title：Frontiers in pharmacology

authors： Seshadri DR,Ramamurthi A

更新日期：2018-07-16 00:00:00

abstract：:Fertility issues are common amongst women with rheumatoid arthritis (RA). Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα), known key players in RA pathogenesis, have been associated with reproductive disorders. This study investigates the role of these cytokines in decreased fertility in women with active ...

journal_title：Frontiers in pharmacology

authors： Bongenaar M,Smeele HTW,Lubberts E,Dolhain RJEM

更新日期：2020-12-10 00:00:00

abstract：:Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cyto...

journal_title：Frontiers in pharmacology

authors： Zhang X,Liu Y,Lu L,Huang S,Ding Y,Zhang Y,Guo Q,Li Z,Zhao L

更新日期：2017-08-11 00:00:00

abstract：:Enterovirus 71 (EV71) was implicated in a widespread outbreak of hand-foot-and-mouth disease (HFMD) across the Asia Pacific area since 1997 and has also been reported sporadically in patients with brain stem encephalitis. Neurogenic shock with pulmonary edema (PE) is a fatal complication of EV71 infection. Among inotr...

journal_title：Frontiers in pharmacology

authors： Wang SM

更新日期：2016-03-29 00:00:00