IRAP Inhibitors: M1-Aminopeptidase Family Inspiration.

Abstract:

:The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 aminopeptidase family, IRAP shares numerous structural features with the other M1 aminopeptidases. The study of those enzymes and the development of inhibitors provide key learnings and new approaches and are potential sources of inspiration for future IRAP inhibitors.

journal_name

Front Pharmacol

authors

Barlow N,Thompson PE

doi

10.3389/fphar.2020.585930

subject

Has Abstract

pub_date

2020-09-25 00:00:00

pages

585930

issn

1663-9812

journal_volume

11

pub_type

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