Tnfrsf12a-Mediated Atherosclerosis Signaling and Inflammatory Response as a Common Protection Mechanism of Shuxuening Injection Against Both Myocardial and Cerebral Ischemia-Reperfusion Injuries.

abstract：:PIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis-trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depen...

journal_title：Frontiers in pharmacology

authors： El Boustani M,De Stefano L,Caligiuri I,Mouawad N,Granchi C,Canzonieri V,Tuccinardi T,Giordano A,Rizzolio F

更新日期：2019-01-22 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：:Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pan...

journal_title：Frontiers in pharmacology

authors： Kamatham S,Shahjehan F,Kasi PM

更新日期：2020-02-10 00:00:00

abstract：:Impetigo is the most common childhood skin infection in the world. There are two patterns of impetigo: nonbullous (or impetigo contagiosa) and bullous. The nonbullous type is due to Staphylococcus aureus and group A beta-haemolytic Streptococcus and occurs in 70% of impetigo cases. Impetigo is often a self-limited dis...

journal_title：Frontiers in pharmacology

authors： Davino G,D'Alvano T,Esposito S

更新日期：2020-11-18 00:00:00

abstract：:Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported to be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, has been previously involved in...

journal_title：Frontiers in pharmacology

authors： Lu YS,Jiang Y,Yuan JP,Jiang SB,Yang Y,Zhu PY,Sun YZ,Qi RQ,Liu T,Wang HX,Wu Y,Gao XH,Chen HD

更新日期：2020-05-15 00:00:00

abstract：:Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 increased the activity ...

journal_title：Frontiers in pharmacology

authors： Jiang X,Li Y,Wang W,Han X,Han J,Chen M,Zhang J,Wang C,Li S,Luo J,Wang X,Xu Y,Xu Y,Cheng J,Si S

更新日期：2020-11-16 00:00:00

abstract：:This paper reported a feasibility study strategy of identifying pharmacokinetic (PK) markers for a cardiovascular herbal medicine, Guanxin Danshen drop pill (GDDP). First, quantification analysis revealed the constituent composition in the preparation by high-performance liquid chromatography (HPLC). Subsequently, phy...

journal_title：Frontiers in pharmacology

authors： Yao H,Huang X,Xie Y,Huang X,Ruan Y,Lin X,Huang L,Shi P

更新日期：2018-12-21 00:00:00

abstract：:Digoxin is widely used to treat heart failure. Epidemiological studies suggested it might be used as an anticancer drug or sensitizing agent for cancer therapy. Adriamycin is a well-known anticancer drug, but often causes cardiotoxicity which limits its use. We recently investigated the anticancer effects of digoxin a...

journal_title：Frontiers in pharmacology

authors： Wang Y,Ma Q,Zhang S,Liu H,Zhao B,Du B,Wang W,Lin P,Zhang Z,Zhong Y,Kong D

更新日期：2020-02-28 00:00:00

abstract：:Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD in vivo would also...

journal_title：Frontiers in pharmacology

authors： Wheal AJ,Jadoon K,Randall MD,O'Sullivan SE

更新日期：2017-05-18 00:00:00

abstract：:Aims and Hypothesis: This study aims to investigate the mechanism involved in intracellular regulation of EGFR degradation induced by EGF. Methods: Phosphorylation of proteins related to EGFR signaling was examined by western blot analysis. Activation, connection between Rab35 and folliculin (FLCN) were assessed by pu...

journal_title：Frontiers in pharmacology

authors： Zheng J,Duan B,Sun S,Cui J,Du J,Zhang Y

更新日期：2017-09-26 00:00:00

abstract：:Reports in the last decade have suggested that the role of platelets in atherosclerosis and its thrombotic complications may be mediated, in part, by local secretion of platelet-derived microvesicles (pMVs), small cell blebs released during the platelet activation process. MVs are the most abundant cell-derived microv...

journal_title：Frontiers in pharmacology

authors： Badimon L,Suades R,Fuentes E,Palomo I,Padró T

更新日期：2016-08-31 00:00:00

abstract：:Fibrosis is a common, persistent and potentially debilitating complication of chemotherapy and radiation regimens used for the treatment of cancer. The molecular mechanisms underlying fibrosis have been well studied and reveal overall processes that are largely ubiquitous. However, it is important to note that althoug...

journal_title：Frontiers in pharmacology

authors： Mancini ML,Sonis ST

更新日期：2014-03-27 00:00:00

abstract：:Introduction: T helper 17 (Th17) has been implicated in a variety of inflammatory lung and immune system diseases. However, little is known about the expression and biological role of IL-17 in acute lung injury (ALI). We investigated the mechanisms involved in the effect of anti-IL17 in a model of lipopolysaccharide (...

journal_title：Frontiers in pharmacology

authors： Righetti RF,Dos Santos TM,Camargo LDN,Aristóteles LRCRB,Fukuzaki S,de Souza FCR,Santana FPR,de Agrela MVR,Cruz MM,Alonso-Vale MIC,Genaro IS,Saraiva-Romanholo BM,Leick EA,Martins MA,Prado CM,Tibério IFLC

更新日期：2018-10-04 00:00:00

abstract：:Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

journal_title：Frontiers in pharmacology

authors： Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

更新日期：2020-08-21 00:00:00

abstract：:Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis and exert subsequent atheroprotective effects. Our previous study also demonstrated the role of autophagy in the inhibitio...

journal_title：Frontiers in pharmacology

authors： Peng S,Xu LW,Che XY,Xiao QQ,Pu J,Shao Q,He B

更新日期：2018-05-03 00:00:00

abstract：:The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3-300.0 mg/kg (p.o.) was performed in mice using a hot-plate test. Anti-inflammatory activity was assessed on carrageenan-induced paw e...

journal_title：Frontiers in pharmacology

authors： Bednarczyk-Cwynar B,Wachowiak N,Szulc M,Kamińska E,Bogacz A,Bartkowiak-Wieczorek J,Zaprutko L,Mikolajczak PL

更新日期：2016-07-12 00:00:00

abstract：:Background: Currently, although non-steroidal anti-inflammatory drugs (NSAIDs) were recommended for acute renal colic in the 2018 European Association of Urology guidelines, there are no specific NSAIDs and no specific routes of administration in this guideline. The clinical practice of advocating intravenous opioids ...

journal_title：Frontiers in pharmacology

authors： Gu HY,Luo J,Wu JY,Yao QS,Niu YM,Zhang C

更新日期：2019-02-22 00:00:00

abstract：Background and Purpose:Predictors of response to type-1 hepatorenal syndrome (HRS) therapy are urgently needed. This study's purpose is to evaluate the proposed predictors in these patients. Methods:Forty-two type-1 HRS patients with cirrhosis were treated with albumin and terlipressin. Clinical, biochemical, and demo...

journal_title：Frontiers in pharmacology

authors： Abdel-Razik A,Mousa N,Abdelsalam M,Abdelwahab A,Tawfik M,Tawfik AM,Hasan AS,Elhelaly R,El-Wakeel N,Eldars W

更新日期：2020-01-31 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:Background and Purpose: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduced ventricular contractility, and reduction in ejection fraction and, if severe, can lead to death. To date, there is no specific therapy that exists, and i...

journal_title：Frontiers in pharmacology

authors： Tan S,Long Z,Hou X,Lin Y,Xu J,You X,Wang T,Zhang Y

更新日期：2019-08-05 00:00:00

abstract：:In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have lon...

journal_title：Frontiers in pharmacology

authors： Agúndez JA,Del Barrio J,Padró T,Stephens C,Farré M,Andrade RJ,Badimon L,García-Martín E,Vilahur G,Lucena MI

更新日期：2012-01-19 00:00:00

abstract：:Protein allosteric modulation is a pillar of metabolic regulatory mechanisms; this concept has been extended to include ion channel regulation. P2XRs are ligand-gated channels activated by extracellular ATP, sensitive to trace metals and other chemicals. By combining in silico calculations with electrophysiological re...

journal_title：Frontiers in pharmacology

authors： Latapiat V,Rodríguez FE,Godoy F,Montenegro FA,Barrera NP,Huidobro-Toro JP

更新日期：2017-12-15 00:00:00

abstract：:MYC target 1 (MYCT1), a direct target gene of c-Myc, is a novel candidate tumor suppressor gene first cloned from laryngeal squamous cell carcinoma. The downregulation of MYCT1 has been reported to be associated with carcinogenesis. However, the role of MYCT1 in the development and progress of acute myeloid leukemia (...

journal_title：Frontiers in pharmacology

authors： Fu S,Fu Y,Chen F,Hu Y,Quan B,Zhang J

更新日期：2018-09-18 00:00:00

abstract：:Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regardin...

journal_title：Frontiers in pharmacology

authors： van Schaik RHN,Müller DJ,Serretti A,Ingelman-Sundberg M

更新日期：2020-09-11 00:00:00

abstract：:Anatomical Therapeutic Chemical (ATC) classification system proposed by the World Health Organization is a widely accepted drug classification scheme in both academic and industrial realm. It is a multilabeling system which categorizes drugs into multiple classes according to their therapeutic, pharmacological, and ch...

journal_title：Frontiers in pharmacology

authors： Wang X,Wang Y,Xu Z,Xiong Y,Wei DQ

更新日期：2019-09-05 00:00:00

abstract：:Chronic kidney disease (CKD) is characterized by renal dysfunction, which is a common feature of other major diseases, such as hypertension and diabetes. Unilateral ureteral obstruction (UUO) has been used as a model of CKD in experimental animals and consists of total obstruction of one kidney ureter. The UUO decreas...

journal_title：Frontiers in pharmacology

authors： Figueroa SM,Lozano M,Lobos C,Hennrikus MT,Gonzalez AA,Amador CA

更新日期：2019-11-14 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the major leading cause of disease with high-mortality worldwide. Cigarette smoke (CS) is a major factor for COPD. CS causes chronic inflammation and oxidative stress, which contributes to lung dysfunction in COPD. Isoliquiritigenin (ILG), a natural flavonoid derived fro...

journal_title：Frontiers in pharmacology

authors： Yu D,Liu X,Zhang G,Ming Z,Wang T

更新日期：2018-09-20 00:00:00

abstract：:The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two protein families: the AT...

journal_title：Frontiers in pharmacology

authors： César-Razquin A,Girardi E,Yang M,Brehme M,Saez-Rodriguez J,Superti-Furga G

更新日期：2018-09-07 00:00:00

abstract：Aim:To investigate the variations and the frequencies of the SLCO1B1 gene in the Thai population. Methods:Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the SLCO1B1, using TaqMan® real-time PCR. Results:The minor allele frequenci...

journal_title：Frontiers in pharmacology

authors： Na Nakorn C,Waisayarat J,Dejthevaporn C,Srisawasdi P,Wongwaisayawan S,Sukasem C

更新日期：2020-06-05 00:00:00

abstract：:Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

journal_title：Frontiers in pharmacology

authors： Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

更新日期：2016-10-13 00:00:00