Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of SLCO1B1 in the Thai Population.

abstract：:Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of...

journal_title：Frontiers in pharmacology

authors： Peres FF,Levin R,Suiama MA,Diana MC,Gouvêa DA,Almeida V,Santos CM,Lungato L,Zuardi AW,Hallak JE,Crippa JA,Vânia D,Silva RH,Abílio VC

更新日期：2016-09-28 00:00:00

abstract：:Several studies have pointed to soluble oligomers of beta amyloid peptide (SOAβ) as the principal neurotoxic agents responsible for the generation of synaptotoxic events that can explain the main symptoms of Alzheimer's disease (AD). Among the toxic features associated with SOAβ, one of the most notorious is the forma...

journal_title：Frontiers in pharmacology

authors： Godoy PA,Ramírez-Molina O,Fuentealba J

更新日期：2019-11-07 00:00:00

abstract：:Saponins are natural compounds and possess the most promising anti-cancer function. Here, a saponin gleditsia saponin C (GSC), extracted from gleditsiae fructus abnormalis, could induce apoptosis of lung tumor cell line A549 via caspase dependent cascade and this effect could be prevented by the caspase inhibitors. In...

journal_title：Frontiers in pharmacology

authors： Cheng Y,He W,He Y

更新日期：2018-01-15 00:00:00

abstract：:Anti-inflammatory properties of cacao, fruits of Theobroma cacao L. (Sterculiaceae), are well documented, and therapeutic applications are described for gastrointestinal, nervous, and cardiovascular abnormalities. Most, if not all of these disease conditions involve inflammation or immune activation processes. The pro...

journal_title：Frontiers in pharmacology

authors： Becker K,Geisler S,Ueberall F,Fuchs D,Gostner JM

更新日期：2013-12-12 00:00:00

abstract：:Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, the...

journal_title：Frontiers in pharmacology

authors： Guo P,Cai C,Wu X,Fan X,Huang W,Zhou J,Wu Q,Huang Y,Zhao W,Zhang F,Wang Q,Zhang Y,Fang J

更新日期：2019-08-06 00:00:00

abstract：:Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allody...

journal_title：Frontiers in pharmacology

authors： Silva RV,Oliveira JT,Santos BLR,Dias FC,Martinez AMB,Lima CKF,Miranda ALP

更新日期：2017-10-17 00:00:00

abstract：:Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system - Ayurveda - it is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therape...

journal_title：Frontiers in pharmacology

authors： Balkrishna A,Thakur P,Varshney A

更新日期：2020-03-03 00:00:00

abstract：:Background: Genetic variability in some of the genes that affect absorption, distribution, metabolism, and elimination ("pharmacogenes") can significantly influence an individual's response to the drug and consequently the effectiveness of treatment and possible adverse drug events. The rapid development of sequencing...

journal_title：Frontiers in pharmacology

authors： Hočevar K,Maver A,Peterlin B

更新日期：2019-03-14 00:00:00

abstract：:Agrocybe aegerita has long been utilized for promoting diuresis in traditional Chinese medicine (TCM) with a close correlation to hypouricemia. Ethanol (AAE) and water (AAW) extracts of the compound led to a remarkable decrease in serum uric acid levels (SUA) in hyperuricemia mice, approaching that of the normal contr...

journal_title：Frontiers in pharmacology

authors： Yong T,Chen S,Xie Y,Shuai O,Li X,Chen D,Su J,Jiao C,Liang Y

更新日期：2018-05-15 00:00:00

abstract：:Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the pre...

journal_title：Frontiers in pharmacology

authors： de Freitas RCC,Bortolin RH,Lopes MB,Tamborlin L,Meneguello L,Silbiger VN,Hirata RDC,Hirata MH,Luchessi AD,Luchessi AD

更新日期：2017-12-12 00:00:00

abstract：:15-F2t-Isoprostane, a reliable biomarker of oxidative stress, has been found elevated in exhaled breath condensate (EBC), a non-invasive technique for sampling of airway secretions, in patients with cystic fibrosis (CF). Azithromycin has antioxidant properties in experimental models of CF, but its effects on oxidative...

journal_title：Frontiers in pharmacology

authors： Montuschi P,Lucidi V,Paris D,Montemitro E,Shohreh R,Mores N,Melck D,Santini G,Majo F,Motta A

更新日期：2018-06-18 00:00:00

abstract：:Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. Most of these patients with non-small cell lung cancer (NSCLC) present with the advanced stage of the disease at the time of diagnosis, and thus decrease the 5-year survival rate to about 5%. Immune checkpoint inhib...

journal_title：Frontiers in pharmacology

authors： Huang Z,Su W,Lu T,Wang Y,Dong Y,Qin Y,Liu D,Sun L,Jiao W

更新日期：2020-10-07 00:00:00

abstract：:Impaired homeostasis of the carboxylic acids oxalate and citrate, dramatically increases the risk for the formation of Ca2+-oxalate kidney stones, which is the most common form of kidney stones in humans. Renal homeostasis of oxalate and citrate is controlled by complex mechanisms including epithelial transport protei...

journal_title：Frontiers in pharmacology

authors： Shimshilashvili L,Aharon S,Moe OW,Ohana E

更新日期：2020-04-07 00:00:00

abstract：:Biopeptides derived from marine species have garnered significant research interest owing to their anti-inflammatory, antibacterial, and anticancer activities. In our previous study, Hydrostatin-SN1, a bioactive peptide extracted from the Hydrophis cyanocinctus venom gland T7 phage display library, demonstrated anti-i...

journal_title：Frontiers in pharmacology

authors： Zhang C,Guo S,Wang J,Li A,Sun K,Qiu L,Li J,Wang S,Ma X,Lu Y

更新日期：2020-06-19 00:00:00

abstract：:Despite an improved understanding of the genetic background and the pathomechanisms of amyotrophic lateral sclerosis (ALS) no novel disease-modifying therapies have been successfully implemented in clinical routine. Riluzole still remains the only clinically approved substance in human ALS treatment with limited effic...

journal_title：Frontiers in pharmacology

authors： Günther R,Balck A,Koch JC,Nientiedt T,Sereda M,Bähr M,Lingor P,Tönges L

更新日期：2017-01-31 00:00:00

abstract：Background:Brazilian patients have legal right to access unlicensed medicines undergoing clinical research, if there is evidence of efficacy and safety. This study investigated the occurrence of serious adverse events related to very high-cost medicines from clinical studies, expanded access and compassionate use progr...

journal_title：Frontiers in pharmacology

authors： da Silva RE,Lima EDC,Novaes MRCG,Osorio-de-Castro CGS

更新日期：2020-05-19 00:00:00

abstract：:Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis and exert subsequent atheroprotective effects. Our previous study also demonstrated the role of autophagy in the inhibitio...

journal_title：Frontiers in pharmacology

authors： Peng S,Xu LW,Che XY,Xiao QQ,Pu J,Shao Q,He B

更新日期：2018-05-03 00:00:00

abstract：:Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability ...

journal_title：Frontiers in pharmacology

authors： Filatova E,Kasian A,Kolomin T,Rybalkina E,Alieva A,Andreeva L,Limborska S,Myasoedov N,Pavlova G,Slominsky P,Shadrina M

更新日期：2017-02-28 00:00:00

abstract：:The serotonin [5-hydroxytryptamine (5-HT)] system has been implicated in the pathogenesis of major depressive disorder (MDD). Among the 5-HT receptor subtypes, 5-HT2 is one of the major pharmacological therapeutic targets for MDD. There have been inconsistent findings in previous pharmacogenetic studies investigating ...

journal_title：Frontiers in pharmacology

authors： Kao CF,Kuo PH,Yu YW,Yang AC,Lin E,Liu YL,Tsai SJ

更新日期：2020-12-03 00:00:00

abstract：:Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca(2) (+)-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser(16) by PKA or Thr(17) by Ca(2) (+)-calmodulin-dependent protei...

journal_title：Frontiers in pharmacology

authors： Mattiazzi A,Kranias EG

更新日期：2014-01-27 00:00:00

abstract：:The ecto-5'-nucleotidase (ecto-5'NT/CD73) represents a crucial enzyme for endogenous adenosine generation. Several findings have shown that CD73 plays an important role in regulating vascular permeability and immune cell function. Adenosine 5'-(α,β-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharm...

journal_title：Frontiers in pharmacology

authors： Caiazzo E,Morello S,Carnuccio R,Ialenti A,Cicala C

更新日期：2019-07-11 00:00:00

abstract：:Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cyto...

journal_title：Frontiers in pharmacology

authors： Zhang X,Liu Y,Lu L,Huang S,Ding Y,Zhang Y,Guo Q,Li Z,Zhao L

更新日期：2017-08-11 00:00:00

abstract：:A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight ...

journal_title：Frontiers in pharmacology

authors： Díaz-Castro F,Monsalves-Álvarez M,Rojo LE,Del Campo A,Troncoso R

更新日期：2020-04-24 00:00:00

abstract：:Background: Patients undergoing percutaneous coronary intervention (PCI) who require anticoagulant therapy are at increased risk of bleeding. The optimal regimen for these patients is uncertain. This study aimed to compare safety and efficacy of antithrombotic regimens used in patients undergoing PCI with concomitant ...

journal_title：Frontiers in pharmacology

authors： Bunmark W,Jinatongthai P,Vathesatogkit P,Thakkinstian A,Reid CM,Wongcharoen W,Chaiyakunapruk N,Nathisuwan S

更新日期：2018-11-19 00:00:00

abstract：:This study aimed to determine the population pharmacokinetic (Pop PK) parameters of cefazolin administered prophylactically at 25 mg/kg intravenously (IV) 30 min before surgery in a canine population of 78 dogs and assess whether covariates, such as sex, age, body weight (BW), breed, health status, creatinine level, a...

journal_title：Frontiers in pharmacology

authors： Cagnardi P,Di Cesare F,Toutain PL,Bousquet-Mélou A,Ravasio G,Villa R

更新日期：2018-10-09 00:00:00

abstract：:Crataegus oxyacantha is an important herbal supplement and famous for its antioxidant potential. The antioxidant in combination with anticholinesterase activity can be considered as an important target in the management of Alzheimer's disease. The compounds isolated from C. oxyacantha were evaluated for cholinesterase...

journal_title：Frontiers in pharmacology

authors： Ali M,Muhammad S,Shah MR,Khan A,Rashid U,Farooq U,Ullah F,Sadiq A,Ayaz M,Ali M,Ahmad M,Latif A

更新日期：2017-06-07 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:Mainstay chemotherapy for malaria is often faced with the problem of instability and poor bio-distribution thus resulting in impaired pharmacokinetics. Nanomedicine has been acclaimed for its success in drug delivery and improved efficacy. The aim of the study was to assess the antiplasmodial efficacy and safety of cu...

journal_title：Frontiers in pharmacology

authors： Oyeyemi O,Morenkeji O,Afolayan F,Dauda K,Busari Z,Meena J,Panda A

更新日期：2018-05-30 00:00:00

abstract：:Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environment...

journal_title：Frontiers in pharmacology

authors： Sundar IK,Rahman I

更新日期：2011-08-30 00:00:00

abstract：:Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signali...

journal_title：Frontiers in pharmacology

authors： Sun X,Chen WD,Wang YD

更新日期：2017-08-23 00:00:00