Exploring the Role of P2X Receptors in Alzheimer's Disease.

abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs. The absence of this channel results in an imbalance of ion concentrations across the cell membrane and results in more a...

journal_title：Frontiers in pharmacology

authors： Bardin P,Sonneville F,Corvol H,Tabary O

更新日期：2018-10-08 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00

abstract：:Striatal cholinergic interneurons (CINs) are the main source of acetylcholine in the striatum and are believed to play an important role in basal ganglia physiology and pathophysiology. The role of CINs in striatal function is known mostly from extracellular recordings of tonically active striatal neurons in monkeys, ...

journal_title：Frontiers in pharmacology

authors： Mallet N,Leblois A,Maurice N,Beurrier C

更新日期：2019-12-13 00:00:00

abstract：:Various isoforms of myocyte enhancer factor 2 (MEF2) have been shown to play a role in the activation of rat hepatic stellate cells (HSCs) in culture. The signals that regulate MEF2 in HSCs are unknown. In addition, whether MEF2s regulate the activation of human HSCs (H-HSCs) is unclear. Here, we studied the expressio...

journal_title：Frontiers in pharmacology

authors： Zhang W,Ping J,Zhou Y,Chen G,Xu L

更新日期：2019-04-11 00:00:00

abstract：:Red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM) induce endothelial dysfunction and impair cardiac function following ischemia via increase in RBC arginase and oxidative stress. Here, we aimed to elucidate whether the effect of RBC-mediated cardiac impairment following ischemia and endothelial...

journal_title：Frontiers in pharmacology

authors： Mahdi A,Jiao T,Yang J,Kövamees O,Alvarsson M,von Heijne M,Zhou Z,Pernow J

更新日期：2019-08-02 00:00:00

abstract：:Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. Scutellarin is a active flavone extracted from Erigeron breviscapus Hand-Mazz t...

journal_title：Frontiers in pharmacology

authors： Sun CY,Zhu Y,Li XF,Wang XQ,Tang LP,Su ZQ,Li CY,Zheng GJ,Feng B

更新日期：2018-02-13 00:00:00

abstract：:The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistan...

journal_title：Frontiers in pharmacology

authors： Lima R,Del Fiol FS,Balcão VM

更新日期：2019-06-21 00:00:00

abstract：:Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management inc...

journal_title：Frontiers in pharmacology

authors： Jelin AC,O'Hare E,Blakemore K,Jelin EB,Valle D,Hoover-Fong J

更新日期：2017-03-06 00:00:00

abstract：PURPOSE:Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery. METHODS:A rat model of renal I/R injury was indu...

journal_title：Frontiers in pharmacology

authors： Li J,Hong Z,Liu H,Zhou J,Cui L,Yuan S,Chu X,Yu P

更新日期：2016-04-22 00:00:00

abstract：:Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed to investigate the hepatoprotective effects of costunolide again...

journal_title：Frontiers in pharmacology

authors： Mao J,Yi M,Wang R,Huang Y,Chen M

更新日期：2018-12-20 00:00:00

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with a high incidence, mortality and disability rate. Danhong injection (DHI) is beneficial for ischemic stroke, but is prohibited for ICH due to risk of bleeding. The present study aims to explore the potential therapeutic time window and molecular me...

journal_title：Frontiers in pharmacology

authors： Wang S,Yu L,Sun G,Liu Y,Hu W,Liu Y,Peng T,Wang X,Cheng J,Sr A,Qin B,Lu H

更新日期：2020-03-25 00:00:00

abstract：:The Health Improvement Network UK primary care database was used to identify a cohort of 38 077 individuals aged 50-84 years with a first prescription of low-dose acetylsalicylic acid (ASA; 75-300 mg/day) for secondary prevention of cardiovascular or cerebrovascular events during 2000-2007. From this cohort, 169 incid...

journal_title：Frontiers in pharmacology

authors： Cea Soriano L,Rodríguez LA

更新日期：2010-10-14 00:00:00

abstract：:Synthetic cannabinoid receptor agonists (SCRAs) are the largest class of new psychoactive substances (NPS). New examples are detected constantly, and some are associated with a series of adverse effects, including seizures. CUMYL-4CN-BINACA (1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide) is structural...

journal_title：Frontiers in pharmacology

authors： Kevin RC,Anderson L,McGregor IS,Boyd R,Manning JJ,Glass M,Connor M,Banister SD

更新日期：2019-05-29 00:00:00

abstract：:Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO(®), a...

journal_title：Frontiers in pharmacology

authors： Tan T,Watts SW,Davis RP

更新日期：2011-07-29 00:00:00

abstract：:Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG acts to induce neuri...

journal_title：Frontiers in pharmacology

authors： Kubota K,Fukue H,Sato H,Hashimoto K,Fujikane A,Moriyama H,Watanabe T,Katsurabayashi S,Kainuma M,Iwasaki K

更新日期：2017-11-21 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2018.00361.]. ...

journal_title：Frontiers in pharmacology

authors： Liu Q,Lei Z,Wu Q,Huang D,Xie S,Wang X,Pan Y,Yuan Z

更新日期：2018-11-29 00:00:00

abstract：:Background: Sorafenib (Nexavar®) is an FDA-approved systemic therapy for advanced hepatocellular carcinoma (HCC). However, the low efficacy and adverse effects at high doses limit the clinical application of sorafenib and strongly recommend its combination with other agents aiming at ameliorating its drawbacks. OSU-2S...

journal_title：Frontiers in pharmacology

authors： Omar HA,Tolba MF,Hung JH,Al-Tel TH

更新日期：2016-11-30 00:00:00

abstract：:SARS-CoV-2 is a positive sense RNA coronavirus that constitutes a new threat for the global community and economy. While vaccines against SARS-CoV-2 are being developed, the mechanisms through which this virus takes control of an infected cell to replicate remains poorly understood. Upon infection, viruses completely ...

journal_title：Frontiers in pharmacology

authors： Gatti P,Ilamathi HS,Todkar K,Germain M

更新日期：2020-08-28 00:00:00

abstract：:Local people in the Sudhnoti district of Pakistan share a rich practice of traditional medicine for the treatment of a variety of ailments. We selected nine plants from the Sudhnoti ethnopharmacological tradition used for the treatment of infectious and inflammatory disease. Our aim was to evaluate the in vitro anti-i...

journal_title：Frontiers in pharmacology

authors： Khan MF,Tang H,Lyles JT,Pineau R,Mashwani ZU,Quave CL

更新日期：2018-08-02 00:00:00

abstract：:Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive. Recent studies have suggested novel roles of the habenula in the onset of depres...

journal_title：Frontiers in pharmacology

authors： Zhao YW,Pan YQ,Tang MM,Lin WJ

更新日期：2018-05-15 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface. Fibroblast growth factor (FGF) family members play an important role in angiogenesis to induce corneal neovascularization, which significantly a...

journal_title：Frontiers in pharmacology

authors： Chen M,Bao L,Zhao M,Cao J,Zheng H

更新日期：2020-02-25 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified to regulate a variety of signaling molecules, among which may be a...

journal_title：Frontiers in pharmacology

authors： Palikhe S,Ohashi W,Sakamoto T,Hattori K,Kawakami M,Andoh T,Yamazaki H,Hattori Y

更新日期：2019-02-04 00:00:00

abstract：:Inborn cardiac diseases are among the most frequent congenital anomalies and are the main cause of death in infants within the first year of age in industrialized countries when not adequately treated. They can be divided into simple and complex cardiac malformations. The former ones, for instance atrial and ventricul...

journal_title：Frontiers in pharmacology

authors： Salameh A,Blanke K,Daehnert I

更新日期：2013-06-03 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:The inhibitors for EGF receptor tyrosine kinase (EGFR-TKIs) such as gefitinib have been used as a standard treatment for non-small cell lung cancer (NSCLC), but the increasingly occurrence of drug resistance, the associated adverse effects and the enrichment of cancer stem cells significantly impedes its clinical appl...

journal_title：Frontiers in pharmacology

authors： Cheng H,Ge X,Zhuo S,Gao Y,Zhu B,Zhang J,Shang W,Xu D,Ge W,Shi L

更新日期：2018-11-30 00:00:00

abstract：:The root of Aconitum kusnezoffii (Caowu in Chinese, CW) is not only commonly used as a traditional Chinese medicine (TCM), but also served as a tonic in China. Due to its high toxicity, clinical poisoning cases induced by CW have frequently been reported. However, the mechanism is still unclear. In this study, Aconitu...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Bian X,Yang J,Wu H,Wu JL,Li N

更新日期：2019-03-22 00:00:00

abstract：:[This corrects the article on p. 402 in vol. 7, PMID: 27877128.]. ...

journal_title：Frontiers in pharmacology

authors： Zhang C,Sun PP,Guo HT,Liu Y,Li J,He XJ,Lu AP

更新日期：2017-02-15 00:00:00