Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation.

abstract：:The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effe...

journal_title：Frontiers in pharmacology

authors： Sakhnevych SS,Yasinska IM,Fasler-Kan E,Sumbayev VV

更新日期：2019-04-05 00:00:00

abstract：:Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h) enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a cyclooxygenase (COX)-mediated mechanism. The aim of the present study was to determine whether treatment with CBD in vivo would also...

journal_title：Frontiers in pharmacology

authors： Wheal AJ,Jadoon K,Randall MD,O'Sullivan SE

更新日期：2017-05-18 00:00:00

abstract：:Oxidative insult, inflammation, apoptosis and autophagy play a pivotal role in the etiology of diabetic nephropathy, a global health concern. Ferulic acid, a phytochemical, is reported to protect against varied diseased conditions. However, the ameliorative role and mechanisms of ferulic acid in averting STZ-mediated ...

journal_title：Frontiers in pharmacology

authors： Chowdhury S,Ghosh S,Das AK,Sil PC

更新日期：2019-02-05 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：Aims:SUMOylation is a post-translational modification that plays a crucial role in the cellular stress response. We aimed to demonstrate whether and how the SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Methods and Results:Adenovirus expressing Ubc9 was administrated by multipoint inje...

journal_title：Frontiers in pharmacology

authors： Xiao Q,Chen XH,Jiang RC,Chen SY,Chen KF,Zhu X,Zhang XL,Huang JJ,Qin Y,Zhang GP,Yi Q,Luo JD

更新日期：2020-09-15 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its cont...

journal_title：Frontiers in pharmacology

authors： Guo Y,Sun L,Xiao L,Gou R,Fang Y,Liang Y,Wang R,Li N,Liu F,Tang L

更新日期：2017-10-30 00:00:00

abstract：:Autophagy is an evolutionary conserved physiological process with a fundamental role during development, differentiation, and survival of eukaryotic cells. On the other hand, autophagy dysregulation is observed in many pathological conditions, including cancer. In particular, tumor growth and progression are accompani...

journal_title：Frontiers in pharmacology

authors： Sharma P,Dando I,Strippoli R,Kumar S,Somoza A,Cordani M,Tafani M

更新日期：2020-07-24 00:00:00

abstract：:The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. However, the specific mechanism of N. chinensis is not yet clear. Nardochinoid C (DC) is a new compound with new skeleton isolated from N. chinensis and this study for the first time explored the anti-inflammat...

journal_title：Frontiers in pharmacology

authors： Luo JF,Shen XY,Lio CK,Dai Y,Cheng CS,Liu JX,Yao YD,Yu Y,Xie Y,Luo P,Yao XS,Liu ZQ,Zhou H

更新日期：2018-09-04 00:00:00

abstract：:Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca(2) (+)-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser(16) by PKA or Thr(17) by Ca(2) (+)-calmodulin-dependent protei...

journal_title：Frontiers in pharmacology

authors： Mattiazzi A,Kranias EG

更新日期：2014-01-27 00:00:00

abstract：:Arsenic is a toxic environmental contaminant. Long-term exposure to arsenic through drinking water induces human cancers. However, it is as yet uncertain about the mechanisms of arsenic induced carcinogenesis. Although the effects of low-dose arsenicals on proliferation and cell cycle have been revealed by short time ...

journal_title：Frontiers in pharmacology

authors： Chen Y,Liu X,Wang H,Liu S,Hu N,Li X

更新日期：2019-10-11 00:00:00

abstract：:Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern heal...

journal_title：Frontiers in pharmacology

authors： Marshall ML,Wagstaff KM

更新日期：2020-07-24 00:00:00

abstract：:In the heterogeneous hub represented by the lateral hypothalamus, neurons containing the orexin/hypocretin peptides play a key role in vigilance state transitions and wakefulness stability, energy homeostasis, and other functions relevant for motivated behaviors. Orexin neurons, which project widely to the neuraxis, a...

journal_title：Frontiers in pharmacology

authors： Azeez IA,Del Gallo F,Cristino L,Bentivoglio M

更新日期：2018-09-25 00:00:00

abstract：:[This corrects the article on p. 216 in vol. 5, PMID: 25295006.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Production Office.

更新日期：2014-11-19 00:00:00

abstract：:Glucocorticoids (GCs) are the most commonly used drugs for treatment of autoimmune and inflammatory diseases. Their efficacy is due to their ability to bind cytoplasmic receptors (glucocorticoid receptors, GR) and other cytoplasmic proteins, thus regulating gene expression. Although GCs are potent life-saving drugs, t...

journal_title：Frontiers in pharmacology

authors： Bereshchenko O,Migliorati G,Bruscoli S,Riccardi C

更新日期：2019-03-27 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:Li-Ru-Kang (LRK), a formula of eight traditional Chinese medicines (TCM), has been used to treat hyperplasia of mammary gland (HMG) in TCM clinics. However, how LRK works in HMG patients is unclear. To explore the possible mechanisms of LRK against HMG, the network pharmacology was used to screen the potential targets...

journal_title：Frontiers in pharmacology

authors： Wang Y,Wei S,Gao T,Yang Y,Lu X,Zhou X,Li H,Wang T,Qian L,Zhao Y,Zou W

更新日期：2018-11-20 00:00:00

abstract：:BY VIRTUE OF BEING THE PRODUCT OF THE GENETIC ADMIXTURE OF THREE ANCESTRAL ROOTS: Europeans, Africans, and Amerindians, the present-day Brazilian population displays very high levels of genomic diversity, which have important pharmacogenetic/-genomic (PGx) implications. Recognition of this fact has prompted the creati...

journal_title：Frontiers in pharmacology

authors： Suarez-Kurtz G,Pena SD,Struchiner CJ,Hutz MH

更新日期：2012-11-06 00:00:00

abstract：:A large and growing body of literature has focused on the association between "white coat hypertension" (WCH) and the underlying target organ damage. The evidence suggests that WCH is may not an entirely benign phenomenon. However, whether patients with WCH should receive antihypertensive drugs is unresolved. Therefor...

journal_title：Frontiers in pharmacology

authors： Xiang H,Xue Y,Wang J,Weng Y,Rong F,Peng Y,Ji K

更新日期：2020-09-17 00:00:00

abstract：:Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

journal_title：Frontiers in pharmacology

authors： Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

更新日期：2016-10-13 00:00:00

abstract：:Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the late part of cholester...

journal_title：Frontiers in pharmacology

authors： Režen T,Ogris I,Sever M,Merzel F,Golic Grdadolnik S,Rozman D

更新日期：2017-06-30 00:00:00

abstract：:Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising of pneumonitis and fibrosis, poses challenge in its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from the toxic effects ...

journal_title：Frontiers in pharmacology

authors： Arora A,Bhuria V,Hazari PP,Pathak U,Mathur S,Roy BG,Sandhir R,Soni R,Dwarakanath BS,Bhatt AN

更新日期：2018-04-24 00:00:00

abstract：:The synthesis, antimicrobial activity evaluations, biomolecule-binding properties (DNA), and absorption and emission properties of a new series of (Z)-1,1,1-trichloro-4-alkyl(aryl)amino-4-arylbut-3-en-2-ones (4, 5) and 2,2-difluoro-3-alkyl(aryl)amino-4-aryl-6-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uides (6, 7...

journal_title：Frontiers in pharmacology

authors： Rosa WC,Rocha IO,Rodrigues MB,Coelho HS,Denardi LB,Ledur PC,Zanatta N,Acunha TV,Iglesias BA,Bonacorso HG

更新日期：2020-09-02 00:00:00

abstract：:Several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants for retinaldehyde is...

journal_title：Frontiers in pharmacology

authors： Ruiz FX,Porté S,Parés X,Farrés J

更新日期：2012-04-17 00:00:00

abstract：:Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied for...

journal_title：Frontiers in pharmacology

authors： Chang JB,Lane ME,Yang M,Heinrich M

更新日期：2018-10-05 00:00:00

abstract：:More than a century has passed since the first surgical mesh for hernia repair was developed, and, to date, this is still the most widely used method despite the great number of complications it poses. The purpose of this study was to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in ...

journal_title：Frontiers in pharmacology

authors： Marinaro F,Casado JG,Blázquez R,Brun MV,Marcos R,Santos M,Duque FJ,López E,Álvarez V,Usón A,Sánchez-Margallo FM

更新日期：2020-09-25 00:00:00

abstract：:A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic exposure to cortisol is associated with risk factors related to metabolic syndrome like weight ...

journal_title：Frontiers in pharmacology

authors： Díaz-Castro F,Monsalves-Álvarez M,Rojo LE,Del Campo A,Troncoso R

更新日期：2020-04-24 00:00:00

abstract：:G protein-coupled receptor kinase 2 (GRK2) is a ubiquitous member of the GRK family that restrains cellular activation by G protein-coupled receptor (GPCR) phosphorylation leading to receptor desensitization and internalization, but has been identified to regulate a variety of signaling molecules, among which may be a...

journal_title：Frontiers in pharmacology

authors： Palikhe S,Ohashi W,Sakamoto T,Hattori K,Kawakami M,Andoh T,Yamazaki H,Hattori Y

更新日期：2019-02-04 00:00:00

abstract：:Background: Metronomic chemotherapy (MC) is defined as the frequent administration of chemotherapy at doses below the maximal tolerated dose and with no prolonged drug-free break. MC has shown its efficacy in adult tumor types such as breast and ovarian cancer and has to some extent been studied in pediatrics. Objecti...

journal_title：Frontiers in pharmacology

authors： Verschuur A,Heng-Maillard MA,Dory-Lautrec P,Truillet R,Jouve E,Chastagner P,Leblond P,Aerts I,Honoré S,Entz-Werle N,Sirvent N,Gentet JC,Corradini N,André N

更新日期：2018-09-27 00:00:00

abstract：:B lymphocytes play a critical role in humoral immunity. Abnormal B cell development and function cause a variety of hematological malignancies such as myeloma, B cell lymphoma, and leukemia. Histone deacetylase 6 (HDAC6) inhibitors alone or in combination with other drugs have shown efficacy in several hematological m...

journal_title：Frontiers in pharmacology

authors： Yang J,Li D,Zhou J

更新日期：2020-06-26 00:00:00