Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

abstract：Background:Depression and dementia are common incapacitating diseases in old age. The exact nature of the relationship between these conditions remains unclear, and multiple explanations have been suggested: depressive symptoms may be a risk factor for, a prodromal symptom of, or a coincidental finding in dementia. The...

journal_title：Frontiers in pharmacology

authors： Wiels W,Baeken C,Engelborghs S

更新日期：2020-02-07 00:00:00

abstract：:In metastatic renal cell carcinoma, complete response to first-line antiangiogenic agents is rare and resistance to therapy often develops. Protocols for sequential treatment with angiogenesis and mTOR inhibitors are under evaluation to improve outcomes. In this observational, real-world study, patients received a fir...

journal_title：Frontiers in pharmacology

authors： Rossetti S,D'Aniello C,Iovane G,Scagliarini S,Laterza MM,De Vita F,Savastano C,Cartenì G,Porricelli MA,Berretta M,Pisconti S,Facchini G,Cavaliere C

更新日期：2017-07-20 00:00:00

abstract：Background:Pancreatic cancer is one of the most aggressive malignancies. Bufalin, a traditional Chinese medicine, has been used to treat pancreatic cancer as an antitumor agent although the mechanism by which it exerts its effects is still unclear. c-Myc has been found to be overexpressed in more than half of human can...

journal_title：Frontiers in pharmacology

authors： Liu X,Zhou Y,Peng J,Xie B,Shou Q,Wang J

更新日期：2020-04-17 00:00:00

abstract：UNLABELLED:Gender-related differences in the pharmacological effects of drug are an emerging topic. This review examines gender differences in both pharmacokinetic and pharmacodynamic aspects of methadone, a long-acting opioid agonist that is prescribed as a treatment for opioid dependence and the management of chronic...

journal_title：Frontiers in pharmacology

authors： Graziani M,Nisticò R

更新日期：2015-06-09 00:00:00

abstract：BACKGROUND:Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) bo...

journal_title：Frontiers in pharmacology

authors： de Bruijn W,Ibáñez C,Frisk P,Bak Pedersen H,Alkan A,Vella Bonanno P,Brkičić LS,Bucsics A,Dedet G,Eriksen J,Fadare JO,Fürst J,Gallego G,Godói IP,Guerra Júnior AA,Gürsöz H,Jan S,Jones J,Joppi R,Kerman S,Laius O,Ma

更新日期：2016-07-22 00:00:00

abstract：PURPOSE:The importance of a framework for a systematic structured assessment of the benefits and risks has been established, but in addition, it is necessary that the benefit-risk decisions and the processes to derive those decisions are documented and communicated to various stakeholders for accountability. Hence ther...

journal_title：Frontiers in pharmacology

authors： Leong J,Walker S,Salek S

更新日期：2015-06-11 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nu...

journal_title：Frontiers in pharmacology

authors： Mangieri RA,Maier EY,Buske TR,Lasek AW,Morrisett RA

更新日期：2017-08-15 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:Phosphorylation waves drive the propagation of signals generated in response to hormones and growth factors in target cells. cAMP is an ancient second messenger implicated in key biological functions. In mammals, most of the effects elicited by cAMP are mediated by protein kinase A (PKA). Activation of the kinase by c...

journal_title：Frontiers in pharmacology

authors： Rinaldi L,Sepe M,Donne RD,Feliciello A

更新日期：2015-09-04 00:00:00

abstract：:Wenxin Keli (WXKL) is a widely used Chinese botanical drug for the treatment of arrhythmia, which is consisted of four herbs and amber. In the present study, we analyzed the chemical composition of WXKL using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) to tentatively identify 71 comp...

journal_title：Frontiers in pharmacology

authors： Liu H,Chen X,Zhao X,Zhao B,Qian K,Shi Y,Baruscotti M,Wang Y

更新日期：2018-11-13 00:00:00

abstract：:Pancreatic cancer decreases survival time and quality of life because of drug resistance and peripheral neuropathy during conventional treatment. This study was undertaken to investigate whether αvβ3 integrin receptor antagonist compounds NDAT and XT199 can suppress the development of cisplatin resistance and cisplati...

journal_title：Frontiers in pharmacology

authors： Debreli Coskun M,Sudha T,Bharali DJ,Celikler S,Davis PJ,Mousa SA

更新日期：2020-02-27 00:00:00

abstract：Introduction:Practical adherence barriers (e.g., medication frequency) are generally more amenable to intervention than perceptual barriers (e.g., beliefs). Measures which assess adherence barriers exist, however these tend to measure a mix of factors. There is a need to identify what practical barriers are captured by...

journal_title：Frontiers in pharmacology

authors： Chan AHY,Cooper V,Lycett H,Horne R

更新日期：2020-05-13 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. ...

journal_title：Frontiers in pharmacology

authors： Michalak A,Mosińska P,Fichna J

更新日期：2016-12-01 00:00:00

abstract：:The recent approval of a therapeutic for a circadian disorder has increased interest in developing additional medicines for disorders characterized by circadian disruption. However, previous experience demonstrates that drug development for central nervous system (CNS) disorders has a high failure rate. Personalized m...

journal_title：Frontiers in pharmacology

authors： Skelton RL,Kornhauser JM,Tate BA

更新日期：2015-06-19 00:00:00

abstract：:The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substanti...

journal_title：Frontiers in pharmacology

authors： Hon KW,Abu N,Ab Mutalib NS,Jamal R

更新日期：2017-08-28 00:00:00

abstract：:Pregnant women appear to be more susceptible to infectious diseases than women in reproductive age. According to the California Department of Public Health pregnant women were 9.6-folds more likely to be hospitalized during the 2009 influenza outbreak when compared to non-pregnant women in reproductive age. In contras...

journal_title：Frontiers in pharmacology

authors： Acosta-Elias J,Espinosa-Tanguma R

更新日期：2020-07-16 00:00:00

abstract：:Disruptions in iron homeostasis are linked to a broad spectrum of chronic conditions including cardiovascular, malignant, metabolic, and neurodegenerative disease. Evidence supporting this contention derives from a variety of analytical approaches, ranging from molecular to population-based studies. This review focuse...

journal_title：Frontiers in pharmacology

authors： Basuli D,Stevens RG,Torti FM,Torti SV

更新日期：2014-05-20 00:00:00

abstract：:Orientin is a flavonoid extracted from Chinese traditional herb, Polygonum orientale L. Previous study has reported that orientin protected myocardial from ischemia reperfusion injury. However, whether orientin could protect against cardiac remodeling after myocardial injury remains unclear. The aim of our study is to...

journal_title：Frontiers in pharmacology

authors： Li F,Zong J,Zhang H,Zhang P,Xu L,Liang K,Yang L,Yong H,Qian W

更新日期：2017-12-21 00:00:00

abstract：:Endocrine fibroblast growth factor (FGF) 19 has been shown to be capable of maintaining bile acid (BA) homeostasis and thus hold promise to be a potential therapeutic agent for cholestasis liver disease. However, whether paracrine FGFs possess this BA regulatory activity remains to be determined. In our study, we iden...

journal_title：Frontiers in pharmacology

authors： Lin H,Zhou C,Hou Y,Li Q,Qiao G,Wang Y,Huang Z,Niu J

更新日期：2019-12-20 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy (CIPN) is a severe, toxic side effect that frequently occurs in anticancer treatment and may result in discontinuation of treatment as well as a serious reduction in life quality. The CIPN incidence rate is as high as 85-90%. Unfortunately, there is currently no standard evid...

journal_title：Frontiers in pharmacology

authors： Meng J,Zhang Q,Yang C,Xiao L,Xue Z,Zhu J

更新日期：2019-04-09 00:00:00

abstract：:Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are importan...

journal_title：Frontiers in pharmacology

authors： Fu L,Han B,Zhou Y,Ren J,Cao W,Patel G,Kai G,Zhang J

更新日期：2020-03-19 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) that target cytotoxic T lymphocyte antigen 4, programmed cell death-1, and PD-ligand 1 have revolutionized cancer treatment, achieving unprecedented efficacy in multiple malignancies. ICIs are increasingly being used in early cancer settings and in combination with various other typ...

journal_title：Frontiers in pharmacology

authors： Zhou YW,Zhu YJ,Wang MN,Xie Y,Chen CY,Zhang T,Xia F,Ding ZY,Liu JY

更新日期：2019-11-29 00:00:00

abstract：:The foundations of innate immunity in neurodegenerative disorders were first laid by Del Rio Hortega (1919). He identified and named microglia, recognizing them as cells of mesodermal origin. Van Furth in 1969 elaborated the monocyte phagocytic system with microglia as the brain representatives. Validation of these co...

journal_title：Frontiers in pharmacology

authors： McGeer PL,McGeer EG

更新日期：2011-12-02 00:00:00

abstract：:Arsenic is a toxic environmental contaminant. Long-term exposure to arsenic through drinking water induces human cancers. However, it is as yet uncertain about the mechanisms of arsenic induced carcinogenesis. Although the effects of low-dose arsenicals on proliferation and cell cycle have been revealed by short time ...

journal_title：Frontiers in pharmacology

authors： Chen Y,Liu X,Wang H,Liu S,Hu N,Li X

更新日期：2019-10-11 00:00:00

abstract：:Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio-informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeu...

journal_title：Frontiers in pharmacology

authors： Balasopoulou A,Patrinos GP,Katsila T

更新日期：2016-10-27 00:00:00

abstract：:One of the most difficult challenges in clinical hepatology is the diagnosis of a drug-induced liver injury (DILI). The timing of the events, exclusion of alternative causes, and taking into account the clinical context should be systematically assessed and scored in a transparent manner. RUCAM (Roussel Uclaf Causalit...

journal_title：Frontiers in pharmacology

authors： Teschke R

更新日期：2019-07-23 00:00:00

abstract：:Objective: This research aimed to validate the therapeutic effect of losmapimod and explore the underlying mechanism in its treatment of epilepsy. Methods: A rat model of epilepsy was constructed with an injection of pilocarpine. Microarray analysis was performed to screen aberrantly expressed mRNAs and activated sign...

journal_title：Frontiers in pharmacology

authors： Li M,Cui L,Feng X,Wang C,Zhang Y,Wang L,Ding Y,Zhao T

更新日期：2019-06-07 00:00:00

abstract：:Trichloroethylene (TCE) is a common volatile organic solvent which is considered as an ubiquitous environmental pollutant. It is claimed to be a developmental neurotoxicant. Our group evaluated previously its impact on three-dimensional neurospheres in vitro. The current work aims to investigate the neurotoxic effects...

journal_title：Frontiers in pharmacology

authors： Salama MM,El-Naggar DA,Abdel-Rahman RH,Elhak SAG

更新日期：2018-07-10 00:00:00

abstract：:P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene. In this study, the transcription start site of the pig Abcb1 gene was identified by 5'-RACE. A 1.9-kb fra...

journal_title：Frontiers in pharmacology

authors： Guo T,Huang J,Huan C,He F,Zhang Y,Bhutto ZA,Wang L

更新日期：2018-05-04 00:00:00

abstract：:Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags. Here, we have used a non-imaging plate reader (PHERAstar FS) to monitor the bin...

journal_title：Frontiers in pharmacology

authors： Arruda MA,Stoddart LA,Gherbi K,Briddon SJ,Kellam B,Hill SJ

更新日期：2017-12-13 00:00:00