The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients.

abstract：Background:Depression and dementia are common incapacitating diseases in old age. The exact nature of the relationship between these conditions remains unclear, and multiple explanations have been suggested: depressive symptoms may be a risk factor for, a prodromal symptom of, or a coincidental finding in dementia. The...

journal_title：Frontiers in pharmacology

authors： Wiels W,Baeken C,Engelborghs S

更新日期：2020-02-07 00:00:00

abstract：:[This retracts the article DOI: 10.3389/fphar.2018.00987.]. ...

journal_title：Frontiers in pharmacology

authors： Frontiers Editorial Office.

更新日期：2019-02-07 00:00:00

abstract：:Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface. Fibroblast growth factor (FGF) family members play an important role in angiogenesis to induce corneal neovascularization, which significantly a...

journal_title：Frontiers in pharmacology

authors： Chen M,Bao L,Zhao M,Cao J,Zheng H

更新日期：2020-02-25 00:00:00

abstract：Objective:Drawing a growth curve of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) provides a foundation for susceptibility testing. By observing in vitro antibacterial activity and ultrastructure cthanges on MDR-PA of the effective components in the drug-containing serum of rats after the administration of Fuzhen...

journal_title：Frontiers in pharmacology

authors： Xu H,Liu C,Li M,Wang C,Liu G,Wang H,Ma J,Li L,Chen M,Cheng M,Yao X,Lin Y,Zhao S,Wang Y,Wang M

更新日期：2020-02-12 00:00:00

abstract：:Marantodes pumilum (Primulaceae) has been used in Malaysian folk medicine to help women regain strength after delivery and for "sickness in the bones." It was previously revealed that its extracts inhibited xanthine oxidase (XO) activity in vitro. The leaves and roots of M. pumilum var. alata (MPA), var. pumila (MPP),...

journal_title：Frontiers in pharmacology

authors： Rahmi EP,Kumolosasi E,Jalil J,Husain K,Buang F,Abd Razak AF,Jamal JA

更新日期：2020-03-17 00:00:00

abstract：:Etiology of colorectal cancer (CRC) is related, at least in part, with nutritional profile and epidemiological data indicating a key role of dietary fat on CRC pathogenesis. Moreover, inflammation and eicosanoids produced from arachidonic acid might have a pivotal role in CRC development. However, the effect of specif...

journal_title：Frontiers in pharmacology

authors： Storniolo CE,Cabral M,Busquets MA,Martín-Venegas R,Moreno JJ

更新日期：2020-09-04 00:00:00

abstract：:Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for effective drugs an urgent need. Neurodegeneration is triggered by the activation of several cellular processes, including oxidative stress, mitochondrial impairme...

journal_title：Frontiers in pharmacology

authors： de Souza JM,Goncalves BDC,Gomez MV,Vieira LB,Ribeiro FM

更新日期：2018-02-23 00:00:00

abstract：:Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAA receptors. These data suggest that the molecular mechanism of the effect of Selank may also be related to its ability ...

journal_title：Frontiers in pharmacology

authors： Filatova E,Kasian A,Kolomin T,Rybalkina E,Alieva A,Andreeva L,Limborska S,Myasoedov N,Pavlova G,Slominsky P,Shadrina M

更新日期：2017-02-28 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the major public health problem and a leading cause of morbidity and mortality on a global basis. Wenxin Keli (WXKL), a formally classical Chinese patent medicine with obvious efficacy and favorable safety, plays a great role in the management of patients with CVDs. Accumulating evid...

journal_title：Frontiers in pharmacology

authors： Tian G,Sun Y,Liu S,Li C,Chen S,Qiu R,Zhang X,Li Y,Li M,Shang H

更新日期：2018-09-05 00:00:00

abstract：:The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recently we demonstrated...

journal_title：Frontiers in pharmacology

authors： Thomas M,Winter S,Klumpp B,Turpeinen M,Klein K,Schwab M,Zanger UM

更新日期：2015-11-04 00:00:00

abstract：:Direct-to-consumer (DTC) DNA testing has grown from contentious beginnings into a global industry, by providing a wide range of personal genomic information directly to its clients. These companies, typified by the well-established 23andMe, generally carry out a gene-chip analysis of single-nucleotide polymorphisms (S...

journal_title：Frontiers in pharmacology

authors： Chua EW,Kennedy MA

更新日期：2012-08-20 00:00:00

abstract：:Traditionally, the solution to reduce parameter dimensionality in a physiologically-based pharmacokinetic (PBPK) model is through expert judgment. However, this approach may lead to bias in parameter estimates and model predictions if important parameters are fixed at uncertain or inappropriate values. The purpose of ...

journal_title：Frontiers in pharmacology

authors： Hsieh NH,Reisfeld B,Bois FY,Chiu WA

更新日期：2018-06-08 00:00:00

abstract：:Atherosclerosis is a chronic disease comprising intima malfunction and arterial inflammation. Recent studies have demonstrated that autophagy could inhibit inflammatory response in atherosclerosis and exert subsequent atheroprotective effects. Our previous study also demonstrated the role of autophagy in the inhibitio...

journal_title：Frontiers in pharmacology

authors： Peng S,Xu LW,Che XY,Xiao QQ,Pu J,Shao Q,He B

更新日期：2018-05-03 00:00:00

abstract：:Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coro...

journal_title：Frontiers in pharmacology

authors： Gu ZC,Shi FH,Zhu J,Wan F,Shen L,Li H

更新日期：2019-01-15 00:00:00

abstract：:Cervical cancer is the fourth most common cancer that affects women, mainly through human papilloma virus (HPV) infection with high-risk HPV16 and HPV18. The present study investigated the in vitro anticancer activity and mechanism of action of a proanthocyanidin polymer-rich fraction of Stryphnodendron adstringens (F...

journal_title：Frontiers in pharmacology

authors： Kaplum V,Ramos AC,Consolaro MEL,Fernandez MA,Ueda-Nakamura T,Dias-Filho BP,Silva SO,de Mello JCP,Nakamura CV

更新日期：2018-07-03 00:00:00

abstract：:The ecto-5'-nucleotidase (ecto-5'NT/CD73) represents a crucial enzyme for endogenous adenosine generation. Several findings have shown that CD73 plays an important role in regulating vascular permeability and immune cell function. Adenosine 5'-(α,β-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharm...

journal_title：Frontiers in pharmacology

authors： Caiazzo E,Morello S,Carnuccio R,Ialenti A,Cicala C

更新日期：2019-07-11 00:00:00

abstract：:ORY-1001, an inhibitor of covalent lysine (K)-specific demethylase 1A (KDM1A), has been used as a therapy for the treatment of acute leukemia. However, the underlying mechanisms of anticancer are still not fully elucidated. Here, we report that KDM1A is highly expressed in lung cancers, where it appears to drive aggre...

journal_title：Frontiers in pharmacology

authors： Lu Z,Guo Y,Zhang X,Li J,Li L,Zhang S,Shan C

更新日期：2018-12-04 00:00:00

abstract：:The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistan...

journal_title：Frontiers in pharmacology

authors： Lima R,Del Fiol FS,Balcão VM

更新日期：2019-06-21 00:00:00

abstract：:Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e., α1A and α1B) in antiarrhyth...

journal_title：Frontiers in pharmacology

authors： Pytka K,Lustyk K,Żmudzka E,Kotańska M,Siwek A,Zygmunt M,Dziedziczak A,Śniecikowska J,Olczyk A,Gałuszka A,Śmieja J,Waszkielewicz AM,Marona H,Filipek B,Sapa J,Mogilski S

更新日期：2016-08-03 00:00:00

abstract：:Cancer stem cells are involved in cancer establishment, progression, and resistance to current treatments. We demonstrated the in vitro and in vivo anti-breast cancer effect of bakuchiol in a previous study. However, the ability of bakuchiol to target breast cancer stem cells (BCSCs) and inhibit breast cancer metastas...

journal_title：Frontiers in pharmacology

authors： Li L,Liu CC,Chen X,Xu S,Hernandez Cortes-Manno S,Cheng SH

更新日期：2017-10-18 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin D' (OPD', a natural product extracted from a traditional Chinese medicine (Radix Ophiopogonis) against androgen-independent prostate cancer cells and to explore the underlying molecular mechanism(s) of action. Methods: The CCK-...

journal_title：Frontiers in pharmacology

authors： Lu Z,Wang H,Zhu M,Song W,Wang J,Wu C,Kong Y,Guo J,Li N,Liu J,Li Y,Xu H

更新日期：2018-04-30 00:00:00

abstract：:Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and explored the underlyi...

journal_title：Frontiers in pharmacology

authors： Chen T,Wang Y,Zhang T,Zhang B,Chen L,Zhao L,Chen L

更新日期：2018-04-12 00:00:00

abstract：:Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A...

journal_title：Frontiers in pharmacology

authors： Chen YA,Shih HW,Lin YC,Hsu HY,Wu TF,Tsai CH,Wu CL,Wu HY,Hsieh JT,Tang CH,Lai CH

更新日期：2018-06-13 00:00:00

abstract：Background:Among factors influencing the higher risk of developing unknown or rare adverse drug reactions (ADRs) among children and adolescents, there is the frequent off-label use of drugs that seems to be very common in pediatric oncological patients. Our study aim to collect and evaluate data on the safety profile o...

journal_title：Frontiers in pharmacology

authors： Mascolo A,Scavone C,Bertini M,Brusco S,Punzo F,Pota E,Di Martino M,Di Pinto D,Rossi F

更新日期：2020-05-07 00:00:00

abstract：:Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD ...

journal_title：Frontiers in pharmacology

authors： Massari CM,López-Cano M,Núñez F,Fernández-Dueñas V,Tasca CI,Ciruela F

更新日期：2017-10-04 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician know...

journal_title：Frontiers in pharmacology

authors： Weller CD,Team V,Sussman G

更新日期：2020-02-28 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts. Emerging evidence suggests that more effective treatments are required to overcome tumor heterogeneity, drug resistance and a complex tumor-supporting microenvironme...

journal_title：Frontiers in pharmacology

authors： Colapietro A,Yang P,Rossetti A,Mancini A,Vitale F,Martellucci S,Conway TL,Chakraborty S,Marampon F,Mattei V,Gravina GL,Biordi AL,Wei D,Newman RA,Festuccia C

更新日期：2020-09-11 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：Background:Patients with locally advanced rectal cancer (LARC) are at higher risk of local and distant recurrence and are thus more vulnerable to metastatic diseases. Neoadjuvant chemoradiotherapy (nCRT) and subsequent curative resection with total mesorectal excision (TME) followed by adjuvant chemotherapy have been r...

journal_title：Frontiers in pharmacology

authors： Zhong X,Zhou Y,Cui W,Su X,Guo Z,Hidasa I,Li Q,Wang Z,Song Y

更新日期：2020-05-15 00:00:00