Abstract:
:Objective: This research aimed to validate the therapeutic effect of losmapimod and explore the underlying mechanism in its treatment of epilepsy. Methods: A rat model of epilepsy was constructed with an injection of pilocarpine. Microarray analysis was performed to screen aberrantly expressed mRNAs and activated signaling pathways between epileptic rats and normal controls. A TdT-mediated dUTP nick-end labeling (TUNEL) assay was used to identify cell apoptosis. Hippocampal cytoarchitecture was visualized with Nissl staining. The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. A Morris water maze navigation test evaluated the rats' cognitive functions. Results: Activation of the MAPK signaling pathway was observed in epilepsy rats. A decrease in the MAPK phosphorylation level by application of losmapimod protected against epilepsy by reducing neuron loss. Losmapimod effectively improved memory, reduced the frequency of seizures, protected the neuron from damage, and limited the apoptosis of neurons in epilepsy rats. Conclusion: The application of losmapimod could partly reverse the development of epilepsy.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Li M,Cui L,Feng X,Wang C,Zhang Y,Wang L,Ding Y,Zhao Tdoi
10.3389/fphar.2019.00625subject
Has Abstractpub_date
2019-06-07 00:00:00pages
625issn
1663-9812journal_volume
10pub_type
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journal_title:Frontiers in pharmacology
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journal_title:Frontiers in pharmacology
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doi:10.3389/fphar.2017.00089
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abstract::With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...
journal_title:Frontiers in pharmacology
pub_type: 杂志文章,评审
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abstract::The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recently and shown to suppress tumor growth in preclinical in vivo models. ...
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pub_type: 杂志文章
doi:10.3389/fphar.2018.00785
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abstract::B lymphocytes play a critical role in humoral immunity. Abnormal B cell development and function cause a variety of hematological malignancies such as myeloma, B cell lymphoma, and leukemia. Histone deacetylase 6 (HDAC6) inhibitors alone or in combination with other drugs have shown efficacy in several hematological m...
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pub_type: 杂志文章,评审
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journal_title:Frontiers in pharmacology
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doi:10.3389/fphar.2016.00487
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pub_type: 杂志文章
doi:10.3389/fphar.2013.00070
更新日期:2013-06-03 00:00:00
abstract::Statin therapy may induce skeletal muscle damage ranging from myalgia to severe rhabdomyolysis. Our previous preclinical studies showed that statin treatment in rats involves the reduction of skeletal muscle ClC-1 chloride channel expression and related chloride conductance (gCl). An increase of the activity of protei...
journal_title:Frontiers in pharmacology
pub_type: 杂志文章
doi:10.3389/fphar.2017.00500
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abstract:Aims:SUMOylation is a post-translational modification that plays a crucial role in the cellular stress response. We aimed to demonstrate whether and how the SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Methods and Results:Adenovirus expressing Ubc9 was administrated by multipoint inje...
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pub_type: 杂志文章
doi:10.3389/fphar.2020.561306
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journal_title:Frontiers in pharmacology
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abstract:Background:As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods:We used cell proliferation assay, scratch and transwell experiments, and cell cycle ...
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doi:10.3389/fphar.2020.01211
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章
doi:10.3389/fphar.2019.00771
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fphar.2018.00210
更新日期:2018-03-27 00:00:00
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章
doi:10.3389/fphar.2018.01389
更新日期:2018-12-04 00:00:00
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journal_title:Frontiers in pharmacology
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doi:10.3389/fphar.2018.00723
更新日期:2018-07-09 00:00:00
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章,评审
doi:10.3389/fphar.2016.00327
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abstract:BACKGROUND:Abiraterone Acetate (AA) is approved for the treatment of mCRPC after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated and for treatment of mCRPC progressed during or after docetaxel-based chemotherapy regimen. The aim of this study is to evaluate the role of early...
journal_title:Frontiers in pharmacology
pub_type: 杂志文章
doi:10.3389/fphar.2016.00123
更新日期:2016-05-18 00:00:00
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journal_title:Frontiers in pharmacology
pub_type: 杂志文章
doi:10.3389/fphar.2016.00128
更新日期:2016-05-24 00:00:00
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pub_type: 杂志文章
doi:10.3389/fphar.2020.564131
更新日期:2020-09-08 00:00:00
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pub_type: 杂志文章
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更新日期:2020-10-19 00:00:00
abstract:RATIONALE:Alzheimer's disease (AD) is a debilitating disease with complex pathophysiology. Amyloid beta (Aβ) (1-42) is a reliable model of AD that recapitulates many aspects of human AD. OBJECTIVE:The intent of the present study was to investigate the neuroprotective potential of Coenzyme Q10 (CoQ10) and its modulatio...
journal_title:Frontiers in pharmacology
pub_type: 杂志文章
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更新日期:2015-11-09 00:00:00