Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.

abstract：:Introduction and objectives: Metastatic penile squamous cell carcinoma (PSCC) is associated with dismal outcomes with median overall survival (OS) of 6-12 months in the first-line and <6 months in the salvage setting. Given the rarity of this disease, randomized trials are difficult. Prognostic risk models may assist ...

journal_title：Frontiers in pharmacology

authors： Buonerba C,Di Lorenzo G,Pond G,Cartenì G,Scagliarini S,Rozzi A,Quevedo FJ,Dorff T,Nappi L,Lanzetta G,Pagliaro L,Eigl BJ,Naik G,Ferro M,Galdiero M,De Placido S,Sonpavde G

更新日期：2016-12-20 00:00:00

abstract：:Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular le...

journal_title：Frontiers in pharmacology

authors： Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DA

更新日期：2020-02-25 00:00:00

abstract：:Background: Rheumatoid arthritis is a type of systemic and complex autoimmune other disease characterized by chronic joint inflammation. Spleen tyrosine kinase (Syk) inhibitors are regarded as an effective alternative to existing drugs for the treatment of this disease. However, studies evaluating fostamatinib, a new ...

journal_title：Frontiers in pharmacology

authors： Kang Y,Jiang X,Qin D,Wang L,Yang J,Wu A,Huang F,Ye Y,Wu J

更新日期：2019-08-14 00:00:00

abstract：Background:Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with nondiabetic men. Corpus cavernosum vascular dysfunction plays a pivotal role in the occurrence of diabetes mellitus ED (DMED). The aim of this study was to investigate the prote...

journal_title：Frontiers in pharmacology

authors： Yuan P,Ma D,Gao X,Wang J,Li R,Liu Z,Wang T,Wang S,Liu J,Liu X

更新日期：2020-08-12 00:00:00

abstract：:Chijabyukpi-tang (CBT) is an oriental herbal formula consisting of three herbs (Gardeniae Fructus (Gardenia jasminoides J.Ellis.), Phellodendri Cortex (Phellodendron amurense Rupr.), Glycyrrhizae Radix (Glycyrrhiza uralensis Fisch. ex DC.) at the ratio of 2: 2: 1. CBT has traditionally been used to treat eczema with i...

journal_title：Frontiers in pharmacology

authors： Lee JH,Lim JY,Jo EH,Noh HM,Park S,Park MC,Kim DK

更新日期：2020-07-07 00:00:00

abstract：:[This corrects the article on p. 42 in vol. 9, PMID: 29487522.]. ...

journal_title：Frontiers in pharmacology

authors： Uttl L,Petrasek T,Sengul H,Svojanovska M,Lobellova V,Vales K,Radostova D,Tsenov G,Kubova H,Mikulecka A,Svoboda J,Stuchlik A

更新日期：2018-06-20 00:00:00

abstract：:Objectives: The aim of this study was to review the requirements for the reimbursement of biosimilars and to compare the reimbursement status, market share, and reimbursement costs of biosimilars in selected Central and Eastern European (CEE) countries. Methods: A questionnaire-based survey was conducted between Novem...

journal_title：Frontiers in pharmacology

authors： Kawalec P,Stawowczyk E,Tesar T,Skoupa J,Turcu-Stiolica A,Dimitrova M,Petrova GI,Rugaja Z,Männik A,Harsanyi A,Draganic P

更新日期：2017-06-08 00:00:00

abstract：:Acute lung injury (ALI) which is featured by a strong pulmonary inflammation, is a major cause of morbidity and mortality in critically ill patients. Magnoflorine, a quaternary alkaloid isolated from Chinese herb Magnolia or Aristolochia, has been reported to have potent anti-inflammatory properties. However, the effe...

journal_title：Frontiers in pharmacology

authors： Guo S,Jiang K,Wu H,Yang C,Yang Y,Yang J,Zhao G,Deng G

更新日期：2018-08-30 00:00:00

abstract：:Patient-derived cell lines and animal models have proven invaluable for the understanding of human intestinal diseases and for drug development although both inherently comprise disadvantages and caveats. Many genetically determined intestinal diseases occur in specific tissue microenvironments that are not adequately...

journal_title：Frontiers in pharmacology

authors： Liu F,Huang J,Ning B,Liu Z,Chen S,Zhao W

更新日期：2016-09-22 00:00:00

abstract：:Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a central role in antiviral responses, tissue repair, and fibrosis. Macrophages can be reprogrammed by environmental cues, thus changing their phenotype during an ant...

journal_title：Frontiers in pharmacology

authors： Gracia-Hernandez M,Sotomayor EM,Villagra A

更新日期：2020-10-29 00:00:00

abstract：:The pathological superoxidative condition that retinal pigment epithelium (RPE) cells experience contributed to the advancement of age-related macular degeneration (AMD), which was accompanied by significant neovascularization. Therefore, the discovery of novel pharmacological candidates to ameliorate oxidative damage...

journal_title：Frontiers in pharmacology

authors： Luo X,Gu S,Zhang Y,Zhang J

更新日期：2018-03-20 00:00:00

abstract：:Arsenic is a toxic environmental contaminant. Long-term exposure to arsenic through drinking water induces human cancers. However, it is as yet uncertain about the mechanisms of arsenic induced carcinogenesis. Although the effects of low-dose arsenicals on proliferation and cell cycle have been revealed by short time ...

journal_title：Frontiers in pharmacology

authors： Chen Y,Liu X,Wang H,Liu S,Hu N,Li X

更新日期：2019-10-11 00:00:00

abstract：:Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed to investigate the hepatoprotective effects of costunolide again...

journal_title：Frontiers in pharmacology

authors： Mao J,Yi M,Wang R,Huang Y,Chen M

更新日期：2018-12-20 00:00:00

abstract：:Rifampicin exhibits complexities in its pharmacokinetics (PK), including high inter-occasion variability (IOV), which is challenging for dose individualization. Model-informed precision dosing (MIPD) can be used to optimize individual doses. In this simulation-based study we investigated the magnitude of IOV in rifamp...

journal_title：Frontiers in pharmacology

authors： Keutzer L,Simonsson USH

更新日期：2020-05-27 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:Urothelial cells, myofibroblasts, and smooth muscle cells are important cell types contributing to bladder function. Multiple receptors including muscarinic (M3/M5), tachykinin (NK1/NK2), and purinergic (P2X1/P2Y6) receptors are involved in bladder motor and sensory actions. Using female pig bladder, our aim was to di...

journal_title：Frontiers in pharmacology

authors： Bahadory F,Moore KH,Liu L,Burcher E

更新日期：2013-11-28 00:00:00

abstract：:Endothelium dysfunction induced by reactive oxygen species (ROS) is an important initial event at the onset of myocardial ischemia/reperfusion in which the Egr-1 transcription factor often serves as a master switch for various damage pathways following reperfusion injury. We hypothesized that an intracellular ROS/MAPK...

journal_title：Frontiers in pharmacology

authors： Lu S,Zhang Y,Zhong S,Gao F,Chen Y,Li W,Zheng F,Shi G

更新日期：2017-01-05 00:00:00

abstract：:Objective: To investigate the effects of Suo Quan Wan (SQW), a traditional Chinese herbal formula, on the overactive bladder (OAB) of type 2 diabetes mellitus (T2DM) mouse models, particularly on its function of mediating the gene and protein expression levels of myosin Va and SLC17A9. Materials and Methods: After 4 w...

journal_title：Frontiers in pharmacology

authors： Wang J,Lian DW,Yang XF,Xu YF,Chen FJ,Lin WJ,Wang R,Tang LY,Ren WK,Fu LJ,Huang P,Cao HY

更新日期：2019-05-24 00:00:00

abstract：:Uncontrolled bacteremia is a common and life threatening condition that can lead to sepsis and septic shock with significant morbidity and mortality. Neutrophil granulocytes, the most abundant phagocytic leukocyte of the innate immune system, play an essential role in capturing and killing invading pathogens. Their an...

journal_title：Frontiers in pharmacology

authors： Meier A,Chien J,Hobohm L,Patras KA,Nizet V,Corriden R

更新日期：2019-04-05 00:00:00

abstract：:Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

journal_title：Frontiers in pharmacology

authors： Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

更新日期：2020-08-21 00:00:00

abstract：:Hepatosteatosis (HS), a clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation of the maintenance of liver lipid homeostasis. Samjunghwan (SJH) is an herbal formula used mostly in Korean traditional medicine that is effective against ...

journal_title：Frontiers in pharmacology

authors： Ansari A,Bose S,Patra JK,Shin NR,Lim DW,Kim KW,Wang JH,Kim YM,Chin YW,Kim H

更新日期：2018-06-19 00:00:00

abstract：Background and Aim:Platycodon grandiflorum (PG) has been widely used for treating chronic bronchitis (CB). However, the material basis and underlying mechanism of action of PG against CB have not yet been elucidated. Methods:To analyze the ingredients in PG, ultraperformance liquid chromatography-quadrupole-time-of-fl...

journal_title：Frontiers in pharmacology

authors： Deng Y,Ren H,Ye X,Xia L,Liu M,Liu Y,Yang M,Yang S,Ye X,Zhang J

更新日期：2020-09-08 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:Diabetic kidney disease (DKD) is a major health problem and one of the leading causes of end-stage renal disease worldwide. Despite recent advances, there exists an urgent need for the development of new treatments for DKD. DKD is characterized by the excessive synthesis and deposition of extracellular matrix proteins...

journal_title：Frontiers in pharmacology

authors： Sakuma H,Hagiwara S,Kantharidis P,Gohda T,Suzuki Y

更新日期：2020-11-13 00:00:00

abstract：:P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene. In this study, the transcription start site of the pig Abcb1 gene was identified by 5'-RACE. A 1.9-kb fra...

journal_title：Frontiers in pharmacology

authors： Guo T,Huang J,Huan C,He F,Zhang Y,Bhutto ZA,Wang L

更新日期：2018-05-04 00:00:00

abstract：:High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumptio...

journal_title：Frontiers in pharmacology

authors： Lederer S,Dijkstra TMH,Heskes T

更新日期：2018-02-06 00:00:00

abstract：:Hypertension is a prevalent, complex, and polygenic cardiovascular disease, which is associated with increased mortality and morbidity. Across the world, traditional Chinese medicine (TCM) constituted by herbal medicine and non-pharmacological therapies is used to assist blood pressure management. Though widely accept...

journal_title：Frontiers in pharmacology

authors： Yang M,Lao L

更新日期：2019-03-08 00:00:00

abstract：:Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Ca...

journal_title：Frontiers in pharmacology

authors： Lashmanova E,Zemskaya N,Proshkina E,Kudryavtseva A,Volosnikova M,Marusich E,Leonov S,Zhavoronkov A,Moskalev A

更新日期：2017-12-07 00:00:00

abstract：:Background and Objectives: Limited research focuses on the risk of ischemic cerebrovascular disease associated with use of dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) in patients with type 2 diabetes mellitus in Taiwan. This study aimed to investigate the association between DPP-4 inhibitors use and the first...

journal_title：Frontiers in pharmacology

authors： Lai SW,Liao KF,Lin CL,Lin HF

更新日期：2017-11-22 00:00:00

abstract：INTRODUCTION:Reliable and precise measurement of patient adherence to medications is feasible by incorporating a microcircuitry into pharmaceutical packages of various designs, such that the maneuvers needed to remove a dose of drug are detected, time-stamped, and stored. The principle is called "electronic medication ...

journal_title：Frontiers in pharmacology

authors： Arnet I,Walter PN,Hersberger KE

更新日期：2013-03-13 00:00:00