Abstract:
:Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular level to drive action potentials and to maintain action potential propagation and electrical homogeneity at the tissue level. Any imbalance in Ca2+ homeostasis of a cardiac myocyte can lead to electrical disturbances. This review aims to discuss cardiac physiology and pathophysiology from the elementary membrane processes that can cause the electrical instability of the ventricular myocytes through intracellular Ca2+ handling maladies to inherited and acquired arrhythmias. Finally, the paper will discuss the current therapeutic approaches targeting cardiac arrhythmias.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DAdoi
10.3389/fphar.2020.00072subject
Has Abstractpub_date
2020-02-25 00:00:00pages
72issn
1663-9812journal_volume
11pub_type
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