Gene expression of muscarinic, tachykinin, and purinergic receptors in porcine bladder: comparison with cultured cells.

abstract：:Background: Genetic variability in some of the genes that affect absorption, distribution, metabolism, and elimination ("pharmacogenes") can significantly influence an individual's response to the drug and consequently the effectiveness of treatment and possible adverse drug events. The rapid development of sequencing...

journal_title：Frontiers in pharmacology

authors： Hočevar K,Maver A,Peterlin B

更新日期：2019-03-14 00:00:00

abstract：:[This corrects the article on p. 287 in vol. 7, PMID: 27630568.]. ...

journal_title：Frontiers in pharmacology

authors： Cecere SC,Rossetti S,Cavaliere C,Della Pepa C,Di Napoli M,Crispo A,Iovane G,Piscitelli R,Sorrentino D,Ciliberto G,Maiolino P,Muto P,Perdonà S,Berretta M,Pignata S,Facchini G,D'Aniello C

更新日期：2016-12-05 00:00:00

abstract：:Acute lung injury (ALI) which is featured by a strong pulmonary inflammation, is a major cause of morbidity and mortality in critically ill patients. Magnoflorine, a quaternary alkaloid isolated from Chinese herb Magnolia or Aristolochia, has been reported to have potent anti-inflammatory properties. However, the effe...

journal_title：Frontiers in pharmacology

authors： Guo S,Jiang K,Wu H,Yang C,Yang Y,Yang J,Zhao G,Deng G

更新日期：2018-08-30 00:00:00

abstract：:Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16 single nucleotide polymorphisms (SNPs) covering 5'-UTR and coding regi...

journal_title：Frontiers in pharmacology

authors： Jhun EH,Sadhu N,Hu X,Yao Y,He Y,Wilkie DJ,Molokie RE,Wang ZJ

更新日期：2019-02-07 00:00:00

abstract：Background and Purpose:Predictors of response to type-1 hepatorenal syndrome (HRS) therapy are urgently needed. This study's purpose is to evaluate the proposed predictors in these patients. Methods:Forty-two type-1 HRS patients with cirrhosis were treated with albumin and terlipressin. Clinical, biochemical, and demo...

journal_title：Frontiers in pharmacology

authors： Abdel-Razik A,Mousa N,Abdelsalam M,Abdelwahab A,Tawfik M,Tawfik AM,Hasan AS,Elhelaly R,El-Wakeel N,Eldars W

更新日期：2020-01-31 00:00:00

abstract：:Aconitine is the main bioactive ingredient of Aconitum plants, which are well-known botanical herbs in China. Aconitine is also notorious for its high cardiotoxicity, as it can induce life-threatening ventricular arrhythmias. Unfortunately, there are few effective antidotes to aconitine toxicity. This study aimed to e...

journal_title：Frontiers in pharmacology

authors： Ma LQ,Yu Y,Chen H,Li M,Ihsan A,Tong HY,Huang XJ,Gao Y

更新日期：2018-10-25 00:00:00

abstract：:Numerous protein kinases encoded in the genome have become attractive targets for the treatment of different types of cancer. As of January 2020, a total of 52 small-molecule kinase inhibitors (SMKIs) have been approved by the FDA. With the numerous clinical trials and a heavy focus on drug safety, SMKI-induced cardio...

journal_title：Frontiers in pharmacology

authors： Jin Y,Xu Z,Yan H,He Q,Yang X,Luo P

更新日期：2020-06-12 00:00:00

abstract：:Trichloroethylene (TCE) is a common volatile organic solvent which is considered as an ubiquitous environmental pollutant. It is claimed to be a developmental neurotoxicant. Our group evaluated previously its impact on three-dimensional neurospheres in vitro. The current work aims to investigate the neurotoxic effects...

journal_title：Frontiers in pharmacology

authors： Salama MM,El-Naggar DA,Abdel-Rahman RH,Elhak SAG

更新日期：2018-07-10 00:00:00

abstract：Background:5α-reductase type 2 deficiency (5αRD) is an autosomal recessive hereditary disease of the group of 46, XY disorders of sex development (DSD). Objective:To study the growth pattern in Chinese pediatric patients with 5αRD. Subjects:Data were obtained from 141 patients with 5αRD (age: 0-16 years old) who visi...

journal_title：Frontiers in pharmacology

authors： Zhao X,Song Y,Chen S,Wang X,Luo F,Yang Y,Chen L,Chen R,Chen H,Su Z,Wu D,Gong C

更新日期：2019-03-15 00:00:00

abstract：:Over recent years, utilization of green synthesized nanomaterials has been widely growing on human body because of its special properties. With the increasing acceptance of nanoparticle approach for various clinical treatments, the biosafety and toxicological effects on the vital organs such as central nervous system,...

journal_title：Frontiers in pharmacology

authors： Yadav E,Singh D,Yadav P,Verma A

更新日期：2018-05-23 00:00:00

abstract：:Endothelial cells play a critical role in the process of angiogenesis during skin wound healing. The migration and proliferation of endothelial cells are processes that are initiated by the hypoxic microenvironment in a wound, but the underlying mechanisms remain largely unknown. Here, we identified a novel role for m...

journal_title：Frontiers in pharmacology

authors： Zhang J,Li L,Zhang Q,Yang X,Zhang C,Zhang X,Zhang D,Lv Y,Song H,Chen B,Liu Y,Hu J,Huang Y

更新日期：2019-04-16 00:00:00

abstract：Background:MicroRNAs are known to regulate carcinogenesis of osteosarcoma. Although, miR-16-5p is known to exert inhibitory effects on several forms of cancers, its effects on the growth and invasion of osteosarcoma have not been studied. Methods:We collected human osteosarcoma specimens and adjacent tissues to detect...

journal_title：Frontiers in pharmacology

authors： Gu Z,Li Z,Xu R,Zhu X,Hu R,Xue Y,Xu W

更新日期：2020-08-26 00:00:00

abstract：:Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signali...

journal_title：Frontiers in pharmacology

authors： Sun X,Chen WD,Wang YD

更新日期：2017-08-23 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. ...

journal_title：Frontiers in pharmacology

authors： Michalak A,Mosińska P,Fichna J

更新日期：2016-12-01 00:00:00

abstract：:The increase of non-communicable diseases at all ages has fostered the general concern for sustaining population health worldwide. Unhealthy lifestyles and dietary habits impacting physical and psycho-social health are well known risk factors for developing life threatening diseases. Identifying the determinants of qu...

journal_title：Frontiers in pharmacology

authors： Ruano-Rodríguez C,Serra-Majem L,Dubois D

更新日期：2015-05-08 00:00:00

abstract：:Cucurbitacin C (CuC), a novel analogue of triterpenoids cucurbitacins, confers a bitter taste in cucumber. Genes and signaling pathways responsive for biosynthesis of CuC have been identified in the recent years. In the present study, we explored the anti-cancer effects of CuC against human cancers in vitro and in viv...

journal_title：Frontiers in pharmacology

authors： Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

更新日期：2019-11-08 00:00:00

abstract：:Ethanol-induced gastric mucosal injury is a common gastrointestinal disorder. Polysaccharides separated from herbs have been shown to be effective for ethanol-induced gastric mucosal injury, but whether the polysaccharides from Dendrobium officinale Kimura & Migo leaves (LDOP-1) protected mucosa from ethanol-induced i...

journal_title：Frontiers in pharmacology

authors： Ke Y,Zhan L,Lu T,Zhou C,Chen X,Dong Y,Lv G,Chen S

更新日期：2020-11-11 00:00:00

abstract：:Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

journal_title：Frontiers in pharmacology

authors： Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

更新日期：2020-06-05 00:00:00

abstract：:Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity. However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use. Effects and side effects of platinum-based drugs are in part caused by their transporter-mediated ...

journal_title：Frontiers in pharmacology

authors： Harrach S,Ciarimboli G

更新日期：2015-04-24 00:00:00

abstract：:Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes in patient samples....

journal_title：Frontiers in pharmacology

authors： Barrett MT,Lenkiewicz E,Evers L,Holley T,Ruiz C,Bubendorf L,Sekulic A,Ramanathan RK,Von Hoff DD

更新日期：2013-01-28 00:00:00

abstract：:Exposure to bisphenol A (BPA), one of the most widespread endocrine disruptors present in our environment, has been associated with the recent increased prevalence and severity of several diseases such as diabetes, obesity, autism, reproductive and neurological defects, oral diseases, and cancers such as breast tumors...

journal_title：Frontiers in pharmacology

authors： Merzoug-Larabi M,Youssef I,Bui AT,Legay C,Loiodice S,Lognon S,Babajko S,Ricort JM

更新日期：2020-01-31 00:00:00

abstract：:The Health Improvement Network UK primary care database was used to identify a cohort of 38 077 individuals aged 50-84 years with a first prescription of low-dose acetylsalicylic acid (ASA; 75-300 mg/day) for secondary prevention of cardiovascular or cerebrovascular events during 2000-2007. From this cohort, 169 incid...

journal_title：Frontiers in pharmacology

authors： Cea Soriano L,Rodríguez LA

更新日期：2010-10-14 00:00:00

abstract：:Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly influenced by the surrounding microenvironment of the tumor. Therefore, the ability to change these surroundings represents an important property through which tumor cells are able to acquire specific functions necessary for tumor ...

journal_title：Frontiers in pharmacology

authors： Noël A,Gutiérrez-Fernández A,Sounni NE,Behrendt N,Maquoi E,Lund IK,Cal S,Hoyer-Hansen G,López-Otín C

更新日期：2012-07-17 00:00:00

abstract：:Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Ch...

journal_title：Frontiers in pharmacology

authors： Yu B,Yuan B,Li J,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Fan Y,Pei X,Takagi N

更新日期：2020-07-17 00:00:00

abstract：:Marantodes pumilum (Primulaceae) has been used in Malaysian folk medicine to help women regain strength after delivery and for "sickness in the bones." It was previously revealed that its extracts inhibited xanthine oxidase (XO) activity in vitro. The leaves and roots of M. pumilum var. alata (MPA), var. pumila (MPP),...

journal_title：Frontiers in pharmacology

authors： Rahmi EP,Kumolosasi E,Jalil J,Husain K,Buang F,Abd Razak AF,Jamal JA

更新日期：2020-03-17 00:00:00

abstract：:The potential of multifunctional wound heal biomaterial relies on the optimal content of therapeutic constituents as well as the desirable physical, chemical, and biological properties to accelerate the healing process. Formulating biomaterials such as amnion or collagen based scaffolds with natural products offer an ...

journal_title：Frontiers in pharmacology

authors： Sivasubramanian S,Chandrasekar G,Svensson Akusjärvi S,Thangam R,Sathuvan M,Kumar RBS,Hussein H,Vincent S,Madhan B,Gunasekaran P,Kitambi SS

更新日期：2017-07-18 00:00:00

abstract：:Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developi...

journal_title：Frontiers in pharmacology

authors： Yeung AWK,Heinrich M,Atanasov AG

更新日期：2018-03-15 00:00:00

abstract：:The lignan-rich fraction (SWR) of Sambucus Williamsii Ramulus, a folk herbal medicine in China for treatment of bone diseases, has previously reported to exert protective effects on bone without exerting uterotrophic effects in ovariectomized (OVX) mice. The aim of the present study was to identify the potential metab...

journal_title：Frontiers in pharmacology

authors： Xiao HH,Sham TT,Chan CO,Li MH,Chen X,Wu QC,Mok DK,Yao XS,Wong MS

更新日期：2018-08-21 00:00:00

abstract：:Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical a...

journal_title：Frontiers in pharmacology

authors： Sadu Singh BK,Narayanan SS,Khor BH,Sahathevan S,Abdul Gafor AH,Fiaccadori E,Sundram K,Karupaiah T

更新日期：2020-04-29 00:00:00

abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...

journal_title：Frontiers in pharmacology

authors： Huang YH,Chaousis S,Cheneval O,Craik DJ,Henriques ST

更新日期：2015-02-09 00:00:00