Resins and Gums in Historical Iatrosophia Texts from Cyprus - A Botanical and Medico-pharmacological Approach.

abstract：:The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over acti...

journal_title：Frontiers in pharmacology

authors： Arshad L,Jantan I,Bukhari SN,Haque MA

更新日期：2017-01-30 00:00:00

abstract：:Hepatitis C virus, human immunodeficiency virus, and hepatitis B virus are chronic viral infections that cause considerable morbidity and mortality throughout the world. In the decades following the identification and sequencing of these viruses, in vitro experiments demonstrated that heme oxygenase-1, its oxidative p...

journal_title：Frontiers in pharmacology

authors： Schmidt WN,Mathahs MM,Zhu Z

更新日期：2012-10-04 00:00:00

abstract：:Purpose: To analyze MiRs expression in serum of UM patients, respect to healthy donors, and to compare this data with MiRs expressed in formalin-fixed, paraffin-embedded UM samples. Methods: Expression profile of 754 miRNAs was performed in serum of patients with uveal melanoma who underwent primary enucleation. The l...

journal_title：Frontiers in pharmacology

authors： Russo A,Caltabiano R,Longo A,Avitabile T,Franco LM,Bonfiglio V,Puzzo L,Reibaldi M

更新日期：2016-11-15 00:00:00

abstract：:Cucurbitacin C (CuC), a novel analogue of triterpenoids cucurbitacins, confers a bitter taste in cucumber. Genes and signaling pathways responsive for biosynthesis of CuC have been identified in the recent years. In the present study, we explored the anti-cancer effects of CuC against human cancers in vitro and in viv...

journal_title：Frontiers in pharmacology

authors： Wu D,Wang Z,Lin M,Shang Y,Wang F,Zhou J,Wang F,Zhang X,Luo X,Huang W

更新日期：2019-11-08 00:00:00

abstract：:Pulmonary fibrosis is closely associated with the recruitment of fibroblasts from capillary vessels with damaged endothelial cells, the epithelial mesenchymal transition (EMT) of type II alveolar epithelial cells, and the transformation of fibroblasts to myofibroblasts. Recent studies suggest that EMT is a key factor ...

journal_title：Frontiers in pharmacology

authors： Xie L,Zeng Y

更新日期：2020-12-04 00:00:00

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：:The Glp-1 analog, liraglutide (Lir), has been shown to reduce infarct size and improve cardiac function after myocardial ischemia in rodents with or without diabetes. However, the effect of Lir on angiotensin II (AngII) and pressure overload induced cardiac hypertrophy in nondiabetic mice and the underlying mechanisms...

journal_title：Frontiers in pharmacology

authors： Li R,Shan Y,Gao L,Wang X,Wang X,Wang F

更新日期：2019-06-05 00:00:00

abstract：:Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to increase during metabolic syndrome and obesity. In addition, previous studies have implicated PAI-1 in adipose tissue (AT) expansion while also contributing to insulin resistance. As inflammation is also known to occur in AT during ob...

journal_title：Frontiers in pharmacology

authors： Wang L,Chen L,Liu Z,Liu Y,Luo M,Chen N,Deng X,Luo Y,He J,Zhang L,Hill MA,Li R,Wu J

更新日期：2018-09-26 00:00:00

abstract：:Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked...

journal_title：Frontiers in pharmacology

authors： Beltrán LR,Dawid C,Beltrán M,Levermann J,Titt S,Thomas S,Pürschel V,Satalik M,Gisselmann G,Hofmann T,Hatt H

更新日期：2017-06-26 00:00:00

abstract：:Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene encoding the CFTR chloride channel. The ion transport abnormalities related to CFTR mutation generate a dehydrated airway surface liquid (ASL) layer, which is responsible for an a...

journal_title：Frontiers in pharmacology

authors： Briottet M,Shum M,Urbach V

更新日期：2020-09-02 00:00:00

abstract：:Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical a...

journal_title：Frontiers in pharmacology

authors： Sadu Singh BK,Narayanan SS,Khor BH,Sahathevan S,Abdul Gafor AH,Fiaccadori E,Sundram K,Karupaiah T

更新日期：2020-04-29 00:00:00

abstract：:The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cance...

journal_title：Frontiers in pharmacology

authors： Horbach T,Götz C,Kietzmann T,Dimova EY

更新日期：2015-02-18 00:00:00

abstract：:Endothelial cells play a critical role in the process of angiogenesis during skin wound healing. The migration and proliferation of endothelial cells are processes that are initiated by the hypoxic microenvironment in a wound, but the underlying mechanisms remain largely unknown. Here, we identified a novel role for m...

journal_title：Frontiers in pharmacology

authors： Zhang J,Li L,Zhang Q,Yang X,Zhang C,Zhang X,Zhang D,Lv Y,Song H,Chen B,Liu Y,Hu J,Huang Y

更新日期：2019-04-16 00:00:00

abstract：:Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

journal_title：Frontiers in pharmacology

authors： Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

更新日期：2018-06-15 00:00:00

abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...

journal_title：Frontiers in pharmacology

authors： Huang YH,Chaousis S,Cheneval O,Craik DJ,Henriques ST

更新日期：2015-02-09 00:00:00

abstract：:Background: New treatment platforms that can prevent acute respiratory distress syndrome (ARDS) or reduce its mortality rate in high-risk coronavirus disease 2019 (COVID-19) patients, such as those with an underlying cancer, are urgently needed. Rejuveinix (RJX) is an intravenous formulation of anti-oxidants and anti-...

journal_title：Frontiers in pharmacology

authors： Uckun FM,Carlson J,Orhan C,Powell J,Pizzimenti NM,van Wyk H,Ozercan IH,Volk M,Sahin K

更新日期：2020-11-10 00:00:00

abstract：:In metastatic renal cell carcinoma, complete response to first-line antiangiogenic agents is rare and resistance to therapy often develops. Protocols for sequential treatment with angiogenesis and mTOR inhibitors are under evaluation to improve outcomes. In this observational, real-world study, patients received a fir...

journal_title：Frontiers in pharmacology

authors： Rossetti S,D'Aniello C,Iovane G,Scagliarini S,Laterza MM,De Vita F,Savastano C,Cartenì G,Porricelli MA,Berretta M,Pisconti S,Facchini G,Cavaliere C

更新日期：2017-07-20 00:00:00

abstract：PURPOSE:Hydrogen is a proven novel antioxidant that selectively reduces hydroxyl radicals. In this study, we investigated the effects of hydrogen-rich saline solution on the prevention of renal injury induced by ischemia/reperfusion (I/R) and on renal function recovery. METHODS:A rat model of renal I/R injury was indu...

journal_title：Frontiers in pharmacology

authors： Li J,Hong Z,Liu H,Zhou J,Cui L,Yuan S,Chu X,Yu P

更新日期：2016-04-22 00:00:00

abstract：:The glycoengineering approach is used to improve biophysical properties of protein-based drugs, but its direct impact on binding affinity and kinetic properties for the glycoengineered protein and its binding partner interaction is unclear. Type I interferon (IFN) receptors, composed of IFNAR1 and IFNAR2, have differe...

journal_title：Frontiers in pharmacology

authors： Lee S,Son WS,Yang HB,Rajasekaran N,Kim SS,Hong S,Choi JS,Choi JY,Song K,Shin YK

更新日期：2019-01-24 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its cont...

journal_title：Frontiers in pharmacology

authors： Guo Y,Sun L,Xiao L,Gou R,Fang Y,Liang Y,Wang R,Li N,Liu F,Tang L

更新日期：2017-10-30 00:00:00

abstract：:Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the regulation of vascular tone remains unclear. The perspective that ET-1 plays little role in the on-going regulation of vascular tone at least under physiologic conditio...

journal_title：Frontiers in pharmacology

authors： Rapoport RM,Merkus D

更新日期：2017-10-24 00:00:00

abstract：:The interaction between programmed cell death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) induces exhaustions of cytotoxic lymphocytes in the tumor microenvironment, which facilitates tumor immune evasion. PD-1/PD-L1 blockade therapy, which prevents the receptors and ligands from binding to each ...

journal_title：Frontiers in pharmacology

authors： Yang J,He X,Lv Q,Jing J,Shi H

更新日期：2019-07-02 00:00:00

abstract：:Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotectio...

journal_title：Frontiers in pharmacology

authors： Inserra A

更新日期：2018-04-05 00:00:00

abstract：:Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isola...

journal_title：Frontiers in pharmacology

authors： Amin A,Tuenter E,Foubert K,Iqbal J,Cos P,Maes L,Exarchou V,Apers S,Pieters L

更新日期：2017-05-01 00:00:00

abstract：:Endocrine fibroblast growth factor (FGF) 19 has been shown to be capable of maintaining bile acid (BA) homeostasis and thus hold promise to be a potential therapeutic agent for cholestasis liver disease. However, whether paracrine FGFs possess this BA regulatory activity remains to be determined. In our study, we iden...

journal_title：Frontiers in pharmacology

authors： Lin H,Zhou C,Hou Y,Li Q,Qiao G,Wang Y,Huang Z,Niu J

更新日期：2019-12-20 00:00:00

abstract：:Cognitive impairment is a central feature of schizophrenia and has shown to play a crucial role in the psychosocial function of the disorder. Over the past few years, several cognitive remediation (CR) interventions have been developed for schizophrenia, whose effectiveness has also been widely demonstrated by systema...

journal_title：Frontiers in pharmacology

authors： Barlati S,Deste G,Galluzzo A,Perin AP,Valsecchi P,Turrina C,Vita A

更新日期：2019-01-10 00:00:00

abstract：:Background: There is conflicting evidence on the impact of biologic treatment on the rate of complications and surgeries in Crohn's disease (CD). We aimed to assess real-world consequences of biologic treatment of CD. Methods: All adult patients with CD treated with infliximab and adalimumab in the years 2012-2014 wer...

journal_title：Frontiers in pharmacology

authors： Holko P,Kawalec P,Pilc A

更新日期：2018-06-11 00:00:00

abstract：:There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac myocytes for this p...

journal_title：Frontiers in pharmacology

authors： Mistry HB,Davies MR,Di Veroli GY

更新日期：2015-03-24 00:00:00

abstract：:Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio-informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeu...

journal_title：Frontiers in pharmacology

authors： Balasopoulou A,Patrinos GP,Katsila T

更新日期：2016-10-27 00:00:00

abstract：:With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

journal_title：Frontiers in pharmacology

authors： Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

更新日期：2016-09-29 00:00:00