Potential Targeting of Renal Fibrosis in Diabetic Kidney Disease Using MicroRNAs.

abstract：:The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregulated. Silencing of...

journal_title：Frontiers in pharmacology

authors： Cai S,Liu R,Wang P,Li J,Xie T,Wang M,Cao Y,Li Z,Liu P

更新日期：2020-12-10 00:00:00

abstract：:Atherosclerotic cardiovascular disease (CVD) is a lipid-driven chronic inflammatory disease, in which macrophages are responsible for taking up these lipids and driving disease progression. Over the years, we and others have uncovered key pathways that regulate macrophage number/function and identified how metabolic d...

journal_title：Frontiers in pharmacology

authors： Flynn MC,Pernes G,Lee MKS,Nagareddy PR,Murphy AJ

更新日期：2019-06-13 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developi...

journal_title：Frontiers in pharmacology

authors： Yeung AWK,Heinrich M,Atanasov AG

更新日期：2018-03-15 00:00:00

abstract：:Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat osteoclast-related bone diseases. Fumitremorgin C (Fum) is a mycotoxin...

journal_title：Frontiers in pharmacology

authors： Yuan Y,Chen K,Chen X,Wang C,Qiu H,Cao Z,Song D,Sun Y,Guo J,Tickner J,Xu J,Zou J

更新日期：2020-03-10 00:00:00

abstract：:Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca(2) (+)-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser(16) by PKA or Thr(17) by Ca(2) (+)-calmodulin-dependent protei...

journal_title：Frontiers in pharmacology

authors： Mattiazzi A,Kranias EG

更新日期：2014-01-27 00:00:00

abstract：:Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a central role in antiviral responses, tissue repair, and fibrosis. Macrophages can be reprogrammed by environmental cues, thus changing their phenotype during an ant...

journal_title：Frontiers in pharmacology

authors： Gracia-Hernandez M,Sotomayor EM,Villagra A

更新日期：2020-10-29 00:00:00

abstract：:Objective: This research aimed to validate the therapeutic effect of losmapimod and explore the underlying mechanism in its treatment of epilepsy. Methods: A rat model of epilepsy was constructed with an injection of pilocarpine. Microarray analysis was performed to screen aberrantly expressed mRNAs and activated sign...

journal_title：Frontiers in pharmacology

authors： Li M,Cui L,Feng X,Wang C,Zhang Y,Wang L,Ding Y,Zhao T

更新日期：2019-06-07 00:00:00

abstract：Background:5α-reductase type 2 deficiency (5αRD) is an autosomal recessive hereditary disease of the group of 46, XY disorders of sex development (DSD). Objective:To study the growth pattern in Chinese pediatric patients with 5αRD. Subjects:Data were obtained from 141 patients with 5αRD (age: 0-16 years old) who visi...

journal_title：Frontiers in pharmacology

authors： Zhao X,Song Y,Chen S,Wang X,Luo F,Yang Y,Chen L,Chen R,Chen H,Su Z,Wu D,Gong C

更新日期：2019-03-15 00:00:00

abstract：:Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interaction between SARS-CoV-2 spike protein and its cognate receptor ACE2, w...

journal_title：Frontiers in pharmacology

authors： Bojadzic D,Alcazar O,Buchwald P

更新日期：2021-01-13 00:00:00

abstract：:The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer's disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total number of molecules investigated remains quite small. As a member the M1 ...

journal_title：Frontiers in pharmacology

authors： Barlow N,Thompson PE

更新日期：2020-09-25 00:00:00

abstract：:The development of epilepsy, a process known as epileptogenesis, often occurs later in life following a prenatal or early postnatal insult such as cerebral ischemia, stroke, brain trauma, or infection. These insults share common pathophysiological pathways involving innate immune activation including neuroinflammation...

journal_title：Frontiers in pharmacology

authors： Semple BD,Dill LK,O'Brien TJ

更新日期：2020-02-04 00:00:00

abstract：:Quinoxaline 1,4-di-N-oxides (QdNOs) have manifold biological properties, including antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities. These diverse activities endow them broad applications and prospects in human and veterinary medicines. As QdNOs arouse widespread interest, the e...

journal_title：Frontiers in pharmacology

authors： Cheng G,Sa W,Cao C,Guo L,Hao H,Liu Z,Wang X,Yuan Z

更新日期：2016-03-21 00:00:00

abstract：:The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS), and specific identification of complex by T cells including two...

journal_title：Frontiers in pharmacology

authors： Tai Y,Wang Q,Korner H,Zhang L,Wei W

更新日期：2018-06-26 00:00:00

abstract：:Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira or guabiroba, exhibits pharmacological properties including antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer ...

journal_title：Frontiers in pharmacology

authors： Campos JF,Espindola PPT,Torquato HFV,Vital WD,Justo GZ,Silva DB,Carollo CA,de Picoli Souza K,Paredes-Gamero EJ,Dos Santos EL

更新日期：2017-08-14 00:00:00

abstract：:Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the late part of cholester...

journal_title：Frontiers in pharmacology

authors： Režen T,Ogris I,Sever M,Merzel F,Golic Grdadolnik S,Rozman D

更新日期：2017-06-30 00:00:00

abstract：:Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, suggesting that microglia and neuroinflammation are involved in the path...

journal_title：Frontiers in pharmacology

authors： Rodrigues-Neves AC,Aires ID,Vindeirinho J,Boia R,Madeira MH,Gonçalves FQ,Cunha RA,Santos PF,Ambrósio AF,Santiago AR

更新日期：2018-01-24 00:00:00

abstract：:A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Ther...

journal_title：Frontiers in pharmacology

authors： Lewenhofer V,Schweighofer L,Ledermüller T,Eichsteininger J,Kählig H,Zehl M,Nguyen CH,Krupitza G,Özmen A,Krenn L

更新日期：2018-04-03 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with a high incidence, mortality and disability rate. Danhong injection (DHI) is beneficial for ischemic stroke, but is prohibited for ICH due to risk of bleeding. The present study aims to explore the potential therapeutic time window and molecular me...

journal_title：Frontiers in pharmacology

authors： Wang S,Yu L,Sun G,Liu Y,Hu W,Liu Y,Peng T,Wang X,Cheng J,Sr A,Qin B,Lu H

更新日期：2020-03-25 00:00:00

abstract：:Impetigo is the most common childhood skin infection in the world. There are two patterns of impetigo: nonbullous (or impetigo contagiosa) and bullous. The nonbullous type is due to Staphylococcus aureus and group A beta-haemolytic Streptococcus and occurs in 70% of impetigo cases. Impetigo is often a self-limited dis...

journal_title：Frontiers in pharmacology

authors： Davino G,D'Alvano T,Esposito S

更新日期：2020-11-18 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) are bioactive lipids which modulate inflammation and immunity. They gained recognition in nutritional therapy and are recommended dietary supplements. There is a growing body of evidence suggesting the usefulness of PUFAs in active therapy of various gastrointestinal (GI) diseases. ...

journal_title：Frontiers in pharmacology

authors： Michalak A,Mosińska P,Fichna J

更新日期：2016-12-01 00:00:00

abstract：:DT-13, a saponin monomer 13 from the dwarf lilyturf tuber, was reported to exhibit anti-inflammatory, hepatoprotective, cardioprotective as well as antitumor activities in a number of tumor cells. Prostate cancer is the second leading cause of cancer death in males, discovery of novel antitumor drug for therapy of pro...

journal_title：Frontiers in pharmacology

authors： Wang Z,Wang Y,Zhu S,Liu Y,Peng X,Zhang S,Zhang Z,Qiu Y,Jin M,Wang R,Zhong Y,Kong D

更新日期：2018-12-07 00:00:00

abstract：:Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e., a type of sensiti...

journal_title：Frontiers in pharmacology

authors： Wuo-Silva R,Fukushiro-Lopes DF,Fialho BP,Hollais AW,Santos-Baldaia R,Marinho EAV,Mári-Kawamoto E,Yokoyama TS,Lopes-Silva LB,Berro LF,Frussa-Filho R,Longo BM

更新日期：2019-03-11 00:00:00

abstract：:Marantodes pumilum (Primulaceae) has been used in Malaysian folk medicine to help women regain strength after delivery and for "sickness in the bones." It was previously revealed that its extracts inhibited xanthine oxidase (XO) activity in vitro. The leaves and roots of M. pumilum var. alata (MPA), var. pumila (MPP),...

journal_title：Frontiers in pharmacology

authors： Rahmi EP,Kumolosasi E,Jalil J,Husain K,Buang F,Abd Razak AF,Jamal JA

更新日期：2020-03-17 00:00:00

abstract：:Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric car...

journal_title：Frontiers in pharmacology

authors： Hua S,Wu SY

更新日期：2013-11-21 00:00:00

abstract：:Objective: Children with autism spectrum disorder (ASD) commonly exhibit comorbid symptoms such as aggression, hyperactivity and anxiety. Several studies are being conducted worldwide on cannabidiol use in ASD; however, these studies are still ongoing, and data on the effects of its use is very limited. In this study ...

journal_title：Frontiers in pharmacology

authors： Barchel D,Stolar O,De-Haan T,Ziv-Baran T,Saban N,Fuchs DO,Koren G,Berkovitch M

更新日期：2019-01-09 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically used to treat acute promyelocytic leukemia (APL) by targeting PML/RARA. However, the drug's activity is broader and the mechanisms of action in other tumor types remain unclear. In this study, we investigated molecular ...

journal_title：Frontiers in pharmacology

authors： Dawood M,Hamdoun S,Efferth T

更新日期：2018-02-27 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:[This corrects the article on p. 161 in vol. 3, PMID: 22993507.]. ...

journal_title：Frontiers in pharmacology

authors： Villalba-Galea CA

更新日期：2015-05-29 00:00:00