Chijabyukpi-Tang Inhibits Pro-Inflammatory Cytokines and Chemokines via the Nrf2/HO-1 Signaling Pathway in TNF-α/IFN-γ-Stimulated HaCaT Cells and Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice.

abstract：:Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adult...

journal_title：Frontiers in pharmacology

authors： Ragavendran C,Srinivasan R,Kim M,Natarajan D

更新日期：2018-11-26 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:We evaluated the prevalence of and risk factors for hypersensitivity reactions related to carboplatin, which is commonly used to treat gynecological malignancies. All women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with carboplatin alone or a carboplatin-based combina...

journal_title：Frontiers in pharmacology

authors： Tai YH,Tai YJ,Hsu HC,Lee SP,Chen YY,Chiang YC,Chen YL,Chen CA,Cheng WF

更新日期：2017-11-06 00:00:00

abstract：:Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment exits for them; likely as result of the absence of neural markers associated to memory. Neurotransmitter systems and signaling pathways have been implicated in memory and dysfunctional memory; however, their role is poorly under...

journal_title：Frontiers in pharmacology

authors： Meneses A

更新日期：2015-07-21 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic autoimmune and degenerative disease of the central nervous system, and conventional treatments have limited efficacy or side effects. Ghrelin, a 28-amino acid octanoylated peptide, has been reported to have neuroprotective effects, including anti-oxidation, anti-inflammation, and a...

journal_title：Frontiers in pharmacology

authors： Liu F,Li Z,He X,Yu H,Feng J

更新日期：2019-11-06 00:00:00

abstract：:Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research. The recent availability of iPRECIO(®), a...

journal_title：Frontiers in pharmacology

authors： Tan T,Watts SW,Davis RP

更新日期：2011-07-29 00:00:00

abstract：:This study explores historical iatrosophia texts from Cyprus from a botanical and medico-pharmacological point of view focusing on remedies containing resins and gums. The iatrosophia are a genre of Greek medical literature of Byzantine origin and can be described as medicine handbooks which serve as therapeutic repos...

journal_title：Frontiers in pharmacology

authors： Lardos A,Prieto-Garcia J,Heinrich M

更新日期：2011-07-01 00:00:00

abstract：:Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described - OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2), and OAT2 transcript variant 3 (OAT2-tv3). Early studies helping to define the liga...

journal_title：Frontiers in pharmacology

authors： Hotchkiss AG,Berrigan L,Pelis RM

更新日期：2015-10-06 00:00:00

abstract：:Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

journal_title：Frontiers in pharmacology

authors： Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

更新日期：2020-04-22 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with a high incidence, mortality and disability rate. Danhong injection (DHI) is beneficial for ischemic stroke, but is prohibited for ICH due to risk of bleeding. The present study aims to explore the potential therapeutic time window and molecular me...

journal_title：Frontiers in pharmacology

authors： Wang S,Yu L,Sun G,Liu Y,Hu W,Liu Y,Peng T,Wang X,Cheng J,Sr A,Qin B,Lu H

更新日期：2020-03-25 00:00:00

abstract：:The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumacaftor (VX-809), stab...

journal_title：Frontiers in pharmacology

authors： Laselva O,Marzaro G,Vaccarin C,Lampronti I,Tamanini A,Lippi G,Gambari R,Cabrini G,Bear CE,Chilin A,Dechecchi MC

更新日期：2018-07-04 00:00:00

abstract：:Aims: The present study aims to detect the effect of acanthoic acid (AA) on alcohol exposure-induced liver lipid deposition and inflammation, and to explore the mechanisms. Methods: C57BL/6 mice were pretreated with single dose of AA (20 and 40 mg/kg) by oral gavage or equal volume of saline, and then exposed to three...

journal_title：Frontiers in pharmacology

authors： Yao YL,Han X,Li ZM,Lian LH,Nan JX,Wu YL

更新日期：2017-03-16 00:00:00

abstract：:The hepatotoxicity induced by Polygoni Multiflori Radix Praeparata (PM) has aroused great concern throughout the world. Hence, it is worthwhile to perform studies on the detoxification with the combined use of medicinal herbs based on the compatibility theory of traditional Chinese medicine. In this work, the rat mode...

journal_title：Frontiers in pharmacology

authors： Gao D,Pang JY,Zhang CE,Li CY,Tu C,Zhang HZ,Niu M,Xiong Y,Xiao XH,Zhao KJ,Gao WW,Wang JB

更新日期：2016-10-18 00:00:00

abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...

journal_title：Frontiers in pharmacology

authors： Huang YH,Chaousis S,Cheneval O,Craik DJ,Henriques ST

更新日期：2015-02-09 00:00:00

abstract：:Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely ...

journal_title：Frontiers in pharmacology

authors： Ménard C,Quirion R

更新日期：2012-10-12 00:00:00

abstract：:Lead is a multi-organ toxicant implicated in various cancers, diseases of the hepatic, renal, and reproductive systems etc. In search of cheap and readily available antidote this study has investigated the role of activated charcoal in chronic lead exposure in albino rats. Eighteen mature male albino rats were used, d...

journal_title：Frontiers in pharmacology

authors： Offor SJ,Mbagwu HO,Orisakwe OE

更新日期：2017-03-14 00:00:00

abstract：:Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environment...

journal_title：Frontiers in pharmacology

authors： Sundar IK,Rahman I

更新日期：2011-08-30 00:00:00

abstract：:Background: Isorhapontigenin (trans-3,5,4'-trihydroxy-3'-methoxystilbene, ISO), a dietary resveratrol (trans-3,5,4'-trihydroxystilbene) derivative, possesses various health-promoting activities. To further evaluate its medicinal potentials, the pharmacokinetic and metabolomic profiles of ISO were examined in Sprague-D...

journal_title：Frontiers in pharmacology

authors： Dai Y,Yeo SCM,Barnes PJ,Donnelly LE,Loo LC,Lin HS

更新日期：2018-07-11 00:00:00

abstract：:The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial transport. Although...

journal_title：Frontiers in pharmacology

authors： Kunzelmann K,Ousingsawat J,Cabrita I,Doušová T,Bähr A,Janda M,Schreiber R,Benedetto R

更新日期：2019-01-29 00:00:00

abstract：RATIONALE:Alzheimer's disease (AD) is a debilitating disease with complex pathophysiology. Amyloid beta (Aβ) (1-42) is a reliable model of AD that recapitulates many aspects of human AD. OBJECTIVE:The intent of the present study was to investigate the neuroprotective potential of Coenzyme Q10 (CoQ10) and its modulatio...

journal_title：Frontiers in pharmacology

authors： Singh A,Kumar A

更新日期：2015-11-09 00:00:00

abstract：:The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. However, the specific mechanism of N. chinensis is not yet clear. Nardochinoid C (DC) is a new compound with new skeleton isolated from N. chinensis and this study for the first time explored the anti-inflammat...

journal_title：Frontiers in pharmacology

authors： Luo JF,Shen XY,Lio CK,Dai Y,Cheng CS,Liu JX,Yao YD,Yu Y,Xie Y,Luo P,Yao XS,Liu ZQ,Zhou H

更新日期：2018-09-04 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. In this study, we found that a traditional Chinese decoction, Juanbi-Tang (JBT), JBT attenuated the symptoms of collagen-induced arthritis (CIA) mice and in tumor necrosis factor transgenic (TNF-Tg) mice...

journal_title：Frontiers in pharmacology

authors： Wang T,Jia Q,Chen T,Yin H,Tian X,Lin X,Liu Y,Zhao Y,Wang Y,Shi Q,Huang C,Xu H,Liang Q

更新日期：2020-02-14 00:00:00

abstract：:2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT2A), 2B (5-HT2B), and (5-HT2C) rec...

journal_title：Frontiers in pharmacology

authors： Papaseit E,Olesti E,Pérez-Mañá C,Torrens M,Grifell M,Ventura M,Pozo OJ,de Sousa Fernandes Perna EB,Ramaekers JG,de la Torre R,Farré M

更新日期：2020-03-18 00:00:00

abstract：:Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves has specific characteristics and responds differently to alleviating drugs at cephalic versus extracephalic level. This is especially true for tricyclic antidepressants currently used for alleviating neuropathic pain in humans...

journal_title：Frontiers in pharmacology

authors： M'Dahoma S,Poitevin M,Dabala E,Payan H,Gabriel C,Mocaër E,Bourgoin S,Hamon M

更新日期：2018-06-07 00:00:00

abstract：:The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables...

journal_title：Frontiers in pharmacology

authors： Sercombe L,Veerati T,Moheimani F,Wu SY,Sood AK,Hua S

更新日期：2015-12-01 00:00:00

abstract：:Purpose: The present study compared the risk of ischemic stroke in atrial fibrillation (AF) patients receiving digoxin and amiodarone. Methods: A retrospective cohort study was conducted using the longitudinal population-based database of Taiwan's National Health Insurance program. Patients with AF who received amioda...

journal_title：Frontiers in pharmacology

authors： Lai KC,Chen SJ,Lin CS,Yang FC,Lin CL,Hsu CW,Huang WC,Kao CH

更新日期：2018-05-07 00:00:00

abstract：:Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system. Recently it has been demonstrated that Salvinorin A inhibits acute inflammatory response affecting leukotriene (LT) production. Since LTs are pot...

journal_title：Frontiers in pharmacology

authors： Rossi A,Caiazzo E,Bilancia R,Riemma MA,Pagano E,Cicala C,Ialenti A,Zjawiony JK,Izzo AA,Capasso R,Roviezzo F

更新日期：2017-01-13 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Zhao L,Hu C,Wang T,Lu J,Wu C,Chen L,Jin M,Hu H,Ji G,Cao Q,Jiang Y

更新日期：2020-02-28 00:00:00

abstract：:Red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM) induce endothelial dysfunction and impair cardiac function following ischemia via increase in RBC arginase and oxidative stress. Here, we aimed to elucidate whether the effect of RBC-mediated cardiac impairment following ischemia and endothelial...

journal_title：Frontiers in pharmacology

authors： Mahdi A,Jiao T,Yang J,Kövamees O,Alvarsson M,von Heijne M,Zhou Z,Pernow J

更新日期：2019-08-02 00:00:00