Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer.

abstract：:Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developi...

journal_title：Frontiers in pharmacology

authors： Yeung AWK,Heinrich M,Atanasov AG

更新日期：2018-03-15 00:00:00

abstract：:The increase of non-communicable diseases at all ages has fostered the general concern for sustaining population health worldwide. Unhealthy lifestyles and dietary habits impacting physical and psycho-social health are well known risk factors for developing life threatening diseases. Identifying the determinants of qu...

journal_title：Frontiers in pharmacology

authors： Ruano-Rodríguez C,Serra-Majem L,Dubois D

更新日期：2015-05-08 00:00:00

abstract：:Despite improvements in early diagnosis and treatment, breast cancer is still a major health problem worldwide. Among breast cancer subtypes, the most challenging and harder to treat is represented by triple-negative molecular subtype. Due to its intrinsic features this subtype cannot be treated neither with hormonal ...

journal_title：Frontiers in pharmacology

authors： Lastraioli E

更新日期：2020-05-20 00:00:00

abstract：:Background: There is conflicting evidence on the impact of biologic treatment on the rate of complications and surgeries in Crohn's disease (CD). We aimed to assess real-world consequences of biologic treatment of CD. Methods: All adult patients with CD treated with infliximab and adalimumab in the years 2012-2014 wer...

journal_title：Frontiers in pharmacology

authors： Holko P,Kawalec P,Pilc A

更新日期：2018-06-11 00:00:00

abstract：:Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with intravenous drug self-administration procedure to verify whether depr...

journal_title：Frontiers in pharmacology

authors： Amchova P,Kucerova J,Giugliano V,Babinska Z,Zanda MT,Scherma M,Dusek L,Fadda P,Micale V,Sulcova A,Fratta W,Fattore L

更新日期：2014-03-20 00:00:00

abstract：:Emerging evidence has demonstrated that epigenetic regulation plays a vital role in gene expression under normal and pathological conditions. Alterations in the expression and activation of histone methyltransferases (HMTs) have been reported in preclinical models of multiple kidney diseases, including acute kidney in...

journal_title：Frontiers in pharmacology

authors： Yu C,Zhuang S

更新日期：2019-12-06 00:00:00

abstract：:In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the therapeutic effect of a ...

journal_title：Frontiers in pharmacology

authors： Reinehr S,Gomes SC,Gassel CJ,Asaad MA,Stute G,Schargus M,Dick HB,Joachim SC

更新日期：2019-12-02 00:00:00

abstract：:Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcriptio...

journal_title：Frontiers in pharmacology

authors： Axelsen LN,Calloe K,Holstein-Rathlou NH,Nielsen MS

更新日期：2013-10-22 00:00:00

abstract：:Neuronal insulin resistance is implicated in neurodegenerative diseases. Icariin has been reported to improve insulin resistance in skeletal muscle cells and to restore impaired hypothalamic insulin signaling in the rats with chronic unpredictable mild stress. In addition, icariin can exert the neuroprotective effects...

journal_title：Frontiers in pharmacology

authors： Zou X,Feng X,Fu Y,Zheng Y,Ma M,Wang C,Zhang Y

更新日期：2020-06-09 00:00:00

abstract：:A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Ther...

journal_title：Frontiers in pharmacology

authors： Lewenhofer V,Schweighofer L,Ledermüller T,Eichsteininger J,Kählig H,Zehl M,Nguyen CH,Krupitza G,Özmen A,Krenn L

更新日期：2018-04-03 00:00:00

abstract：:Several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low K(m) and k(cat) values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants for retinaldehyde is...

journal_title：Frontiers in pharmacology

authors： Ruiz FX,Porté S,Parés X,Farrés J

更新日期：2012-04-17 00:00:00

abstract：Background:The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstream of the CYP2D6 gene ...

journal_title：Frontiers in pharmacology

authors： Boone EC,Wang WY,Gaedigk R,Cherner M,Bérard A,Leeder JS,Miller NA,Gaedigk A

更新日期：2020-05-08 00:00:00

abstract：:Background: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), which is commonly used today in treating cardiovascular diseases. SBP consists of seven materials thereof, including Moschus, extract of Ginseng Radix et Rhizoma, Bovis Calculus Artifactus, Cinnamomi Cortex,...

journal_title：Frontiers in pharmacology

authors： Xu ML,Zheng ZY,Xia YJ,Liu EY,Chan SK,Hu WH,Duan R,Dong TT,Zhan CS,Shang XH,Tsim KW

更新日期：2019-10-09 00:00:00

abstract：:Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cyto...

journal_title：Frontiers in pharmacology

authors： Zhang X,Liu Y,Lu L,Huang S,Ding Y,Zhang Y,Guo Q,Li Z,Zhao L

更新日期：2017-08-11 00:00:00

abstract：:Intestinal barrier dysfunction is an important clinical problem in various acute and chronic pathological conditions. Ferulic acid (FA) can attenuate the intestinal epithelial barrier dysfunction, however, the underlying mechanism remains unclear. The present study aimed to uncover the protective effect of FA on intes...

journal_title：Frontiers in pharmacology

authors： He S,Guo Y,Zhao J,Xu X,Wang N,Liu Q

更新日期：2020-04-03 00:00:00

abstract：:Three new dimeric naphthoquinones, 5,4'-dihydroxy-1'-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,5',8'-tetraone (1), 5',8'-dihydroxy-5-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2) and 8,5',8'-trihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (3), were isolated from the roots of Diospyros lotus....

journal_title：Frontiers in pharmacology

authors： Rauf A,Uddin G,Siddiqui BS,Molnár J,Csonka Á,Ahmad B,Szabó D,Farooq U,Khan A

更新日期：2015-12-16 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before...

journal_title：Frontiers in pharmacology

authors： Puiu AA,Radke S,Votinov M,Habel U,Herpertz-Dahlmann B,Turetsky B,Konrad K

更新日期：2019-11-21 00:00:00

abstract：:Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

journal_title：Frontiers in pharmacology

authors： Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

更新日期：2020-08-12 00:00:00

abstract：:The inhibitors for EGF receptor tyrosine kinase (EGFR-TKIs) such as gefitinib have been used as a standard treatment for non-small cell lung cancer (NSCLC), but the increasingly occurrence of drug resistance, the associated adverse effects and the enrichment of cancer stem cells significantly impedes its clinical appl...

journal_title：Frontiers in pharmacology

authors： Cheng H,Ge X,Zhuo S,Gao Y,Zhu B,Zhang J,Shang W,Xu D,Ge W,Shi L

更新日期：2018-11-30 00:00:00

abstract：:Oncogenic activation of the KRAS gene via point mutations occurs in 20-30% of patients with non-small cell lung cancer (NSCLC). The RAS-RAF-ERK and RAS-PI3K-AKT pathways are the major hyper-activated downstream pathways in RAS mutation, which promotes the unlimited lifecycle of cancer cells and their metastasis in hum...

journal_title：Frontiers in pharmacology

authors： Lai H,Wang Y,Duan F,Li Y,Jiang Z,Luo L,Liu L,Leung ELH,Yao X

更新日期：2018-08-22 00:00:00

abstract：:Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has a multitude of deleterious side-effects including skeletal muscle wasting and fatigue, which considerably reduces patient quality of life and survivability. As such, a defense against chemotherapy-induced skeletal muscle d...

journal_title：Frontiers in pharmacology

authors： Sorensen JC,Petersen AC,Timpani CA,Campelj DG,Cook J,Trewin AJ,Stojanovska V,Stewart M,Hayes A,Rybalka E

更新日期：2017-04-10 00:00:00

abstract：:Antipsychotic drugs are often used for the treatment of behavioral and psychological symptoms of dementia (BPSD), especially psychosis and behavioral disturbances (e.g., aggression and agitation). They are prescribed alone or in conjunction with anti-dementia (e.g., anti-Alzheimer's disease drugs) and other psychotrop...

journal_title：Frontiers in pharmacology

authors： Ohno Y,Kunisawa N,Shimizu S

更新日期：2019-09-17 00:00:00

abstract：:Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern heal...

journal_title：Frontiers in pharmacology

authors： Marshall ML,Wagstaff KM

更新日期：2020-07-24 00:00:00

abstract：:Neonatal epileptic encephalopathy (NEE), as a result of pyridoxine 5'-phosphate oxidase (PNPO) deficiency, is a rare neural disorder characterized by intractable seizures and usually leads to early infant death. The clinical phenotypes do not respond to antiepileptic drugs but are alleviated in most cases by giving la...

journal_title：Frontiers in pharmacology

authors： Chen PY,Tu HC,Schirch V,Safo MK,Fu TF

更新日期：2019-09-20 00:00:00

abstract：:Over 1 million cases of scorpion stings are estimated every year, whereas current treatment is limited to antivenom serum combined with supportive therapy. Tityus serrulatus scorpion venom (TsV) is composed of diverse molecules, including toxins that induce a catecholamine storm and mediate classical symptoms of scorp...

journal_title：Frontiers in pharmacology

authors： Zoccal KF,Gardinassi LG,Bordon KCF,Arantes EC,Marleau S,Ong H,Faccioli LH

更新日期：2019-03-01 00:00:00

abstract：:Diabetic kidney disease (DKD) is a major health problem and one of the leading causes of end-stage renal disease worldwide. Despite recent advances, there exists an urgent need for the development of new treatments for DKD. DKD is characterized by the excessive synthesis and deposition of extracellular matrix proteins...

journal_title：Frontiers in pharmacology

authors： Sakuma H,Hagiwara S,Kantharidis P,Gohda T,Suzuki Y

更新日期：2020-11-13 00:00:00

abstract：:The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, we have investigated...

journal_title：Frontiers in pharmacology

authors： Saleh N,Kleinau G,Heyder N,Clark T,Hildebrand PW,Scheerer P

更新日期：2018-06-01 00:00:00

abstract：:Hypoxia is an important micro-environmental characteristic of rheumatoid arthritis (RA). Hypoxia-inducible factors (HIF) are key transcriptional factors that are highly expressed in RA synovium to regulate the adaptive responses to this hypoxic milieu. Accumulating evidence supports hypoxia and HIFs in regulating a nu...

journal_title：Frontiers in pharmacology

authors： Hua S,Dias TH

更新日期：2016-06-27 00:00:00

abstract：:Normal aging is generally characterized by a slow decline of cognitive abilities albeit with marked individual differences. Several animal models have been studied to explore the molecular and cellular mechanisms underlying this phenomenon. The excitatory neurotransmitter glutamate and its receptors have been closely ...

journal_title：Frontiers in pharmacology

authors： Ménard C,Quirion R

更新日期：2012-10-12 00:00:00