Abstract：
:Orientin is a flavonoid extracted from Chinese traditional herb, Polygonum orientale L. Previous study has reported that orientin protected myocardial from ischemia reperfusion injury. However, whether orientin could protect against cardiac remodeling after myocardial injury remains unclear. The aim of our study is to investigate the effects of orientin in the progression of cardiac remodeling after myocardial infarction (MI). Mice cardiac remodeling model was established by left coronary artery ligation surgery. Experimental groups were as follows: vehicle-sham, orientin-sham, vehicle-MI, and orientin-MI. Animals were treated with vehicle or orientin (40 mg/kg) for 25 days starting 3 days after surgery. After 4 weeks of MI, mice with orientin treatment had decreased mortality and improved cardiac function. Significantly, at 4 weeks post-MI, orientin treatment decreased fibrosis, inflammatory response, and cardiomyocyte apoptosis. Furthermore, orientin treatment attenuated the hypoxia-induced neonatal rat cardiomyocyte apoptosis and increased cell viability. Additionally, orientin supplementation mitigated oxidative stress in remodeling heart tissue and cardiomyocytes exposed to hypoxia as measured by 2',7'-dichlorodihydrofluorescein diacetate fluorescent probe. Mechanistically, orientin promotes cardioprotection by activating the eNOS/NO signaling cascades, which was confirmed by eNOS inhibitor (L-NAME) in vitro and in vivo. Inhibition of oxidative stress by orientin via eNOS/NO signaling cascades in the heart may represent a potential therapy for cardiac remodeling.
journal_name
Front Pharmacoljournal_title
Frontiers in pharmacologyauthors
Li F,Zong J,Zhang H,Zhang P,Xu L,Liang K,Yang L,Yong H,Qian Wdoi
10.3389/fphar.2017.00926subject
Has Abstractpub_date
2017-12-21 00:00:00pages
926issn
1663-9812journal_volume
8pub_type
杂志文章abstract：:Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, the...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00857
更新日期：2019-08-06 00:00:00
abstract：:The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. However, the specific mechanism of N. chinensis is not yet clear. Nardochinoid C (DC) is a new compound with new skeleton isolated from N. chinensis and this study for the first time explored the anti-inflammat...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.00911
更新日期：2018-09-04 00:00:00
abstract：:Persistent activation of STAT3 plays an important role in the development of triple-negative breast cancer (TNBC), and suppression of STAT3 is considered as a novel approach for cancer therapy. In this project, we aimed to examine the anticancer activity and molecular mechanism of eupalinolide J (EJ) in TNBC cells. Th...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01071
更新日期：2019-09-19 00:00:00
abstract：:The immune system is complex and pervasive as it functions to prevent or limit infections in the human body. In a healthy organism, the immune system and the redox balance of immune cells maintain homeostasis within the body. The failure to maintain the balance may lead to impaired immune response and either over acti...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2017.00022
更新日期：2017-01-30 00:00:00
abstract：INTRODUCTION:Nicotinic acetylcholine receptors are present in the cerebral white matter (WM). We hypothesized that WM response to nicotine can be detected by diffusion tensor imaging (DTI); and that such responses may be associated with nicotine-led cognitive enhancement in sustained attention. METHODS:A randomized, n...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2013.00117
更新日期：2013-09-18 00:00:00
abstract：:Cannabis has been used for medicinal purposes for thousands of years. The prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years there is a growing debate about the use of cannabis for medical purposes. The term 'medical cannabis' refers to physician-recommended use o...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2018.01259
更新日期：2018-11-13 00:00:00
abstract：:Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases. Tanshinones are the main active ingredients in S. miltiorrhiza and exhi...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2019.00202
更新日期：2019-03-14 00:00:00
abstract：:SARS-CoV-2 is the most recent coronavirus which crossed the species barrier in 2019 and provoked a still ongoing and dangerous pandemic known as coronavirus disease 2019 (COVID-19). The SARS-CoV-2 infection has triggered an impressive amount of clinical and experimental studies to identify an effective and safe therap...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.01224
更新日期：2020-08-26 00:00:00
abstract：:Radiotherapy and chemotherapy are widespread clinical modalities for cancer treatment. Among other biological influences, hypoxia is a main factor limiting the efficacy of radiotherapy, primarily because oxygen is involved in the stabilization of the DNA damage caused by ionizing radiations. Radiobiological hypoxia is...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2012.00094
更新日期：2012-05-21 00:00:00
abstract：:Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are well-known complications affecting patients undergoing intestinal surgery. GI symptoms include nausea, vomiting, pain, abdominal distention, bloating, and constipation. These iatrogenic disorders are associated with extended hosp...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.583422
更新日期：2020-11-24 00:00:00
abstract：:Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00162
更新日期：2020-02-28 00:00:00
abstract：:Asthma is a chronic inflammatory disease characterized by airflow limitation and variable respiratory symptoms. It is characterized by variable symptoms such as cough, wheeze, chest tightness, and shortness of breath which vary in intensity and time. In order to reach a comprehensive approach of disease management, th...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.00542
更新日期：2020-05-06 00:00:00
abstract：:Cyclic adenosine monophosphate (cAMP) is a well-known intracellular and intercellular second messenger. The membrane permeability of such molecules has potential importance for autocrine-like or paracrine-like delivery. Here experiments have been designed to demonstrate whether gap junction hemichannels, composed of c...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2013.00075
更新日期：2013-06-06 00:00:00
abstract：:The dysregulation of hepatic lipid metabolism is one of the hallmarks in many liver diseases including alcoholic liver diseases (ALD) and non-alcoholic fatty liver diseases (NAFLD). Hepatic inflammation, lipoperoxidative stress as well as the imbalance between lipid availability and lipid disposal, are direct causes o...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2020.00351
更新日期：2020-03-24 00:00:00
abstract：:There is urgent need for the development of mechanistically different and less side-effect prone antipsychotic compounds. The endocannabinoid system has been suggested to represent a potential new target in this indication. While the chronic use of cannabis itself has been considered a risk factor contributing to the ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章,评审
doi：10.3389/fphar.2016.00422
更新日期：2016-11-08 00:00:00
abstract：:Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critical for hypertensive...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.00176
更新日期：2018-03-09 00:00:00
abstract：:Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.00985
更新日期：2020-07-09 00:00:00
abstract：:As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes. Intracellular calcium is critical for TRPM2 channel activation and the IQ-like motif in th...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.00581
更新日期：2018-06-04 00:00:00
abstract：:Background: Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), which is commonly used today in treating cardiovascular diseases. SBP consists of seven materials thereof, including Moschus, extract of Ginseng Radix et Rhizoma, Bovis Calculus Artifactus, Cinnamomi Cortex,...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01130
更新日期：2019-10-09 00:00:00
abstract：:Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the bioactive compounds...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01427
更新日期：2019-12-19 00:00:00
abstract：:Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and instead exert their effects through other receptors. Here, we in...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01124
更新日期：2019-09-27 00:00:00
abstract：:In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtuall...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2017.00610
更新日期：2017-09-08 00:00:00
abstract：:Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP). Methods: This study adopted a multicenter, prospective, and real world design. BPH patients undergoing TUPKP ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.01426
更新日期：2019-11-27 00:00:00
abstract：:Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2015.00204
更新日期：2015-09-22 00:00:00
abstract：:The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistan...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2019.00692
更新日期：2019-06-21 00:00:00
abstract：:Studies proved that among all α1-adrenoceptors, cardiac myocytes functionally express only α1A- and α1B-subtype. Scientists indicated that α1A-subtype blockade might be beneficial in restoring normal heart rhythm. Therefore, we aimed to determine the role of α1-adrenoceptors subtypes (i.e., α1A and α1B) in antiarrhyth...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2016.00229
更新日期：2016-08-03 00:00:00
abstract：:There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on the strength of the correlation between biomarker concentrations and exposure/effects. In the current study, a combined exposur...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2014.00246
更新日期：2014-11-18 00:00:00
abstract：:A better understanding of the negative impact of general anesthetics on gastrointestinal motility requires thorough knowledge of their molecular targets. In this respect the muscarinic cationic current (mICAT carried mainly via TRPC4 channels) that initiates cholinergic excitation-contraction coupling in the gut is of...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2020.594882
更新日期：2020-12-18 00:00:00
abstract：:The hepatotoxicity induced by Polygoni Multiflori Radix Praeparata (PM) has aroused great concern throughout the world. Hence, it is worthwhile to perform studies on the detoxification with the combined use of medicinal herbs based on the compatibility theory of traditional Chinese medicine. In this work, the rat mode...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2016.00386
更新日期：2016-10-18 00:00:00
abstract：:Introduction: There are increasing concerns world-wide with growing rates of antibiotic resistance necessitating urgent action. There have been a number of initiatives in the Republic of Srpska in recent years to address this and improve rational antibiotic prescribing and dispensing despite limited resources to fund ...
journal_title：Frontiers in pharmacology
pub_type： 杂志文章
doi：10.3389/fphar.2018.00442
更新日期：2018-05-29 00:00:00
